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Susana de las Mercedes Contreras Duarte

Assistant Professor

Universidad San Sebastián

Santiago, Chile

Metabolismo lipídico; Funcionalidad de las Lipoproteinas de alta densidad (HDL) en patologías metabólicas; Antioxidantes sobre el metabolismo del colesterol y aterosclerósis; diabetes gestacional, dislipidemias postparto y embarazo, leche materna

Medical Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2016
Licenciado en Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2010

PhD student (ANID) Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2012 - 2016
Postdoctor (ANID) Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2018 - 2021
Assistant Professor Full Time

Universidad San Sebastián

Health Care Sciences

Santiago, Chile

2021 - A la fecha

Research assistant Full Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2010 - 2011
Research assistant Part Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2008 - 2009
Research assistant Other

Universidad de Chile

Santiago, Chile

2009 - 2009
Postdoctor Full Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2017 - 2017

Extension PhD Fellowship

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2016

6 month extension PhD funding
PhD Fellowship 2012-2016

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2012

Funding for the development of the Medical Science PhD program
Internship PhD Fellowship

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2015

Funding to develop one goal of the PhD thesis abroad (Austria)
Congresses and short courses abroad PhD Fellowship

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2012

Attendance to Lyon, to the European Atherosclerosis Society congress


High total cholesterol and triglycerides levels increase arginases metabolism, impairing nitric oxide signaling and worsening fetoplacental endothelial dysfunction in gestational diabetes mellitus pregnancies Contreras-Duarte, S.; Cantin, C.; Farias, M.; Leiva, A. Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)
Cholesterol uptake and efflux are impaired in human trophoblast cells from pregnancies with maternal supraphysiological hypercholesterolemia Fuenzalida B.; Cantin C.; Kallol S.; Carvajal L.; PastÃ©n V.; Contreras-Duarte S.; Albrecht C.; Gutierrez J.; Leiva A. Article ISI SCOPUS SCIENTIFIC REPORTS (2020)
Gestational Diabetes Mellitus Treatment Schemes Modify Maternal Plasma Cholesterol Levels Dependent to Women's Weight: Possible Impact on Feto-Placental Vascular Function Contreras-Duarte S.; Carvajal L.; Garchitorena M.J.; Subiabre M.; Fuenzalida B.; Cantin C.; FarÃas M.; Leiva A. Article ISI SCOPUS NUTRIENTS (2020)
Interferon-gamma and high glucose-induced opening of Cx43 hemichannels causes endothelial cell dysfunction and damage Saez, Juan C.; Contreras-Duarte, Susana; Labra, Valeria C.; Santibanez, Cristian A.; Mellado, Luis A.; Inostroza, Carla A.; Alvear, Tanhia F.; Retamal, Mauricio A.; Velarde, Victoria; Orellana, Juan A. Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2020)
Attenuation of atherogenic apo B-48-dependent hyperlipidemia and high density lipoprotein remodeling induced by vitamin C and E combination and their beneficial effect on lethal ischemic heart disease in mice Contreras-Duarte, S.; Chen, P.; Andía, M.; Uribe, S.; Irarrázaval, P.; Kopp, S.; Kern, S.; Marsche, G.; Busso, D.; Wadsack, C.; Rigotti, A. Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2018)
Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function Sáez, Juan C.; Contreras-Duarte, Susana; Gómez, Gonzalo I.; Labra, Valeria C.; Santibañez, Cristian A.; Gajardo-Gómez, Rosario; Avendaño, Beatriz C.; Díaz, Esteban F.; Montero, Trinidad D.; Velarde, Victoria; Orellana, Juan A. Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2018)
Foetoplacental epigenetic changes associated with maternal metabolic dysfunction. Kerr, Bredford; Leiva, Andrea; Farías, Marcelo; Contreras-Duarte, Susana; Toledo, Fernando; Stolzenbach, Francisca; Silva, Luis; Sobrevia, Luis Article Placenta (2018)
High density lipoprotein cholesterol and proteome in SR-B1 KO mice: lost in precipitation Contreras-Duarte, Susana; Santander, Nicolas; Birner-Gruenberger, Ruth; Wadsack, Christian; Rigotti, Attilio; Busso, Dolores Article ISI SCOPUS JOURNAL OF TRANSLATIONAL MEDICINE (2018)
Maternal supraphysiological hypercholesterolemia associates with endothelial dysfunction of the placental microvasculature Fuenzalida, B; Sobrevia, B; Cantin, C; Carvajal, L; Salsoso, R; Gutierrez, J; Contreras-Duarte, S; Sobrevia, L; Leiva, A Article ISI SCOPUS SCIENTIFIC REPORTS (2018)
Role of extracellular vesicles in glioma progression. Quezada, Claudia; Torres, Ángelo; Niechi, Ignacio; Uribe, Daniel; Contreras-Duarte, Susana; Toledo, Fernando; San Martín, Rody; Gutiérrez, Jaime; Sobrevia, Luis Article Molecular aspects of medicine (2018)
Adenosine receptors=> Modulators of lipid availability that are controlled by lipid levels Leiva, Andrea; Guzmán-Gutiérrez, Enrique; Contreras-Duarte, Susana; Fuenzalida, Bárbara; Cantin, Claudette; Carvajal, Lorena; Salsoso, Rocío; Gutiérrez, Jaime; Pardo, Fabián; Sobrevia, Luis. Article MOLECULAR ASPECTS OF MEDICINE (2017)
Gugulipid causes hypercholesterolemia leading to endothelial dysfunction, increased atherosclerosis, and premature death by ischemic heart disease in male mice. Leiva, Andrea; Contreras-Duarte, Susana; Amigo, Ludwig; Sepúlveda, Esteban; Boric, Mauricio; Quiñones, Verónica; Busso, Dolores; Rigotti, Attilio Article PloS one (2017)
Platelet tissue factor activity and membrane cholesterol are increased in hypercholesterolemia and normalized by rosuvastatin, but not by atorvastatin Panes O.; González C.; Hidalgo P.; Valderas J.P.; Acevedo M.; Contreras S.; Sánchez X.; Pereira J.; Rigotti A.; Mezzano D. Article ISI SCOPUS ATHEROSCLEROSIS (2017)
[ANTIOXIDANT DYSFUNCTIONALITY OF HIGH-DENSITY LIPOPROTEINS (HDL) IN DECOMPENSATED DIABETIC PATIENTS]. Awad, Fernanda; Contreras-Duarte, Susana; Molina, Patricia; Quiñones, Verónica; Serrano, Valentina; Abbott, Eduardo; Maiz, Alberto; Busso, Dolores; Rigotti, Attilio Article Nutricion hospitalaria (2015)
[Protective role of high density lipoproteins in sepsis=> basic issues and clinical implications]. Contreras-Duarte, Susana; Varas, Pablo; Awad, Fernanda; Busso, Dolores; Rigotti, Attilio Article Revista chilena de infectologia => organo oficial de la Sociedad Chilena de Infectologia (2014)
Developmental abnormalities in mouse embryos lacking the HDL receptor SR-BI. Santander, Nicolás Guillermo; Contreras-Duarte, Susana; Awad, María Fernanda; Lizama, Carlos; Passalacqua, Isabella; Rigotti, Attilio; Busso, Dolores Article Human molecular genetics (2013)
Glucose increases intracellular free Ca(2+) in tanycytes via ATP released through connexin 43 hemichannels. Orellana, Juan A; Sáez, Pablo J; Cortés-Campos, Christian; Elizondo, Roberto J; Shoji, Kenji F; Contreras-Duarte, Susana; Figueroa, Vania; Velarde, Victoria; Jiang, Jean X; Nualart, Francisco; Sáez, Juan C; García, María A Article Glia (2012)
Hemichannels in the neurovascular unit and white matter under normal and inflamed conditions Orellana JA, Figueroa XF, Sánchez HA, Contreras-Duarte S, Velarde V, Sáez JC Article CNS Neurol Disord Drug Targets (2011)
Sitagliptina, un inhibidor de la enzima DPP-IV, aumenta el colesterol plasmático total, altera el perfil de colesterol lipoproteico y disminuye el transporte reverso de colesterol en ratones Leiva, Andrea; Varas, Pablo; Amigo, Ludwig; Contreras Duarte Susana; Maiz, Alberto; Rigotti, Attilio Article SCIELO Revista chilena de cardiología (2010)


Maternal Dyslipidaemia in Pregnancy with Gestational Diabetes Mellitus: Possible Impact on Foetoplacental Vascular Function and Lipoproteins in the Neonatal Circulation Contreras-Duarte, S; Carvajal, L; Fuenzalida, B; Cantin, C; Sobrevia, L; Leiva, A Review ISI CURRENT VASCULAR PHARMACOLOGY (2019)