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Attilio G Rigotti Rivera

Full Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

Our research groups is focused in studying the determinants of lipid and glucose metabolism and oxidative stress that are relevant in understanding the pathogenesis on dyslipidemia and diabetes as conditions leading to chronic diseases.

Medical Doctor, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1988
Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2000
Internal Medicine, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1991

Assistant Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicine

Chile

1998 - 2002
Visiting professor Full Time

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Estados Unidos

2001 - 2001
Full Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicine

Chile

2012 - A la fecha
Associate Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicine

Chile

2002 - A la fecha

Regular Member, Research Committee Part Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2000 - A la fecha
Regular Member, Committee of Ph.D. Program in Medical Sciences Part Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2002 - A la fecha
Research Director, School of Medicine Part Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2008 - A la fecha
Regular Member, Committee of Master Program in Nutrition Part Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2011 - A la fecha
Chairman, Department of Nutrition, Diabetes and Metabolism Part Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2012 - 2013
Director, Center of Molecular Nutrition and Chronic Diseases Full Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2012 - A la fecha

Postdoctoral Fellows
Álvaro MARTÍNEZ (BQ, PhD) 2008-2009
Nora MORGADO (PhD) 2001-2004

Master and Ph.D. Students
Víctor CORTES. Doctorado en Ciencias Médicas. Pontificia Universidad Católica de Chile. 2005
Cristina OLIVOS. Magíster en Nutrición. Pontificia Universidad Católica de Chile. 2007
Andrea LEIVA. Doctorado en Ciencias Médicas. Pontificia Universidad Católica de Chile. 2010
Patricia MOLINA. Magíster en Nutrición. Pontificia Universidad Católica de Chile. 2011
Grettel MARTELO. Magíster en Nutrición. Pontificia Universidad Católica de Chile. 2001

Undergraduate Students
Pablo MARDONES, Bioquímico. Pontificia Universidad Católica de Chile. 2001
Carla FERRADA, Bioquímico. Pontificia Universidad Católica de Chile. 2003
Andrea LEIVA, Bioquímico. Pontificia Universidad Católica de Chile. 2004
Gabriela MORALES, Bioquímico. Pontificia Universidad Católica de Chile. 2004
Mariela MUÑOZ, Bioquímico. Cotutela: Silvana Zanlungo. Pontificia Universidad Católica de Chile. 2007
Katherine DONOSO, Bioquímico. Pontificia Universidad Católica de Chile. 2008
Dania VALDOVINOS, Bioquímico. Pontificia Universidad Católica de Chile. 2009
Nicolás SANTANDER, Bioquímico. Pontificia Universidad Católica de Chile. 2012
Fernanda AWAD, Bioquímico. Pontificia Universidad Católica de Chile. 2012

Education and promotion of lifestyle changes through websites www.alimentatesano.cl and www.mifitbook.cl as a population level strategy to prevent chronic diseases in Chile

Medical Undergraduate Scholarship

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 1981

Best undergraduate medical student
Medical Undergraduate Scholarship

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 1982

Best undergraduate medical student
Best Publication of the Year Award

Medical Society of Chile

Chile, 1988

Award for best publication in basic science
Internal Medicine Fellowship

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 1988

Support for clinical training in Internal Medicine
PhD Scholarship

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 1991

Support for doctoral studies
Research Fellowship

Howard Hughes Medical Institute

Estados Unidos, 1994

Support for research training at Massachusetts Institute of Technology
Young Investigator Award

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 2001

Research award
Chilean Academy of Medicine

INSTITUTO DE CHILE

Chile, 2008

Research award
Senior Investigator Award

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 2012

Research award presented by School of Medicine


Cholesterol Levels and the Association of Statins With In-Hospital Mortality of Myocardial Infarction Patients Insights From a Chilean Registry of Myocardial Infarction Martinez, G; Rigotti, A.; Acevedo M.; Navarrete C.; Rosales, J.; Giugliano, RP; Corbalan, R Article ISI SCOPUS Clinical Cardiology (2013)
APOA5 Q97X Mutation Identified through homozygosity mapping causes severe hypertriglyceridemia in a Chilean consanguineous family Dussaillant C.; Serrano, V; Maiz A.; Eyheramendy, S; Cataldo L.R.; Chavez M.; Smalley S.V.; Fuentes M.; Rigotti, A.; Rubio, L.; Lagos, C. F.; Martínez J.A.; Santos, J.L. Article ISI SCOPUS BMC Medical Genetics (2012)
Niemann-Pick C2 Protein Expression Regulates Lithogenic Diet-Induced Gallstone Formation and Dietary Cholesterol Metabolism in Mice Balboa E.; Morales G.; Aylwin, P; Carrasco, G; Amigo, L; Castro J.; Rigotti, A.; Zanlungo S. Article ISI SCOPUS Lipids (2012)
"Cholesteryl ester transfer protein inhibition in the management of atherosclerotic cardiovascular disease: Second act ""a rebirth of hope"" Inhibición de la proteína de transferencia de ésteres de colesterol para el manejo de la enfermedad cardiovascular ateroesclerótica: El segundo acto ""una esperanza que renace""" Arteaga A.; Rigotti, A. Article REVISTA MEDICA DE CHILE (2011)
Apolipoprotein A-I deficiency does not affect biliary lipid secretion and gallstone formation in mice Amigo, L; Quiñones V.; Leiva A.; Busso, D.; Zanlungo S.; Nervi, F; Rigotti, A. Article ISI SCOPUS Liver International (2011)
Applying positive psychology to medical education Pedrals N.; Rigotti, A.; Bitran, M Article ISI REVISTA MEDICA DE CHILE (2011)
Cholecystectomy increases hepatic triglyceride content and very-low-density lipoproteins production in mice Amigo, L; Husche, C; Zanlungo S.; Lutjohann, D; Arrese M.; Miquel, JF; Rigotti, A.; Nervi, F Article ISI SCOPUS Liver International (2011)
Cholesteryl ester transfer protein inhibition in the management of atherosclerotic cardiovascular disease: second act "A rebirth of hope" Arteaga A.; Rigotti, A. Article ISI REVISTA MEDICA DE CHILE (2011)
Npc1 deficiency in the C57BL/6J genetic background enhances Niemann-Pick disease type C spleen pathology Parra J.; Klein, AD; Castro J.; Morales, MG; Mosqueira, M; Valencia I.; Cortés V.; Rigotti, A.; Zanlungo S. Article ISI SCOPUS Biochemical and Biophysical Research Communications (2011)
Deficiency of Niemann-Pick C1 protein protects against diet-induced gallstone formation in mice Morales, MG; Amigo, L; Balboa E.; Acuña M.; Castro J.; Molina, H; Miquel, JF; Nervi, F; Rigotti, A.; Zanlungo S. Article ISI SCOPUS Liver International (2010)
Prevalence of Metabolic Syndrome among Chilean adults Valenzuela, BAA; Maiz A.; Margozzini P.; Ferreccio C.; Rigotti, A.; Olea, R; Arteaga A. Article ISI REVISTA MEDICA DE CHILE (2010)
Prevalence of metabolic syndrome among chilean adults Prevalencia de síndrome metabólico en población adulta chilena: Datos de la encuesta nacional de salud 2003 Valenzuela Andrea A B.; Maiz A.; Arteaga A.; Margozzini P.; Ferreccio C.; Rigotti, A.; Olea, R Article REVISTA MEDICA DE CHILE (2010)
Prevalencia de síndrome metabólico en población adulta Chilena: Datos de la Encuesta Nacional de Salud 2003 VALENZUELA B, ANDREA A; Maiz, Alberto; Margozzini, Paula; Ferreccio, Catterina; Rigotti, Attilio; Olea, Ricardo; Arteaga, Antonio Article SCIELO REVISTA MEDICA DE CHILE (2010)
Sitagliptina, un inhibidor de la enzima DPP-IV, aumenta el colesterol plasmático total, altera el perfil de colesterol lipoproteico y disminuye el transporte reverso de colesterol en ratones Leiva, Andrea; Varas, Pablo; Amigo, Ludwig; Contreras Duarte Susana; Maiz, Alberto; Rigotti, Attilio Article SCIELO Revista chilena de cardiología (2010)
Age-related influence of the HDL receptor SR-BI on synaptic plasticity and cognition Chang, EH; Rigotti, A.; Huerta, PT Article ISI SCOPUS NEUROBIOLOGY OF AGING (2009)
Non-alcoholic fatty liver disease and its association with obesity, insulin resistance and increased serum levels of C-reactive protein in Hispanics Riquelme A.; Arrese M.; Soza A.; Morales A.; Baudrand R.; Perez-Ayuso, RM; González R.; Alvarez M.; Hernández, V.; Garcia-Zattera, MJ; Otarola, F.; Medina, B.; Rigotti, A.; Miquel, JF; Marshall G.; Nervi, F Article ISI SCOPUS LIVER INTERNATIONAL (2009)
Normal Hepatic Cell Surface Localization of the High Density Lipoprotein Receptor, Scavenger Receptor Class B, Type I, Depends on All Four PDZ Domains of PDZK1 Fenske, SA; Yesilaltay A.; Pal, R; Daniels K.; Barker, C; Quiñones V.; Rigotti, A.; Krieger M.; Kocher O. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
A NEW TWIST IN THE CHOLESTEROL METABOLISM-BASED ENTEROHEPATIC CONNECTION. Nervi, Flavio; Zanlungo, Silvana.; Rigotti, Attilio Article GASTROENTEROLOGY (2008)
Overexpression of the PDZ1 domain of PDZK1 blocks the activity of hepatic scavenger receptor, class B, type I by altering its abundance and cellular localization Fenske, SA; Yesilaltay A.; Pal, R; Daniels K.; Rigotti, A.; Krieger M.; Kocher O. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Trends in obesity and diabetes prevalence in a Chilean urban population: 1993-2001 Cuevas, A.; Molina A.; Reyes, S; Rigotti, A.; Miquel, J.F; Nervi, F; Marshall G. Article SCOPUS METABOLIC SYNDROME AND RELATED DISORDERS (2008)
Adenovirus-mediated hepatic syndecan-1 overexpression induces hepatocyte proliferation and hyperlipidaemia in mice Cortés V.; Amigo, L; Donoso K.; Valencia I.; Quiñones V.; Zanlungo S.; Brandan, E.; Rigotti, A. Article ISI SCOPUS LIVER INTERNATIONAL (2007)
CETP expression enhances liver HDL-cholesteryl ester uptake but does not alter VLDL and biliary lipid secretion Harada, LM; Amigo, L; Cazita, PM; Salerno, AG; Rigotti, AA; Quintao, ECR; Oliveira, HCF Article ISI SCOPUS ATHEROSCLEROSIS (2007)
Genetic evidence that apolipoprotein E4 is not a relevant susceptibility factor for cholelithiasis in two high-risk populations Mella, JG; Schirin-Sokhan, R; Rigotti, A.; Pimentel, F; Villarroel L.; Wasmuth, HE; Sauerbruch, T; Nervi, F; Lammert, F; Miquel, JF Article ISI SCOPUS JOURNAL OF LIPID RESEARCH (2007)
Hypertension and the cardiometabolic syndrome in Chile: A review of concepts and consequences for the developing world Margozzini P.; Ferreccio C.; Quezada, N; Garrido M.; Rigotti, A.; Valdes G. Article Therapeutic advances in cardiovascular disease (2007)
Increased expression of syndecan-1 protects against cardiac dilatation and dysfunction after myocardial infarction Vanhoutte, D; Schellings, MWM; Gotte, M; Swinnen, M; Herias, V; Wild, MK; Vestweber, D; Chorianopoulos, E; Cortés V.; Rigotti, A.; Stepp, MA; Van de Werf, F; Carmeliet, P; Pinto, YM; Heymans, S Article ISI SCOPUS CIRCULATION (2007)
Liver heparan sulfate proteoglycans: Old molecules provide new insights on lipoprotein metabolism - Commentary Cortés V.; Rigotti, A. Article HEPATOLOGY (2007)
Molecular diagnosis and combined lipid lowering therapy of heterozygous familial hypercholesterolemia. Report of one case Arteaga A.; Cuevas, A.; Rigotti, A.; González F; Castillo, S.; mata, P; alonso, r Article ISI REVISTA MEDICA DE CHILE (2007)
Overexpression of the cholesterol-binding protein MLN64 induces liver damage in the mouse Tichauer, JE; Morales, MG; Amigo, L; Galdames L.; Klein, A.; Quiñones V.; Ferrada C.; Alvarez A.; Rio, MC; Miquel, JF; Rigotti, A.; Zanlungo S. Article ISI SCOPUS WORLD JOURNAL OF GASTROENTEROLOGY (2007)
Role of plasma and liver cholesterol- and lipoprotein-metabolism determinants in LpX formation in the mouse Bravo, I; Amigo, L; Cohen, DE; Nervi, F; Rigotti, A.; Francone, O; Zanlungo S. Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2007)
Gallbladder disease is associated with insulin resistance in a high risk Hispanic population Nervi, F; Miquel, JF; Alvarez M.; Ferreccio C.; Garcia-Zattera, MJ; González R.; Perez-Ayuso, RM; Rigotti, A.; Villarroel L. Article ISI SCOPUS JOURNAL OF HEPATOLOGY (2006)
NPC2 is expressed in human and murine liver and secreted into bile: Potential implications for body cholesterol homeostasis Klein, A.; Amigo, L; Retamal, MJ; Morales, MG; Miquel, JF; Rigotti, A.; Zanlungo S. Article ISI SCOPUS HEPATOLOGY (2006)
PDZK1 is required for maintaining hepatic scavenger receptor, class B, type I (SR-BI) steady state levels but not its surface localization or function Yesilaltay A.; Kocher O.; Pal, R; Leiva A.; Quiñones V.; Rigotti, A.; Krieger M. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Comparative effect of fish oil feeding and other dietary fatty acids on plasma lipoproteins, biliary lipids, and hepatic expression of proteins involved in reverse cholesterol transport in the rat Morgado, N; Rigotti, A.; Valenzuela A. Article ISI SCOPUS ANNALS OF NUTRITION AND METABOLISM (2005)
EFECTO DE LA INFECCION PERIODONTAL POR PORPHYROMONAS GINGIVALIS EN EL DESARROLLO DE ATEROESCLEROSIS EN RATONES DEFICIENTES DE APOLIPOPROTEINA E Varas, G; Valenzuela J.; Guarda E.; Ferrada, Carla; Rigotti, Attilio; Schultz M.; Hernandez, Daniel Article REVISTA CHILENA DE CARDIOLOGIA (2005)
EFECTO DE SIMVASTATINA, CIPROFIBRATO Y ROSIGLITAZONA EN EL MANEJO DE LA DISLIPIDEMIA CAUSADA POR LA ADMINISTRACION DE RITONAVIR EN EL RATON Florenzano, Alejandra; Perez, Enrique; Quezada, Nicolas; Rebolledo, Rolando; Klaassen, Julieta; Pérez, Carlos; Rigotti, Attilio Article REVISTA CHILENA DE CARDIOLOGIA (2005)
EL RATON DEFICIENTE EN LA APOLIPOPROTEINA E COMO MODELO EXPERIMENTAL DE ATEROESCLEROSIS (COMENTARIO EDITORIAL) Rigotti, Attilio Article REVISTA CHILENA DE CARDIOLOGIA (2005)
Nuevos receptores nucleares heterodiméricos: reguladores metabólicos con impacto en fisiopatología y su proyección terapéutica en dislipidemias y diabetes mellitus Cortés, Víctor; Quezada, Nicolas; Rigotti, Attilio; Maiz, Alberto Article REVISTA MEDICA DE CHILE (2005)
Peroxisome proliferator-activated receptor gamma is a novel target of the nerve growth factor signaling pathway in PC12 cells Fuenzalida, KM; Aguilera, MC; Piderit, DG; Ramos, PC; Contador D.; Quiñones V.; Rigotti, A.; Bronfman, FC; Bronfman, M Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Physicians in biomedical research in Chile: A species under risk of extinction? Salas, SP; Rigotti, A. Article ISI REVISTA MEDICA DE CHILE (2005)
Cellular mechanisms of vitamin e uptake: Relevance in ?-tocopherol metabolism and potential implications for disease Mardones P.; Rigotti, A. Article JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2004)
Cholesterol depletion induces PKA-mediated basolateral-to-apical transcytosis of the scavenger receptor class B type I in MDCK cells Burgos, PV; Klattenhoff, C; De La Fuente E.; Rigotti, A.; González A Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
FUNCTION AND REGULATION OF HEPATIC SCAVENGER RECEPTOR CLASS B TYPE I (SR-BI) Rigotti, Attilio Article EQUILIBRIUM RESEARCH, CLINICAL EQUILIBRIOMETRY AND MODERN TREATMENT (2004)
Biliary lipid secretion, bile acid metabolism, and gallstone formation are not impaired in hepatic lipase-deficient mice Amigo, L; Mardones P.; Ferrada C.; Zanlungo S.; Nervi, F; Miquel, JF; Rigotti, A. Article ISI SCOPUS HEPATOLOGY (2003)
Expression and regulation of scavenger receptor class B type I (SR-BI) in gall bladder epithelium Miquel, JF; Moreno, M.; Amigo, L; Molina, H; Mardones P.; Wistuba, II; Rigotti, A. Article ISI SCOPUS GUT (2003)
Fibrates down-regulate hepatic scavenger receptor class B type I protein expression in mice Mardones P.; Pilon, A; Bouly, M; Duran, D; Nishimoto, T; Arai H.; Kozarsky, KF; Altayo, M; Miquel, JF; Luc, G; Clavey, V; Staels, B; Rigotti, A. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Hepatic overexpression of caveolins increases bile salt secretion in mice Moreno, M.; Molina, H; Amigo, L; Zanlungo S.; Arrese M.; Rigotti, A.; Miquel, JF Article ISI SCOPUS HEPATOLOGY (2003)
Hepatic overexpression of sterol carrier protein-2 inhibits VLDL production and reciprocally enhances biliary lipid secretion Amigo, L; Zanlungo S.; Miquel, JF; Glick, JM; Hyogo, H; Cohen, DE; Rigotti, A.; Nervi, F Article ISI SCOPUS JOURNAL OF LIPID RESEARCH (2003)
Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism Kocher O.; Yesilaltay A.; Cirovic, C; Pal, R; Rigotti, A.; Krieger M. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
?-tocopherol metabolism is abnormal in scavenger receptor class B type I (SR-BI)-deficient mice Mardones P.; Quiñones V.; Amigo, L; Rigotti, A.; Rozowski J.; Strobel P.; Miranda, S.; Leighton F.; Krieger M. Article SCOPUS JOURNAL OF NUTRITION (2002)
alpha-tocopherol metabolism is abnormal in scavenger receptor class B type I (SR-BI)-deficient mice Mardones P.; Strobel P.; Miranda, S.; Leighton F.; Quiñones V.; Amigo, L; Rozowski J.; Krieger M.; Rigotti, A. Article ISI JOURNAL OF NUTRITION (2002)
Down-regulation of intestinal scavenger receptor class B, type I (SR-BI) expression in rodents under conditions of deficient bile delivery to the intestine Voshol, PJ; Schwarz M.; Rigotti, A.; Krieger M.; Groen, AK; Kuipers, F Article ISI BIOCHEMICAL JOURNAL (2001)
Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice Mardones P.; Quiñones V.; Amigo, L; Moreno, M.; Miquel, JF; Schwarz M.; Miettinen, HE; Trigatti, B; Krieger M.; Vanpatten, S; Cohen, DE; Rigotti, A. Article ISI SCOPUS JOURNAL OF LIPID RESEARCH (2001)
Down-regulation of intestinal scavenger receptor class B, type I (SR-BI) expression in rodents under conditions of deficient bile delivery to the intestinal lumen. Kuipers, F; Voshol, PJ; Rigotti, A.; Krieger M. Article HEPATOLOGY (2000)
Impaired biliary cholesterol secretion and decreased gallstone formation in apolipoprotein E-deficient mice fed a high-cholesterol diet Amigo, L; Quiñones V.; Mardones P.; Zanlungo S.; Miquel, JF; Nervi, F; Rigotti, A. Article ISI SCOPUS GASTROENTEROLOGY (2000)
Scavenger receptor class B type I (SR-BI) and high-density lipoprotein metabolism: Recent lessons from genetically manipulated mice Trigatti, B; Rigotti, A. Article ISI INTERNATIONAL JOURNAL OF TISSUE REACTIONS-EXPERIMENTAL AND CLINICAL ASPECTS (2000)
Scavenger Receptors and Atherosclerosis Rigotti, A. Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2000)
Sterol carrier protein 2 gene transfer changes lipid metabolism and enterohepatic sterol circulation in mice Zanlungo S.; Amigo, L; Mendoza, H; Miquel, JF; Vio, C; Glick, JM; Rodríguez A.; Kozarsky, K; Quiñones V.; Rigotti, A.; Nervi, F Article ISI SCOPUS GASTROENTEROLOGY (2000)
Enrichment of canalicular membrane with cholesterol and sphingomyelin prevents bile salt-induced hepatic damage Amigo, L; Mendoza, H; Zanlungo S.; Miquel, J.F; Rigotti, A.; Nervi, F; Gonzalez S. Article JOURNAL OF LIPID RESEARCH (1999)
Getting a handle on 'good' cholesterol with the high-density lipoprotein receptor Rigotti, A.; Krieger M. Article NEW ENGLAND JOURNAL OF MEDICINE (1999)
Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology Trigatti, B; Rayburn H.; Vinals M.; Braun A.; Miettinen H.; Penman M.; Hertz M.; Rigotti, A.; Krieger M.; Schrenzel M.; Amigo, L Article PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1999)
MOLECULAR MEDICINE - PRESENT AND FUTURE Zanlungo, Silvana.; Arrese, Marco; Rigotti, Attilio Article REVISTA MEDICA DE CHILE (1999)
MOLECULAR-BIOLOGY AND MEDICINE - BASIC CONCEPTS Zanlungo, Silvana.; Rigotti, Attilio; Arrese, Marco Article REVISTA MEDICA DE CHILE (1999)
THE HDL RECEPTOR SR-BI: A NEW THERAPEUTIC TARGET FOR ATHEROSCLEROSIS? Rigotti, Attilio; Kozarsky, Karen; Acton, Susan Article MOLECULAR MEDICINE TODAY (1999)
Cholesterol saturation, not proteins or cholecystitis, is critical for crystal formation in human gallbladder bile Miquel, J.F; Nuñez L.; Amigo, L; Gonzalez S.; Raddatz, A; Rigotti, A.; Nervi, F Article GASTROENTEROLOGY (1998)
Temporal and spatial pattern of expression of the HDL receptor SR-BI during murine embryogenesis Hatzopoulos A.K.; Rigotti, A.; Rosenberg R.D.; Krieger M. Article JOURNAL OF LIPID RESEARCH (1998)
A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism Rigotti, A.; Trigatti B.L.; Penman M.; Rayburn H.; Krieger M.; Herz J. Article PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1997)
Fibrates induce mdr2 gene expression and biliary phospholipid secretion in the mouse Chianale, J; Vollrath, V; Wielandt A.M.; Amigo, L; Rigotti, A.; Nervi, F; Pizarro M.; Accatino L.; Gonzalez S.; Andrade L. Article BIOCHEMICAL JOURNAL (1996)
Modulation of intrahepatic cholesterol trafficking: Evidence by in vivo antisense treatment for the involvement of sterol carrier protein-2 in newly synthesized cholesterol transport into rat bile Puglielli, L; Rigotti, A.; Amigo, L; Nuñez L.; Nervi, F; Greco A.V.; Santos M.J. Article BIOCHEMICAL JOURNAL (1996)
Molecular mechanisms underlying the link between nuclear receptor fuDevelopmental abnormalities in mouse embryos lacking the HDL receptor SR-BI Santander NG, Contreras-Duarte S, Awad MF, Lizama C, Passalacqua I, Rigotti A, Busso D. Article 1604-2004: SUPERNOVAE AS COSMOLOGICAL LIGHTHOUSES
Molecular mechanisms underlying the link between nuclear receptor function and cholesterol gallstone formation 130. Vázquez MC, Rigotti A, Zanlungo S Article 1604-2004: SUPERNOVAE AS COSMOLOGICAL LIGHTHOUSES


THE LACK OF THE HDL RECEPTOR SR-BI AFFECTS EMBRYO CHOLESTEROL CONTENT AND NEURAL TUBE CLOSURE IN MICE Santander N.; Leiva A.; Contreras S.; Rigotti, A.; Busso, D. Abstract PLACENTA (2011)
Cardiovascular risk, cholesterol goal attainment, and lipid-lowering eligibility in chile. Findings from the first national health survey Olivos C.; Valenzuela A.; Arteaga A.; Margozzini P.; Olea, R; Maiz A.; Rigotti, A.; Ferreccio C.; Aguilera X.; González C Abstract ISI ATHEROSCLEROSIS SUPPLEMENTS (2007)
High level of agreement between the NCEP ATPIII and IDF metabolic syndrome definition in the Chilean general population: Results from the first National Health Survey 2003 Valenzuela A.; Olivos C.; Rigotti, A.; Margozzini P.; Olea, R; Maiz A.; Arteaga A.; Ferreccio C.; Aguilera X.; González C Abstract ISI ATHEROSCLEROSIS SUPPLEMENTS (2007)
Adenovirus-mediated hepatic overexpression of syndecan-1 increases plasma lipoprotein cholesterol without changes in liver and biliary cholesterol content in mice Cortés V.; Donoso K.; Amigo, L; Zanlungo S.; Brandan, E.; Rigotti, A. Abstract CIRCULATION (2005)
Hepatic HDL cholesterol uptake, VLDL production and biliary lipid secretion in human CETP transgenic mice Quintao, ECR; Harada, LM; Amigo, L; Cazita, PM; Salerno, AG; Rigotti, A.; Oliveira, HCF Abstract ATHEROSCLEROSIS SUPPLEMENTS (2005)
Functional role and regulation of hepatic scavenger receptor class B type I (SR-BI) Rigotti, A. Abstract ISI ATHEROSCLEROSIS SUPPLEMENTS (2003)
Cholesterol depletion induces PKA activity and transcytosis of the HDL scavenger receptor class B type I (SR-BI) Burgos P.; de la Fuente, EA; Rigotti, A.; González A Abstract MOLECULAR BIOLOGY OF THE CELL (2002)
Increased plasma lipoprotein cholesterol levels and impaired biliary lipid secretion in mice with loss of function of Niemann-Pick C1 protein Amigo, L; Mendoza, H; Nervi, F; Rigotti, A.; Zanlungo S. Abstract CIRCULATION (2002)
Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I (SR-BI)-deficient mice Mardones P.; Quiñones V.; Amigo, L; Moreno, M.; Miquel, JF; Schwarz M.; Miettinen, HE; Trigatti, B; Krieger M.; Vanpatten, S; Cohen, DE; Rigotti, A. Abstract GASTROENTEROLOGY (2001)
Relevance of Niemann-Pick C1 (NPC1) protein in controlling biliary lipid secretion of dietary cholesterol in mice. Zanlungo S.; Amigo, L; Mendoza, H; Rigotti, A.; Nervi, F Abstract HEPATOLOGY (2001)
Biliary lipid secretion in Niemann-Pick C1 protein-deficient mice. Zanlungo S.; Amigo, L; Mendoza, H; Morera, F; Miquel, JF; Rigotti, A.; Nervi, F Abstract GASTROENTEROLOGY (2000)
Expression and regulation of scavenger receptor class B type I (SR-BI) in humun and murine gallbladder epithelial cells. Miquel, JF; Rigotti, A.; Moreno, M.; Santibanez, E; Amigo, L; Wistuba, I Abstract GASTROENTEROLOGY (2000)
Overexpression of sterol carrier protein-2 in mice leads to increased hepatic cholesterol content and enterohepatic circulation of bile acids. Zanlungo S.; Amigo, L; Mendoza, H; Glick, J; Rodríguez A.; Kozarsky, K; Miquel, JF; Rigotti, A.; Nervi, F Abstract GASTROENTEROLOGY (2000)


STARTing to understand MLN64 function in cholesterol transport Rigotti, A.; Cohen, DE; Zanlungo S. EditorialMaterial ISI SCOPUS Journal of Lipid Research (2010)
The Tangier disease gene encodes yet another pathophysiologically relevant ATP-binding cassette protein Rigotti, A.; Cohen, DE EditorialMaterial ISI HEPATOLOGY (2000)


Focusing on Students' Talents and Strengths in Medical Education Pedrals N.; Rigotti, A.; Bitran, M Letter ISI SCOPUS Academic Medicine (2010)
Health research in Latin America Valdivieso V.; Rigotti, A. Letter LANCET (2010)
HDL receptor SR-BI and cholesterol gallstones Rigotti, A.; Zanlungo S.; Miquel, JF; Wang, DQH Letter ISI HEPATOLOGY (2002)


Advances in the physiological and pathological implications of cholesterol Cortes, VA; Busso, D.; Mardones P.; Maiz A.; Arteaga A.; Nervi, F; Rigotti, A. Review ISI SCOPUS Biological Reviews (2013)
Rememorando la contribución de Goldstein y Brown al estudio del metabolismo del colesterol: a un cuarto de siglo del Premio Nobel de Medicina Cortés V.; Vasquez, T; Arteaga A.; Nervi, F; Rigotti, A. Review SCIELO SCOPUS REVISTA MEDICA DE CHILE (2012)
Abnormalities of lipid metabolism, gallstone disease and gallbladder function Zanlungo S.; Rigotti, A.; Miquel, JF; Nervi, F Review ISI SCOPUS Clinical Lipidology (2011)
Mechanisms regulating hepatic SR-BI expression and their impact on HDL metabolism Leiva A.; Verdejo H.; Benitez ML; Martínez A; Busso, D.; Rigotti, A. Review ISI SCOPUS Atherosclerosis (2011)
El síndrome metabólico: De factor agravante a principal factor de riesgo patogénico en diversas enfermedades crónicas von Bernhardi *, Rommy; Zanlungo, Silvana.; Arrese, Marco; Arteaga, Antonio; Rigotti, Attilio Review SCIELO REVISTA MEDICA DE CHILE (2010)
Determinants of transhepatic cholesterol flux and their relevance for gallstone formation Zanlungo S.; Rigotti, A. Review ISI SCOPUS Liver International (2009)
Myocardial infarction following atherosclerosis in murine models Braun A.; Rigotti, A.; Trigatti, BL Review CURRENT DRUG TARGETS (2008)
Absorption, transport, and tissue delivery of vitamin E Rigotti, A. Review ISI MOLECULAR ASPECTS OF MEDICINE (2007)
Intensive cholesterol lowering therapy to reduce cardiovascular risk Rigotti, A.; Arteaga A.; Maiz A. Review REVISTA MEDICA DE CHILE (2006)
HDL cholesterol: A new target in the treatment of lipid disorders and atherosclerosis? Laris, MD; Arteaga A.; Cuevas, A.; Rigotti, A. Review REVISTA MEDICA DE CHILE (2005)
NEW HETERODIMERIC NUCLEAR RECEPTORS: KEY METABOLIC REGULATORS WITH RELEVANCE IN THE PATHOPHYSIOLOGY AND THERAPY OF DYSLIPIDEMIAS AND DIABETES MELLITUS Cortés, Víctor; Quezada, Nicolas; Rigotti, Attilio; Maiz, Alberto Review REVISTA MEDICA DE CHILE (2005)
New heterodimeric nuclear receptors: Key metabolic regulators with relevance in the pathophysiology and therapy of dyslipidemias and diabetes mellitus Nuevos receptores nucleares heterodiméricos reguladores metabólicos con impacto en fisiopatología y su proyección terapéutica en dislipidemias y diabetes mellitus Cortés V.; Rigotti, A.; Maiz A.; Quezada, N Review REVISTA MEDICA DE CHILE (2005)
Regulation of SR-BI-mediated high-density lipoprotein metabolism by the tissue-specific adaptor protein PDZK1 Yesilaltay A.; Kocher O.; Rigotti, A.; Krieger M. Review ISI Current Opinion in Lipidology (2005)
Cellular mechanisms of vitamin E uptake: relevance in alpha-tocopherol metabolism and potential implications for disease Mardones P.; Rigotti, A. Review JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2004)
Hepatic cholesterol transport from plasma into bile: implications for gallstone disease Zanlungo S.; Rigotti, A.; Nervi, F Review Current Opinion in Lipidology (2004)
Influence of the HDL receptor SR-BI on lipoprotein - Metabolism and atherosclerosis Trigatti, BL; Krieger M.; Rigotti, A. Review ISI ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2003)
The role of the high-density lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissues Rigotti, A.; Miettinen, HE; Krieger M. Review ISI ENDOCRINE REVIEWS (2003)
Cellular and physiological roles of SR-BI, a lipoprotein receptor which mediates selective lipid uptake Trigatti, BL; Rigotti, A.; Braun A. Review ISI BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2000)
The role of the high-density lipoprotein receptor SR-BI in cholesterol metabolism Trigatti, B; Rigotti, A.; Krieger M. Review ISI Current Opinion in Lipidology (2000)

162

Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

121

Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

Juan Miquel

Full Professor

Gastroenterology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Silvana Zanlungo

Full Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

Pablo Mardones

Research Associate

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

MARCO ARRESE

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Victor Cortes

Associate professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

Nicolas Quezada

Adjunct Researcher

Digestive Surgery

Pontificia Universidad Catolica de Chile

Santiago, Chile

fresia ferreccio

Full Professor, Director PhD Epidemiolgy Program

Public Health

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE FACULTAD DE MEDICINA, ESCUELA DE MEDICINA, DEPARTAMENTO DE SALUD PÚBLICA.

Santiago, Chile

Andrea Leiva

Profesor Asociado

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

paula margozzini

Associate Professor

Public Health

Pontificia Universidad Católica de Chile

Santiago, Chile

Manuel Alvarez

Gastroenterologist and Chief of Institute of Medicine

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

Dolores Busso

Associate Professor

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

ANDRES KLEIN

Assistant Professor/Director (Head) Center for Genetics and Genomics; Director, PhD Program in Sciences and Innovation in Medicine

Centro de Genética y Genómica

Universidad del Desarrollo-Clínica Alemana

SANTIAGO, Chile

ELISA BALBOA

Académico Investigador

Facultad de Medicina

Universidad Finis Terrae

SANTIAGO, Chile

Maria Jose Garcia

Profesor Asistente Adjunto

Estadistica

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Guillermo Marshall

Pablo Strobel

Prrofesional de laboratorio

Facultad Ciencias Veterinarias

Universidad Austral de Chile

Valdivia, Chile

Ximena Aguilera

Full Professor; Director Centro de Epidemiología y Políticas de Salud /Center of Epidemiology and Health Policy

Centro de Epidemiología y Políticas de Salud (CEPS)/ Center of Epidemiology and Health Policy/Centro de Epidemiología y Políticas de Salud (CEPS)

Universidad del Desarrollo

Santiago, Chile

Luis Villarroel

Profesor Asociado

Salud Publica

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE SALUD PÚBLICA

Santiago, Chile

Ada Cuevas

Médico

Nutrición Clínica

CLINICA LAS CONDES

Santiago, Chile

Marcela Bitran

Profesor Asociado

Escuela de Medicina

Pontificia Universidad Catolica de Chile

Santiago , Chile

valentina serrano

PROFESOR ASISTENTE

NUTRICION, DIABETES Y METABOLISMO

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Claudia Gonzalez

Associate Professor and Resarcher

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

JOSE SANTOS

Full Professor

Department of Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Karen Fuenzalida

Investigador responsable de la Unidad de investigación y desarrollo del Laboratorio de Enfermedades Metabólicas, área de laboratorio.

Instituto de Nutrición y Tecnología de Alimentos

Universidad de Chile

Santiago, Chile

Patricio Ramos

academico

Instituto de ciencias biológicas

UNIVERSIDAD DE TALCA

Talca, Chile

Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

Carlos Valenzuela

INTA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Ramon Corbalan

Director

Division of Cardiovascular Diseases

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

MONICA ACEVEDO

Titular Professor

Division of Cardiovascular Diseases

P. UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

David Contador

Universidad del Desarrollo

Santiago, Chile

Rodrigo Alonso

Director Jefe Departamento

Nutrición Clínica

Clínica Las Condes

Santiago, Chile

Gonzalo Martínez

Director

División de Enfermedades Cardiovasculares

Hospital Clínico Universidad Católica

Santiago, Chile

Susana Eyheramendy

Full Professor

Universidad Adolfo Ibánez

Santiago, Chile

Margarita Pizarro

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

PATRICIA BURGOS

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

Erwin de la Fuente

PROFESOR ASOCIADO

CIENCIAS BIOMÉDICAS

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

Rene Baudrand

Profesor Asociado

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

Arnoldo Riquelme

Profesor titular

Gastroenterología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE GASTROENTEROLOGÍA

Santiago, Chile

Hugo Verdejo

Profesor Asociado

División de Enferemedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Arnoldo Riquelme

Director UDA Ciencias de la Salud (Carreras de Nutrición y dietética, Fonoaudiología y Kinesiología)

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

Alvaro Martínez

Director Asociado de Propiedad Intelectual y Transferencia Tecnológica

FUNDACIÓN CIENCIA PARA LA VIDA (FCV)

Santiago, Chile

Francisca Bronfman

Full Professor

Instituto de Ciencias Biomédicas

Universidad Andrés Bello

Santiago, Chile

David Contador

Professor Instructor

School of Medicine

Universidad del Desarrollo

Santiago, Chile

Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

daniel duran

Profesor

Bioquímica Clínica e Inmunología

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Susana Contreras

Assistant Professor

Nutrition and Dietetics

Universidad San Sebastián

Santiago, Chile

Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Hegaly Mendoza

Académico

Universidad Andrés Bello

Santiago, Chile

Attilio G Rigotti Rivera

Líneas de Investigación

Educación

Medical Doctor, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1988

Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2000

Internal Medicine, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1991

Experiencia Académica

Assistant Professor Full Time

Visiting professor Full Time

Full Professor Full Time

Associate Professor Full Time

Experiencia Profesional

Regular Member, Research Committee Part Time

Regular Member, Committee of Ph.D. Program in Medical Sciences Part Time

Research Director, School of Medicine Part Time

Regular Member, Committee of Master Program in Nutrition Part Time

Chairman, Department of Nutrition, Diabetes and Metabolism Part Time

Director, Center of Molecular Nutrition and Chronic Diseases Full Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

Medical Undergraduate Scholarship

Medical Undergraduate Scholarship

Best Publication of the Year Award

Internal Medicine Fellowship

PhD Scholarship

Research Fellowship

Young Investigator Award

Chilean Academy of Medicine

Senior Investigator Award

Article (70)

Abstract (13)

EditorialMaterial (2)

Letter (3)

Review (19)