Reproduction,pathophysiology and prediction of preeclampsia and preterm labor.

Tesis Dirigidas:
1. Alexander Uamai. Tesis para el grado de Magister. University of Bristol. Molecular mechanisms involved in the Pathogenesis of Pre-Eclampsia and their use in the early detection of the condition. A critical Review of Literature. 2010
2. Fatima Firdous. Tesis para el grado de Magister. University of Bristol. Detection of streptococcus agalactiae in pregnant women. 2014.
3. Macarena Manriquez. Tesis para el grado de Magister. Universidad de los Andes. Asociación entre estado nutricional materno y crecimiento fetal intrauterino. 2014.
4. Roberto Araneda. Tesis para el grado de Magister. Universidad de Chile. Determinacion del papel de las microparticulas de Sincitotrofoblasto (STBM) como marcador precoz de disfunción endotelial en mujeres que presentan factores de riesgo para presentar preeclampsia. 2014.
5. Paula Valenzuela. Tesis de pregrado. Universidad Andrés Bello. Efecto de estrógeno (e2) y progesterona (p4) en las propiedades inmunomodulatorias de las células madres mesenquimales derivadas de fluido menstrual (mensc). 2015. Enmarcado en el Proyecto FONDECYT 1140119.
6. Rocio Salsoso. Tesis de Doctorado (PhD). Pontificia Universidad Católica de Chile. Regulación de la ruta l-arginina/no endotelial por receptores de insulina y de adenosina a2a y a2b en endotelio de vena umbilical humana en preeclampsia tardía. 2017.
7. Maria Farren. Tesis de Doctorado (PhD). University College Dublin. A Study of the Effect of Inositol on Women at risk of Developing Gestational Diabetes Mellitus. 2017.
8. Sebastian Venegas. Tesis de pregrado. Universidad de Chile. Efecto de Progesterona y Estradiol sobre la expresión de marcadores de implantación y propiedades de células madre endometriales obtenidas desde fluido menstrual. 2018. Enmarcado en el Proyecto FONDECYT 1140119.
9. Claudette Cantin. Tesis de Doctorado (PhD). Pontificia Universidad Católica de Chile. Caracterización y efectos de las ldl y hdl de mujeres con hipercolesterolemia durante el embarazo sobre la función vascular materna y la comunicación entre células endoteliales y macrófagos. 2019.

Tutorías:
1. Javier Caradeux; Fellow. Project: prediction of preeclampsia in the first trimester of pregnancy using a combination of variables combining maternal factors, Doppler of uterine arteries and blood pressure. Period 2009-2011. Source FONIS, Chile. Product of this work we published: First trimester prediction of early onset preeclampsia using demographic, clinical, and sonographic data: a cohort study. Prenat Diagn. 2013 Aug; 33:732-736. PMID: 23584890
2. Lara Monterio; Posdoctoral student. Project: The role of the aromatase pathway in 2-methoxyestradiol synthesis in the pathogenesis of preeclampsia. Period 2012-2013. Source Fondecyt, Chile. Product of this work we published: Placental aromatase is deficient in placental ischemia and preeclampsia. PLoS One. 2015 Oct 7; 10:e0139682. After his postdoctoral fellowship we started a second project: Role of FOXM1 in trophoblast invasion. Period 2018-2019. Source FONDECYT inicio, Chile. Product of this work we published: Reduced FOXM1 expression limits trophoblast migration and angiogenesis and is associated with preeclampsia. Reprod Sci. 2019 May; 26:580-590.
3. Alejandra Perez; postdoctoral student. Project: possible alteration in trophoblast-endothelial communication mediated by exosomes and miRNA, in preeclamptic patient. Period 2011-2012. Source Fondecyt, Chile.
4. Ignacio Valenzuela; Fellow. Project: we developed an early detection method based on the use of PCR to establish the use of an antibiotic prophylaxis to significantly reduce neonatal sepsis. Period 2012-2013. Source: FONDEF, Chile. Product of this work we published: Prevention of early-onset neonatal Group B streptococcal disease. Rev Obstet Gynecol. 2013; 6:63-68.
5. Paula Correa; Fellow. Project. prediction of gestational diabetes in the first trimester of pregnancy using maternal factors and biochemical biomarkers. Period 20014-2015. Source FONIS, Chile. Product of this work we published: First trimester prediction of gestational diabetes mellitus using plasma biomarkers: a case-control study. J Perinat Med. 2019 Feb 25; 47:161-168.
6. Jose Galaz; Student. Project: evaluation of endothelial markers for prediction of FGR and PE. Product of this work we published: Maternal plasma concentrations of the placental specific sFLT-1 variant, sFLT-1 e15a, in fetal growth restriction and preeclampsia. J Matern Fetal Neonatal Med. 2017 Mar;30(6):635-639
7. Yasna Palmeiro; Fellow. Project: evaluation of the impact of Chilean earthquake in neonatal outcomes. Product of this work we published: Effects of earthquake on perinatal outcomes: a Chilean register-based study. PLoS One. 2018 Feb 23; 13:e0191340.
8. Max Monckeberg; Fellow. Project: use of amniocentesis for management of bulging membranes. Product of this work we published: Patients with acute cervical insufficiency without intra-amniotic infection/inflammation treated with cerclage have a good prognosis. J Perinat Med. 2019 Jul 26;47:500-509.

2019 Invited Speaker "Stress prenatal y neurodesarrollo” LXXIV Congreso anual de la Sociedad de Neurocirugía, Psiquiatría y eurología (SONESPYN) Puerto Varas, Chile. Nov 2019.
2019 Invited Speaker “Maternal brain-to-fetal brain communication mediated by small extracellular vesicles: A role in prenatal stress” 23rd International Conference on Prenatal Diagnosis and Therapy Singapore, Singapore. Sep 2019.
2019 Invited Speaker “First trimester gingival crevicular fluid placental alkaline phosphatase and the prediction of preeclampsia” 23rd International Conference on Prenatal Diagnosis and Therapy, Singapore, Singapore. Sep 2019.
2019 Invited Speaker "Predicción de patologías del embarazo en el primer trimestre”. Tópicos de Actualidad. Curso Dávila Santa María. Santiago, Chile. Jun 2019.
2018 Poster presentation: "Performance of First Trimester Screening of Preeclampsia Based on Uterine Artery Pulsatility Index and Maternal Risk Factors in Routine Clinical Care". International Society of Prenatal Diagnosis (ISPD) 22th International Conference, Amberes, Belgica. July 2018.
2018 Poster presentation: "Role of Amniocentesis in the Management of Cervical Insufficiency with Exposed Fetal Membranes in the Second Trimester of Pregnancy". International Society of Prenatal Diagnosis (ISPD) 22th International Conference, Amberes, Belgica. July 2018.
2017 Invited Speaker "Enfermedad periodontal; antigua relación nueva mirada”. CONGRESO FLASOG, Cancún, México. Nov 2017.
2017 Invited Speaker “Predicción DG que tan cerca estamos” CONGRESO FLASOG, Cancún, México. Nov 2017.
2017 Invited Speaker “Exámenes prenatales no invasivos”. CONGRESO FLASOG, Cancún, México. Nov 2017.
2017 Invited Speaker. "Fetal well-being in diabetic pregnancy”. Global Obstetrics Update 2017, Melbourne, Australia. Nov 2017.
2017 Invited Speaker. “Preclinical strategies for treating placental dysfunction”. International Federation of Placenta Associations (IFPA), Manchester, UK. Agu 2017.
2017 Poster presentation: "Plasmatic extracellular vesicles in first trimester of patients who develop spontaneous abortion. International Society of Prenatal Diagnosis (ISPD) 21th International Conference, San Diego, CA, USA, 9 - 12 July 2017.
2017 Poster presentation: "Implantation Properties of Endometrial Mesenchymal Stem Cells Isolated from Menstrual Fluid are Modulated by Menstrual Cycle Hormones". ISPD 21st International Conference on Prenatal Diagnosis. San Diego, CA, USA, 9 - 12 July 2017.
2017 Invited Speaker: "Periodontitis and pregnancy, una nueva mirada para una antigua relación. III Jornada de Investigación Clínica O&G. División de Obstetricia y Ginecología
Escuela de Medicina Pontificia Universidad Católica de Chile. Hotel Enjoy, Viña del Mar, Chile, May 3rd 2017.
2016 Invited Speaker: Diabetes, obesity and pregnancy: Deadly combination. XXI COMEGO. Mexico city, México, Jun 2016
2015 Invited speaker. “Fetal Programming”. 66 congreso Federación Mexicana de Colegios de Obstetricia y Ginecología (Femecog), Acapulco, Mexico, Nov 2015.
2015 Invited speaker. “Complications of pregnancy: clinical traslation of biomarkers”. International Federation of placental association meeting meeting (IFPA 2015), Brisbane, Australia, September 2015.
2015 Invited speaker. “Placental exosomes; good predictors of bad pregnancy outcomes?”. Workshop in exosomes, Karolinska institute, Stockholm, Sweden, June 2015.
2014 Invited speaker. “Exosomes as biomarkers in Biology of Reproduction”. Fetoscopy Meeting 2014, New York, USA.
2014 Invited speaker. “First trimester screening for adverse pregnancy outcomes: a reality?”, International Society of Prenatal Diagnosis (ISPD), 18th International Conference on Prenatal Diagnosis and Therapy, Brisbane, Australia, July.
2014 Invited speaker. “Prediction of preeclampsia: Pointing to the origin of the disease”, VII encuentro internacional de O & G, Pontificia Universidad Católica, Viña del Mar, Chile, April.
2013 Invited Speaker. “NIPD in pregnancy complications" and “exosomes, biomarkers of placental dysunction”. Consenso Latinoamericano en NIPD. Isla de Pascua. Dic, Chile.
2013 Invited Speaker. “Prenatal diagnosis without images”. XXXIV Congreso de la Sociedad Chilena de Obstetricia y Ginecología. Dic, Viña del Mar, Chile.
2013 Invited Speaker. “Prediction of preeclampsia: are we reaching the goal”. SICOG 2103 Singapore International Congress of Obstetrics & Gynaecology. Singapore August.
2013 Invited Speaker. “Non Invasive Prenatal Diagnosis for various diseases”. III Jornadas de Actualización en Obstetricia y Ginecología, jun 26th. Hotel Sheraton Santiago.
2013 Invited Speaker. “The embryo as a patient: Challenges for 21 century”. Inaugural Lecture of the academic year University of los Andes. Santiago, Chile. April.
2013 Invited Speaker. “Prediction of preeclampsia: pointing to the origin of the pathology”. I jornada de investigación clínico-básica en patologías del embarazo. Chillán, Santiago, Chile. April.
2012 Invited Speaker. “Non invasive prenatal diagnosis in the XXI century”. III Reunión Bienal ACOG-SOCHOG. Concepción, Chile. November.
2012 Invited Speaker. “Fetal programming: Rethinking the objectives of the specialty”. XLIII Reunión Nacional Anual FASGO 2012. Mendoza, Argentina. October.
2012 Invited Participant. “Biomarkers for the prediction of preeclampsia: metabolic pathways involved in 2-methoxyestradiol synthesis”. Fetoscopy Meeting 2012. Dublin, Ireland. October.
2012 Invited Speaker. “The role of methionine-homocysteine metabolism (MHM) in the physiopathology of preeclampsia (PE)”. Society of Gynecological Investigation 5th international summit meeting. Brisbane.