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Carlos Alejandro Flores Pinilla

Researcher

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

Transepithelial transport; Ion channels; Epithelial physiology and pathophysiology; Cystic fibrosis, Transgenic mice, cell migration and volume regulation.

Cellular and Molecular Biology, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2007
Physiology, UNIVERSIDAD DE CONCEPCION. Chile, 2001
Tecnologo Medico, UNIVERSIDAD DE LA FRONTERA. Chile, 1997

Investigador/Profesor Asociado Full Time

Universidad San Sebastian

Medicina y Ciencia

Valdivia, Chile

2022 - A la fecha

Researcher Full Time

Centro de Estudios Cientificos (CECs)

Valdivia, Chile

2010 - A la fecha

2021
“Reposicionamiento de tamoxifeno para el tratamiento de un modelo murino de enfermedad pulmonar obstructiva crónica”.
Agustín Mansilla Mansilla.
Para optar a Licenciatura y Grado de Tecnología Médica.
Universidad Austral de Chile.

2020
“Physiological role of KCa3.1 in the lower airways and its potential therapeutic role in a muco-obstructive and pulmonary emphysema model”
Génesis Vega Hormazábal.
Para optar a grado de Doctor en Ciencias Biológicas, mención Biología Celular y Molecular.
Universidad Austral de Chile.

2018
“Caracterización del transporte de lactato en macrófagos”
Romina Alarcón Barrandeguy.
Para optar a Licenciatura y Grado de Químico Farmacéutico.
Universidad Austral de Chile.

2017
“Administración de tamoxifeno como tratamiento en un modelo animal de lesión pulmonar aguda”
Jaime I.J. Soto Leal.
Para optar a Licenciatura y Grado de Químico Farmacéutico.
Universidad Austral de Chile.

2014
Profesor Patrocinante
"Rol de los Mastocitos en la Inflamación Crónica Alérgica de las Vías Aéreas"
Amber R. Philp
Para optar al título profesional de Bioquímico (en desarrollo)

Profesor Patrocinante
“Caracterización de mastocitos STAT6 knock out”
Rodrigo Gonzalez Kindley.
Para optar a Licenciatura y Grado de Tecnología Médica.
Universidad Austral de Chile.

Profesor Patrocinante
“Subclonamiento del promotor de músculo liso SMP8 para la generación del animal SMP8-TMEM16A+/+/TMEM16A-/-”
José Álvarez Iturra.
Para optar a Licenciatura y Grado de Tecnología Médica.
Universidad Austral de Chile.

Profesor Patrocinante
“Rol de KCNN4 en neutrófilos”
Daniel Vera Díaz.
Para optar a Licenciatura y Grado de Tecnología Médica.
Universidad Austral de Chile.

2013
Profesor Patrocinante
“Generación del animal SMP8-TMEM16A+/+/TMEM16A-/- y estudio de la distribución del canal TMEM16A en tejidos de ratón.”
José Arellano Ruiz.
Para optar a Licenciatura y Grado de Tecnología Médica.
Universidad Austral de Chile.

Profesor Patrocinante
“Inactivación de genes involucrados en enfermedades humanas del epitelio intestinal.”
Pamela Millar Büchner.
Para optar a Licenciatura en Biología.
Universidad Austral de Chile.

Profesor Patrocinante
“Regulación de mastocitos en la fibrosis quística por el canal KCNN4.”
Texia Riquelme Mora.
Para optar a Licenciatura y Grado de Tecnología Médica.
Universidad Austral de Chile.

Best Poster Presentation

European Cystic Fibrosis Society

España, 2013

Best Poster Presentation


Inhibition of the sodium-dependent HCO 3- transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype Saint-Criq, Vinciane; Guequen, Anita; Philp A.R.; Villanueva, Sandra; Apablaza, Tábata; Fernández-Moncada, Ignacio; Mansilla, A; Delpiano, Livia; Ruminot, Ivan; Carrasco, Cristian; Gray, Michael A; Flores, Carlos A. Article ELIFE (2022)
KCa3.1 differentially regulates trachea and bronchi epithelial gene expression in a chronic-asthma mouse model Philp A.R.; Miranda, Fernando; Gianotti, Ambra; Mansilla, Agustin; Scudieri, Paolo; Musante, Ilaria; Vega, Génesis; Figueroa, Carlos D.; Galietta, Luis J.; José M. Sarmiento; Flores, Carlos A. Article PHYSIOLOGICAL GENOMICS (2022)
Nocturnal Light Pollution Induces Weight Gain in Mice and Reshapes the Structure, Functions, and Interactions of Their Colonic Microbiota Sarmiento, Jose; Pulgar, Rodrigo.; Mandakovic, Dinka; Porras, Omar; Flores, Carlos A.; Luco, Diego; Trujillo, Carlos A.; Diaz-Esquivel, Briam; Alvarez, Cinthya; Acevedo, Alejandro; Catalan, Marcelo A. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Lack of Kcnn4 improves mucociliary clearance in muco-obstructive lung disease Vega, Genesis; Guequen, Anita; Philp, Amber R.; Gianotti, Ambra; Arzola, Llilian; Villalon, Manuel; Zegarra-Moran, Olga; Galietta, Luis J. V.; Mall, Marcus A.; Flores, Carlos A. Article ISI JCI INSIGHT (2020)
Lack of Kcnn4 improves mucociliary clearance in muco-obstructive lung disease. Vega, Génesis; Guequen, Anita; Philp, Amber R.; Gianotti, Ambra; Arzola, Llilian; Villalón, Manuel; Zegarra-Morán, Olga; Galietta, Luis J. V.; Mall, Marcus A.; Flores, Carlos A. Article ISI JCI Insight (2020)
Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments Contreras-Baeza, Yasna; Sandoval, Pamela Y.; Alarcon, Romina; Galaz, Alex; Cortes-Molina, Francisca; Alegria, Karin; Baeza-Lehnert, Felipe; Arce-Molina, Robinson; Guequen, Anita; Flores, Carlos A.; San Martin, Alejandro; Felipe Barros, L. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium Vega, Genesis; Guequen, Anita; Johansson, Malin E., V; Arike, Liisa; Martinez-Abad, Beatriz; Scudieri, Paolo; Pedemonte, Nicoletta; Millar-Buchner, Pamela; Philp, Amber R.; Galietta, Luis J.; Hansson, Gunnar C.; Flores, Carlos A. Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2019)
Kcnn4 is a modifier gene of intestinal cystic fibrosis preventing lethality in the Cftr-F508del mouse Philp, AR; Riquelme, TT; Millar-Buchner, P; Gonzalez, R; Sepulveda, FV; Cid, LP; Flores, CA Article ISI SCOPUS SCIENTIFIC REPORTS (2018)
Delphinidin Reduces Glucose Uptake in Mice Jejunal Tissue and Human Intestinal Cells Lines through FFA1/GPR40 Hidalgo J.; Teuber S.; Morera F.J.; Ojeda C.; Flores C.A.; Hidalgo M.A.; Núñez L.; Villalobos C.; Burgos R.A. Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
ClC-2 and intestinal chloride secretion Flores, Carlos A. Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2016)
Pharmacological analysis of epithelial chloride secretion mechanisms in adult murine airways Gianotti A.; Ferrera L.; Philp A.R.; Caci E.; Zegarra-Moran O.; Galietta L.J.V.; Flores C.A. Article ISI SCOPUS EUROPEAN JOURNAL OF PHARMACOLOGY (2016)
Severe changes in colon epithelium in the Mecp2-null mouse model of Rett syndrome Millar-Büchner, Pamela; Philp, Amber R.; Gutierrez, Noemí; Villanueva, Sandra; Kerr, Bredford; Flores, Carlos A. Article Pubmed Molecular and Cellular Pediatrics (2016)
The calcium-activated potassium channel KCa3.1 plays a central role in the chemotactic response of mammalian neutrophils Henriquez, C; Riquelme, TT; Vera, D.; Julio-Kalajzic, F; Ehrenfeld, P; Melvin, JE; Figueroa, CD; Sarmiento J.; Flores, CA Article ISI SCOPUS ACTA PHYSIOLOGICA (2016)
Delphinol® standardized maqui berry extract reduces postprandial blood glucose increase in individuals with impaired glucose regulation by novel mechanism of sodium glucose cotransporter inhibition Hidalgo, Jorge; Flores, Carlos; Hidalgo, Maria A; Perez, Moises; Yañez, Alejandro; Quiñones, L; Caceres, DD; Burgos, Rafael A Article BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus PANMINERVA MEDICA (2014)
Disruption of CDH2/N-cadherin-based adherens junctions leads to apoptosis of ependymal cells and denudation of brain ventricular walls Oliver C.; GonzÃ¡lez C.A.; Alvial G.; Flores C.A.; RodrÃguez E.M.; BÃ¡tiz L.F. Article ISI SCOPUS Journal of Neuropathology and Experimental Neurology (2013)
Severe Defects in Absorptive Ion Transport in Distal Colons of Mice That Lack ClC-2 Channels Catalan, M. A.; Flores C.A.; Gonzalezbegne M.; Zhang, Y.; Sepulveda, F. V.; Melvin, J. E. Article ISI SCOPUS Gastroenterology (2012)
Strain-dependent differences in electrogenic secretion of electrolytes across mouse colon epithelium Flores, CA; Cid, LP; Sepulveda, FV Article ISI SCOPUS Experimental Physiology (2010)
Abolition of Ca 2+-mediated intestinal anion secretion and increased stool dehydration in mice lacking the intermediate conductance Ca 2+-dependent K + channel Kcnn4 Flores C.A.; Sepulveda, F. V.; Figueroa C.D.; Melvin, J. E. Article Journal of Physiology (2007)
Abolition of Ca2+-mediated intestinal anion secretion and increased stool dehydration in mice lacking the intermediate conductance Ca2+-dependent K+ channel Kcnn4 Flores, CA; Melvin, JE; Figueroa, CD; Sepulveda, FV Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2007)
Two splice variants derived from a Drosophila melanogaster candidate ClC gene generate ClC-2-type Cl(-) channels Flores, CA; Niemeyer, MI; Sepulveda, FV; Cid, LP Article ISI SCOPUS MOLECULAR MEMBRANE BIOLOGY (2006)
Functional evaluation of human ClC-2 chloride channel mutations associated with idiopathic generalized epilepsies Niemeyer M.I.; Yusef Y.R.; Cornejo I.; Flores C.A.; Sepulveda, F. V.; Cid, L. P. Article SCOPUS Physiological Genomics (2005)
Cell signalling-mediating insulin increase of mRNA expression for cationic amino acid transporters-1 and-2 and membrane hyperpolarization in human umbilical vein endothelial cells Gonzalez, M.; Flores C.; Pearson, JD; Casanello, P; Sobrevia L. Article ISI PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2004)
Rapid stimulation of L-arginine transport by D-glucose involves P42/44(mapk) and nitric oxide in human umbilical vein endothelium Flores C.; Rojas, S.; Aguayo, C.; Parodi, J; Mann G.; Pearson, JD; Casanello, P; Sobrevia L. Article ISI CIRCULATION RESEARCH (2003)
Inhibition of nitrobenzylthioinosine-sensitive adenosine transport by elevated D-glucose involves activation of P-2Y2 purinoceptors in human umbilical vein endothelial cells Parodi, J; Flores C.; Aguayo, C.; Rudolph, MI; Casanello, P; Sobrevia L. Article ISI CIRCULATION RESEARCH (2002)
Modulation of adenosine transport by insulin in human umbilical artery smooth muscle cells from normal or gestational diabetic pregnancies Aguayo, C.; Flores C.; Parodi, J; Rojas, R.; Mann, GE; Pearson, JD; Sobrevia L. Article ISI JOURNAL OF PHYSIOLOGY-LONDON (2001)
Regulation of adenosine transport by D-glucose in human fetal endothelial cells: involvement of nitric oxide, protein kinase C and mitogen-activated protein kinase Montecinos, VP; Aguayo, C.; Flores C.; Wyatt, AW; Pearson, JD; Mann, GE; Sobrevia L. Article ISI JOURNAL OF PHYSIOLOGY-LONDON (2000)
Complementary studies to histologic diagnosis in surgical pathology Roa, Ivan; Araya, Juan; Villaseca, Miguel; Roa, Juan; Melo, Angelica; Flores, Carlos Article REVISTA CHILENA DE CIRUGIA (1997)


Diabetes and hyperglicemia induced L-arginine/nitric oxide (NO) pathway in human fetal endothelium Parodi, J; Flores C.; Aguayo, C.; Rojas, S.; Guijarro, MV; Sobrevia L. Abstract HYPERTENSION (2001)
Elevated D-glucose induces expression of the cationic amino acid transport system y(+)/CAT-2B and endothelial nitric oxide synthase in human fetal endothelial cells Flores C.; Aguayo, C.; Parodi, J; Sugden, D; Mann, GE; Pearson, JD; Sobrevia L. Abstract JOURNAL OF PHYSIOLOGY-LONDON (2001)
Acute effect of D-glucose on L-arginine transport and nitric oxide synthesis in human fetal endothelium Flores C.; Sobrevia L. Abstract ISI JOURNAL OF PHYSIOLOGY-LONDON (2000)
Diabetes- and insulin-increased adenosine transport is associated with a higher number of nucleoside transporters in human umbilical artery smooth muscle cells Aguayo, C.; Flores C.; Sobrevia L. Abstract JOURNAL OF PHYSIOLOGY-LONDON (2000)
Differential role of protein kinase C in D-glucose-induced inhibition of L-leucine and thymidine incorporation into macromolecules in human fetal endothelium Rojas, S.; Aguayo, C.; Flores C.; Sobrevia L. Abstract JOURNAL OF PHYSIOLOGY-LONDON (2000)


Monitoring Lactate Dynamics in Individual Macrophages with a Genetically Encoded Probe Baeza-Lehnert, Felipe; Flores, Carlos A.; Guequen, Anita; Barros, Luis Felipe.; Mishra, S BookSection (2020)


B lymphocytes taken to task: a role for a background conductance K-2P K+ channel in B cells. Focus on "Expression of TASK-2 and its upregulation by B cell receptor stimulation in WEHI-231 mouse immature B cells" Flores, CA; Cid, LP; Niemeyer, MI; Sepulveda, FV EditorialMaterial ISI SCOPUS American Journal of Physiology - Cell Physiology (2011)
A tale from the Crypt: splice variants of BK channels in colonic potassium secretion Flores, CA; Cid, LP; Sepulveda, FV EditorialMaterial ISI SCOPUS Journal of Physiology (2010)


Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium (vol 10, 694, 2019) Vega G.; GuequÃ©n A.; Johansson M.E.V.; Arike L.; MartÃnez-Abad B.; NystrÃ¶m E.E.L.; Scudieri P.; Pedemonte N.; Millar-BÃ¼chner P.; Philp A.R.; Galietta L.J.; Hansson G.C.; Flores C.A. Errata ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2019)


ROLE OF KCNN4 IN THE TRANSEPITHELIAL TRANSPORT OF ELECTROLYTES IN THE AIRWAYS. IMPLICATIONS IN HEALTH AND OBSTRUCTIVE AIRWAY DISEASES. FONDECYT (1151142) Proyecto 2015-2019 Director(a)
IDENTIFICATION OF POTASSIUM CHANNELS INVOLVED IN SODIUM-COUPLED ABSORPTION NUTRIENTS AND IN THE SECRETION OF ELECTROLYTES AND FLUID IN INTESTINAL EPITHELIUM. FONDECYT (1120743) Proyecto 2012-2016 Coinvestigador(a)
KCNN4 AS A MODIFIER GENE OF INTESTINAL CYSTIC FIBROSIS SEVERITY. POSSIBLE ROLE OF MAST CELLS. FONDECYT (11100408) Proyecto 2010-2013 Inv. Responsable
MODIFICACION DEL FENOTIPO INTESTINAL EN LA FIBROSIS QUISTICA POR EL CANAL DE POTASIO KCNN4 Y EL BACKGROUND GENETICO EN RATONES. FONDECYT (3085023) Proyecto 2007-2009 Inv. Responsable


TMEM16 proteins: the long awaited calcium-activated chloride channels? Flores, CA; Cid, LP; Sepulveda, FV; Niemeyer, MI Review ISI SCOPUS Brazilian Journal of Medical and Biological Research (2009)
Tumorogenesis and mdm2 protein Flores C.; Sobrevia L. Review REVISTA MEDICA DE CHILE (2000)

Carlos Flores

Researcher

Biology Lab

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

Francisco Sepúlveda

Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Luis Cid

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTIFICOS CECs

Valdivia, Chile

Claudio Aguayo

Profesor Asociado

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Anita Guequen

Asistente de investigación

Biología

Centro Estudios Científicos (CECs)

Valdivia, Chile

Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

Maria Niemeyer

Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTIFICOS CECS

Valdivia, Chile

Marcelo Catalan

Profesor Auxiliar

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

Viviana Montecinos

Assistant Professor

Hematology Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

Jorge Hidalgo

Profesor Auxiliar

Instituto de Medicina

Universidad Austral de Chile

Valdivia, Chile

Rafael Burgos

FULL PROFESSOR

PHARMACOLOGY AND MORPHOPHYSIOLOGY

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

MARIA HIDALGO

Associate professor

Pharmacology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Isabel Cornejo

Investigadora

Biología

Centro de Estudios Científicos

Valdivia, Chile

Pamela Sandoval

Postdoctoral Researcher

Biología

Centro de Estudios Científicos -CECs-

Valdivia, Chile

César González

Profesor Asistente

Facultad de Medicina y Ciencias

Universidad San Sebastián

Puerto Montt, Chile

Alejandro San Martin

Senior Reseacher

Biología

CENTRO DE ESTUDIOS CIENTIFICOS

Valdivia, Chile

Genesis Vega

Investigador

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

ALEX GALAZ

COFOUNDER (Co-CEO)

INFOOD PROTEIN AND BIOTECHNOLOGY

VALDIVIA, Chile

Jose Sarmiento

Assistant Professor

Physiology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

INGRID EHRENFELD

FULL PROFESSOR

ANATOMIA; HISTOLOGIA & PATOLOGIA

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

Claudio Henríquez

Associate Professor

Farmacology and Morphophysiology

Universidad Austral de Chile

Valdivia, Chile

Carlos Figueroa

Head

Anatomy, Histology and Pathology

Universidad Austral de Chile

Valdivia, Chile

Rodrigo Pulgar

Profesor/Investigador asistente

INTA

UNIVERSIDAD DE CHILE - INSTITUTO DE NUTRICION Y TECNOLOGIA DE ALIMENTOS

Santiago, Chile

Luis Federico Batiz

Full Professor

Center for Biomedical Research and Innovation (CIIB)

Universidad de Los Andes

Santiago, Chile

DINKA MANDAKOVIC

Assistant Professor

GEMA Center

Universidad Mayor

Santiago, Chile

Alejandro Acevedo

Omar Porras

Associate professor

Lab. Biología Celular

UNIVERSIDAD DE CHILE

Santiago, Chile

Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

Carlos Alejandro Flores Pinilla

Líneas de Investigación

Educación

Cellular and Molecular Biology, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2007

Physiology, UNIVERSIDAD DE CONCEPCION. Chile, 2001

Tecnologo Medico, UNIVERSIDAD DE LA FRONTERA. Chile, 1997

Experiencia Académica

Investigador/Profesor Asociado Full Time

Experiencia Profesional

Researcher Full Time

Formación de Capital Humano

Premios y Distinciones

Best Poster Presentation

Article (27)

Abstract (5)

BookSection (1)

EditorialMaterial (2)

Errata (1)

Proyecto (4)

ROLE OF KCNN4 IN THE TRANSEPITHELIAL TRANSPORT OF ELECTROLYTES IN THE AIRWAYS. IMPLICATIONS IN HEALTH AND OBSTRUCTIVE AIRWAY DISEASES.

IDENTIFICATION OF POTASSIUM CHANNELS INVOLVED IN SODIUM-COUPLED ABSORPTION NUTRIENTS AND IN THE SECRETION OF ELECTROLYTES AND FLUID IN INTESTINAL EPITHELIUM.

KCNN4 AS A MODIFIER GENE OF INTESTINAL CYSTIC FIBROSIS SEVERITY. POSSIBLE ROLE OF MAST CELLS.

MODIFICACION DEL FENOTIPO INTESTINAL EN LA FIBROSIS QUISTICA POR EL CANAL DE POTASIO KCNN4 Y EL BACKGROUND GENETICO EN RATONES.

Review (2)