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INGRID PAMELA EHRENFELD SLATER

FULL PROFESSOR

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

Rol of inflammation in the malignant behavior of human breast cancer cells and tumor microenvironment. Biomarker in Cancer Inflammation and immunity innate response Anti-inflammatory, antioxidant and antitumor properties of natural extracts

Biologia Celular y Molecular, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2007
Patologia, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2002
Medical Technology, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1997

PROFESOR ASOCIADO Full Time

UNIVERSIDAD AUSTRAL DE CHILE

MEDICINA

VALDIVIA, Chile

2015 - 2020
PROFESOR TITULAR Full Time

UNIVERSIDAD AUSTRAL DE CHILE

MEDICINA

VALDIVIA, Chile

2021 - A la fecha
ASSISTANT PROFESOR Full Time

UNIVERSIDAD AUSTRAL DE CHILE

MEDICINA

VALDIVIA, Chile

2010 - 2015

ASSISTANT PROFESSOR Full Time

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

2010 - 2015
ASSOCIATE PROFESSOR Full Time

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

2015 - 2021
Directora Escuela de Graduados Facultad de Medicina Full Time

Universidad Austral de Chile

Valdivia, Chile

2018 - 2023
TECNOLOGO MEDICO Other

CLINICA ALEMANA DE VALDIVIA

VALDIVIA, Chile

1997 - 2003
FULL PROFFESSOR Full Time

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

2021 - A la fecha
DIRECTORA DEL PROGRAMA HONOR DE LA FACULTAD DE MEDICINA Part Time

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

2016 - 2021
DIRECTORA OFICINA DE INVESTIGACION FACULTAD DE MEDICINA Part Time

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

2017 - 2018
PROFFESSOR Part Time

UNIVERSIDAD SAN SEBASTIAN

VALDIVIA, Chile

2003 - 2018
REPRESENTANTE MESA REGIONAL DEL CANCER Part Time

SEREMI REGION DE LOS RIOS

VALDIVIA, Chile

2018 - A la fecha
DECANA FACULTAS DE MEDICINA Full Time

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

2023 - A la fecha

Adriana Stuardo. Rol de calicreína 5 en la resistencia a cisplatino en células de adenocarcinoma de pulmón. Candidate of PhD in Medical Science UACh. In course (2022), patrocinante.

Paulina Fuentes. Posible contribución de KLK4 a la resistencia a Tamoxifeno en el cáncer de mama receptor de estrógeno positivo. Candidate of PhD in Medical Science UACh. In course (2022), patrocinate

Laura Hernandez. Rol de HERPUD1 en la agresividad del cáncer de mama triple negativo. Candidate of PhD in Celular and Biomedicine USS. In course (2022), Co-patrocinate

Priscilla Scheffer. modula la biodisponibilidad de factores proangiogénicos desde células tumorales de cáncer de mama estrógeno positivo. Medical Technology undergraduate student, patrocinante.

Bryan Hinrichsen. “Inflammation in CNS Remyelination: Can Macrophage Polarization Shape the Contribution of Pericytes in OPC Differentiation?". Candidate of PhD in Cellular and molecular biology. Co-advisor. **(Francisco Rivera Advisor). In course (2019)

Iraidi Ramos. "Asociación entre la dieta proinflamatoria y los niveles de klk3 en pacientes con cáncer de mama: un estudio piloto de casos y controles. Candidate of PhD in Medical Science. In course (2019)

Francisco Olivares. La activación de GPR30/GPER-1 modula los niveles de calicreínas asociadas a peptidasas (KLKs); posible utilidad como biomarcadores en el cáncer de mama estrógeno sensible. Undergraduate Medical technology thesis. 2019

Cinthia Mellado. Productive infection by Herpes Simplex Virus Type 1 alters the levels of KLK6 and its effects neuroinflammatories through the PAR1 and PAR2 receptors in the Central Nervous System. Candidate of PhD in Microbiology. 2019

Teresa Ross. Rol del receptor B1 de cininas en la transición epitelio mesénquima de las células de cáncer de mama. Candidate a Master of Science. 2019.

Felipe Bustamante. Roles no canónicos de ? -SNAP en la patogenia de desórdenes del desarrollo neural: Actividad AMPK en células madre neurales. Candidate of PhD in Biomedicine. 2019

Beatriz Teuber. " B1R y la activación the uPA/uPAR in breast cancer" Undergraduate Medical Technology thesis. 2017

Erwin Budinich. “Rol of kinin B1 receptor to induces the epithelial-mesenchymal and mesenchymal-epithelial transition in breast cáncer cells”. Master of Sciences. 2016.

Francisca Pavicic. “The activation of kinin B1 receptor induces the secretion and/or expression of VEGF and metalloproteases in tumoral microenvironment cells”. Master of Sciences. 2015.

Francisco Córdova. S-nitrosylation regulates ELAM-1 and the ICAM-1 expression on the endothelial surface in response to IL-8. UACh. Medical Technology. 2016.

Alejandra Aguilar. Mechanisms of regulation of ICAM-1 involved eNOS activation at the onset of the inflammatory response. Doctorate Program in Veterinary Sciences. 2017

Daniela Ruiz Ulloa. “ Mechanism of transactivation of epidermal growth factor receptor (EGFR), use by kinin B1 receptor stimulation in breast cancer cell”. Medical Technology. 2015

Erwin Budinich E. ''Rol of kinin B1 receptor in the epithelial-mesenchymal transition of breast cáncer cells''. Biochemistry. 2013.

Yessica Andrade. “Effect of B1 receptor activation by transactivation of EGFR in the phosphorylation of MAPKs JNK y p38, AKT y mTOR in breast cáncer cells. Medical Technology. 2013.

Carlos Borquez. “ The kinin B1 receptor agonist induces the expression of tisular kallikrein in breast cáncer cells”. Medical Technology. 2012.

Manuel Barría. “Level expression of adhesión molecules, ELAM-1 and PECAM-1 in endothelial cells stimulated with Bradykinin 1 receptor agonist. Medical Technology. 2008.

The researcher actively participates in Explora programs of scientific diffusion, from talks in "Open science explores" Región de Los Ríos, "let's open our laboratories," and "let's investigate at home," among others. It is noteworthy that her students have already been selected twice for the national congress organized by Explora.
In addition, the researcher actively participates with the health service, the Valdivia Base Hospital, the Seremi de Salud, civil society, schools, and patient organizations, among others, in campaigns for the promotion, prevention and dissemination of scientific advances in cancer, particularly in breast cancer With the regional government and through the FIC17-06 project, she develops a campaign "Your health in your hands" that included talks on prevention of breast cancer in the different districts of the region, both in schools and clinics.
She also participates in radio programs, press releases in the Austral newspaper, and webpages of the Universidad Austral de Chile, reinforcing these themes.

¿Can tumoral cells talk with the endothelial cells?

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2014

This work was realized by Maribel Muñoz and Abigail Vásquez of " Instituto Superior de Administración y Turismo " (Valdivia) and they studied the effect of conditioned medium from estrogen sensitive breast cancer cell lines in the S-nitrosylation of endothelial proteins; these protein controls the endothelial barrier and the vascular permeability.
Premio a la investigadora del año

GOBIERNO REGIONAL REGION DE LOS RIOD

Chile, 2022

Reconocimiento por su destacado aporte a la ciencia, innovación y tecnología al territorio de Los Ríos, en el lanzamiento de los proyectos del Fondo de Innovación a la Competitividad 2021 del Gobierno Regional. La Dra. Pamela Ehrenfeld Slater uno de los dos premios, por su contribución en diversos proyectos FIC, principalmente en investigaciones sobre el cáncer de mama manteniendo a su vez una destacada colaboración en otras iniciativas FIC a lo largo de su carrera académica
Mujer y Academia

UNIVERSIDAD AUSTRAL DE CHILE

Chile, 2022

Premio en conmemoración de la Dra Carola Otth y que destaca el compromiso de las mujeres de la Facultad de Medicina de la Universidad Austral de Chile al compromiso institucional, la docencia, investigación, vinculación con la sociedad, politicas de género, entre otras.


Circulating platelets modulate oligodendrocyte progenitor cell differentiation during remyelination Philp, Amber R.; Reyes, Carolina R.; Mansilla, Josselyne; Sharma, Amar; Zhao, Chao; Valenzuela-Krugmann, Carlos; Rawji, Khalil S.; Martinez, Ginez A. Gonzalez; Dimas, Penelope; Hinrichsen, Bryan; Ulloa-Leal, Cesar; Waller, Amie K.; de Sousa, Diana M. Bessa; Castro, Maite A.; Aigner, Ludwig; Ehrenfeld, Pamela; Silva, Maria Elena; Kazanis, Ilias; Ghevaert, Cedric; Franklin, Robin J. M.; Rivera, Francisco J. Article ISI ELIFE (2024)
Galectin-8 counteracts folic acid-induced acute kidney injury and prevents its transition to fibrosis Perez-Moreno, Elisa; Toledo, Tomas; Campusano, Pascale; Zuniga, Sebastian; Azocar, Lorena; Feuerhake, Teo; Mendez, Gonzalo P.; Labarca, Mariana; Perez-Molina, Francisca; de la Pena, Adely; Herrera-Cid, Cristian; Ehrenfeld, Pamela; Godoy, Alejandro S.; Gonzalez, Alfonso; Soza, Andrea Article ISI BIOMEDICINE & PHARMACOTHERAPY (2024)
Moderate-Intensity Constant and High-Intensity Interval Training Confer Differential Metabolic Benefits in Skeletal Muscle, White Adipose Tissue, and Liver of Candidates to Undergo Bariatric Surgery Ruiz-Uribe, Matias; Enriquez-Schmidt, Javier; Monrroy-Uarac, Manuel; Mautner-Molina, Camila; Kalazich-Rosales, Mariana; Munoz, Maximiliano; Fuentes-Leal, Francisca; Carcamo-Ibaceta, Carlos; Fazakerley, Daniel J.; Larance, Mark; Ehrenfeld, Pamela; Martinez-Huenchullan, Sergio Article ISI Journal of Clinical Medicine (2024)
Moderate-intensity constant or high-intensity interval training? Metabolic effects on candidates to undergo bariatric surgery Enriquez-Schmidt, Javier; Molina, Camila Mautner; Rosales, Mariana Kalazich; Munoz, Maximiliano; Ruiz-Uribe, Matias; Leal, Francisca Fuentes; Uarac, Manuel Monrroy; Ibaceta, Carlos Carcamo; Fazakerley, Daniel J.; Larance, Mark; Ehrenfeld, Pamela; Martinez-Huenchullan, Sergio Article ISI NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2024)
The Long Non-Coding RNA MALAT1 Modulates NR4A1 Expression through a Downstream Regulatory Element in Specific Cancer Cell Types Wernig-Zorc, Sara; Schwartz, Uwe; Martinez-Rodriguez, Paulina; Inalef, Josefa; Pavicic, Francisca; Ehrenfeld, Pamela; Laengst, Gernot; Maldonado, Rodrigo Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2024)
Difference in Receptor Activator of Nuclear Factor k B Expression in Tumoral Tissue by Different Periodontal Pathogens Diferencia en la Expresión del Ligando de Receptor Activador para el Factor Nuclear k B, en Tejido Tumoral Frente a la Infección por Diferentes Patógenos Periodontales Maher, Anushiravan; Munoz, David Nicolas; Pavicic, Maria Francisca; GONZALEZ-FUENTES, MARIO JOSE; Ehrenfeld, Pamela; Halabi, Diego; Munoz-Kramm, Alejandra; Munoz, Helmuth Article ISI SCIELO SCOPUS INTERNATIONAL JOURNAL OF MORPHOLOGY (2023)
Expression and Distribution of Kallikrein-related Peptidases 5, 7, 8 and 10 in Normal Apocrine Gland of Canine Skin Pamela Ehrenfeld; Carlos D Figueroa; Luis Molina; Tania Koning; Myriam Velasco; Felipe A Bustamante-Barrientos; Alexander Ortloff Article SCIELO INTERNATIONAL JOURNAL OF MORPHOLOGY (2023)
From gestational chronodisruption to noncommunicable diseases: Pathophysiological mechanisms of programming of adult diseases, and the potential therapeutic role of melatonin Mendez, Natalia; Corvalan, Fernando; Halabi, Diego; Ehrenfeld, Pamela; Maldonado, Rodrigo; Vergara, Karina; Seron-Ferre, Maria; Torres-Farfan, Claudia Article ISI JOURNAL OF PINEAL RESEARCH (2023)
Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer Stuardo-Parada, Adriana; Lopez-Munoz, Rodrigo; Villarroel-Espindola, Franz; Figueroa, Carlos D.; Ehrenfeld, Pamela Article ISI MEDICAL ONCOLOGY (2023)
Tamoxifen triggers the in vitro release of neutrophil extracellular traps in healthy horses Salinas, Constanza; Barriga, Kassandra; Albornoz, Alejandro; Alarcon, Pablo; Quiroga, John; Uberti, Benjamin; Sarmiento, Jose; Henriquez, Claudio; Ehrenfeld, Pamela; Burgos, Rafael A.; Moran, Gabriel Article ISI FRONTIERS IN VETERINARY SCIENCE (2023)
Effects of aerobic exercise on fibroblast growth factor 21 in overweight and obesity. A systematic review Porflitt-Rodríguez M,; Guzmán-Arriagada V,; Sandoval-Valderrama R,; Tam CS,; Pavicic F,; Ehrenfeld P,; Martínez-Huenchullán S Article SCOPUS, (2022)
Antibacterial and cytotoxic evaluation of copper and zinc oxide nanoparticles as a potential disinfectant material of connections in implant provisional abutments: An in-vitro study Vergara-Llanos, Diego; Koning, Tania; Pavicic, Maria Francisca; Bello-Toledo, Helia; Díaz-Gómez, Andrés; Jaramillo, Andrés; Melendrez-Castro, Manuel; Ehrenfeld, Pamela; Sánchez-Sanhueza, Gabriela Article ISI Archives of Oral Biology (2021)
Combining Materials Obtained by 3D-Printing and Electrospinning from Commercial Polylactide Filament to Produce Biocompatible Composites Romero-Araya, Pablo; Pino, Victor; Nenen, Ariel; Cardenas, Verena; Pavicic, Francisca; Ehrenfeld, Pamela; Serandour Guillaume; Lisoni, Judit G.; Moreno-Villoslada, Ignacio; Flores, Mario E. Article ISI POLYMERS (2021)
Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity nanobody Valenzuela Nieto, Guillermo; Jara, Ronald; Watterson, Daniel; Modhiran, Naphak; Amarilla, Alberto A.; Himelreichs, Johanna; Khromykh, Alexander A.; Salinas-Rebolledo, Constanza; Pinto, Teresa; Cheuquemilla, Yorka; Margolles, Yago; Gonzalez del Rey, Natalia Lopez; Miranda-Chacon, Zaray; Cuevas, Alexei; Berking, Anne; Deride, Camila; Gonzalez-Moraga, Sebastian; Mancilla, Hector; Maturana, Daniel; Langer, Andreas; Pablo Toledo, Juan; Muller, Ananda; Uberti, Benjamin; Krall, Paola; Ehrenfeld, Pamela; Blesa, Javier; Chana-Cuevas, Pedro; Rehren, German; Schwefel, David; Angel Fernandez, Luis; Rojas-Fernandez, Alejandro Article ISI SCIENTIFIC REPORTS (2021)
TNF-α-activated eNOS signaling increases leukocyte adhesion through the <i>S</i>- nitrosylation pathway Aguilar, Gaynor; Cordova, Francisco; Koning, Tania; Sarmiento, Jose; Boric, Mauricio P.; Birukov, Konstantin; Cancino, Jorge; Varas-Godoy, Manuel; Soza, Andrea; Alves, Natascha G.; Mujica, Patricio E.; Duran, Walter N.; Ehrenfeld, Pamela; Sanchez, Fabiola A. Article ISI AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2021)
Constant-moderate versus high-intensity interval training on heart adiponectin levels in high-fat fed mice: a preventive and treatment approach Martinez-Huenchullan, Sergio F.; Fox, Sarah L.; Tam, Charmaine S.; Maharjan, Babu Raja; Olaya-Agudo, Luisa F.; Ehrenfeld, Pamela; Williams, Paul F.; Mclennan, Susan, V; Twigg, Stephen M. Article ISI ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2020)
Continuous Exposure of Breast Cancer Cells to Tamoxifen Upregulates GPER-1 and Increases Cell Proliferation Molina, Luis; Bustamante, Felipe; Ortloff, Alexander; Ramos, Iraidi; Ehrenfeld, Pamela; Figueroa, Carlos D. Article ISI FRONTIERS IN ENDOCRINOLOGY (2020)
Involvement of Kallikrein-Related Peptidases in Nervous System Disorders Mella, Cinthia; Figueroa, Carlos D.; Otth, Carola; Ehrenfeld, Pamela Article ISI FRONTIERS IN CELLULAR NEUROSCIENCE (2020)
Kallikrein-related Peptidase 5 (KLK5) Expression and Distribution in Canine Cutaneous Squamous Cell Carcinoma. Ortloff A, Bustamante FA, Molina L, Ojeda J, Figueroa CD, Ehrenfeld P. Article ISI SCOPUS (2020)
Role of NO and S-nitrosylation in the Expression of Endothelial Adhesion Proteins That Regulate Leukocyte and Tumor Cell Adhesion Aguilar, Gaynor; Koning, Tania; Ehrenfeld, Pamela; Sanchez, Fabiola A. Article ISI FRONTIERS IN PHYSIOLOGY (2020)
Biodentine Induce Proteínas Apoptóticas Caspasa 3 y PARP-1 en Células de la Pulpa Dental Humana Pablo. F Romero; Mario E Flores; Pamela Ehrenfeld; Tania Köning; Francisca Pavicic Article SCIELO INTERNATIONAL JOURNAL OF ODONTOSTOMATOLOGY (2019)
Extracellular adenosine promotes cell migration/invasion of Glioblastoma Stem-like Cells through A(3) Adenosine Receptor activation under hypoxia Torres, Angelo; Ignacio Erices, Jose; Sanchez, Fabiola; Ehrenfeld, Pamela; Turchi, Laurent; Virolle, Thierry; Uribe, Daniel; Niechi, Ignacio; Spichiger, Carlos; Dellis Rocha, Jose; Ramirez, Marcos; Salazar-Onfray, Flavio; San Martin, Rody; Quezada, Claudia Article ISI SCOPUS CANCER LETTERS (2019)
Galectin-8 induces endothelial hyperpermeability through the eNOS pathway involving S-nitrosylation-mediated adherens junction disassembly Zamorano P, Koning T, Oyanadel C, Mardones GA, Ehrenfeld P, Boric MP, González A, Soza A, Sánchez FA. Article ISI SCOPUS CARCINOGENESIS (2019)
Role of adherens junctions and apical-basal polarity of neural stem/progenitor cells in the pathogenesis of neurodevelopmental disorders: a novel perspective on congenital Zika syndrome Bustamante, Felipe A.; Miró, MarÍa Paz; VelÁsquez, Zahady D.; Molina, Luis; Ehrenfeld, Pamela; Rivera, Francisco J.; BÁtiz, Luis Federico Article ISI SCOPUS TRANSLATIONAL RESEARCH (2019)
Role of adherens junctions and apical-basal polarity of neural stem/progenitor cells in the pathogenesis of neurodevelopmental disorders: a novel perspective on congenital Zika syndrome. Bustamante FA, Miró MP, VelÁsquez ZD, Molina L, Ehrenfeld P, Rivera FJ, BÁtiz LF. Article WOS CORE collection ISI TRANSLATIONAL RESEARCH (2019)
The knocking down of the oncoprotein Golgi phosphoprotein 3 in T98G cells of glioblastoma multiforme disrupts cell migration by affecting focal adhesion dynamics in a focal adhesion kinase-dependent manner Arriagada, C; Luchsinger, C; Gonzalez, AE; Schwenke, T; Arriagada, G; Folch, H; Ehrenfeld, P; Burgos, PV; Mardones, GA Article ISI SCOPUS PLOS ONE (2019)
Functional disruption of the Golgi apparatus protein ARF1 sensitizes MDA-MB-231 breast cancer cells to the antitumor drugs Actinomycin D and Vinblastine through ERK and AKT signaling Luchsinger, Charlotte; Aguilar, Marcelo; Burgos, Patricia, V; Ehrenfeld, Pamela; Mardones, Gonzalo A.; Jackson, Catherine L. Article ISI SCOPUS PLOS ONE (2018)
Functional interrelationships between the kallikrein-related peptidases family and the classical kinin system in the human neutrophil. Ehrenfeld, Pamela; Bhoola, Kanti D; Matus, Carola E; Figueroa, Carlos D Article Biological chemistry (2018)
Overview of tissue kallikrein and kallikrein-related peptidases in breast cancer. Figueroa, Carlos D; Molina, Luis; Bhoola, Kanti D; Ehrenfeld, Pamela Article Biological chemistry (2018)
Possible role of phytoestrogens in breast cancer via GPER-1/GPR30 signaling Molina, Luis; Bustamante, Felipe A.; Bhoola, Kanti D.; Figueroa, Carlos D.; Ehrenfeld, Pamela Article ISI SCOPUS CLINICAL SCIENCE (2018)
The Adenosine A(3) Receptor Regulates Differentiation of Glioblastoma Stem-Like Cells to Endothelial Cells under Hypoxia Rocha, R; Torres, A; Ojeda, K; Uribe, D; ROCHA, D.; Erices, J; Niechi, I; Ehrenfeld, P; San Martin, R; Quezada, C Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
alpha-SNAP is expressed in mouse ovarian granulosa cells and plays a key role in folliculogenesis and female fertility Arcos, Alexis; Paola, Matilde de; Gianetti, Diego; Acuña, Diego; Velásquez, Zahady D.; Miró, María Paz; Toro, Gabriela; Hinrichsen, Bryan; Muñoz, Rosa Iris; Lin, Yimo; Mardones, Gonzalo A.; Ehrenfeld, Pamela; Rivera, Francisco J.; Michaut, Marcela A.; Batiz, Luis Federico Article ISI SCOPUS SCIENTIFIC REPORTS (2017)
GPER-1/GPR30 a novel estrogen receptor sited in the cell membrane: therapeutic coupling to breast cancer Molina, Luis; Figueroa, Carlos D.; Bhoola, Kanti D.; Ehrenfeld, Pamela Article ISI SCOPUS EXPERT OPINION ON THERAPEUTIC TARGETS (2017)
Activation of the human keratinocyte B1 bradykinin receptor induces expression and secretion of metalloproteases 2 and 9 by transactivation of epidermal growth factor receptor Matus, Carola E.; Ehrenfeld, Pamela; Pavicic, Francisca; González, Carlos B.; Concha, Miguel; Bhoola, Kanti D.; Burgos, Rafael A.; Figueroa, Carlos D. Article ISI SCOPUS EXPERIMENTAL DERMATOLOGY (2016)
Distinct biochemical pools of Golgi phosphoprotein 3 in the human breast cancer cell lines MCF7 and MDA-MB-231 Tenorio M.J., Ross B.H.; Luchsinger, C; Rivera-Dictter, A; Arriagada C., Acuña D.; Aguilar, M; Cavieres, V; Burgos, P.V.; Ehrenfeld, P Article PLoS ONE (2016)
Distinct Biochemical Pools of Golgi Phosphoprotein 3 in the Human Breast Cancer Cell Lines MCF7 and MDA-MB-231. Tenorio MJ; Ross BH; Luchsinger C; Rivera-Dictter A: Arriagada C; Acuña D; Aguilar M; Cavieres V; Burgos PV; Ehrenfeld P; Mardones GA. Article PLoS One (2016)
The calcium-activated potassium channel KCa3.1 plays a central role in the chemotactic response of mammalian neutrophils Henriquez, C; Riquelme, TT; Vera, D.; Julio-Kalajzic, F; Ehrenfeld, P; Melvin, JE; Figueroa, CD; Sarmiento J.; Flores, CA Article ISI SCOPUS ACTA PHYSIOLOGICA (2016)
Expression and bioregulation of the kallikrein-related peptidases family in the human neutrophil Lizama, AJ; Andrade, Y; Colivoro, P; Sarmiento J.; Matus, CE; Gonzalez, CB; Bhoola, KD; Ehrenfeld, P; Figueroa, CD Article ISI SCOPUS Innate Immunity (2015)
Intracellular signaling pathways involved in the release of IL-4 and VEGF from human keratinocytes by activation of kinin B-1 receptor: functional relevance to angiogenesis Mejia, AJ; Matus, CE; Pavicic, F.; Concha M.; Ehrenfeld, P; Figueroa, CD Article ISI SCOPUS Archives of Dermatological Research (2015)
Kinin B-1 receptor regulates interactions between neutrophils and endothelial cells by modulating the levels of Mac-1, LFA-1 and intercellular adhesion molecule-1 Figueroa, CD; Matus, CE; Pavicic, F.; Sarmiento J.; Hidalgo, MA; Burgos, RA; Gonzalez, CB; Bhoola, KD; Ehrenfeld, P Article ISI SCOPUS Innate Immunity (2015)
Up-regulation of the kinin B2 receptor pathway modulates the TGF-beta/Smad signaling cascade to reduce renal fibrosis induced by albumin Cardenas, A; Campos J.; Ehrenfeld, P; Mezzano S.; Ruiz-Ortega, M; Figueroa, CD; Ardiles L. Article ISI SCOPUS Peptides (2015)
Bioregulation of Kallikrein-related Peptidases 6, 10 and 11 by the Kinin B-1 Receptor in Breast Cancer Cells Ehrenfeld, P; Manso, L; Pavicic, MF; Matus, CE; Borquez, C; Lizama A.; Sarmiento J.; Poblete, MT; Bhoola, KD; Naran, A; Figueroa, CD Article ISI Anticancer research. (2014)
Bioregulation of kallikrein-related peptidases 6, 10 and 11 by the kinin B1 receptor in breast cancer cells. Ehrenfeld P, Manso L, Pavicic MF, Matus CE, Borquez C, Lizama A, Sarmiento J, Poblete MT, Bhoola KD, Naran A, Figueroa CD Article Anticancer Research (2014)
Antihypertensive and renoprotective effect of the kinin pathway activated by potassium in a model of salt sensitivity following overload proteinuria Ardiles L.; Cardenas, A; BURGOS, ME; Droguett A.; Ehrenfeld, P; Carpio, D; Mezzano S.; Figueroa, CD Article ISI SCOPUS American Journal of Physiology - Renal Physiology (2013)
S-nitrosation of proteins: An emergent regulatory mechanism in microvascular permeability and vascular function Sánchez, Fabiola A.; Ehrenfeld, Ingrid P.; Durán, Walter N. Article Tissue Barriers (2013)
Expression of HER2 and bradykinin B1 receptors in precursor lesions of gallbladder carcinoma Toledo C.; Matus C.E.; Barraza, X; Arroyo, P; Ehrenfeld, P; Figueroa C.D.; Bhoola K.D.; del Pozo M.; Poblete M.T. Article ISI SCOPUS World Journal of Gastroenterology (2012)
Activation of kinin B-1 receptor increases the release of metalloproteases-2 and-9 from both estrogen-sensitive and -insensitive breast cancer cells Ehrenfeld, Ingrid; Conejeros, Ivan; Pavicic, Maria; Matus, Carola; Gonzalez, Carlos; Quest, andrew; Bhoola, Daya Article ISI SCOPUS CANCER LETTERS (2011)
Kinin B-1 receptor activation turns on exocytosis of matrix metalloprotease-9 and myeloperoxidase in human neutrophils: involvement of mitogen-activated protein kinase family Ehrenfeld, P; Matus, CE; Pavicic, F.; Toledo C.; Nualart, F.; Gonzalez, CB; Burgos, RA; Bhoola, KD; Figueroa, CD Article ISI SCOPUS JOURNAL OF LEUKOCYTE BIOLOGY (2009)
Postnatal expression of V-2 vasopressin receptor splice variants in the rat cerebellum Vargas, KJ; Sarmiento, JM; Ehrenfeld, P; Anazco CC; Villanueva, CI; Carmona, PL; Brenet, M.; Navarro, J.; Muller-Esterl, W; Gonzalez, CB Article ISI SCOPUS DIFFERENTIATION (2009)
Stimulation of the bradykinin B-1 receptor induces the proliferation of estrogen-sensitive breast cancer cells and activates the ERK1/2 signaling pathway Molina, L; Matus, CE; Astroza, A; Pavicic, F.; Tapia, E; Toledo C.; Perez, JA; Nualart, F.; Gonzalez, CB; Burgos, RA; Figueroa, CD; Ehrenfeld, P; Poblete, MT Article ISI SCOPUS BREAST CANCER RESEARCH AND TREATMENT (2009)
Activation of kinin B(1) receptor triggers differentiation of cultured human keratinocytes Matus, CE; Ehrenfeld, P; Pavicic, F.; Sarmiento, JM; Astroza, A; Sánchez T; Salem, C; Concha M.; Vidal MA; Gonzalez, CB; Figueroa, CD Article ISI SCOPUS BRITISH JOURNAL OF DERMATOLOGY (2008)
Activation of kinin B-1 receptors induces chemotaxis of human neutrophils Ehrenfeld, P; Millán C; Matus, CE; Figueroa JE; Burgos, RA; Nualart, F.; Bhoola, KD; Figueroa, CD Article ISI SCOPUS JOURNAL OF LEUKOCYTE BIOLOGY (2006)
Modulation of renal kallikrein by a high potassium diet in rats with intense proteinuria Ardiles, LG; Loyola F.; Ehrenfeld, P; BURGOS, ME; Flores, CA; Valderrama, G; CAORSI, I; Egido, J; Mezzano, SA; Figueroa, CD Article ISI SCOPUS KIDNEY INTERNATIONAL (2006)
Differential distribution of the vasopressin V-2 receptor along the rat nephron during renal ontogeny and maturation Sarmiento, JM; Ehrenfeld, P; Anazco CC; Reyes, CE; Troncoso S.; Figueroa, CD; Muller-Esterl, W; Gonzalez, CB Article ISI SCOPUS KIDNEY INTERNATIONAL (2005)
Kinin B2 receptor-coupled signal transduction in human cultured keratinocytes Vidal MA; Astroza, A; Matus, CE; Ehrenfeld, P; Pavicic, F.; Sánchez T; Salem, C; Figueroa J.; Concha M.; Gonzalez, CB; Figueroa, CD Article ISI SCOPUS JOURNAL OF INVESTIGATIVE DERMATOLOGY (2005)
Effect of mycophenolate mofetil on kallikrein expression in the kidney of 516 nephrectomized rats Ardiles, LG; Ehrenfeld, P; Quiroz, Y; Rodriguez-Iturbe, B; Herrera-Acosta, J; Mezzano S.; Figueroa, CD Article ISI SCOPUS Kidney & Blood Pressure Research (2002)
Renal kallikrein-kinin system (KK) compromise in a 5/6 renal ablation model modulated by mycophenolate mofetil (MMF). Ardiles L.; Figueroa, CD; Ehrenfeld, P; Quiroz, Y; Rodriguez-Iturbe, B; Herrera-Acosta, J; Mezzano S. Article HYPERTENSION (2001)
Temporospatial changes of kinin B2 receptors during the estrous cycle and pregnancy in the rat uterus Figueroa, CD; Chacon, C.; Corthorn, J; Ehrenfeld, P; Muller-Esterl, W; Valdes G. Article ISI SCOPUS BIOLOGY OF REPRODUCTION (2001)


Analysis of GOLPH3 depletion on protein glycosylation in human glioblastoma multiforme T98G cells Arriagada C.; Cavieres, V; Alexis, G; Ross, BH; Aguilar, M; Folch H.; Ehrenfeld, P; Burgos, PV; Mardones, GA Abstract ISI FEBS JOURNAL (2015)
Study of the role of extracellular adenosine on chemoresistance in glioblastoma stem-like cells Quezada C.; Garrido, W; ROCHA, D.; González C; Hueicha, K; Ehrenfeld, P; Oyarzún C.; Martin, RS Abstract FEBS JOURNAL (2013)
Kinins and their receptors, a new autocrine-paracrine signaling pathway that contributes to breast cancer malignancy Ehrenfeld, P; Pavicic, MF; Matus, CE; Borquez, C; Lizama A.; Sarmiento J.; Bhoola, KD; Figueroa, CD Abstract ISI INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2012)
Kinin B1 but not B2 receptor agonists induce human neutrophil chemotaxis Ehrenfeld, P; Millán C; Figueroa J.; Nualart, F.; Figueroa, CD Abstract JOURNAL OF LEUKOCYTE BIOLOGY (2004)
Expression of CD40 and the mitogenic peptide hormone receptors vasopressin V1 and kinin B1 and B2 receptors in psoriatic epidermis Vidal MA; Ehrenfeld, P; Astroza, A; Moreno, MI; Figueroa J.; Salem, C; Gonzalez, CB; Figueroa, CD; Concha M. Abstract JOURNAL OF INVESTIGATIVE DERMATOLOGY (2001)
Kinin B2 receptors during the estrous cycle and pregnancy in the rat uterus Figueroa, CD; Chacon, C.; Corthorn, J; Ehrenfeld, P; Muller-Esterl, W; Valdes G. Abstract HYPERTENSION (2001)
Characterization and distribution of renal bradykinin and vasopressin receptors Figueroa, CD; Ehrenfeld, P; Reyes, CE; Troncoso S.; Muller-Esterl, W; Gonzalez, CB Abstract JOURNAL OF PHYSIOLOGY-LONDON (2000)


Classical kallikreins and kinins in Cancer Ehrenfeld, P; Figueroa, CD; Bhoola K. BookReview In Cancer field Kinins (2012)


BDCM: Biomarcador para el cáncer de mama Ehrenfeld, Ingrid Pamela; Alejandro Rojas Fernandez Proyecto Esta es la continuidad del Proyecto FIC17-06 que realizo prevalidación de 5 posibles biomarcadorrs, resultando uno de ellos con signifiacncia estadistica entre población sana y con cáncer de mama. (2022)
Title: Unvealing the functional role, signaling and biomarker utilityof KLK4 and KLK12 in breast cancer Ehrenfeld, Pamela; Figueroa, Carlos Dario; Sanchez, Fabian; Rojas, Alejandro; Torres - Farfán, Claudia Proyecto We strongly believe that our study will contribute to a better understanding of the functional role of KLK 4 and KLK12 in breast cancer, if the proposed mechanisms are validated, the use of specific inhibitors for KLK4 or KLK12 or antagonists to their PARs partners should be considerer (2020)
Development of nanobodies directed to human kallikrein-related peptidase 4 (KLK4)=> Analysis of its immunomodulatory properties in ovarian cancer BAYLAT ALEMANIA (BAYLAT2019) Proyecto 2019-2020 Coinvestigador(a)
Gestational chronodisruption programs the adult offspring pineal gland in rats altering development of the melatonin circadian rhythm=> assessing the impact of melatonin restoration in adult chronic disease onset. FONDECYT (1191207) Proyecto 2019-2023 Coinvestigador(a)
Rejuvenated Brain Network – ReBrainNet Castro, Maite.; Rivera, Francisco; Ehrenfeld, Pamela Proyecto Support of International Networking between Research centers. Collaboration with Francisco Rivera and Maite Castro. (2019)
Rejuvenated Brain Network – ReBrainNet. PCI (N° REDES 1) Proyecto 2019-2021 Coinvestigador(a)
Grant Provision Program Innovation Fund for Competitiveness Innovation (Programa Provisión Fondo de Innovación para la Competitividad), Región de los Ríos, Chile. Implementation of a regional strategy for the early detection of breast cancer. REGIONAL (FIC17-6) Proyecto 2018-2020 Inv. Responsable
Interdisciplinary Network for Naturopathic Regeneration - Net4NatuRe Rivera, Francisco; Ehrenfeld, Pamela; simirgiotis, mario Proyecto Collaboration with Francisco Rivera (2018)
Interdisciplinary Network for Naturopathic Regeneration - Net4NatuRe. PCI (REDES17023) Proyecto 2018-2020 Coinvestigador(a)
Prevención y Diagnóstico precoz del cancer de mama Ehrenfeld, P; Figueroa CD, Rojas A Proyecto Desarrollar mediante la generación de anticuerpos policlonales o nanobodies un test de detección tipo ELISA para la detección precoz del cáncer de mama en mujeres. Una vez validado contra un banco de suero de pacientes con cáncer de mama, esperamos que esta tecnología pueda ser patentada. (2018)
“Kinin B1 receptor stimulation shifts breast tumor microenvironment cells (endothelial and tumoral) towards a dissemination promoting state” Ehrenfeld, P; Sanchez, F Proyecto (2015)
“Kinin B1 receptor stimulation shifts breast tumor microenvironment cells (endothelial and tumoral) towards a dissemination promoting state” DID UACH (2015-61) Proyecto 2015-2017 Inv. Responsable
CANONICAL AND NON-CANONICAL ROLES OF .-SNAP IN THE PATHOGENESIS OF NEURODEVELOPMENTAL DISORDERS=> FOCUS ON MODULATION OF AUTOPHAGY AND AMPK SIGNALING. FONDECYT (1141015) Proyecto 2014-2018 Coinvestigador(a)
Golgi proteome in cancer=> identification of new therapeutic targets FONDECYT (1130710) Proyecto 2013-2016 Coinvestigador(a)
Signaling Mechanisms Regulated by eNOS-S-nitrosation at the Onset of the Inflammatory Process FONDEF (1130769) Proyecto 2013-2016 Coinvestigador(a)
“Golgi proteome in cancer: identification of new therapeutic targets”. Mardones, G; Ehrenfeld, P Proyecto (2013)
“Signaling Mechanisms Regulated by eNOS-S-nitrosation at the Onset of the Inflammatory Process” Sanchez, F; Ehrenfeld, P Proyecto (2013)
“Regulation of human neutrophil function by the bradykinin B1 receptor” Figueroa, CD; Ehrenfeld, P Proyecto (2011)
Regulation of human neutrophil function by the bradykinin B1 receptor”. FONDECYT (1110464) Proyecto 2011-2014 Coinvestigador(a)
Modulation of the malignant behavior of human breast cancer cells by the bradykinin B1 receptor Ehrenfeld, P Proyecto (2009)
“Modulation of the malignant behavior of human breast cancer cells by the bradykinin B1 receptor”. FONDECYT (11090292) Proyecto 2009-2013 Inv. Responsable
"The kin receptor B1 regulates the invasive ability of cells derived from MCF-7 breast cancer." Ehrenfeld, P Proyecto (2007)
“El receptor B1 de cininas regula la capacidad invasiva de las células derivadas de cáncer de mama MCF-7” FONDECYT (3085006) Proyecto 2007-2009 Inv. Responsable
“Modulación de la respuesta inflamatoria y antineoplasica del leucocito neutrófilo humano por el receptor B1 de cininas” FONDECYT (1070398) Proyecto 2007-2010 Coinvestigador(a)
“Modulación de la respuesta inflamatoria y antineoplasica del leucocito neutrófilo humano por el receptor B1 de cininas”. Figueroa, CD; Ehrenfeld, P Proyecto (2007)
“Rol del receptor B1 de cininas en la activación del leucocito neutrófilo” DID, UNIVERSIDAD AUSTRAL DE CHILE (200510) Proyecto 2005-2007 Inv. Responsable
“Role of the kin receptor B1 in the activation of neutrophil leukocyte " Ehrenfeld, P Proyecto Grant for PhD students (2005)
“Canonical and non-canonical roles of α-SNAP in the pathogenesis of neurodevelopmental disorders: focus on modulation of autophagy and AMPK signaling” Batiz FL; Ehrenfeld, P Proyecto I am a Co-Principal investigator from 2016. (0)


Effects of exercise on irisin in subjects with overweight or obesity. A systematic review of clinical studies Bernal-Rivas, Camila; Llamunao-Tropa, Angela; Reyes-Barria, Andres; Halabi, Diego; Pavicic, Francisca; Ehrenfeld, Pamela; Martinez-Huenchullan, Sergio Review ISI Nutricion Hospitalaria (2022)
Skeletal muscle adiponectin induction in obesity and exercise Martinez-Huenchullan S.F.; Tam C.S.; Ban L.A.; Ehrenfeld-Slater P.; Mclennan S.V.; Twigg S.M. Review ISI SCOPUS (2020)
S-nitrosylation and its role in breast cancer angiogenesis and metastasis Ehrenfeld P.; Cordova F.; Duran W.N.; Sanchez F.A. Review ISI SCOPUS Nitric Oxide (2019)
Kinin receptors as targets for cancer therapy Figueroa C.D.; Ehrenfeld, P; Bhoola K.D. Review ISI SCOPUS Expert Opinion on Therapeutic Targets (2012)

INGRID EHRENFELD

FULL PROFESSOR

ANATOMIA; HISTOLOGIA & PATOLOGIA

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

Carlos Figueroa

Head

Anatomy, Histology and Pathology

Universidad Austral de Chile

Valdivia, Chile

Jose Sarmiento

Assistant Professor

Physiology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Rafael Burgos

FULL PROFESSOR

PHARMACOLOGY AND MORPHOPHYSIOLOGY

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

Luis Molina

PROFESOR ASISTENTE

CIENCIAS BÁSICAS

Universidad San Sebastián

Puerto Montt, Chile

Fabiola Sánchez

Associate Profesor

Immunology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Leopoldo Ardiles

Profesor Titular

Medicina

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

Sergio Martínez

Investigador

Universidad San Sebastián

Valdivia, Chile

Sergio Mezzano

Catedratico

Medicina

Universidad Austral de Chile

Valdivia, Chile

Maria Poblete

Profesor Auxiliar

Anatomia, Histologia y Patologia

Universidad Austral de Chile

Valdivia, Chile

Carolina Añazco

Profesora Asociada

Universidad San Sebastián

Valdivia, Chile

Francisco Rivera

Associate Professor in Integrative Neurobiology

Molecular and Integrative Biosciences Research Programme

University of Helsinki

Helsinki, Finlandia

Luis Federico Batiz

Full Professor

Center for Biomedical Research and Innovation (CIIB)

Universidad de Los Andes

Santiago, Chile

PATRICIA BURGOS

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

María Miró

Académico

Facultad de Salud

Universidad Santo Tomás

Valdivia, Chile

GONZALO MARDONES

Associate Professor

Medicine

Universidad San Sebastián

Valdivia, Chile

ARELI CÁRDENAS

Académica e Investigadora

Universidad Bernardo O'Higgins

Santiago, Chile

Cesar Toledo

Estudiante de posgrado Doctorado en Ciencias Agropecuarias

Ciencias Agropecuarias y Acuícolas

Universidad Católica de Temuco

Temuco, Chile

Ángelo Torres

Postdoctorado/Profesor Adjunto

Microbiología y Bioquímica

Universidad Austral de Chile

Valdivia, Chile

María Vidal

Profesor Asociado

Anatomía, Histología y Patología

Universidad Austral de Chile

Valdivia, Chile

José Rocha

Postdoctoral Researcher

Facultad de Veterinaria

Universidad San Sebastián

Puerto Montt, Chile

mario gonzalez

Profesor

microbiologia clinica

Universidad Austral de Chile

Valdivia, Chile

Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

J Daniel Carpio

Director Ejecutivo-Profesor Asociado

Unidad Microscopía Electrónica

Universidad Austral de Chile

Valdivia, Chile

Javier Ojeda

Docente instructor en el INstituto de Ciencias Clínicas Veterinarias.

Universidad Austral de Chile

Valdivia, Chile

Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

Ronald Jara

Docente

Universidad Austral de Chile

valdivia, Chile

María Pinto

Nanobodies generation manager of preclinical assays

Medicina

Universidad Austral de Chile

Isla Teja, Valdivia, Chile

Carlos Flores

Researcher

Biology Lab

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

Daniel Uribe

Profesor Adhonorem

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

Claudia Quezada

Full Professor

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

Rody San Martín

Professor

Sciences Faculty

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Carlos Spichiger

Profesor Adjunto

Facultad de Ciencias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Paola Krall

Profesor Auxiliar

Universidad Austral de Chile

Valdivia, Chile

Pedro Chana Cuevas

Profesor Titular

Facultad de Ciencias Medicas

Universidad de Santiago

Santiago, Chile

Gloria Arriagada

Profesor Asociado-Investigador Principal

Instituto de Ciencias Biomédicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

MARIANNE BRENET

Investigador

SymbiOx Inc.

Macul, Chile

Guillermo Valenzuela

Docente Investigador

Facultad de Ciencias para el cuidado de la Salud

Universidad San Sebastián

Valdivia, Chile

CECILIA ARRIAGADA

Postdoctoral Fellow

Rutgers University

Newark, Estados Unidos

Claudio Henríquez

Associate Professor

Farmacology and Morphophysiology

Universidad Austral de Chile

Valdivia, Chile

MARIA HIDALGO

Associate professor

Pharmacology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Constanza Salinas

Postdoctorado

Centro Interdisciplinario de Estudios del Sistema Nervioso (CISNe)

Universidad Austral de Chile

Valdivia, Chile

María Pavicic

Profesor asociado Adjunto

Universidad Austral de Chile

VALDIVIA, Chile

Guillaume Sérandour

Profesor Asociado

Facultad de Ciencias de la Ingeniería

Universidad Austral de Chile

Valdivia, Chile

Helmuth Muñoz

Instructor Professor

Universidad Austral de Chile

Valdivia, Chile

Gabriel Morán

Full Professor

Pharmacology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Ignacio Moreno

Full Professor

Facultad de Ciencias

Universidad Austral de Chile

Valdivia, Chile

Mario Flores

Académico Cat. III

Ciencias

Universidad Austral de Chile

Valdivia, Chile

Ivan Conejeros

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

Paulina Martínez

Asistente de Investigación

Universidad de La Frontera

Temuco, Chile

Carola Millan

Profesor

de Ciencias

UNIVERSIDAD ADOLFO IBAÑEZ FACULTAD DE ARTES LIBERALES

Viña del Mar, Chile

Jaime Figueroa

Profesor Titular

Bioquimica y Microbiologia

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

INGRID PAMELA EHRENFELD SLATER

Líneas de Investigación

Educación

Biologia Celular y Molecular, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2007

Patologia, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2002

Medical Technology, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1997

Experiencia Académica

PROFESOR ASOCIADO Full Time

PROFESOR TITULAR Full Time

ASSISTANT PROFESOR Full Time

Experiencia Profesional

ASSISTANT PROFESSOR Full Time

ASSOCIATE PROFESSOR Full Time

Directora Escuela de Graduados Facultad de Medicina Full Time

TECNOLOGO MEDICO Other

FULL PROFFESSOR Full Time

DIRECTORA DEL PROGRAMA HONOR DE LA FACULTAD DE MEDICINA Part Time

DIRECTORA OFICINA DE INVESTIGACION FACULTAD DE MEDICINA Part Time

PROFFESSOR Part Time

REPRESENTANTE MESA REGIONAL DEL CANCER Part Time

DECANA FACULTAS DE MEDICINA Full Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

¿Can tumoral cells talk with the endothelial cells?

Premio a la investigadora del año

Mujer y Academia

Article (58)

Abstract (7)

BookReview (1)

Proyecto (28)

Development of nanobodies directed to human kallikrein-related peptidase 4 (KLK4)=> Analysis of its immunomodulatory properties in ovarian cancer

Gestational chronodisruption programs the adult offspring pineal gland in rats altering development of the melatonin circadian rhythm=> assessing the impact of melatonin restoration in adult chronic disease onset.

Rejuvenated Brain Network – ReBrainNet.

Grant Provision Program Innovation Fund for Competitiveness Innovation (Programa Provisión Fondo de Innovación para la Competitividad), Región de los Ríos, Chile. Implementation of a regional strategy for the early detection of breast cancer.

Interdisciplinary Network for Naturopathic Regeneration - Net4NatuRe.

“Kinin B1 receptor stimulation shifts breast tumor microenvironment cells (endothelial and tumoral) towards a dissemination promoting state”

CANONICAL AND NON-CANONICAL ROLES OF .-SNAP IN THE PATHOGENESIS OF NEURODEVELOPMENTAL DISORDERS=> FOCUS ON MODULATION OF AUTOPHAGY AND AMPK SIGNALING.

Golgi proteome in cancer=> identification of new therapeutic targets

Signaling Mechanisms Regulated by eNOS-S-nitrosation at the Onset of the Inflammatory Process

Regulation of human neutrophil function by the bradykinin B1 receptor”.

“Modulation of the malignant behavior of human breast cancer cells by the bradykinin B1 receptor”.

“El receptor B1 de cininas regula la capacidad invasiva de las células derivadas de cáncer de mama MCF-7”

“Modulación de la respuesta inflamatoria y antineoplasica del leucocito neutrófilo humano por el receptor B1 de cininas”

“Rol del receptor B1 de cininas en la activación del leucocito neutrófilo”

Review (4)