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Jose Mauricio Sarmiento Vargas

Assistant Professor

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Signal transduction; Inflammation; Structural Biology; Immunology; Cellular Biology; Immune system; adaptive Immune response; Chronobiology

Molecular and Cell Biology, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2005
Bioquimico, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1997

Assistan Professor Full Time

UNIVERSIDAD AUSTRAL DE CHILE

Medicine

Valdivia, Chile

2005 - A la fecha

Technical Academic Full Time

Universidad Austral de Chile

Valdivia, Chile

1999 - 2005

2014
"Rol de los Mastocitos en la Inflamación Crónica Alérgica de las Vías Aéreas"
Amber R. Philp
Para optar al título profesional de Bioquímico (en desarrollo)

“Caracterización de mastocitos STAT6 knock out”
Rodrigo Gonzalez Kindley.
Para optar a Licenciatura y Grado de Tecnología Médica.
Universidad Austral de Chile.

“Subclonamiento del promotor de músculo liso SMP8 para la generación del
animal SMP8-TMEM16A+/+/TMEM16A-/-”
José Álvarez Iturra.
Para optar a Licenciatura y Grado de Tecnología Médica.
Universidad Austral de Chile.

“Rol de KCNN4 en neutrófilos”
Daniel Vera Díaz.
Para optar a Licenciatura y Grado de Tecnología Médica.
Universidad Austral de Chile.

"Rol del óxido nítrico sobre la permeabilidad microvascular mediada por Interleuquina-8”
Anita Hilda Luisa Guequen Cardenas
Para optar al grado de Bioquímico y Título Profesional de Bioquímico
Universidad Austral de Chile.

2013
“Generación del animal SMP8-TMEM16A+/+/TMEM16A-/- y estudio de la
distribución del canal TMEM16A en tejidos de ratón.”
José Arellano Ruiz.
Para optar a Licenciatura y Grado de Tecnología Médica.
Universidad Austral de Chile.

“Regulación de mastocitos en la fibrosis quística por el canal KCNN4.”
Texia Riquelme Mora.
Para optar a Licenciatura y Grado de Tecnología Médica.
Universidad Austral de Chile.

Short Term Grant MECE Competitive Fund AUSMECESUP Project 006

UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON

Chile, 2002

Short Term Grant MECE Competitive Fund AUSMECESUP Project 006 Institution: UNIVERSITY OF TEXAS MEDICAL BRANCH Country of Studies: ESTADOS UNIDOS DE AMERICA Year awarded: 2002
Becas Chile

UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON

Estados Unidos, 2008

Postdoctoral Position at the Department of Neuroscience and Cell Biology Institution: UNIVERSITY OF TEXAS MEDICAL BRANCH Country of Studies: ESTADOS UNIDOS DE AMERICA Year awarded: 2008


Interleukin-8 Secreted by Glioblastoma Cells Induces Microvascular Hyperpermeability Through NO Signaling Involving S-Nitrosylation of VE-Cadherin and p120 in Endothelial Cells GuequÃ©n A.; Zamorano P.; CÃ³rdova F.; Koning T.; Torres A.; Ehrenfeld P.; Boric M.P.; Salazar-Onfray F.; Gavard J.; DurÃ¡n W.N.; Quezada C.; Sarmiento J.; SÃ¡nchez F.A. Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2019)
Long-Term Effects of Altered Photoperiod During Pregnancy on Liver Gene Expression of the Progeny Carmona P.; PÃ©rez B.; Trujillo C.; Espinosa G.; Miranda F.; Mendez N.; Torres-Farfan C.; Richter H.G.; Vergara K.; Brebi P.; Sarmiento J. Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2019)
Tamoxifen induces apoptotic neutrophil efferocytosis in horses Olave, C.; Morales, N; Uberti B.; Henriquez, C; Sarmiento J.; Ortloff, A; Folch, H; Moran, G Article ISI SCOPUS VETERINARY RESEARCH COMMUNICATIONS (2018)
Tamoxifen inhibits chemokinesis in equine neutrophils Morales N.; Henriquez C.; Sarmiento J.; Uberti B.; Moran G. Article ISI SCOPUS Irish Veterinary Journal (2018)
In Vitro effects of tamoxifen on equine neutrophils. Borlone, C; Morales, N; Henriquez, C; Folch, H; Olave, C; Sarmiento, J; Uberti, B; Moran, G Article Research in veterinary science (2017)
Modulatory role of regulatory T cells in a murine model of severe equine asthma. Henríquez, Claudio; Morán, Gabriel; Carrasco, Cristian; Sarmiento, José; Barría, Miguel; Folch, Hugo; Uberti, Benjamin Article BMC veterinary research (2017)
S-nitrosylation of VASP at Cysteine 64 Mediates Inflammation Stimulated Increase in Microvascular Permeability. Zamorano, Patricia; Marin, Natalie; Córdova, Francisco; Aguilar, Alejandra; Meininger, Cynthia J; Boric, Mauricio P; Golenhofen, Nikola; Contreras, Jorge; Sarmiento, José; Duran, Walter N; Sánchez, Fabiola A Article American journal of physiology. Heart and circulatory physiology (2017)
Gestational Chronodisruption Impairs Circadian Physiology in Rat Male Offspring, Increasing the Risk of Chronic Disease Mendez, Natalia; Halabi, Diego; Spichiger, Carlos; Salazar, Esteban R.; Vergara, Karina; Alonso-Vasquez, Pamela; Carmona, Pamela; Sarmiento, Jose M.; Richter, Hans G.; Seron-Ferre, Maria; Torres-Farfan, Claudia Article ISI SCOPUS ENDOCRINOLOGY (2016)
S-nitrosylation regulates VE-cadherin phosphorylation and internalization in microvascular permeability. Guequén, Anita; Carrasco, Rodrigo; Zamorano, Patricia; Rebolledo, Lorena; Burboa, Pia; Sarmiento, José; Boric, Mauricio P; Korayem, Adam; Durán, Walter N; Sánchez, Fabiola A Article American journal of physiology. Heart and circulatory physiology (2016)
S-nitrosylation regulates VE-cadherin phosphorylation and internalization in microvascular permeability. Guequén, Anita; Carrasco, Rodrigo; Zamorano, Patricia; Rebolledo, Lorena; Burboa, Pia; Sarmiento, José; Boric, Mauricio P; Korayem, Adam; Durán, Walter N; Sánchez, Fabiola A Article American journal of physiology. Heart and circulatory physiology (2016)
Tamoxifen as a new therapeutic tool for neutrophilic lung inflammation Pérez B; Henriquez, C; Sarmiento J.; Morales N.; Folch H.; Galesio, JS; Uberti B.; Moran G. Article ISI SCOPUS RESPIROLOGY (2016)
The calcium-activated potassium channel KCa3.1 plays a central role in the chemotactic response of mammalian neutrophils Henriquez, C; Riquelme, TT; Vera, D.; Julio-Kalajzic, F; Ehrenfeld, P; Melvin, JE; Figueroa, CD; Sarmiento J.; Flores, CA Article ISI SCOPUS ACTA PHYSIOLOGICA (2016)
Expression and bioregulation of the kallikrein-related peptidases family in the human neutrophil Lizama, AJ; Andrade, Y; Colivoro, P; Sarmiento J.; Matus, CE; Gonzalez, CB; Bhoola, KD; Ehrenfeld, P; Figueroa, CD Article ISI SCOPUS Innate Immunity (2015)
Kinin B-1 receptor regulates interactions between neutrophils and endothelial cells by modulating the levels of Mac-1, LFA-1 and intercellular adhesion molecule-1 Figueroa, CD; Matus, CE; Pavicic, F.; Sarmiento J.; Hidalgo, MA; Burgos, RA; Gonzalez, CB; Bhoola, KD; Ehrenfeld, P Article ISI SCOPUS Innate Immunity (2015)
Bioregulation of Kallikrein-related Peptidases 6, 10 and 11 by the Kinin B-1 Receptor in Breast Cancer Cells Ehrenfeld, P; Manso, L; Pavicic, MF; Matus, CE; Borquez, C; Lizama A.; Sarmiento J.; Poblete, MT; Bhoola, KD; Naran, A; Figueroa, CD Article ISI Anticancer research. (2014)
Bioregulation of kallikrein-related peptidases 6, 10 and 11 by the Kinin b1 receptor in breast cancer cells Ehrenfeld, P; Manso, L; Pavicic M.F.; Matus C.E.; Borquez, C; Lizama A.; Sarmiento J.; Poblete M.T.; Bhoola K.D.; Naran, A; Figueroa C.D. Article SCOPUS Anticancer research. (2014)
Kinin B1 receptor regulates interactions between neutrophils and endothelial cells by modulating the levels of Mac-1, LFA-1 and intercellular adhesion molecule-1. Sarmiento J. Article ISI INNATE IMMUNITY (2014)
Participation of T regulatory cells in equine recurrent airway obstruction C Henríquez; B Perez; N Morales; C. Carrasco; J Sarmiento; G Moran; H Folch Article ISI SCOPUS VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2014)
SVCT2 transporter expression is post-natally induced in cortical neurons and its function is regulated by its short isoform Salazar K1, Cerda G, Martínez F, Sarmiento JM, González C, Rodríguez F, García-Robles M, Tapia JC, Cifuentes M, Nualart F. Article ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2014)
Apoptotic effects of tamoxifen on leukocytes from horse peripheral blood and bronchoalveolar lavage fluid Sarmiento J.; Pérez B; Morales N.; Henriquez, C; Vidal, L; Folch H.; Galecio, JS; Moran G. Article ISI SCOPUS Veterinary Research Communications (2013)
Chemokine CXCL1 dimer is a potent agonist for the CXCR2 receptor Sarmiento J. Article ISI The Journal of Biological Chemistry (2013)
Identification of oligomers at early stages of tau aggregation in Alzheimer's disease Lasagna-Reeves C.A.; Castillo-Carranza D.L.; Sengupta U.; Sarmiento J.; Troncoso J.; Jackson G.R.; Kayed R. Article SCOPUS FASEB Journal (2012)
Diverging Mechanisms of Activation of Chemokine Receptors Revealed by Novel Chemokine Agonists Sarmiento J.; Shumate, C; Suetomi, K; Ravindran, A; Villegas, L; Rajarathnam, K; Navarro, J. Article ISI PLOS ONE (2011)
The Splice Variant of the V2 Vasopressin Receptor Adopts Alternative Topologies González A; Borquez, M; Trigo, CA; Brenett, M; Sarmiento, JM; Figueroa, CD; Navarro, J.; Gonzalez, CB Article ISI SCOPUS Biochemistry (2011)
Probing the role of CXC motif in chemokine CXCL8 for high affinity binding and activation of CXCR1 and CXCR2 receptors Sarmiento, JM Article ISI The Journal of Biological Chemistry (2010)
Adenovirus mediated expression "in vivo" of the chemokine receptor CXCR1 Sarmiento, JM Article ISI journal of structural and functional genomics (2009)
Postnatal expression of V-2 vasopressin receptor splice variants in the rat cerebellum Vargas, KJ; Sarmiento, JM; Ehrenfeld, P; Anazco CC; Villanueva, CI; Carmona, PL; Brenet, M.; Navarro, J.; Muller-Esterl, W; Gonzalez, CB Article ISI SCOPUS DIFFERENTIATION (2009)
Activation of kinin B(1) receptor triggers differentiation of cultured human keratinocytes Matus, CE; Ehrenfeld, P; Pavicic, F.; Sarmiento, JM; Astroza, A; Sánchez T; Salem, C; Concha M.; Vidal MA; Gonzalez, CB; Figueroa, CD Article ISI SCOPUS BRITISH JOURNAL OF DERMATOLOGY (2008)
Vasopressin up-regulates the expression of growth-related immediate-early genes via two distinct EGF receptor transactivation pathways Fuentes, LQ; Reyes, CE; Sarmiento, JM; Villanueva, CI; Figueroa, CD; Navarro, J.; Gonzalez, CB Article ISI SCOPUS CELLULAR SIGNALLING (2008)
Differential distribution of the vasopressin V-2 receptor along the rat nephron during renal ontogeny and maturation Sarmiento, JM; Ehrenfeld, P; Anazco CC; Reyes, CE; Troncoso S.; Figueroa, CD; Muller-Esterl, W; Gonzalez, CB Article ISI SCOPUS KIDNEY INTERNATIONAL (2005)
Novel down-regulatory mechanism of the surface expression of the vasopressin V-2 receptor by an alternative splice receptor variant Sarmiento, JM; Anazco CC; Campos, DM; Prado, GN; Navarro, J.; Gonzalez, CB Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Polarized expression of the GFP-tagged rat V-1a vasopressin receptor Campos, DM; Reyes, CE; Sarmiento J.; Navarro, J.; Gonzalez, CB Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Environmental acclimatization of the carp modulates the transcription of beta-actin Sarmiento J.; Leal, S.; Quezada C.; Kausel G.; Figueroa J.; Vera, MI; Krauskopf, M Article ISI JOURNAL OF CELLULAR BIOCHEMISTRY (2000)


Kinins and their receptors, a new autocrine-paracrine signaling pathway that contributes to breast cancer malignancy Ehrenfeld, P; Pavicic, MF; Matus, CE; Borquez, C; Lizama A.; Sarmiento J.; Bhoola, KD; Figueroa, CD Abstract ISI INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2012)
Kinin-induced filaggrin expression is enhanced after blocking EGF receptor transactivation in human keratinocytes Matus, CE; Pavicic, F.; Sarmiento, JM; Concha M.; Vidal MA; Gonzalez, CB; Figueroa, CD Abstract ISI JOURNAL OF INVESTIGATIVE DERMATOLOGY (2005)


EFFECTS OF TAMOXIFEN ON PRO-RESOLUTIVE MECHANISMS OF INFLAMMATION IN HORSES WITH RECURRENT AIRWAY OBSTRUCTION FONDECYT (1160352) Proyecto 2016-2019 Coinvestigador(a)
Gestational chronodisruption=> a novel determinant for allergic asthma in the adulthood? FONDECYT (1150789) Proyecto 2015-2018 Inv. Responsable
SIGNALING MECHANISMS REGULATED BY ENOS-S-NITROSATION AT THE ONSET OF THE INFLAMMATORY PROCESS. FONDECYT (1130769) Proyecto 2013-2017 Coinvestigador(a)
USE OF TAMOXIFEN AS A NEW THERAPEUTIC TOOL FOR HORSES WITH RECURRENT AIRWAY OBSTRUCTION FONDECYT (1130355) Proyecto 2013-2016 Coinvestigador(a)
Mecanismos fisiopatológicos de enfermedades crónicas del adulto impuestas por la alteración circadiana prenatal=> valor terapéutico del tratamiento con melatonina a la madre expuesta a turnos nocturnos durante la gestación PIA (ACT1116) Proyecto 2012-2016 Inv. Principal
ROL DE LA OLIGOMERIZACION EN LA MADURACION DE LOS RECEPTORES V2 DE VASOPRESINA. FONDECYT (1060158) Proyecto 2006-2010 Coinvestigador(a)
FORMACION DE OLIGOMEROS DE RECEPTORES DE VASOPRESINA Y SU PAPEL EN LA MODULACION DE LOS MECANISMOS EN TRANSDUCCION, ESPECIFICAMENTE, AQUELLOS RELACIONADOS CON PROLIFERACION CELULAR FONDECYT (1030261) Proyecto 2003-2006 Personal técnico y/o de apoyo
Formación de multímeros en la isoforma V2 de receptores de Vasopresina Dirección de Investigacion y desarrollo Universidad Austral de Chile (DIDUACH) (DID-UACH 200204) Proyecto 2002-2004 Inv. Responsable
ESTRUCTURA Y FUNCION DE RECEPTORES, CARACTERIZACION DE SUS MECANISMOS DE TRANSDUCCION Y SU ROL EN PROLIFERACION Y DIFERENCIACION CELULAR FONDECYT (8980002) Proyecto 1998-2002 Personal técnico y/o de apoyo

Jose Sarmiento

Assistant Professor

Physiology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

INGRID EHRENFELD

FULL PROFESSOR

ANATOMIA; HISTOLOGIA & PATOLOGIA

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

Carlos Figueroa

Head

Anatomy, Histology and Pathology

Universidad Austral de Chile

Valdivia, Chile

María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Claudio Henríquez

Associate Professor

Farmacology and Morphophysiology

Universidad Austral de Chile

Valdivia, Chile

BENJAMIN UBERTI

Assistant Professor

Facultad de Ciencias Veterinarias

Universidad Austral de Chile

Valdivia, Chile

Carolina Añazco

Profesora Asociada

Universidad San Sebastián

Valdivia, Chile

María Vidal

Profesor Asociado

Anatomía, Histología y Patología

Universidad Austral de Chile

Valdivia, Chile

Gabriel Morán

Full Professor

Pharmacology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

MARIANNE BRENET

Investigador

SymbiOx Inc.

Macul, Chile

Ángelo Torres

Postdoctorado/Profesor Adjunto

Microbiología y Bioquímica

Universidad Austral de Chile

Valdivia, Chile

Priscilla Brebi

Profesor Asociado

Departamento de Anatomía Patológica.

Universidad de La Frontera

Temuco, Chile

Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

Carlos Flores

Researcher

Biology Lab

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

Juan Tapia

Profesor Asociado

UNIVERSIDAD DE TALCA

Talca, Chile

Claudia Torres

Full Professor

Instituto de Anatomía, Histología y Patología

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Diego Halabi

Profesor Auxiliar

Escuela de Odontología

Universidad Austral de Chile

Valdivia, Chile

Claudia Quezada

Full Professor

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

César Trigo

Investigador Postdoctoral

ICBM

Universidad de Chile

Santiago, Chile

Fabiola Sánchez

Associate Profesor

Immunology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Lida Fuentes

Researcher

Centro Regional de Estudios en Alimentos Saludables

Valparaiso, Chile

MARIA HIDALGO

Associate professor

Pharmacology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

Katterine Salazar

Associate Professor

Cell Biology

University of Concepcion

Concepción, Chile

Anita Guequen

Asistente de investigación

Biología

Centro Estudios Científicos (CECs)

Valdivia, Chile

Natalia Mendez

Profesor Auxiliar

UNIVERSIDAD AUSTRAL DE CHILE

valdivia, Chile

María Pavicic

Profesor asociado Adjunto

Universidad Austral de Chile

VALDIVIA, Chile

Hans Richter

Profesor Titular

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

Esteban Salazar

Académico

Escuela de Obstetricia

Universidad San Sebastián

Valdivia, Chile

Hugo Folch

Professor

Immunology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Jaime Figueroa

Profesor Titular

Bioquimica y Microbiologia

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Fernando Martinez

Assistant Professor

Cell Biology

Universidad de Concepción

Concepción, Chile

Jose Mauricio Sarmiento Vargas

Líneas de Investigación

Educación

Molecular and Cell Biology, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2005

Bioquimico, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1997

Experiencia Académica

Assistan Professor Full Time

Experiencia Profesional

Technical Academic Full Time

Formación de Capital Humano

Premios y Distinciones

Short Term Grant MECE Competitive Fund AUSMECESUP Project 006

Becas Chile

Article (33)

Abstract (2)

Proyecto (9)

EFFECTS OF TAMOXIFEN ON PRO-RESOLUTIVE MECHANISMS OF INFLAMMATION IN HORSES WITH RECURRENT AIRWAY OBSTRUCTION

Gestational chronodisruption=> a novel determinant for allergic asthma in the adulthood?

SIGNALING MECHANISMS REGULATED BY ENOS-S-NITROSATION AT THE ONSET OF THE INFLAMMATORY PROCESS.

USE OF TAMOXIFEN AS A NEW THERAPEUTIC TOOL FOR HORSES WITH RECURRENT AIRWAY OBSTRUCTION

Mecanismos fisiopatológicos de enfermedades crónicas del adulto impuestas por la alteración circadiana prenatal=> valor terapéutico del tratamiento con melatonina a la madre expuesta a turnos nocturnos durante la gestación

ROL DE LA OLIGOMERIZACION EN LA MADURACION DE LOS RECEPTORES V2 DE VASOPRESINA.

FORMACION DE OLIGOMEROS DE RECEPTORES DE VASOPRESINA Y SU PAPEL EN LA MODULACION DE LOS MECANISMOS EN TRANSDUCCION, ESPECIFICAMENTE, AQUELLOS RELACIONADOS CON PROLIFERACION CELULAR

Formación de multímeros en la isoforma V2 de receptores de Vasopresina

ESTRUCTURA Y FUNCION DE RECEPTORES, CARACTERIZACION DE SUS MECANISMOS DE TRANSDUCCION Y SU ROL EN PROLIFERACION Y DIFERENCIACION CELULAR