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Clemente Javier Palacios Díez

Académico

Universidad Arturo Prat

Iquique, Chile

Efecto vascular y cardiovascular de extractos de plantas medicinales y sus metabolitos. Estudio de los mecanismos fisiológicos involucrados y rol del estrés oxidativo.

Ciencias Ph.D., Universidad de Navarra. España, 2001
Bioquímico, UNIVERSIDAD COMPLUTENSE DE MADRID. España, 1987

académico e investigador Part Time

UNIVERSIDAD DE LOS ANDES

Medicina

Santiago, Chile

1997 - 2004
académico e investigador Part Time

UNIVERSIDAD CATOLICA DEL NORTE

Ciencias

Antofagasta, Chile

2004 - 2008
Profesor Asociado Full Time

Universidad del Mar

Iquique, Chile

2009 - 2012
Profesor Titular Full Time

UNIVERSIDAD ARTURO PRAT

Facultad Ciencias de la Salud

Iquique, Chile

2013 - A la fecha

Académico Full Time

Universidad Arturo Prat

IQUIQUE, Chile

2013 - A la fecha


A hydroalcoholic extract of <i>Senecio nutans</i> SCh. Bip (Asteraceae); its effects on cardiac function and chemical characterization Palacios, Javier; Paredes, Adrian; Cifuentes, Fredi; Catalan, Marcelo A.; Luis Garcia-Villalon, Angel; Borquez, Jorge; Simirgiotis, Mario J.; Jones, Matthew; Foster, Amy; Greensmith, David J. Article ISI JOURNAL OF ETHNOPHARMACOLOGY (2023)
Alterations of the Oestrous Cycle and Increase in the Blood Pressure in Normotensive Female Rats by Continuous Exposure to Light Palacios, Javier; Nwokocha, Chukwuemeka R.; Yumrutas, Onder; Rios, Miguel; Escobar, Jorge; Parlar, Ali; Vinet, Raul; Jaimes, Luisauris; Martinez, Jose L. Article ISI PAKISTAN VETERINARY JOURNAL (2023)
Chemical Fingerprinting, Aorta Endothelium Relaxation Effect, and Enzymatic Inhibition of Canelo (<i>Drimys winteri</i> J. R. Forst. & G. Forst, (D.C) A. Gray, Family Winteraceae) Fruits Barrientos, Ruth E.; Romero-Parra, Javier; Cifuentes, Fredi; Palacios, Javier; Romero-Jola, Nestor Jaime; Paredes, Adrian; Vargas-Arana, Gabriel; Simirgiotis, Mario J. Article ISI FOODS (2023)
UHPLC-MS Phenolic Fingerprinting, Aorta Endothelium Relaxation Effect, Antioxidant, and Enzyme Inhibition Activities of <i>Azara dentata Ruiz & Pav</i> Berries Ramos, Lucia Cuesta; Palacios, Javier; Barrientos, Ruth E.; Gomez, Jessica; Castagnini, Juan Manuel; Barba, Francisco J.; Tapia, Alejandro; Paredes, Adrian; Cifuentes, Fredi; Simirgiotis, Mario J. Article ISI FOODS (2023)
<i>Lepidium meyenii</i> Walp (red maca) Supplementation Prevents Acrylamide-Induced Oxidative Stress and Liver Toxicity in Rats: Phytochemical Composition by UHPLC-ESI-MS/MS Ybanez-Julca, Roberto O.; Palacios, Javier; Asuncion-Alvarez, Daniel; Quispe-Diaz, Ivan; Nwokocha, Chukwuemeka R.; Duarte Galhardo de Albuquerque, Ricardo Diego Article ISI PLANT FOODS FOR HUMAN NUTRITION (2022)
Artocarpus Altilis (Breadfruit) could Reverse Myocardial Infarction Through the Normalization of the Oxygen Haemoglobin Dissociation Curve Thomas, Jemesha; Anderson, Tanya; James-Green, Tameika; Nwokocha, Magdalene; PALACIOS-COLLAO, JAVIER ALEJANDRO; Pepple, Dagogo; Nwokocha, Chukwuemeka Article SCOPUS Cardiovascular and Hematological Agents in Medicinal Chemistry (2022)
Novel Oxime Synthesized from a Natural Product of <i>Senecio nutans</i> SCh. Bip. (Asteraceae) Enhances Vascular Relaxation in Rats by an Endothelium-Independent Mechanism Palacios, Javier; Paredes, Adrian; Catalan, Marcelo A.; Nwokocha, Chukwuemeka R.; Cifuentes, Fredi Article ISI MOLECULES (2022)
Phenolic Fingerprinting and Bioactivity Profiling of Extracts and Isolated Compounds from <i>Gypothamnium pinifolium</i> Phil. Barrientos, Ruth E.; Ibanez, Elena; Puerta, Adrian; Padron, Jose M.; Paredes, Adrian; Cifuentes, Fredi; Romero-Parra, Javier; Palacios, Javier; Borquez, Jorge; Simirgiotis, Mario J. Article ISI ANTIOXIDANTS (2022)
High-Performance Thin-Layer Chromatography for Rutin, Chlorogenic Acid, Caffeic Acid, Ursolic Acid, and Stigmasterol Analysis in Periploca aphylla Extracts Orfali R; Perveen S; Aati1 AY; Alam P; Palacios, J Article WOS Separations (2021)
Impact of the Potential Antitumor Agent 2-(4-Hydroxyphenyl) Amino-1,4-Naphthoquinone (Q7) on Vasomotion Is Mediated by the Vascular Endothelium, But Not Vascular Smooth Muscle Cell Metabolism Palacios, Javier Article WOS JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2021)
Maca extracts and estrogen replacement therapy in ovariectomized rats exposed at high altitude Ybanez-Julca, Roberto O.; Asuncion-Alvarez, Daniel; Palacios, Javier; Nwokocha, Chukwuemeka R. Article ISI REPRODUCTIVE MEDICINE AND BIOLOGY (2021)
Blood pressure-reducing activity of Gongronema latifolium Benth. (Apocynaeceae) and the identification of its main phytochemicals by UHPLC Q-Orbitrap mass spectrometry Beshel J.A.; Palacios J.; Beshel F.N.; Nku C.O.; Owu D.U.; Nwokocha M.; BÃ³rquez J.; Simirgiotis M.J.; Nwokocha C.R. Article SCOPUS Journal of Basic and Clinical Physiology and Pharmacology (2020)
Chemical Fingerprinting, Isolation and Characterization of Polyphenol Compounds fromHeliotropium taltalense(Phil.) IM Johnst and Its Endothelium-Dependent Vascular Relaxation Effect in Rat Aorta Barrientos, Ruth E.; Simirgiotis, Mario J; Palacios, Javier; Paredes, Adrian; Borquez, Jorge; Bravo, Alejandra; Cifuentes, Fredi Article ISI MOLECULES (2020)
Fast Isolation of Flavonoids from the Endemic Species Nolana ramosissima IM Johnst and Its Endothelium-Independent Relaxation Effect in Rat Aorta Cifuentes, Fredi; Palacios, Javier; Borquez, Jorge; Paredes, Adrian; Parra, Claudio; Bravo, Alejandra; Simirgiotis, Mario J Article ISI SCOPUS MOLECULES (2020)
Hypotensive and antihypertensive effects of an aqueous extract from Guinep fruit (Melicoccus bijugatus Jacq) in rats Nwokocha, Chukwuemeka R.; Gordon, Alexia; Palacios, Javier; Paredes, Adrian; Cifuentes, Fredi; Francis, Sheena; Watson, JeAnn; Delgoda, Rupika; Nwokocha, Magdalene; Alexander-Lindo, Ruby; Thompson, Rory; Minott-Kates, Donna; Yakubu, Momoh A. Article ISI SCIENTIFIC REPORTS (2020)
Metabolomic Profiling of Mango (Mangifera indica Linn) Leaf Extract and Its Intestinal Protective Effect and Antioxidant Activity in Different Biological Models Ybanez-Julca, Roberto O.; Asuncion-Alvarez, Daniel; Quispe-Diaz, Ivan M.; Palacios, Javier; Borquez, Jorge; Simirgiotis, Mario J; Perveen, Shagufta; Nwokocha, Chukwuemeka R.; Cifuentes, Fredi; Paredes, Adrian Article ISI MOLECULES (2020)
Protective effects of apocynin against cadmium toxicity and serum parameters; evidence of a cardio-protective influence Nwokocha C.R.; Palacios J.; Rattray V.R.; McCalla G.; Nwokocha M.; McGrowder D. Article ISI SCOPUS (2020)
Modulatory Effect of Guinep (Melicoccus bijugatus Jacq) Fruit Pulp Extract on Isoproterenol-Induced Myocardial Damage in Rats. Identification of Major Metabolites Using High Resolution UHPLC Q-Orbitrap Mass Spectrometry. Nwokocha CR, Warren I; Palacios J, Simirgiotis M; Nwokocha M, Harrison S; Thompson R, Paredes A; Bórquez J, Lavado A Article MOLECULES (2019)
Polyphenolic Composition and Hypotensive Effects of Parastrephia quadrangularis (Meyen) Cabrera in Rat Cifuentes, Fredi; Palacios, Javier; Nwokocha, Chukwuemeka R.; Borquez, Jorge; Simirgiotis, Mario J; Norambuena, Ignacio; Chiong, Mario; Paredes, Adrian Article ISI SCOPUS ANTIOXIDANTS (2019)
8-Oxo-9-Dihydromakomakine Isolated from Aristotelia chilensis Induces Vasodilation in Rat Aorta: Role of the Extracellular Calcium Influx Cifuentes, Fredi; Palacios, Javier; Paredes, Adrian; Nwokocha, Chukwuemeka R.; Paz, Cristian Article ISI SCOPUS MOLECULES (2018)
Ascorbate Attenuates Oxidative Stress and Increased Blood Pressure Induced by 2-(4-Hydroxyphenyl) Amino-1,4-naphthoquinone in Rats Palacios, Javier; Miguel Fonseca, Jose; Ayavire, Fernando; Salas, Felipe; Ortiz, Mirko; Marcelo Sandoval, Juan; Benites, Julio; Nwokocha, Chukwuemeka R.; Zavala, Ewaldo; Paredes, Adrian; Barria, Ivan; Luis Vega, Jose; Cifuentes, Fredi Article ISI SCOPUS OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)
Vasodilator and hypotensive effects of pure compounds and hydroalcoholic extract of Xenophyllum poposum (Phil) V.A Funk (Compositae) on rats Cifuentes, Fredi; Palacios, Javier; Kuzmicic, Jovan; Carvajal, Lorena; Munoz, Fernanda; Quispe, Cristina; Nwokocha, Chukwuemeka R.; Morales, Glauco; Norambuena-Soto, Ignacio; Chiong, Mario; Paredes, Adrian Article ISI SCOPUS PHYTOMEDICINE (2018)
Aqueous extract from leaf of Artocarpus altilis provides cardio-protection from isoproterenol induced myocardial damage in rats: Negative chronotropic and inotropic effects Nwokocha, Chukwuemeka; palacios, javier; Simirgiotis, Mario J.; Thomas, Jemesha; Nwokocha, Magdalene; Young, Lauriann; Thompson, Rory; Cifuentes, Fredi; Paredes, Adrian; Delgoda, Rupika Article ISI SCOPUS JOURNAL OF ETHNOPHARMACOLOGY (2017)
Erratum to: Synchronization in the Heart Rate and the Vasomotion in Rat Aorta: Effect of Arsenic Trioxide. Cifuentes, Fredi; Palacios, Javier; Nwokocha, Chukwuemeka R; Pardo, Fabián; Sobrevia, Luis Article Cardiovascular toxicology (2016)
Hydroalcoholic extract and pure compounds from Senecio nutans Sch Bip (Compositae) induce vasodilation in rat aorta through endothelium-dependent and independent mechanisms Paredes, Adrián; palacios, javier; Quispe, Cristina; Nwokocha, Chukwuemeka R.; Morales, Glauco; Kuzmicic, Jovan; Cifuentes, Fredi Article ISI SCOPUS JOURNAL OF ETHNOPHARMACOLOGY (2016)
Hypotensive and antihypertensive effects of a hydroalcoholic extract from Senecio nutans Sch Bip. (Compositae) in mice: Chronotropic and negative inotropic effect, a nifedipine-like action Cifuentes F.; Paredes A.; Palacios J.; Muñoz F; Carvajal L.; Nwokocha, CR; Morales G. Article ISI SCOPUS JOURNAL OF ETHNOPHARMACOLOGY (2016)
Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta palacios, javier; Cifuentes, Fredi; Valderrama, Jaime A.; Benites, Julio; Ríos, David; González, Constanza; Chiong, Mario; Cartes-Saavedra, Benjamín; Lafourcade, Carlos; Wyneken, Ursula; González, Pamela; Owen, Gareth I.; Pardo, Fabián; Sobrevia, Luis; Buc Calderon, Pedro Article ISI SCOPUS OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)
Synchronization in the Heart Rate and the Vasomotion in Rat Aorta: Effect of Arsenic Trioxide Cifuentes F.; Palacios J.; Nwokocha, CR Article ISI SCOPUS CARDIOVASCULAR TOXICOLOGY (2016)
Effect of phenylephrine and endothelium on vasomotion in rat aorta involves potassium uptake Palacios J.; Vega, JL; Paredes A.; Cifuentes F. Article ISI SCOPUS Journal of Physiological Sciences (2013)
Exposure to Low Level of Arsenic and Lead in Drinking Water from Antofagasta City Induces Gender Differences in Glucose Homeostasis in Rats Palacios J.; Román D.; Cifuentes F. Article ISI SCOPUS Biological Trace Element Research (2012)
Chronic Exposure to Arsenic in Tap Water Reduces Acetylcholine-induced Relaxation in the Aorta and Increases Oxidative Stress in Female Rats Cifuentes F.; Bravo, J.; Norambuena M.; Stegen, S; Ayavire, A; Palacios J. Article ISI SCOPUS INTERNATIONAL JOURNAL OF TOXICOLOGY (2009)
Na+-K+-2Cl(-) cotransporter is implicated in gender differences in the response of the rat aorta to phenylephrine Palacios J.; Espinoza F.; Munita C.; Cifuentes F.; Michea, L. Article ISI SCOPUS BRITISH JOURNAL OF PHARMACOLOGY (2006)
Estradiol-induced expression of Na+-K+-ATPase catalytic isoforms in rat arteries: gender differences in activity mediated by nitric oxide donors Palacios J.; Marusic, ET; Lopez, NC; Gonzalez, M.; Michea, L. Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2004)


The Role of NADP(H) Oxidase Inhibition and Its Implications in Cardiovascular Disease Management Using Natural Plant Products Reid, Melissa. Spence, Janson. Nwokocha, Magdalene. Palacios, Javier. Nwokocha, Chukwuemeka.; Atta-ur-Rahman BookSection (2018)


EFECTO CARDIOVASCULAR DEL EXTRACTO DE PARASTREPHIA LUCIDA (MEYEN) CABRERA EN RATAS NORMOTENSAS Universidad Arturo Prat (VRIIP0006-17) Proyecto 2017-2018 Inv. Principal
EVALUACION DEL EFECTO DE ARTOCARPUS ALTILIS (PARKINSON EX F.A. ZORN) FOSBERG EN EL INFARTO AGUDO AL MIOCARDIO INDUCIDO POR ISOPROTERENOL EN RATAS Universidad Arturo Prat (VRIIP0209-17) Proyecto 2017-2018 Director(a)
PERFECCIONAMIENTO DE ACADEMICOS EN INVESTIGACION DE EDUCACION Y SALUD PUBLICA Universidad Arturo Prat (VRIIP0150-17) Proyecto 2017-2018 Director(a)
Estudio Etnofarmacológico de 7 especies nativas de Senecio Sp de la Región de Tarapacá=> Evaluación Biológica y Perfiles de Compuestos Fenólicos Universidad Arturo Prat (VRIIP0085-15) Proyecto 2015-2017 Coinvestigador(a)
Evaluación Biológica de derivados aril-amino-naftoquinonas sobre el músculo liso vascular=> rol del metabolismo de la glucosa Universidad Arturo Prat (VRIIP0198-14) Proyecto 2015-2016 Inv. Principal
Elaboración y optimización de un protocolo de exámenes clínicos para medir el estrés oxidativo en pacientes de la II Región. Universidad Católica del Norte (DGIP-079-2008) Proyecto 2009-2009 Inv. Principal
Adenosina disminuye el efecto contráctil de ATP mediante la síntesis de oxido nítrico por el endotelio de la vena umbilical humana Universidad de antofagasta (DI-1339-07) Proyecto 2007-2008 Coinvestigador(a)
Enfermedades cerebro vasculares en el Hospital Regional de Antofagasta y la incidencia del consumo de agua potable de la II Región en la respuesta vascular. Universidad Católica del Norte (DGIP-376-2006) Proyecto 2006-2007 Inv. Patrocinante
Fortalecimiento de la Investigación y docencia en el area de la Química. Fundación Andes (11111111) Proyecto 2005-2007 Coinvestigador(a)
REGULACION POR ALDOSTERONA DE ENaC Y TRANSPORTADORES DE SODIO CARDIOVASCULARES=>VIAS DE TRANSDUCCION Y PAPEL EN LA FISIOPATOLOGENIA DEL DAÑO. FONDECYT (1050690) Proyecto 2005-2007 Investigador(a)
Influencia del sexo en el cotransportador Na+-K+-2Cl- (NKCC1) del tejido vascular de la rata Universidad de los Andes (11111110) Proyecto 2003-2004 Inv. Principal
Regulación de la expresión de los receptores arteriales de angiotensina AT1 y AT2 por aldosterona=> efectos en la contractilidad y niveles de calcio intracelular Universidad de los Andes (11111111) Proyecto 2002-2002 Coinvestigador(a)
REGULACION HORMONAL DE TRANSPORTADORES IONICOS DEL MUSCULO LISO VASCULAR Y SU EFECTO EN LA CONTRACTILIDAD Y PROLIFERACION CELULAR FONDECYT (1010185) Proyecto 2001-2004 Investigador(a)
REGULACION HORMONAL DE LOS TRANSPORTES VASCULARES DE SODIO Y SU RELACION CON LA REACTIVIDAD VASCULAR FONDECYT (1970696) Proyecto 1997-2000 Tesista


Oxidant-induced disruption of vascular K<SUP>+</SUP> channel function: Implications for diabetic vasculopathy Nwokocha, Chukwuemeka; Palacios, Javier; Ojukwu, Victoria E.; Nna, Victor Udo; Owu, Daniel Udofia; Nwokocha, Magdalene; McGrowder, Donovan; Orie, Nelson N. Review ISI ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2022)