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Pedro Miguel Buc Calderon

Profesor titular

Universidad Arturo Prat

Iquique, Chile

bioquimica toxicologica; biologia del cancer; estrés oxidativo y radicales libres

Doctorat en sciences pharmaceutiques, UNIVERSITE CATHOLIQUE DE LOUVAIN. Bélgica, 1987
Quimica y Farmacia, UNIVERSIDAD DE CHILE. Chile, 1977

Profesor titular Full Time

UNIVERSITE CATHOLIQUE DE LOUVAIN

Bruselas, Bélgica

2000 - 2016
Profesor titular Full Time

Universidad Arturo Prat

Ciencias de la Salud

Iquique, Chile

2016 - A la fecha

Profesor Full Time

Université catholique de Louvain

Bruselas, Bélgica

2000 - 2016
Chargé de Cours Full Time

Université catholique de Louvain

Bruselas, Bélgica

1992 - 2000
Premier Assistant Full Time

Université catholique de Louvain

Bruselas, Bélgica

1988 - 1992
Profesor Titular Part Time

Universidad Arturo Prat

Iquique, Chile

2016 - A la fecha
VICERRECTOR DE INVESTIGACIÓN E INNOVACION Full Time

UNIVERSIDAD ARTURO PRAT

IQUIQUE , Chile

2020 - 2022

Dirección de Tesis de Doctorado

1.- Véronique Lefebvre (1989-1993): "Comportement métabolique des hépatocytes de rat soumis à l’hypoxie: effet protecteur du fructose et inhibition de la synthèse protéique". Doctorat en Sciences Pharmaceutiques.
2.- Sandrine Tinton (1991-1994): "Inhibition de la synthèse des protéines par les nucléotides adényliques. Rôle des récepteurs purinergiques et du métabolisme de l’adénosine". Doctorat en Sciences Pharmaceutiques.
3.- Isabelle Latour (1991-1996): "Effet de l'hydroperoxyde du tert-butyle sur l’intégrité de l’ADN et sur la synthèse protéique d’hépatocytes isolés". Doctorat en Sciences Pharmaceutiques.
4.- Jean Baptiste Demoulin (1996-1999): "Signal transduction by the Interleukin-9 receptor". Doctorat en Sciences Pharmaceutiques (co-director).
5.- Ekaterine Evdokimova (1995-2001): "Métabolisme des xénobiotiques lors d’une hypoxie froide suivie d’un réoxygénation à 37°C. Etude sur tranches de foie de rat". Doctorat en Sciences Pharmaceutiques.
6.- Valérie Wauthier (2000-2006): "Influence of ageing on drug metabolizing enzymes in male Wistar rats". Doctorat en Sciences Pharmaceutiques (co-director).
7.- Julien Verrax (2003-2006): "Study of the molecular mechanisms involved in cancer cell death following the exposure to the combination of ascorbate (vitamin C) and menadione (vitamin K3)". Doctorat en Sciences Pharmaceutiques.
8.- Raphaêl Beck (2006-2010): "Molecular mechanisms of oxidative stress-induced cancer cell death: hsp90 chaperone cleavage and consequences". Doctorat en Sciences Biomédicales.
9.- David Vasquez (2007-2009): "Design, synthesis and antitumor activity of aza-analogues of angucyclones and amino pyrimidoisoquinolinequinones derivatives". Doctorat en Cotutelle (WBI-Chile): Chimie (PUC-Chile) et Sciences Pharmaceutiques (UCL-Belgium).
10.- Juan Marcelo Sandoval (2007-2012): "Tellurite toxicity: from bacteria to eukaryotic cells". Doctorat en Cotutelle (WBI-Chile): Microbiologie (USACH-Chile) et Sciences Pharmaceutiques (UCL-Belgium).
11.- Christophe Glorieux (2010-2014): "Role and regulation of catalase and NAD(P)H:quinone oxidoreductase-1 in cancer cells". Doctorat en Sciences pharmaceutiques et Biomédicales.

Dirección de Tesis de pregrado

1.- Jean Louis Pregaldien (1988-1990): "Le fer ionique et le peroxyde d'hydrogène: Etude des effets de leur association sur la viabilité d'hépatocytes isolés". Licence en Technologie Biomédicale.
2.- Olivier Cousin (1988-1991): "Hépatocytes isolés et maintenus en survie en suspension: Etude comparative de l'effet cytotoxique des nucléotides". Licence en Toxicologie.
3.- Ennio De Ros (1988-1990): "Thiols et stress oxydatif. Etude sur hépatocytes isolés". Licence en Toxicologie.
4.- Martine Van Steenbrugge (1989-1991): "Modifications biochimiques lors de l'hypoxie-réoxygénation. Etude sur hépatocytes isolés". Licence en Technologie Biomédicale.
5.- Véronique Beckers (1990-1992): "Transport intracellulaire des acides aminés et inhibition de la synthèse des protéines en état d'hypoxie". Licence en Technologie Biomédicale.
6.- Amaya Leunda (1994-1996): "Implications énergétiques de l'activation de la poly(ADP-ribose) polymérase suite aux dommages de l'ADN par l'hydroperoxyde de tert-butyle". Licence en Technologie Biomédicale.
7.- Hervé Morales (1995-1996): "Influence du fructose sur la viabilité de tranches de foie de rat soumises à un processus d’hypoxie-réoxygénation. Etude biochimique et morphologique". Licence en Technologie Biomédicale.
8.- Agnès Brouet (1996-1997): "Activités d’oxydases à fonction mixte lors de la transition hypoxie froide (4°C)-réoxygénation normothermique (37°C). Etude sur tranches de foie de rats". Licence en Technologie Biomédicale.
9.- Anne-Cecile Massart (1996-1997): "Rôle de la S-thiolation dans l’inhibition de la biosynthèse protéique lors d’un stress oxydatif dans les hépatocytes isolés". Licence en Technologie Biomédicale.
10.- Christophe Lambeau (1996-1997): "Etude de la préservation de tranches de foie de rat lors d’une hypoxie froide suivie d’une réoxygénation normothermique. Etude biochimique et morphologique". Licence en Toxicologie.
11.- Florence Leconte (1997-1998): "Influence de la pression partielle en oxygène sur la synthèse protéique et sur la phosphorylation de résidus tyrosine dans les hépatocytes isolés de rat". Licence en Technologie Biomédicale.
12.- Severine Thielens (2000-2001): "Expression and activity of CYP3A isoforms in rat liver slices under hypoxia-reoxygenation". Licence en Sciences Biomédicales (VUB).
13.- Hong-Ngoc Ngo (2001-2002): "Mécanismes moléculaires impliquées dans la mort cellulaire induite par l'association des vitamines C et K3". Licence en Sciences Biomédicales, orientation Toxicologie.
14.- François Richir (2001-2002): "Influence du processus de vieillissement sur le cytochrome P450 2E1 (CYP2E1) chez le rat Wistar male". Licence en Sciences Biomédicales, orientation Toxicologie.
15.- Carole Marques (2001-2002): "Rôle des vitamines et des antioxydants dans la mort cellulaire induite par l'association des vitamines C et K3". Licence en Sciences Biomédicales, orientation Nutrition.
16.- Marianne Delvaux (2002-2003): "Etude in vitro et in vivo sur l’importance du cycle d’oxydo-réduction des vitamines C et K3 dans leur activité antitumorale". Licence en Sciences Biomédicales, orientation Nutrition.
17.- Pascaline Dubois (2003-2004): "Effet du vieillissement sur le profil sexe-dépendant des enzymes du cytochrome P450 et son influence sur la biotransformation". Licence en Sciences Biomédicales, orientation Toxicologie.
18.- Stéphanie Vanveber (2004-2005): "Rôle des vitamines dans le traitement du cancer: influence de l’état de phosphorylation sur la mort des cellules leucémiques induite par le cycle rédox entre l’ascorbate et la ménadione". Licence en Sciences Biomédicales, orientation Nutrition.
19.- Raphaël Beck (2005-2006): "Etude de l’association ascorbate/menadione sur la viabilité de cellules issues d’un carcinome mammaire (MCF7)". Licence en Sciences Biomédicales, orientation Toxicologie.
20.- Rathnavelu Mohanakumar (2006-2007): "Potential application of the association of vitamins C (sodium ascorbate) and K3 (menadione) as auxiliary therapy in cancer treatment". Master Thesis, Master Program in Medical and Pharmaceutical Research, Vrije Universiteit Brussel (VUB).
21.- Thomas Gonze (2006-2007): "Le clivage de la protéine chaperonne hsp90 par un stress oxydatif provoque la dégradation de la protéine oncogénique Bcr-Abl et mène à la mort des cellules de leucémie myéloïde chronique (K-562)". Licence en Sciences Biomédicales, orientation Nutrition.
22.- Mélanie Creton (2008-2010): "Etude des mécanismes impliqués dans le clivage de la protéine Hsp90 induit par un stress oxydatif". Licence en Sciences Biomédicales, orientation SBEX.
23.- Eva Jacobs (2011-2012): "Rôle du facteur de transcription Nrf2 dans la résistance des cellules cancéreuses à la chimiothérapie". Licence en Sciences Biomédicales, orientation SBEX.

doctor honoris causa

UNIVERSIDAD ARTURO PRAT

Chile, 2009

Reconocimiento al aporte entregado en los campos de docencia, investigacion y vinculacion.


Antifungal activity and in silico studies on 2-acylated benzo- and naphthoquinones Rios, DA; Buc Calderon, P; Benítes, J Article MOLECULES (2022)
On the reactionof 2-alkanoylnaphthohydroquinones with hydroxylamine. Access to cytotoxic 2(hydroxyamino)naphthoquinone and 3-(hydroxyimino)alkyl analogous Valderrama JA; Buc Calderon, P; Benítes, J Article JOURNAL OF CHEMISTRY (2022)
Valeriana pilosa roots essential oil: chemical composition, antioxidant activities and molecular docking studies on enzymes involved in redox biological processes Minchan-Herrera, P; Buc Calderon, P; Benítes, J Article ANTIOXIDANTS (2022)
Chemical Composition and Assessment of Antimicrobial, Antioxidant and Antiproliferative Activities of Essential oil from Clinopodium sericeum, a Peruvian Medicinal Plant Benites, Julio; Rios, David; Guerrero-Castilla, Angelica; Enriquez, Cinthya; Zavala, Ewaldo; Ybanez-Julca, Roberto O.; Quispe-Diaz, Ivan; Jara-Aguilar, Rafael; Calderon, Pedro Buc Article ISI RECORDS OF NATURAL PRODUCTS (2021)
Vitamin C (Ascorbate) and Redox Topics in Cancer Glorieux, Christophe; Buc Calderon, Pedro Article ISI ANTIOXIDANTS & REDOX SIGNALING (2021)
In Vitro Inhibition of Hsp90 Protein by Benzothiazoloquinazolinequinones Is Enhanced in The Presence of Ascorbate. A Preliminary In Vivo Antiproliferative Study Valderrama J.A.; RÃos D.; Muccioli, G. G.; Calderon P.B.; Benites J. Article ISI SCOPUS MOLECULES (2020)
New 2-Acetyl-3-aminophenyl-1,4-naphthoquinones: Synthesis and In Vitro Antiproliferative Activities on Breast and Prostate Human Cancer Cells Rios, David; Valderrama, Jaime A.; Cautin, Miriam; Tapia, Milko; Salas, Felipe; Guerrero-Castilla, Angelica; Muccioli, Giulio G.; Calderon, Pedro Buc; Benites, Julio Article ISI OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)
Cancer Cell Sensitivity to Redox-Cycling Quinones is Influenced by NAD(P)H: Quinone Oxidoreductase 1 Polymorphism Glorieux C.; Calderon P.B. Article ISI SCOPUS ANTIOXIDANTS (2019)
Half-Wave Potentials and In Vitro Cytotoxic Evaluation of 3-Acylated 2,5-Bis(phenylamino)-1,4-benzoquinones on Cancer Cells Benites, Julio; VALDERRAMA, JAIME A; Ramos, Maryan; Valenzuela, Maudy; Guerrero-Castilla, Angélica; Muccioli, Giulio G.; Buc Calderon, Pedro Article ISI SCOPUS MOLECULES (2019)
Catalase down-regulation in cancer cells exposed to arsenic trioxide is involved in their increased sensitivity to a pro-oxidant treatment Glorieux, C; CALDERON, PB Article ISI SCOPUS CANCER CELL INTERNATIONAL (2018)
Chemical composition, in vitro cytotoxicity and antioxidant activities of the essential oil of peruvian Minthostachys mollis Griseb Benítes, J; Guerrero-Castilla, A; Buc Calderon, Pedro Article BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS (2018)
Evaluation of Potential Mechanisms Controlling the Catalase Expression in Breast Cancer Cells Glorieux, C; Sandoval, JM; Dejeans, N; Nonckreman, S; Bahloula, K; Poirel, HA; CALDERON, PB Article ISI SCOPUS OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)
Glucose-regulated protein of 94 kDa contributes to the development of an aggressive phenotype in breast cancer cells Buc Calderon, P.; Seanessen, A.L.; Glorieux, C. Article ISI SCOPUS BIOMEDICINE & PHARMACOTHERAPY (2018)
In Vitro Inhibition of Helicobacter pylori Growth by Redox Cycling Phenylaminojuglones Benites, J; Toledo, H; Salas, F; Guerrero, A; Rios, D; VALDERRAMA, JA; CALDERON, PB Article ISI OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)
Targeting Akt as strategy to kill cancer cells using 3-substituted 5-anilinobenzo[c]isoxazolequinones: A preliminary study Benites, J; Valderrama, JA; Ramos, M; Muccioli, GG; Calderon, PB Article ISI SCOPUS BIOMEDICINE & PHARMACOTHERAPY (2018)
Catalase, a remarkable enzyme: Targeting the oldest antioxidant enzyme to find a new cancer treatment approach. Glorieux, C.; Buc Calderon, P. Article Biol. Chem. (2017)
Silibinin induces hepatic stellate cell cycle arrest via enhancing p53/p27 and inhibiting Akt downstream signaling protein expression Ezhilarasan, Devaraj; Evraerts, Jonathan; Sid, Brice; Calderon, Pedro Buc; Karthikeyan, Sivanesan; Sokal, Etienne; Najimi, Mustapha Article ISI HEPATOBILIARY PANCREATIC DISEASES INTERNATIONAL (2017)
Synthetic approaches and in vitro cytotoxic evaluation of 2-acyl-3-(3,4,5-trimethoxyanilino)-1,4-naphthoquinones Valderrama, Jaime A.; Cabrera, Mónica; Benites, Julio; Ríos, David; Inostroza-Rivera, Ricardo; Muccioli, Giulio G.; Calderon, Pedro Buc Article ISI SCOPUS RSC ADVANCES (2017)
Use of a cocktail of spin traps for fingerprinting large range of free radicals in biological systems Marchand V.; Charlier N.; Verrax J.; Buc-Calderon P.; Levêque P.; Gallez B. Article ISI SCOPUS PLOS ONE (2017)
Chemical composition and antimicrobial activity of essential oil of peruvian Dalea strobilacea Barneby Benites, J; Moiteiro, C; Figueiredo, AC; Rijo, P; Buc-Calderon, P; Bravo, F; Gajardo, S; Sanchez, I; Torres, I; Ganoza, M Article ISI BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS (2016)
Chromatin remodeling regulates catalase expression during cancer cells adaptation to chronic oxidative stress Glorieux, C; Sandoval, JM; Fattaccioli, A; Dejeans, N; Garbe, JC; Dieu, M; Verrax, J; Renard, P; Huang, P; Calderon, PB Article ISI SCOPUS FREE RADICAL BIOLOGY AND MEDICINE (2016)
Determination of sun protection factor and antioxidant properties of six Chilean Altiplano plants Gajardo, S; Aguilar, M; Stowhas, T; Salas, F; Lopez, J; Quispe, C; Buc-Calderon, P; Benites, J Article ISI BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS (2016)
High hydrostatic pressure influences the in vitro response to xenobiotics in Dicentrarchus labrax liver Lemaire, Benjamin; Mignolet, Eric; Debier, Cathy; Calderon, Pedro Buc; Thome, Jean Pierre; Rees, Jean Francois Article ISI AQUATIC TOXICOLOGY (2016)
In vivo inhibition of tumor progression by 5 hydroxy-1,4-naphthoquinone (juglone) and 2-(4-hydroxyanilino)-1,4-naphthoquinone (Q7) in combination with ascorbate Ourique, F; Kviecinski, MR; Zirbel, G; Castro, LSEPW; Castro, AJG; Silva, FRMB; Valderrama, JA; Rios, D; Benites, J; Calderon, PB; Pedrosa, RC Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)
Inhibition of cancer cell growth and migration by dihydroxynaphthyl aryl ketones Benites, Julio; Valderrama, Jaime A.; Ríos, David; Lagos, Rosalba; Monasterio, Octavio; Calderon, Pedro Buc Article ISI SCOPUS Molecular and Cellular Toxicology (2016)
Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta palacios, javier; Cifuentes, Fredi; Valderrama, Jaime A.; Benites, Julio; Ríos, David; González, Constanza; Chiong, Mario; Cartes-Saavedra, Benjamín; Lafourcade, Carlos; Wyneken, Ursula; González, Pamela; Owen, Gareth I.; Pardo, Fabián; Sobrevia, Luis; Buc Calderon, Pedro Article ISI SCOPUS OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)
Overexpression of NAD(P)H: quinone oxidoreductase 1 (NQO1) and genomic gain of the NQO1 locus modulates breast cancer cell sensitivity to quinones Glorieux C.; Sandoval, JM; Dejeans N.; Ameye, G; Poirel, HA; Verrax J.; CALDERON, PB Article ISI SCOPUS LIFE SCIENCES (2016)
Safety assessment of a traditionally used extract from leaves of Boldoa purpurascens Ortega, YH; Mosquera, DMG; Galapththi, S; Santos, BT; Gonzalez, GS; Foubert, K; Pieters, L; Calderon, PB; Apers, S Article ISI SCOPUS JOURNAL OF ETHNOPHARMACOLOGY (2016)
Silibinin induces hepatic stellate cell cycle arrest via enhancing p53/p27 and inhibiting Akt downstream signaling protein expression. Ezhilarasan, D.; Evraerts, J.; Sid, B.; Buc Calderon, P.; Karthikeyan, S.; Sokal, E.; Najimi, M. Article Hepatobiliary Pancreat. Dis. Int. (2016)
Silibinin Inhibits Proliferation and Migration of Human Hepatic Stellate LX-2 Cells Ezhilarasan D.; Evraerts J.; Brice S.; Buc-Calderon P.; Karthikeyan S.; Sokal E.; Najimi M. Article SCOPUS JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY (2016)
Synthesis and Cytotoxic Activity on Human Cancer Cells of Novel Isoquinolinequinone-Amino Acid Derivatives Valderrama, JA; Delgado, V; Sepulveda, S; Benites, J; Theoduloz, C; Calderon, PB; Muccioli, GG Article ISI SCOPUS MOLECULES (2016)
Binding of dihydroxynaphthyl aryl ketones to tubulin colchicine site inhibits microtubule assembly Gutierrez, E.; Benites, J.; VALDERRAMA, JA; CALDERON, PB; Verrax J.; NOVA, E; Villanelo, F; Maturana D.; Escobar C.; Lagos R.; Monasterio O. Article ISI SCOPUS Biochemical and Biophysical Research Communications (2015)
DNA Damage and Inhibition of Akt Pathway in MCF-7 Cells and Ehrlich Tumor in Mice Treated with 1,4-Naphthoquinones in Combination with Ascorbate Ourique, F; Kviecinski, MR; Felipe, KB; Correia, JFG; Farias, MS; Castro, LSEPW; Grinevicius, VMAS; Valderrama J.; Rios, D.; Benites, J.; CALDERON, PB; Pedrosa, RC Article ISI SCOPUS OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)
Hetero-annulation reaction between 2-acylnaphthoquinones and 2-aminobenzothiazoles. A new synthetic route to antiproliferative benzo[g]benzothiazolo[2,3-b] quinazoline-7,12-quinones VALDERRAMA, JA; Rios, D.; Muccioli, GG; CALDERON, PB; Brito, I; Benites, J. Article ISI SCOPUS Tetrahedron Letters (2015)
Regulation of catalase expression in healthy and cancerous cells Glorieux C.; Zamocky, M; Sandoval, JM; Verrax J.; CALDERON, PB Article ISI SCOPUS Free Radical Biology and Medicine (2015)
Acantholippia deserticola essential oil as a natural pesticide against agricultural plagues woolly whitefly [Aleurothrixus floccosus (Maskell)], Chilean false red mite (Brevipalpus chilensis Baker) and two-spotted mite (Tetranychus urticae Koch) Benites, J.; Tello V.; Flores, N.; Tapia, D; Lopez, J.; Rios, D.; Buc Calderon, P. Article ISI BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS (2014)
AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells Sid, B.; Glorieux C.; Valenzuela,M.; Rommelaere, G; Najimi, M.; Dejeans N.; Renard, P; Verrax J.; CALDERON, PB Article ISI SCOPUS BIOCHEMICAL PHARMACOLOGY (2014)
Catalase expression in MCF-7 breast cancer cells is mainly controlled by PI3K/Akt/mTor signaling pathway Glorieux C.; Auquier, J; Dejeans N.; Sid, B.; DEMOULIN, JB; Bertrand, L; Verrax J.; CALDERON, PB Article ISI SCOPUS BIOCHEMICAL PHARMACOLOGY (2014)
Downregulation of Sox9 Expression Associates with Hepatogenic Differentiation of Human Liver Mesenchymal Stem/Progenitor Cells Paganelli, Massimiliano; Nyabi, Omar; Sid, Brice; Evraerts, Jonathan; El Malmi, Imane; Heremans, Yves; Dolle, Laurent; Benton, Carley; Calderon, Pedro-Buc; van Grunsven, Leo; Heimberg, Harry; Campard, David; Sokal, Etienne; Najimi, Mustapha Article ISI STEM CELLS AND DEVELOPMENT (2014)
Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells Valenzuela,M.; Glorieux C.; Stockis, J; Sid, B.; Sandoval, JM; Felipe, KB; Kviecinski, MR; Verrax J.; CALDERON, PB Article ISI SCOPUS BRITISH JOURNAL OF CANCER (2014)
Substituted 3-acyl-2-phenylamino-1,4-naphthoquinones intercalate into DNA and cause genotoxicity through the increased generation of reactive oxygen species culminating in cell death Farias, MS; Pich, CT; Buc Calderon, Pedro Article MOLECULAR MEDICINE REPORTS (2014)
VALIDATION OF A METHOD TO DETECT CENTRAL NERVOUS SYSTEM ACTING DRUGS IN BLOOD BY GC/MS. APPLICATION IN CASES OF DEATH CAUSED BY PHENOTHIAZINES IN THE NORTH OF CHILE Felipe Bravo; Roberto Ulloa; KARINA VENEGAS; MARIA CECILIA CONTZEN; DAVID RÍOS; MARGARITA BRICE; PEDRO BUC CALDERONI; Julio Benites Article SCIELO Journal of the Chilean Chemical Society (2014)
Antidepressant and anxiolytic-like effects of essential oil from Acantholippia deserticola Phil in female rats Benites, J.; Bustos L.; Rios, D.; Bravo F.; Lopez, J.; Gajardo S.; Rojo L.; Buc Calderon, P. Article ISI BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS (2013)
Antiproliferative effects of phenylaminonaphthoquinones are increased by ascorbate and associated with the appearance of a senescent phenotype in human bladder cancer cells Felipe, KB; Benites, J.; Glorieux C.; Sid, B.; Valenzuela,M.; Kviecinski, MR; PedrosaA, RC; VALDERRAMA, JA; Leveque, P; Gallez, B; Verrax J.; CALDERON, PB Article ISI SCOPUS Biochemical and Biophysical Research Communications (2013)
Eco-Friendly Synthesis and Antiproliferative Evaluation of Some Oxygen Substituted Diaryl Ketones Arenas, P; Peña A; Rios, D.; Benites, J.; Muccioli, GG; CALDERON, PB; VALDERRAMA, JA Article ISI SCOPUS MOLECULES (2013)
FORENSIC CASES IN THE NORTH OF CHILE: DETERMINATION OF ANTIDEPRESSANT DRUGS IN HUMAN WHOLE BLOOD Bravo, Felipe; ZAMBRA, CARMEN; VENEGAS, KARINA; Rios, David; Buc Calderon, Pedro; Benites, Julio Article ISI SCIELO SCOPUS Journal of the Chilean Chemical Society (2013)
Role of AMPK activation in oxidative cell damage: Implications for alcohol-induced liver disease Sid, B.; Verrax J.; CALDERON, PB Article ISI SCOPUS Biochemical Pharmacology (2013)
Sodium orthovanadate associated with pharmacological doses of ascorbate causes an increased generation of ROS in tumor cells that inhibits proliferation and triggers apoptosis Fischer Guenther, Tania Mara; Kviecinski, Maicon Roberto; Baron, Carla Cristine; Felipe, Karina Bettega; Farias, Mirelle Sifroni; da Silva, Fabiana Ourique; Falcao Buecker, Nadia Cristina; Pich, Claus Troeger; Ferreira, Eduardo Antonio; Wilhelm Filho, Danilo; Verrax, Julien; Calderon, Pedro Buc; Pedrosa, Rozangela Curi Article ISI BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)
A comparative study of tellurite toxicity in normal and cancer cells Sandoval, J. M.; Verrax J.; Vasquez, C. C.; Calderon P.B. Article ISI SCOPUS Molecular and Cellular Toxicology (2012)
Aminopyrimidoisoquinolinequinone (APIQ) redox cycling is potentiated by ascorbate and induces oxidative stress leading to necrotic-like cancer cell death Vasquez D.R.; Verrax J.; Valderrama, J.A.; Calderon P.B. Article ISI SCOPUS Investigational New Drugs (2012)
Arsenic Trioxide Treatment Decreases the Oxygen Consumption Rate of Tumor Cells and Radiosensitizes Solid Tumors Diepart, Caroline; Karroum, Oussama; Magat, Julie; Feron, Olivier; Verrax, Julien; Calderon, Pedro Buc; Gregoire, Vincent; Leveque, Philippe; Stockis, Julie; Dauguet, Nicolas; Jordan, Benedicte F.; Gallez, Bernard Article ISI CANCER RESEARCH (2012)
Biological Evaluation of 3-Acyl-2-Arylamino-1,4-Naphthoquinones as Inhibitors of Hsp90 Chaperoning Function Rios, David; Benites, Julio; Valderrama, Jaime A.; Farias, Mirelle; Pedrosa, Rozangela C.; Verrax, Julien; Buc Calderon, Pedro Article ISI CURRENT TOPICS IN MEDICINAL CHEMISTRY (2012)
Evaluation of analgesic activities of Tremetone derivatives solated from the chilean altiplano medicine Parastrephia lepidofylla Benites, J; Gutierrez E; Buc Calderon, Pedro Article NATURAL PRODUCT COMMUNICATIONS (2012)
Gut microbiota-derived propionate reduces cancer cell proliferation in the liver Bindels, L. B.; Porporato, P.; Dewulf, E. M.; Verrax, J.; Neyrinck, A. M.; Martin, J. C.; Scott, K. P.; Calderon, P. Buc; Feron, O.; Muccioli, G. G.; Sonveaux, P.; Cani, P. D.; Delzenne, N. M. Article ISI BRITISH JOURNAL OF CANCER (2012)
Hsp90 Is Cleaved by Reactive Oxygen Species at a Highly Conserved N-Terminal Amino Acid Motif Beck R.; Dejeans N.; Glorieux C.; Creton M.; Delaive E.; Dieu M.; Raes M.; Leveque, P; Gallez, B; Depuydt M.; Collet J.-F.; Calderon P.B.; Verrax J. Article ISI SCOPUS PLOS ONE (2012)
Inhibition of cell proliferation and migration by oxidative stress from ascorbate-driven juglone redox cycling in human bladder-derived T24 cells Kviecinski M.R.; Pedrosa R.C.; Felipe K.B.; Farias M.S.; Glorieux C.; Valenzuela,M.; Sid, B.; Benites, J.; Valderrama, J.A.; Verrax J.; Buc Calderon, P. Article ISI SCOPUS Biochemical and Biophysical Research Communications (2012)
Overexpression of GRP94 in breast cancer cells resistant to oxidative stress promotes high levels of cancer cell proliferation and migration: Implications for tumor recurrence Dejeans N.; Glorieux C.; Guenin S.; Beck R.; Sid, B.; Rousseau R.; Bisig B.; Delvenne P.; Buc Calderon, P.; Verrax J. Article ISI SCOPUS Free Radical Biology and Medicine (2012)
Precision-Cut Liver Slices To Investigate Responsiveness of Deep-Sea Fish to Contaminants at High Pressure Lemaire B.; Debier C.; Buc Calderon, P.; Thome J.P.; STEGEMAN, J; Mork J.; Rees J.F. Article ISI SCOPUS ENVIRONMENTAL SCIENCE AND TECHNOLOGY (2012)
Restoring Specific Lactobacilli Levels Decreases Inflammation and Muscle Atrophy Markers in an Acute Leukemia Mouse Model Bindels, Laure B.; Beck, Raphael; Schakman, Olivier; Martin, Jennifer C.; De Backer, Fabienne; Sohet, Florence M.; Dewulf, Evelyne M.; Pachikian, Barbara D.; Neyrinck, Audrey M.; Thissen, Jean-Paul; Verrax, Julien; Calderon, Pedro Buc; Pot, Bruno; Grangette, Corinne; Cani, Patrice D.; Scott, Karen P.; Delzenne, Nathalie M. Article ISI PLOS ONE (2012)
Tumor reoxygenation following administration of Mitogen-Activated Protein Kinase inhibitors: A rationale for combination with radiation therapy Karroum, Oussama; Kengen, Julie; Danhier, Pierre; Magat, Julie; Mignion, Lionel; Bouzin, Caroline; Verrax, Julien; Charette, Nicolas; Starkel, Peter; Calderon, Pedro Buc; Sonveaux, Pierre; Feron, Oliver; Gregoire, Vincent; Gallez, Bernard; Jordan, Benedicte F. Article ISI RADIOTHERAPY AND ONCOLOGY (2012)
Validation of a method to detect cocaine and benzoylecgonine in human whole blood by gas chromatography-mass spectrometry and application in body packers and stuffers cases in the north of Chile Bravo, F; Contzen, C; Buc Calderon, Pedro Article Journal of the Chilean Chemical Society (2012)
An in vitro comparative study with furyl-1,4-quinones endowed with anticancer activities Benites, J.; VALDERRAMA, JA; Taper, H.; CALDERON, PB Article ISI SCOPUS Investigational New Drugs (2011)
Ascorbate/menadione-induced oxidative stress kills cancer cells that express normal or mutated forms of the oncogenic protein Bcr-Abl. An in vitro and in vivo mechanistic study Beck R.; Pedrosa, RC; Dejeans N.; Glorieux C.; Leveque, P; Gallez, B; Taper, H.; Eeckhoudt, S; Knoops L.; CALDERON, PB; Verrax J. Article ISI SCOPUS Investigational New Drugs (2011)
Catalase overexpression in mammary cancer cells leads to a less aggressive phenotype and an altered response to chemotherapy Glorieux C.; Dejeans N.; Sid, B.; Beck R.; CALDERON, PB; Verrax J. Article ISI SCOPUS Biochemical Pharmacology (2011)
In Vitro Differentiated Adult Human Liver Progenitor Cells Display Mature Hepatic Metabolic Functions: A Potential Tool for In Vitro Pharmacotoxicological Testing Dung Ngoc Khuu; Scheers, Isabelle; Ehnert, Sabrina; Jazouli, Nawal; Nyabi, Omar; Buc-Calderon, Pedro; Meulemans, Ann; Nussler, Andreas; Sokal, Etienne; Najimi, Mustapha Article ISI CELL TRANSPLANTATION (2011)
Intracellular ATP levels determine cell death fate of cancer cells exposed to both standard and redox chemotherapeutic agents Verrax J.; Dejeans N.; Sid, B.; Glorieux C.; CALDERON, PB Article ISI SCOPUS Biochemical Pharmacology (2011)
Molecular chaperone Hsp90 as a target for oxidant-based anticancer therapies Beck R.; Dejeans N.; Glorieux C.; Pedrosa R.C.; VÃ³squez D.; Valderrama, J.A.; Calderon P.B.; Verrax J. Article SCOPUS Current Medicinal Chemistry (2011)
Precision-Cut Liver Slices of Salmo salar as a tool to investigate the oxidative impact of CYP1A-mediated PCB 126 and 3-methylcholanthrene metabolism Lemaire B.; Beck, M.; Debier C.; Rees J.F.; Calderon P.B.; Jaspart M.; Thome J.P. Article ISI SCOPUS Toxicology in Vitro (2011)
Redox-Active Quinones and Ascorbate: An Innovative Cancer Therapy That Exploits the Vulnerability of Cancer Cells to Oxidative Stress Verrax, Julien; Beck, Raphael; Dejeans, Nicolas; Glorieux, Christophe; Sid, Brice; Pedrosa, Rozangela C.; Benites, Julio; Vasquez, David; Valderrama, Jaime A.; Buc Calderon, Pedro Article ISI ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2011)
Biological evaluation of donor-acceptor aminonaphthoquinones as antitumor agents Benites, J.; VALDERRAMA, JA; Bettega, K; Pedrosa, RC; CALDERON, PB; Verrax J. Article ISI SCOPUS EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
Comparison of methods for measuring oxygen consumption in tumor cells in vitro Diepart, Caroline; Verrax, Julien; Calderon, Pedro Buc; Feron, Olivier; Jordan, Benedicte F.; Gallez, Bernard Article ISI ANALYTICAL BIOCHEMISTRY (2010)
Endoplasmic reticulum calcium release potentiates the ER stress and cell death caused by an oxidative stress in MCF-7 cells Dejeans N.; Tajeddine, N; Beck R.; Verrax J.; Taper, H.; Gailly, P; CALDERON, PB Article ISI SCOPUS Biochemical Pharmacology (2010)
Evaluation of the hepatotoxic and hepatoprotective effect of Rwandese herbal drugs on in vivo (guinea pigs barbiturate-induced sleeping time) and in vitro (rat precision-cut liver slices, PCLS) models Mukazayire, Marie-Jeanne; Allaeys, Veronique; Calderon, Pedro Buc; Stevigny, Caroline; Bigendako, Marie-Josee; Duez, Pierre Article ISI EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY (2010)
Studies on quinones. Part 46. Synthesis and in vitro antitumor evaluation of aminopyrimidoisoquinolinequinones Vásquez D.; Rodriguez JA.; Theoduloz, C; CALDERON, PB; VALDERRAMA, JA Article ISI SCOPUS EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
Tellurite-induced oxidative stress leads to cell death of murine hepatocarcinoma cells Sandoval, JM; Leveque, P; Gallez, B; Vásquez CC; CALDERON, PB Article ISI SCOPUS BioMetals (2010)
Hsp90 cleavage by an oxidative stress leads to its client proteins degradation and cancer cell death Beck, Raphael; Verrax, Julien; Gonze, Thomas; Zappone, Marianne; Pedrosa, Rozangela Curi; Taper, Henryk; Feron, Olivier; Calderon, Pedro Buc Article ISI BIOCHEMICAL PHARMACOLOGY (2009)
In Situ Modulation of Oxidative Stress: A Novel and Efficient Strategy to Kill Cancer Cells Verrax, J.; Pedrosa, R. Curi; Beck, R.; Dejeans, N.; Taper, H.; Calderon, P. Buc Article ISI CURRENT MEDICINAL CHEMISTRY (2009)
Menadione Reduction by Pharmacological Doses of Ascorbate Induces an Oxidative Stress That Kills Breast Cancer Cells Beck, Raphael; Verrax, Julien; Dejeans, Nicolas; Taper, Henryk; Calderon, Pedro Buc Article ISI INTERNATIONAL JOURNAL OF TOXICOLOGY (2009)
Part 2: Influence of 2-Euryfuryl-1,4-naphthoquinone and Its peri-Hydroxy Derivatives on Both Cell Death and Metabolism of TLT Cells, a Murine Hepatoma Cell Line. Modulation of Cytotoxicity by Vitamin C Benites, Julio; Adolfo Valderrama, Jaime; Taper, Henryk; Calderon, Pedro Buc Article ISI CHEMICAL PHARMACEUTICAL BULLETIN (2009)
Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects Verrax, Julien; Calderon, Pedro Buc Article ISI FREE RADICAL BIOLOGY AND MEDICINE (2009)
Synthesis and antitumor evaluation of 8-phenylaminopyrimido[4,5-c]isoquinolinequinones Vásquez D.; Rodriguez JA.; Theoduloz, C; Verrax J.; CALDERON, PB; VALDERRAMA, JA Article ISI SCOPUS BIOORGANIC MEDICINAL CHEMISTRY LETTERS (2009)
Oxidative stress in the thyroid gland: From harmlessness to hazard depending on the iodine content Poncin, Sylvie; Gerard, Anne-Catherine; Boucquey, Marie; Senou, Maximin; Calderon, Pedro Buc; Knoops, Bernard; Lengele, Benoit; Many, Marie-Christine; Colin, Ides M. Article ISI ENDOCRINOLOGY (2008)
Part 1: Effect of vitamin C on the biological activity of two euryfurylbenzoquinones on TLT, a murine hepatoma cell line Benites, J.; Rojo L.; VALDERRAMA, JA; Taper, H.; CALDERON, PB Article ISI SCOPUS EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2008)
Targeting cancer cells by an oxidant-based therapy Verrax, J; Taper, HS,Buc Calderon, Pedro Article CURRENT MOLECULAR PHARMACOLOGY (2008)
The controversial place of vitamin C in cancer treatment Verrax, J.; Calderon, P. Buc Article ISI BIOCHEMICAL PHARMACOLOGY (2008)
Induction of CYP2C12 expression in senescent male rats is well correlated to an increase of HNF3 beta expression, while the decline of CYP2C11 expression is unlikely due to a decrease of STAT5 activation Wauthier, Valerie; Dubois, Pascaline; Verbeeck, Roger K.; Calderon, Pedro Buc Article ISI BIOCHEMICAL PHARMACOLOGY (2007)
Ontogenic development-associated changes in the expression of genes involved in rat bile acid homeostasis de Juan, Susana Cuesta; Monte, Maria J.; Macias, Rocio I. R.; Wauthier, Valerie; Calderon, Pedro Buc; Marin, Jose J. G. Article ISI JOURNAL OF LIPID RESEARCH (2007)
Role of glycolysis inhibition and poly(ADP-ribose) polymerase activation in necrotic-like cell death caused by ascorbate/menadione-induced oxidative stress in K562 human chronic myelogenous leukemic cells Verrax, Julien; Vanbever, Stephanie; Stockis, Julie; Taper, Henryk; Calderon, Pedro Buc Article ISI INTERNATIONAL JOURNAL OF CANCER (2007)
The effect of ageing on cytochrome P450 enzymes: Consequences for drug biotransformation in the elderly Wauthier, V.; Verbeeck, R. K.; Calderon, P. Buc Article ISI CURRENT MEDICINAL CHEMISTRY (2007)
Ageing is associated with increased expression but decreased activity of CYP2E1 in male Wistar rats Wauthier, Valerie; Schenten, Veronique; Verbeeck, Roger K.; Calderon, Pedro Buc Article ISI LIFE SCIENCES (2006)
Botulinum toxin potentiates cancer radiotherapy and chemotherapy Ansiaux, R; Baudelet, C; Cron, GO; Segers, J; Dessy, C; Martinive, P; De Wever, J; Verrax, J; Wauthier, V; Beghein, N; Gregoire, V; Calderon, PB; Feron, O; Gallez, B Article ISI CLINICAL CANCER RESEARCH (2006)
Decreased CYP3A2 expression and activity in senescent male Wistar rats: Is there a role for HNF4 alpha? Wauthier, Valerie; Verbeeck, Roger K.; Calderon, Pedro Buc Article ISI EXPERIMENTAL GERONTOLOGY (2006)
Oxidative stress by ascorbate/menadione association kills K562 human chronic myelogenous leukaemia cells and inhibits its tumour growth in nude mice Verrax, Julien; Stockis, Julie; Tison, Aurelie; Taper, Henryk S.; Calderon, Pedro Buc Article ISI BIOCHEMICAL PHARMACOLOGY (2006)
Enhancement of quinone redox cycling by ascorbate induces a caspase-3 independent cell death in human leukaemia cells. An in vitro comparative study Verrax, F; Delvaux, M; Beghein, N; Taper, H.; Gallez, B; Calderon, PB Article ISI FREE RADICAL RESEARCH (2005)
New insights about the potential application of the association of vitamins C (sodium ascorbate) and K3 (menadiuone) as auxiliary therapy in cancer treatment Verrax, J; Bollen, S; Delvaux, M; Taper, HS,Buc Calderon, Pedro Article MEDICINAL CHEMISTRY REVIEWS - ONLINE (2005)
Age-related changes in the protein and mRNA levels of CYP2E1 and CYP3A isoforms as well as in their activities in Wistar rats. What role for oxidative stress? Wauthier, V; Verbeeck, RK; Buc Calderon, Pedro Article ARCHIVES OF TOXICOLOGY (2004)
Ascorbate potentiates the cytotoxicity of menadione leading to an oxidative stress that kills cancer cells by a non-apoptotic caspase-3 independent form of cell death Verrax, J; Cadrobbi, J; Marques, C; Taper, H.; Habraken, Y; Piette, J; Calderon, PB Article ISI APOPTOSIS (2004)
Autoschizis: a new form of cell death for human ovarian carcinoma cells following ascorbate : menadione treatment nuclear and DNA degradation Gilloteaux, J; Jamison, JM; Lorimer, HE; Jarjoura, D; Taper, HS; Calderon, PB; Neal, DR; Summers, JL Article ISI TISSUE CELL (2004)
Inhibition of the development of metastases by dietary vitamin C : K-3 combination Taper, HS; Jamison, JM; Gilloteaux, J; Summers, JL; Calderon, PB Article ISI LIFE SCIENCES (2004)
The use of precision-cut liver slices from male Wistar rats as a tool to study age related changes in CYP3A induction and in formation of paracetamol conjugates Wauthier, V; Verbeeck, RK; Calderon, PB Article ISI Toxicology in vitro : an international journal published in association with BIBRA. (2004)
The association of vitamins C and K-3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use coadjuvants in anticancer therapy Verrax, J; Cadrobbi, J; Delvaux, M; Jamison, JM; Gilloteaux, J; Summers, JL; Taper, HS; Calderon, PB Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2003)
Autoschizis: a novel cell death Jamison, JM; Gilloteaux, J; Taper, HS; Calderon, PB; Summers, JL Article ISI BIOCHEMICAL PHARMACOLOGY (2002)
Effects of bacterial endotoxin (lipopolysaccharides) on survival and metabolism of cultured precision-cut rat liver slices Evdokimova, E; Taper, H.; Calderon, PB Article ISI Toxicology in vitro : an international journal published in association with BIBRA. (2002)
Potential therapeutic application of the association of vitamins C and K-3 in cancer treatment Calderon, PB; Cadrobbi, J; Marques, C; Hong-Ngoc, N; Jamison, JM; Gilloteaux, J; Summers, JL; Taper, HS Article ISI CURRENT MEDICINAL CHEMISTRY (2002)
Role of temperature on protein and mRNA cytochrome P450 3A (CYP3A) isozymes expression and midazolam oxidation by cultured rat precision-cut liver slices Rekka, E; Evdokimova, E; Eeckhoudt, S; Labar, G; Calderon, PB Article ISI BIOCHEMICAL PHARMACOLOGY (2002)
Cryopreservation of rat precision-cut liver slices by ultrarapid freezing - Influence on phase I and II metabolism and on cell viability upon incubation for 24 hours Vanhulle, VP; Martiat, GA; Verbeeck, RK; Horsmans, Y; Calderon, PB; Eeckhoudt, SL; Taper, HS; Delzenne, N Article ISI LIFE SCIENCES (2001)
Effect of cold hypoxic storage and reoxygenation at 37°C of cultured precision-cut rat liver slices on paracetamol metabolism Evdokimova, E; Taper, HS; Buc Calderon, Pedro Article ARCHIVES OF TOXICOLOGY (2001)
Reoxygenation after cold hypoxic storage of cultured precision-cut rat liver slices: effects on cellular metabolism and drug biotransformation Rekka, E; Evdokimova, E; Eeckhaudt, S; Calderon, PB Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2001)
Role of ATP and glycogen reserves in both paracetamol sulfation and glucuronidation by cultured precision-cut rat liver slices Evdokimova, E; Taper, H.; Calderon, PB Article ISI Toxicology in vitro : an international journal published in association with BIBRA. (2001)
Role of protein phosphorylation in the inhibition of protein synthesis caused by hypoxia in rat hepatocytes Tinton, S; Buc Calderon, Pedro Article INTERNATIONAL JOURNAL OF TOXICOLOGY (2001)
Activation of poly(ADP-ribose)polymerase in rat hepatocytes does not contribute to their cell death by oxidative stress Latour, I; Leunda-Casi, A; Denef, JF; Calderon, PB Article ISI EXPERIMENTAL CELL RESEARCH (2000)
Hypoxia increases the association of 4E-binding protein 1 with the initiation factor 4E in isolated rat hepatocytes Tinton, SA; Buc-Calderon, PM Article ISI FEBS LETTERS (1999)
Protein S-thiolation can mediate the inhibition of protein synthesis induced by tert-butyl hydroperoxide in isolated rat hepatocytes Latour, I; De Ros, E; Denef, JF; Calderon, PB Article ISI TOXICOLOGY AND APPLIED PHARMACOLOGY (1999)
Survival and metabolic function of freshly isolated rat hepatocytes exposed first to a heat shock and then to an oxidative stress Latour, I; Buc Calderon, Pedro Article INTERNATIONAL JOURNAL OF TOXICOLOGY (1999)
Thermic transition and glycolytic capacity as critical events in the survival of rat liver slices after overnight cold hypoxic preservation Morales, H; Taper, HS; Buc Calderon, Pedro Article JOURNAL OF APPLIED TOXICOLOGY (1998)
Protective effect of fructose on survival and metabolic capacities of hepatocytes kept overnight under cold hypoxia before normothermic reoxygenation Evdokimova, E; Martos, M; Calderon, PMB Article ISI FOOD AND CHEMICAL TOXICOLOGY (1997)
Role of protein-phosphorylation events in the anoxia signal-transduction pathway leading to the inhibition of total protein synthesis in isolated hepatocytes Tinton, S; TranNguyen, QN; BucCalderon, P Article ISI EUROPEAN JOURNAL OF BIOCHEMISTRY (1997)
Adenosine stimulates calcium influx in isolated rat hepatocytes Tinton, SA; Chow, SC; BucCalderon, PM; Kass, GEN Article ISI EUROPEAN JOURNAL OF BIOCHEMISTRY (1996)
Targeting of drug to the hepatocytes by fatty acids. Influence of the carrier (albumin or galactosylated albumin) on the fate of the fatty acids and their analogs Charbon, V; Latour, I; Lambert, DM; BucCalderon, P; Neuvens, L; DeKeyser, JL; Gallez, B Article ISI PHARMACEUTICAL RESEARCH (1996)
Adenosine inhibits protein synthesisin isolated rat hepatocytes. Evidence for a lack of involvement of intracellular calcium in the mechanism of inhibition Tinton, S; Chow, SC; Buc Calderon, Pedro Article EUROPEAN JOURNAL OF BIOCHEMISTRY (1995)
DESFERAL PREVENTS AGAINST CELL-LYSIS INDUCED BY HYDROGEN-PEROXIDE TO HYPOXIC HEPATOCYTES - A ROLE FOR FREE IRON IN HYPOXIA-MEDIATED CELLULAR INJURY LEFEBVRE, V; BUCCALDERON, P Article ISI CHEMICO-BIOLOGICAL INTERACTIONS (1995)
Fructose protects rat hepatocytes during hypoxia and improves protein synthesis recovery during reoxygenation. Lefebvre, Véronique; Buc Calderon, Pedro Article TRANSPLANTATION PROCEEDINGS (1995)
HOMOCYSTEINE ENHANCES THE INHIBITORY EFFECT OF EXTRACELLULAR ADENOSINE ON THE SYNTHESIS OF PROTEINS IN ISOLATED RAT HEPATOCYTES TINTON, S; BUCCALDERON, P Article ISI BIOCHEMICAL JOURNAL (1995)
INHIBITION OF PROTEIN-SYNTHESIS INDUCED BY ADENINE-NUCLEOTIDES REQUIRES THEIR METABOLISM INTO ADENOSINE TINTON, S; BUCCALDERON, P Article ISI BIOCHEMICAL PHARMACOLOGY (1995)
OXIDATIVE DNA-DAMAGE BY T-BUTYL HYDROPEROXIDE CAUSES DNA SINGLE-STRAND BREAKS WHICH IS NOT LINKED TO CELL-LYSIS - A MECHANISTIC STUDY IN FRESHLY ISOLATED RAT HEPATOCYTES LATOUR, I; DEMOULIN, JB; BUCCALDERON, P Article ISI FEBS LETTERS (1995)
FRUCTOSE METABOLISM AND CELL-SURVIVAL IN FRESHLY ISOLATED RAT HEPATOCYTES INCUBATED UNDER HYPOXIC CONDITIONS - PROPOSALS FOR POTENTIAL CLINICAL USE LEFEBVRE, V; GOFFIN, I; BUCCALDERON, P Article ISI HEPATOLOGY (1994)
ADENINE-NUCLEOTIDES AND INHIBITION OF PROTEIN-SYNTHESIS IN ISOLATED HEPATOCYTES INCUBATED UNDER DIFFERENT PO2 LEVELS LEFEBVRE, VHL; VANSTEENBRUGGE, M; BECKERS, V; ROBERFROID, M; BUCCALDERON, P Article ISI ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (1993)
CYTOLYTIC EFFECTS AND BIOCHEMICAL-CHANGES INDUCED BY EXTRACELLULAR ATP TO ISOLATED HEPATOCYTES TINTON, SA; LEFEBVRE, VH; COUSIN, OC; BUCCALDERON, PM Article ISI BIOCHIMICA ET BIOPHYSICA ACTA (1993)
IDENTIFICATION OF THE FREE-RADICAL FORMED BY ADDITION OF HYDROXYL RADICAL TO DEHYDROALANINE COMPOUNDS SIPE, HJ; BUCCALDERON, P; ROBERFROID, M; MASON, RP Article ISI CHEMICO-BIOLOGICAL INTERACTIONS (1993)
CELL-DEATH AND LIPID-PEROXIDATION IN ISOLATED HEPATOCYTES INCUBATED IN THE PRESENCE OF HYDROGEN-PEROXIDE AND IRON SALTS LATOUR, I; PREGALDIEN, JL; BUCCALDERON, P Article ISI ARCHIVES OF TOXICOLOGY (1992)
COMPARATIVE HEPATOTOXICITY OF CHOLIC-ACID, DEOXYCHOLIC-ACID AND LITHOCHOLIC ACID IN THE RAT - INVIVO AND INVITRO STUDIES DELZENNE, NM; CALDERON, PB; TAPER, HS; ROBERFROID, MB Article ISI TOXICOLOGY LETTERS (1992)
BIOCHEMICAL-CHANGES IN ISOLATED HEPATOCYTES EXPOSED TO TERT-BUTYL HYDROPEROXIDE - IMPLICATIONS FOR ITS CYTOTOXICITY BUCCALDERON, P; LATOUR, I; ROBERFROID, M Article ISI CELL BIOLOGY AND TOXICOLOGY (1991)
AD-5, A DEHYDROALANINE DERIVATIVE, DECREASES THE AMOUNT OF REACTIVE OXYGEN SPECIES FORMED DURING NITROFURANTION MICROSOMAL METABOLISM BUCCALDERON, P; ROBERFROID, M Article ISI LIFE SCIENCES (1990)
INCREASE IN THE SURVIVAL-TIME OF MICE EXPOSED TO IONIZING-RADIATION BY A NEW CLASS OF FREE-RADICAL SCAVENGERS BUCCALDERON, P; ROBERFROID, M Article ISI CELLULAR AND MOLECULAR LIFE SCIENCES (1990)
N-ACYL DEHYDROALANINES SCAVENGE OXYGEN RADICALS AND INHIBIT INVITRO FREE-RADICAL MEDIATED PROCESSES BUCCALDERON, P; SIPE, HJ; FLITTER, W; MASON, RP; ROBERFROID, M Article ISI CHEMICO-BIOLOGICAL INTERACTIONS (1990)
PREVENTION BY FREE-RADICAL SCAVENGER AD5 OF PROOXIDANT EFFECTS OF CHOLINE DEFICIENCY GHOSHAL, AK; RUSHMORE, TH; BUCCALDERON, P; ROBERFROID, M; FARBER, E Article ISI FREE RADICAL BIOLOGY AND MEDICINE (1990)
INCREASING THERAPEUTIC EFFECT AND REDUCING TOXICITY OF DOXORUBICIN BY N-ACYL DEHYDROALANINES BUCCALDERON, P; PRAET, M; RUYSSCHAERT, JM; ROBERFROID, M Article ISI EUROPEAN JOURNAL OF CANCER CLINICAL ONCOLOGY (1989)
INHIBITION OF RAT-LIVER MICROSOMAL LIPID-PEROXIDATION BY N-ACYLDEHYDROALANINES - AN INVITRO COMPARATIVE-STUDY BUCCALDERON, P; ROBERFROID, M Article ISI ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (1989)
N-ACYL DEHYDROALANINES PROTECT FROM RADIATION TOXICITY AND INHIBIT RADIATION CARCINOGENESIS IN MICE BUCCALDERON, P; DEFRESNE, MP; BARVAIS, C; ROBERFROID, M Article ISI CARCINOGENESIS (1989)
A NEW CLASS OF FREE-RADICAL SCAVENGERS REDUCING ADRIAMYCIN MITOCHONDRIAL TOXICITY PRAET, M; CALDERON, PB; POLLAKIS, G; ROBERFROID, M; RUYSSCHAERT, JM Article ISI BIOCHEMICAL PHARMACOLOGY (1988)
INHIBITION OF O-2-.-MEDIATED AND HO.-MEDIATED PROCESSES BY A NEW CLASS OF FREE-RADICAL SCAVENGERS - THE N-ACYL DEHYDROALANINES BUCCALDERON, P; ROBERFROID, M Article ISI FREE RADICAL RESEARCH COMMUNICATIONS (1988)
Free radical modulation by N-substituted dehydroalanines, a new way ti imrove therapeutic activity of anticancer drugs. Buc Calderon, Pedro Article CANCER TREATMENT REVIEWS (1987)


Targeting hsp90 family members: A strategy to improve cancer cell death Buc Calderon P.; Beck R.; Glorieux C. Review ISI SCOPUS BIOCHEMICAL PHARMACOLOGY (2019)
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