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Cristian Fabián Paz Robles

Académico

Universidad de La Frontera

Temuco, Chile

Química Medicinal Química de Productos Naturales Síntesis y hemisintesis de compuestos bioactivos Análisis funcional de compuestos activos mediante biología molecular .

Quimica, UNIVERSIDAD DE CONCEPCION. Chile, 2012
Pedagogía en Química, UNIVERSIDAD DE CONCEPCION. Chile, 2007
Quimico Analista, UNIVERSIDAD DE CONCEPCION. Chile, 2003

Académico Full Time

UNIVERSIDAD DE LA FRONTERA

Ingenieria y Ciencias

Temuco, Chile

2014 - A la fecha
Académico Full Time

UNIVERSIDAD DE LA FRONTERA

Medicina

Temuco, Chile

2019 - A la fecha

Operador Full Time

UDT Unidad de Desarrollo Tecnológico UdeC

Coronel, Chile

2004 - 2004

Tesis de Pregrado : 6
Tesis Magister: 1
Tesis Doctorado: 5


ISOLATED LIGNANS OF<i> ARAUCARIA</i><i> ARAUCANA</i> (MOLINA) K. KOCH PROVIDE WOOD PROTECTION AGAINST ATTACK BY THE XYLOPHAGOUS FUNGUS<i> PLEUROTUS</i><i> OSTREATUS</i> (JACQ.) P. KUMM Bravo-Arrepol, Gaston; Torres, Solange; Perez, Claudia; Gonzalez-Ramirez, Mariela; Figueroa, Fabian; Cabrera-Barjas, Gustavo; Aranda, Mario; Tiezzi, Antonio; Gavin, Jose; Paz, Cristian; Becerra, Jose Article ISI Journal of the Chilean Chemical Society (2023)
LOX-1 Activation by oxLDL Induces AR and AR-V7 Expression via NF-kappa B and STAT3 Signaling Pathways Reducing Enzalutamide Cytotoxic Effects Duprat, Felix; Robles, Catalina; Castillo, Maria Paz; Rivas, Yerko; Mondaca, Marcela; Jara, Nery; Roa, Francisco; Bertinat, Romina; Toledo, Jorge; Paz, Cristian; Gonzalez-Chavarria, Ivan Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
Natural Compounds Purified from the Leaves of <i>Aristotelia chilensis</i>: Makomakinol, a New Alkaloid and the Effect of Aristoteline and Hobartine on Na<sub>V</sub> Channels Perez, Rebeca; Figueredo, Claudia; Burgos, Viviana; Cabrera-Pardo, Jaime R.; Schmidt, Bernd; Heydenreich, Matthias; Koch, Andreas; Deuis, Jennifer R.; Vetter, Irina; Paz, Cristian Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
Bromination of eudesmin isolated from araucaria araucana induces epimerization and give bromine derivatives with loss of anti-Candida activity Bravo-Arrepol, Gaston; Becerra, Jose; Ortiz, Leandro; Cabrera-Pardo, Jaime; Schmidt, Bernd; Heydenreich, Matthias; Kelling, Alexandra; Sperlich, Eric; Karpinski, Tomasz M.; Paz, Cristian Article ISI NATURAL PRODUCT RESEARCH (2022)
Drimane Sesquiterpene Aldehydes Control <i>Candida</i> Yeast Isolated from Candidemia in Chilean Patients Marin, Victor; Bart, Bryan; Cortez, Nicole; Jimenez, Veronica A.; Silva, Victor; Leyton, Oscar; Cabrera-Pardo, Jaime R.; Schmidt, Bernd; Heydenreich, Matthias; Burgos, Viviana; Paz, Cristian Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Ginkgolides and Huperzine A for complementary treatment of Alzheimer's disease Villegas, Cecilia; Perez, Rebeca; Petiz, Lyvia Lintzmaier; Glaser, Talita; Ulrich, Henning; Paz, Cristian Article ISI IUBMB LIFE (2022)
Polygodial, a drimane sesquiterpenoid dialdehyde purified from Drimys winteri, inhibits voltage-gated sodium channels Paz, Cristian; Ortiz, Leandro; Deuis, Jennifer R.; Vetter, Irina Article ISI NATURAL PRODUCT RESEARCH (2022)
Curcuma as an adjuvant in colorectal cancer treatment Villegas, Cecilia; Perez, Rebeca; Sterner, Olov; Gonzalez-Chavarria, Ivan; Paz, Cristian Article ISI LIFE SCIENCES (2021)
VOLATILE PROFILE AND CONSUMER ACCEPTABILITY OF NATURAL YOGHURTS ELABORATED WITH CHILEAN NATIVE CULTURES OF ENTEROCOCCUS SP. STRAIN BB3 AND LACTOBACILLUS SP. STRAIN BB6 Viscardi, Sharon; Marileo, Luis; Araos, Maria Paz; Standen, Javiera; Cerna, Silvana; Amato, Mario; Paz, Cristian Article ISI Journal of the Chilean Chemical Society (2021)
Antifungal Effects of Drimane Sesquiterpenoids Isolated from Drimys winteri against Gaeumannomyces graminis var. tritici Paz, Cristian; Viscardi, Sharon; Iturra, Andres; Marin, Victor; Miranda, Felipe; Javier Barra, Patricio; Mendez, Isabel; Duran, Paola Article ISI APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2020)
CHEMICAL CHARACTERIZATION OF LIGNANS FROM Araucaria araucana A NATIVE CONIFER OF CHILE AND EVALUATION OF THEIR CYTOTOXICITY AND ANTIOXIDANT ACTIVITIES Gastón Bravo-Arrepol; Solange Torres; Fabian Figueroa; Claudia Pérez; Cristian Paz; Giovanni Turchetti; Antonio Tiezzi; José Becerra Article SCIELO Journal of the Chilean Chemical Society (2020)
Drimenol, isodrimeninol and polygodial isolated from Drimys winteri reduce monocyte adhesion to stimulated human endothelial cells Burgos, Viviana; Paz, Cristian; Saavedra, Kathleen; Saavedra, Nicolas; Foglio, Mary Ann; Salazar, Luis A. Article ISI FOOD AND CHEMICAL TOXICOLOGY (2020)
Drimys winteri and isodrimeninol decreased foam cell formation in THP-1 derived macrophages Burgos, Viviana; Paz, Cristian; Saavedra, Kathleen; Saavedra, Nicolas; Foglio, Mary Ann; Gonzalez-Chavarria, Ivan; Salazar, Luis A. Article ISI FOOD AND CHEMICAL TOXICOLOGY (2020)
Maytenus disticha Extract and an Isolated beta-Dihydroagarofuran Induce Mitochondrial Depolarization and Apoptosis in Human Cancer Cells by Increasing Mitochondrial Reactive Oxygen Species González-Chavarría, Iván; Duprat, Felix; Roa, Francisco J.; Jara, Nery; Toledo, Jorge R.; Miranda, Felipe; Becerra, José; Inostroza, Alejandro; Kelling, Alexandra; Schilde, Uwe; Heydenreich, Matthias; Paz, Cristian Article ISI SCOPUS BIOMOLECULES (2020)
Oxidation of Isodrimeninol with PCC Yields Drimane Derivatives with Activity against Candida Yeast by Inhibition of Lanosterol 14-Alpha Demethylase Marin, Victor; Iturra, Andres; Opazo, Andres; Schmidt, Bernd; Heydenreich, Matthias; Ortiz, Leandro; Jimenez, Veronica A.; Paz, Cristian Article ISI BIOMOLECULES (2020)
PHYTOCHEMICAL AND CRYSTALLOGRAPHIC STUDIES OF Azara dentata EXTRACTS AND ITS CYTOTOXIC EFFECTS ON HUMAN BREAST CANCER CELL, MCF-7 Paz, Cristian; Gonzalez-Chavarria, Ivan; Freire, Eleonora; Ortiz, Leandro; Karpinski, Tomasz M.; Duprat, Felix; Baggio, Ricardo Article ISI SCIELO Journal of the Chilean Chemical Society (2020)
ADSORPTION ABILITY OF ACTIVATED CARBON OBTAINED FROM SUB-BITUMINOUS COAL (LEBU, CHILE) TO CAPTURE TRIMETHYLAMINE Méndez, Paola; Nuñez, Christian; Cabrera-Pardo, Jaime R.; Paz, Cristian; Barraza, Juan Manuel; Castillo, Rosario; Peña-Farfal, Carlos Article ISI SCIELO SCOPUS Journal of the Chilean Chemical Society (2019)
Alkaloids Purified from Aristotelia chilensis Inhibit the Human alpha 3 beta 4 Nicotinic Acetylcholine Receptor with Higher Potencies Compared with the Human alpha 3 beta 4 and alpha 7 Subtypes Arias H.R.; Ortells M.O.; Feuerbach D.; Burgos V.; Paz C. Article ISI SCOPUS JOURNAL OF NATURAL PRODUCTS (2019)
Aristotelia chilensis (Mol.) Stuntz: A Natural Source of Bioactive Compounds Turchetti, Giovanni; Paz, Cristian Article WOS-ESCI CURRENT TRADITIONAL MEDICINE (2019)
Aristoteline, an Indole-Alkaloid, Induces Relaxation by Activating Potassium Channels and Blocking Calcium Channels in Isolated Rat Aorta Romero, Fernando; Palacios, Javier; Jofre, Ignacio; Paz, Cristian; Nwokocha, Chukwuemeka R.; Paredes, Adrian; Cifuentes, Fredi Article ISI SCOPUS MOLECULES (2019)
Exposure to UV-B Radiation Leads to Increased Deposition of Cell Wall-Associated Xerocomic Acid in Cultures of Serpula himantioides Torres, Solange; González-Ramírez, Mariela; Gavilán, Javiera; Paz, Cristian; Palfner, Goetz; Arnold, Norbert; Fuentealba, Jorge; Becerra, José; Pérez, Claudia; Cabrera-Pardo, Jaime R.; Druzhinina, Irina S. Article ISI SCOPUS APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2019)
Occurrence of Soil Fungi in Antarctic Pristine Environments Durán, Paola; Barra, Patricio J.; Jorquera, Milko A.; Viscardi, Sharon; Fernandez, Camila.; Paz, Cristian; Mora, María de la Luz; Bol, Roland Article ISI SCOPUS FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)
8-Oxo-9-Dihydromakomakine Isolated from Aristotelia chilensis Induces Vasodilation in Rat Aorta: Role of the Extracellular Calcium Influx Cifuentes, Fredi; Palacios, Javier; Paredes, Adrian; Nwokocha, Chukwuemeka R.; Paz, Cristian Article ISI SCOPUS MOLECULES (2018)
Assessment of insecticidal responses of extracts and compounds of Drimys winteri, Lobelia tupa, Viola portalesia and Vestia foetida against the granary weevil Sitophilus granarius Paz, C; Burgos, V; Iturra, A; Rebolledo, R; Ortiz, L; Baggio, R; Becerra, J; Cespedes-Acuna, CL Article ISI SCOPUS INDUSTRIAL CROPS AND PRODUCTS (2018)
Drimane Sesquiterpenoids Noncompetitively Inhibit Human alpha 4 beta 2 Nicotinic Acetylcholine Receptors with Higher Potency Compared to Human alpha 3 beta 4 and alpha 7 Subtypes Arias, Hugo R.; Feuerbach, Dominik; Schmidt, Bernd; Heydenreich, Matthias; Paz, Cristian; Ortells, Marcelo O. Article ISI SCOPUS JOURNAL OF NATURAL PRODUCTS (2018)
Three new dihydro-beta-agarofuran sesquiterpenes from the seeds of Maytenus boaria Paz, Cristian; Heydenreich, Matthias; Schmidt, Bernd; Vadra, Nahir; Baggio, Ricardo Article ISI SCOPUS ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY (2018)
TrypanocidalActivity of Natural Sesquiterpenoids Involves Mitochondrial Dysfunction, ROS Production and Autophagic Phenotype in Trypanosoma cruzi Souza Bombaca, Ana Cristina; Von Dossow, Daniela; Chaves Barbosa, Juliana Magalhaes; Paz, Cristian; Burgos, Viviana; Sadok Menna-Barreto, Rubem Figueiredo Article ISI SCOPUS MOLECULES (2018)
A dihydro-beta-agarofuran sesquiterpene from Maytenus boaria Paz C.; Von Dossow D.; Tiznado V.; Suarez S.; Cukiernik F.D.; Baggio R. Article ISI SCOPUS ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY (2017)
Antibiotic activity of Emerimicin IV isolated from Emericellopsis minima from Talcahuano Bay, Chile Inostroza A.; Lara L.; Paz C.; Perez A.; Galleguillos F.; Hernandez V.; Becerra J.; González-Rocha G.; Silva M. Article SCOPUS Natural Product Research (2017)
Crystal structure of erioflorin isolated from Podanthus mitiqui (L.). Paz Robles, Cristian; Schilde, Uwe Article ISI Acta Cryst. (2017)
Effects of extracts from Maytenus on Aegorhinus superciliosus (Coleoptera: Curculionidae) and Hippodamia convergens (Coleoptera: Coccinellidae) Zavala, A; Hormazabal, E; Montenegro, G; Rosalez, M; Quiroz, A; Paz, C; Rebolledo, R Article ISI SCOPUS Revista Colombiana de Entomologia (2017)
Inhibition on cholinesterase and tyrosinase by alkaloids and phenolics from Aristotelia chilensis leaves Cespedes C.L.; Balbontin C.; Avila J.G.; Dominguez M.; Alarcon J.; Paz C.; Burgos V.; Ortiz L.; Peñaloza-Castro I.; Seigler D.S.; Kubo I. Article ISI SCOPUS FOOD AND CHEMICAL TOXICOLOGY (2017)
(?)-8-oxohobartine a new ?ndole alkaloid from aristotelia chilensis (Mol.) Stuntz Paz, C; Becerra, J. ; Silva M.; Cabrera-Pardo J.; Burgos, V.; Heydenreich, M; Schmidt, B Article SCOPUS Records of Natural Products (2016)
(-)-8-oxohobartine a new indole alkaloid from Aristotelia chilensis (Mol.) Stuntz Cristian Paz; Jose Becerra; Mario Silva; Viviana Burgos; Bernd Schmidt; Matthias Heydenreich Article Rec. Nat. Prod. (2015)
(-)-Pentylsedinine, a New Alkaloid from the Leaves of Lobelia tupa with Agonist Activity at Nicotinic Acetylcholine Receptor Paz, C; Becerra, J. ; Silva M.; Burgos, V.; Heydenreich, M; Schmidt, B; Tran, T; Vetter, I Article ISI SCOPUS Natural Product Communications (2015)
A monoclinic form of dendocarbin A: a borderline case of one-dimensional isostructural polymorphism Paz, C; Burgos, V.; SUAREZ, S.; Baggio R. Article ISI SCOPUS Acta Crystallographica Section C: Structural Chemistry (2015)
Hobartine: a tetracyclic indole alkaloid extracted from Aristotelia chilensis (maqui) Paz Robles Cristian ; Badilla Vidal Natalia ; Suarez Sebastian ; Baggio Ricardo Article Acta Cryst. (2014)
INHIBITION OF QUORUM SENSING BY DRIMANE LACTONES FROM CHILEAN FLORA GERARDO C; Mario Silva; José Becerra; Homero, Urrutia; Katherine Sossa; Cristian Paz Article ISI SCIELO SCOPUS Journal of the Chilean Chemical Society (2014)
Two drimane lactones, valdiviolide and 11-epivaldiviolide, in the form of a 1:1 cocrystal obtained from Drimys winteri extracts Paz Robles Cristian ; Mercado Darı o ; Suarez Sebastian ; Baggio Ricardo Article Acta Cryst. (2014)
(E)-Ethyl 3-(3,4-dihydroxyphenyl)prop-2-enoate: a natural polymorph extracted from Aristotelia chilensis (Maqui) Paz, C; Moreno Y.; Becerra, J. ; Silva M.; Burgos, V.; Freire, E; Baggio R. Article ISI SCOPUS Acta Crystallographica Section C: Crystal Structure Communications (2013)
A natural polymorph of Ethyl 3-(3,4-dihydroxyphenyl)-2-propenoate Paz Cristian; Moreno Yanko; Becerra José; Silva Mario; Burgos Viviana; Freire Eleonora; Baggio Ricardo Article Acta Cryst (2013)
A polymorphic form of 4,4-dimethyl-8-methylene-3-azabicyclo[3.3.1]non-2-en-2-yl 3-indolyl ketone, an indole alkaloid extracted from Aristotelia chilensis (maqui) Paz, C; Becerra, J. ; Silva M.; Freire, E; Baggio R. Article ISI SCOPUS Acta Crystallographica Section C: Crystal Structure Communications (2013)
Drimendiol, A Drimane Sesquiterpene with Quorum Sensing Inhibition Activity Paz, C; Carcamo, G.; Silva M.; Becerra, J. ; Urrutia, H; Sossa, K Article ISI SCOPUS Natural Product Communications (2013)
Synthesis of the ligand (z)-2-(3-methoxyphenylamino)-4-oxo-4-phenylbut-2- enoic acid and its antifungal activity against the wood stain fungi mucor plumbeus Paz, C; Cajas-Madriaga D.; Torres C.; Moreno Y.; FernÃ¡ndez M.J.; Becerra J.; Silva M. Article SCOPUS Journal of the Chilean Chemical Society (2013)
SYNTHESIS OF THE LIGAND (Z)-2-(3-METHOXYPHENYLAMINO)-4-OXO-4-PHENYLBUT-2-ENOIC ACID AND ITS ANTIFUNGAL ACTIVITY AGAINST THE WOOD STAIN FUNGI MUCOR PLUMBEUS Paz, C; Cajas-Madriaga, D; Torres C.; Moreno Y.; FERNÁNDEZ, M. J; Becerra, J. ; Silva M. Article ISI SCIELO Journal of the Chilean Chemical Society (2013)
SYNTHESIS AND AChE INHIBITING ACTIVITY OF 2, 4 SUBSTITUTED 6-PHENYL PYRIMIDINES Paz, C; Peter M.G.; Schmidt, B; Becerra, J. ; Gutiérrez M; Astudillo, L; Silva M. Article ISI SCIELO SCOPUS Journal of the Chilean Chemical Society (2012)
6,6,9a-Trimethyl-5,5a,6,7,8,9,9a,9b-octahydronaphtho[1,2-c]furan-1(3H)-one Brito, I; Lopez-Rodriguez, M; Zarraga, M.; Paz, C; Pérez, C. Article ISI SCOPUS ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE (2008)
Regio- and stereoselective Baeyer-Villiger oxidation on (R)-(+)-camphor adducts Zarraga, M.; Salas, V; Miranda A.; Arroyo, P; Paz, C Article ISI SCOPUS TETRAHEDRON-ASYMMETRY (2008)
Synthesis of a new nitrogenated drimane derivative with antifungal activity Zarraga, M.; Zarraga, AM; Rodríguez, B.; Pérez, C.; Paz, C; Paz, P; Sanhueza C. Article ISI SCOPUS TETRAHEDRON LETTERS (2008)
X-RAY CRYSTALLOGRAPHIC STRUCTURAL STUDY ON A CINNAMOLIDE-CLASS SESQUITERPENE LACTONE FROM DRIMYS WINTERI FORST. VAR. CHILENSIS Brito, I; Cardenas, A; Zarraga, M.; Paz, C; Pérez, C.; Lopez-Rodriguez, M Article ISI Journal of the Chilean Chemical Society (2008)
X-RAY CRYSTALLOGRAPHIC STRUCTURAL STUDY ON A CINNAMOLIDE-CLASS SESQUITERPENE LACTONE FROM DRIMYS WINTERIFORST. VAR. CHILENSIS Brito, Ivan; CÁRDENAS, ALEJANDRO; Zarraga, Miguel; Paz, Cristian; Perez, Claudia; LÓPEZ-RODRÍGUEZ, MATÍAS Article SCIELO SCOPUS Journal of the Chilean Chemical Society (2008)


Drimane sesquiterpenes from Drimys winteri. Paz, Cristian; Tiezzi, Antonio BookSection (2017)


ACTIVIDAD INSECTICIDA DE ARISTOTELIA CHILENSIS SOBRE SITOPHILUS GRANARIUS (COLEOPTERA: CURCULIONIDAE). Paz, Cristian; Burgos,Viviana; Rebolledo, Ramón ConferencePaper


Método para combatir plagas de grano almacenado con extractos de Maytenus boaria Montenegro, Gloria; Zavala, Andrea; Rosales-Villavicencio, Marlene; Rebolledo, Ramón; Paz, Cristian Patent
Sesquiterpenos de drimano con aplicación antifúngica. Paz, Cristian; Durán, Paola; Viscardi, Sharon Patent
“Extracto etanólico de hojas de Maytenus disticha como conantimicrobiano para el control de Pseudomonas aeruginosa, Staphylococcus aureus y Pseudomonas syringae” Montenegro, Gloria; Zavala, Andrea; Villalobos Acuna, Blanca; Rosales-Villavicencio, Marlene; Rebolledo, Ramón; Paz, Cristian Patent Patent pending


Indole Alkaloid sub products of Maqui processing as food additives to treatment of Alzheimer’s disease Paz, Cristian; Paz, Cristian Proyecto Indole alkaloids purified from leaves of Aristotelia chilensis display neuroprotective effects against Alzheimer models on cell lines (2018)
Interdisciplinary network for study of Antarctic fungal bioactive compounds for control of cancer cells, pathogenic yeasts and bacterial strains to human health Paz, Cristian; Paz, Cristian Proyecto Antarctic environment, it makes an unique place in the world for study of fungi as producers of bioactive compounds. The increasing health problem occasioned by cancer, bacteria and yeast, which get resistance to classic drugs, there is an urgent need to find new compounds for their treatment (2018)
Natural and hemisynthetic drimane sesquiterpenoids, inhibitors of nicotinic acetylcholine receptors. Looking for behavioral modulators. Paz, Cristian Proyecto Drimys winteri have drimane sesquiterpenoids which have been shown to be inhibitors of hα4β2 with more selectivity than hα3β4 and hα7 nAChR subtypes. nAChRs may be involved in neurological and mental dysfunctions including drug addictions, depression. We propose the isolation of natural drimanes (mu (2018)
Red de colaboración interdisciplinaria para la generación de medicamentos naturales desde la flora nativa Chilena PCI (REDI170107) Proyecto 2018-2019 Director(a)
Desarrollo de estrategias de control contra Sitophilus granarius y Tribolium castaneum mediante el uso de compuestos naturales obtenidos de plantas vasculares endémicas Universidad de La Frontera (DIUFRO DI17-0049) Proyecto 2017-2019 Director(a)
Red de colaboración interdisciplinaria para la generación de medicamentos naturales desde la flora nativa Chilena Paz, Cristian Proyecto Este proyecto une el trabajo interdisciplinario de 9 grupos de investigación nacional y extranjeros con especialidad de química/ biología, para el estudio de compuestos naturales con actividad biológica en busca de nuevos fármacos (2017)
“Purificación y determinación estructural de metabolitos secundarios de plantas nativas del valle de Trapa Trapa. Evaluación de potencial antibacteriano contra mastitis bovina” DIUFRO - Universidad de La Frontera (DI15-0063) Proyecto 2015-2016 Director(a)
MOLECULAR DETERMINATION OF NATURAL COMPOUNDS FROM NATIVE CHILEAN FLORA. DAAD (A/13/03310) Proyecto 2013-2013 Investigador(a)
Síntesis y evaluación funcional de heterociclos derivados de Isoxazoles y Pirazoles 3-carboxamidas, con potencial actividad analgésica. Inhibición de canales de sodio Nav1.8 PFCHA (3130378) Proyecto 2013-2015 Inv. Responsable
Discovery of novel antimicrobial targeting cell division Universidad de Concepción Proyecto 2010-2010 Tesista


Adjuvant Properties of Caffeic Acid in Cancer Treatment Cortez, Nicole; Villegas, Cecilia; Burgos, Viviana; Cabrera-Pardo, Jaime R.; Ortiz, Leandro; Gonzalez-Chavarria, Ivan; Nchiozem-Ngnitedem, Vaderament-A.; Paz, Cristian Review ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2024)
Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity Villegas, Cecilia; Cortez, Nicole; Ogundele, Ayorinde Victor; Burgos, Viviana; Pardi, Paulo Celso; Cabrera-Pardo, Jaime R.; Paz, Cristian Review ISI BIOMOLECULES (2024)
Therapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment Cortez, Nicole; Villegas, Cecilia; Burgos, Viviana; Ortiz, Leandro; Cabrera-Pardo, Jaime R.; Paz, Cristian Review ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2024)
Thymol as adjuvant in oncology: molecular mechanisms, therapeutic potentials, and prospects for integration in cancer management Herrera-Bravo, Jesus; Belen, Lisandra Herrera; Reyes, Maria Elena; Silva, Victor; Fuentealba, Soledad; Paz, Cristian; Loren, Pia; Salazar, Luis A.; Sharifi-Rad, Javad; Calina, Daniela Review ISI NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2024)
Caffeic Acid Phenethyl Ester (CAPE): Biosynthesis, Derivatives and Formulations with Neuroprotective Activities Perez, Rebeca; Burgos, Viviana; Marin, Victor; Camins, Antoni; Olloquequi, Jordi; Gonzalez-Chavarria, Ivan; Ulrich, Henning; Wyneke, Ursula; Luarte, Alejandro; Ortiz, Leandro; Paz, Cristian Review ISI ANTIOXIDANTS (2023)
Epothilones as Natural Compounds for Novel Anticancer Drugs Development Villegas, Cecilia; Gonzalez-Chavarria, Ivan; Burgos, Viviana; Iturra-Beiza, Hector; Ulrich, Henning; Paz, Cristian Review ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
Licochalcone A: A Potential Multitarget Drug for Alzheimer's Disease Treatment Olloquequi, Jordi; Ettcheto, Miren; Cano, Amanda; Fortuna, Ana; Bicker, Joana; Sanchez-Lopez, Elena; Paz, Cristian; Urena, Jesus; Verdaguer, Ester; Auladell, Carme; Camins, Antoni Review ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment Marin, Victor; Burgos, Viviana; Perez, Rebeca; Maria, Durvanei Augusto; Pardi, Paulo; Paz, Cristian Review ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
Therapeutic Effects of Cannabinoids and Their Applications in COVID-19 Treatment Perez, Rebeca; Glaser, Talita; Villegas, Cecilia; Burgos, Viviana; Ulrich, Henning; Paz, Cristian Review ISI LIFE-BASEL (2022)
Selective Secretase Targeting for Alzheimer's Disease Therapy Miranda, Alvaro; Montiel, Enrique; Ulrich, Henning; Paz, Cristian Review ISI JOURNAL OF ALZHEIMERS DISEASE (2021)

Cristian Paz

Académico

Ciencias Químicas

Universidad de La Frontera

Temuco, Chile

Viviana Burgos

Estudiante

Ciencias básicas

Universidad de La Frontera

Temuco, Chile

Leandro Ortiz

Académico

Química

Universidad Austral de Chile

Valdivia, Chile

JOSE BECERRA

Professor

Botany Department

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Claudia Perez

Academic

Botany

University of Concepción

Concepción, Chile

Jaime Cabrera

Assistant Professor

Chemistry

Universidad del Bio Bio

Concepcion, Chile

Mario Silva

Emeritus Professor

Botany Department

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

Paola Durán

Profesor Asociado

Producción Agropecuaria

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

Ivan Brito

Profesor Titular

Quimica

Universidad de Antofagasta

Antofagasta, Chile

Ivan Brito

Full Professor

Chemsitry

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

Jorge Toledo

Director de Departamento

Fisiopatología

Universidad de Concepción

Concepcion, Chile

Veronica Jimenez

Assistant Professor

Chemistry

Universidad Andres Bello

Talcahuano, Chile

Luis Salazar

Profesor Titular

Ciencias Básicas

Universidad de La Frontera

Temuco, Chile

Homero Urrutia

Profesor titular

Facultad de Ciencias Biológicas

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Solange Torres

Investigador Postdoctoral

Botánica

Universidad de Concepción

Concepción, Chile

Adrian Paredes

Academico

Química

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

Patricio Barra

Profesor Asistente

Scientific and Technological Bioresource Nucleus

Universidad de La Frontera

Temuco, Chile

Nicolás Saavedra

Profesor Asociado

Departamento de Ciencias Básicas

Universidad de La Frontera

Temuco, Chile

María Mora

Full Professor

Ciencias Químicas y Recursos Naturales

Universidad de La Frontera

TEMUCO, Chile

Sharon Viscardi

Full Professor

Departamento de Procesos, Diagnosticos y evaluación

Universidad Católica de Temuco

Temuco , Chile

Cristian Balbontin

Investigador

Produccion Vegetal

Instituto de Investigaciones Agropecuarias

Chillán, Chile

Paola Méndez

Investigadora

Química

Universidad del Bío-Bío

Concepción, Chile

Ignacio Jofré

Postdoctoral Researcher

Departamento de Ciencias Químicas

Universidad de La Frontera

Temuco, Chile

IVAN GONZALEZ

Profesor Asistente

Fisiopatología

Universidad De Concepcion

Concepción, Chile

Götz Palfner

Profesor Asociado

Botánica

Universidad de Concepción

Concepción, Chile

Milko Jorquera

PROFESOR TITULAR

CIENCIAS QUIMICA Y RECURSOS NATURALES

UNIVERSIDAD DE LA FRONTERA

TEMUCO, Chile

Nery Jara

Profesor Asistente

Departamento de Farmacología

Universidad de Concepción

Concepción, Chile

JORGE FUENTEALBA

Dean

Physiology

UNIVERISDAD DE CONCEPCION

Concepcion, Chile

Clemente Palacios

Académico

Química y Farmacia

Universidad Arturo Prat

Iquique, Chile

JAVIERA GAVILAN

Estudiante de Doctorado

Fisiología

Universidad de Concepción

Concepcion, Chile

Andres Opazo

Profesor Asistente

Microbiología

Universidad de Concepción

Concepción, Chile

Christian Nuñez

Director Departamento de Química

Química

Universidad del Bío Bío

Concepción, Chile

Alejandro Luarte

Profesor Investigador

Neurociencias

Universidad de Los Andes

santiago, Chile

CARLOS PEÑA

PROFESOR

INSTITUTO DE CIENCIAS QUIMICAS APLICADAS

Universidad Autónoma de Chile

TEMUCO, Chile

Katherine Sossa

Associate professor

Centro de Biotecnología

Universidad de Concepción

Concepción, Chile

Andrea Zavala

margarita gutierrez

Proffesor

UNIVERSIDAD DE TALCA

Talca, Chile

Gastón Bravo

Docente-Investigador

Ciencias Basicas

Universidad San Sebastián

Concepcion, Chile

Pía Loren

Investigador Freelance

Centro de Biología Molecular y Farmacogenética

Universidad de La Frontera

Temuco, Chile

Cristian Fabián Paz Robles

Líneas de Investigación

Educación

Quimica, UNIVERSIDAD DE CONCEPCION. Chile, 2012

Pedagogía en Química, UNIVERSIDAD DE CONCEPCION. Chile, 2007

Quimico Analista, UNIVERSIDAD DE CONCEPCION. Chile, 2003

Experiencia Académica

Académico Full Time

Académico Full Time

Experiencia Profesional

Operador Full Time

Formación de Capital Humano

Article (51)

BookSection (1)

ConferencePaper (1)

Patent (3)

Proyecto (10)

Red de colaboración interdisciplinaria para la generación de medicamentos naturales desde la flora nativa Chilena

Desarrollo de estrategias de control contra Sitophilus granarius y Tribolium castaneum mediante el uso de compuestos naturales obtenidos de plantas vasculares endémicas

“Purificación y determinación estructural de metabolitos secundarios de plantas nativas del valle de Trapa Trapa. Evaluación de potencial antibacteriano contra mastitis bovina”

MOLECULAR DETERMINATION OF NATURAL COMPOUNDS FROM NATIVE CHILEAN FLORA.

Síntesis y evaluación funcional de heterociclos derivados de Isoxazoles y Pirazoles 3-carboxamidas, con potencial actividad analgésica. Inhibición de canales de sodio Nav1.8

Discovery of novel antimicrobial targeting cell division

Review (10)