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Felipe Alfredo Court Goldsmith

Full Professor and Director

Universidad Mayor

Huechuraba, Chile

My research has been focused in studying the relationship between glial cells and neurons in different biological processes, including axonal degeneration, regeneration and intracellular transfer of cargoes.

Bs. Biological Sciences, Catholic University of Chile. Chile, 1999
MSc, University of Edinburgh, UK. Reino Unido, 2001
PhD, University of Edinburgh, UK. Chile, 2004

Associate Professor Full Time

Catholic University of Chile

Biological Sciences

Santiago, Chile

2007 - 2016
EMBO Postdoctoral fellow Full Time

San Raffaele Scientific Institute

Science

Milan, Italia

2005 - 2007
Full Professor Full Time

Universidad Mayor

CIencias

Santiago, Chile

2016 - A la fecha

Director

Neurounion Biomedical Foundation

Santiago, Chile

2011 - Sin Información
Director Advance Microscopy Unit Part Time

P. Catholic University of Chile

Santiago, Chile

2011 - 2016
Full Professor and Director Center for Integrative Biology Full Time

Universidad Mayor

Santiago, Chile

2016 - A la fecha
Chief Scientific Officer Other

Biome Therapeutics

Santiago, Chile

2019 - A la fecha

(i) Post-doctoral fellows
Dr. Frederic Picou (2012-2015, Fondecyt postdoctoral fellowship)
Dr. Valeria Godoy (2013-2015, Fondecyt postdoctoral fellowship)
Dr. Rosario Villegas (2012-2015, Fondecyt postdoctoral fellowship).
Dr. Mario Sanhueza (2017-2019, Fondecyt postdoctoral fellowship).
Dr. Macarena Arrazaola (2018-2021, Fondecyt postdoctoral fellowship).
Dr. Natalia Salvadores (2018-2021, Fondecyt postdoctoral fellowship).
Dr. Cristian Geronimo (2019-2023, Fondecyt postdoctoral fellowship).
Dr. Genesis Vega (2021-2024,Fondecyt postdoctoral fellowship).

(ii) PhD students
Dr. Eileen Collyer, finished, 2013
Diego Hernandez. PhD program in Physiology, Universidad Católica de Chile.
Nicolas Martinez. PhD program in Physiology, Universidad Católica de Chile.
Dominique Lamaitre. PhD program in Physiology, Universidad Católica de Chile.
Maritza Oñate, PhD program in Physiology, Universidad Católica de Chile.
Francisco Muñoz PhD, program in neurobiology, Universidad Mayor
Andres Fuentes PhD, program in integrative genomics, Universidad Mayor.

(iii) Magister Students
Vicente Spiro Valenzuela, (2009, Universidad de Chile)
Diego Alejandro Reginesi Espinoza (2011, Universidad de Valparaiso)
Maritza Oñate (2016, Universidad de Chile)

(iV) Undergraduate Students
Álvaro Sánchez (2014, Universidad Católica de Chile)
Julis Ibri, (2017, Universidad de Bordeaux)
Francisco Muñoz (2018-2020, Universidad Mayor)


A beta oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer's disease Salvadores, Natalia; Moreno-Gonzalez, Ines; Gamez, Nazaret; Quiroz, Gabriel; Vegas-Gomez, Laura; Escandon, Marcela; Jimenez, Sebastian; Vitorica, Javier; Gutierrez, Antonia; Soto, Claudio; Court, Felipe A. Article ISI ACTA NEUROPATHOLOGICA COMMUNICATIONS (2022)
Dementia in Latin America: Paving the way toward a regional action plan Alfredo Parra, Mario; Baez, Sandra; Sedeno, Lucas; Gonzalez Campo, Cecilia; Santamaria-Garcia, Hernando; Aprahamian, Ivan; Bertolucci, Paulo H. F.; Bustin, Julian; Camargos Bicalho, Maria Aparecida; Cano-Gutierrez, Carlos; Caramelli, Paulo; Chaves, Marcia L. F.; Cogram, Patricia; Beber, Barbara Costa; Court, Felipe A.; de Souza, Leonardo Cruz; Custodio, Nilton; Damian, Andres; de la Cruz, Myriam; Rodriguez, Roberta Diehl; Dozzi Brucki, Sonia Maria; Fajersztajn, Lais; Farias, Gonzalo A.; De Felice, Fernanda G.; Ferrari, Raffaele; de Oliveira, Fabricio Ferreira; Ferreira, Sergio T.; Ferretti, Ceres; Figueredo Balthazar, Marcio Luiz; Ferreira Frota, Norberto Anizio; Fuentes, Patricio; Garcia, Adolfo M.; Garcia, Patricia J.; de Gobbi Porto, Fabio Henrique; Duque Penailillo, Lissette; Willy Engler, Henry; Maier, Irene; Mata, Ignacio F.; Gonzalez-Billault, Christian; Lopez, Oscar L.; Morelli, Laura; Nitrini, Ricardo; Quiroz, Yakeel T.; Guerrero Barragan, Alejandra; Huepe, David; Pio, Fabricio Joao; Suemoto, Claudia Kimie; Kochhann, Renata; Kochen, Silvia; Kumfor, Fiona; Lanata, Serggio; Miller, Bruce; Mansur, Leticia Lessa; Hosogi, Mirna Lie; Lillo, Patricia; Guerra, Jorge Llibre; Lira, David; Lopera, Francisco; Comas, Adelina; Alberto Avila-Funes, Jose; Luisa Sosa, Ana; Ramos, Claudia; Resende, Elisa de Paula Franca; Snyder, Heather M.; Tarnanas, Ioannis; Yokoyama, Jenifer; Llibre, Juan; Cardona, Juan Felipe; Possin, Kate; Kosik, Kenneth S.; Montesinos, Rosa; Moguilner, Sebastian; Lourdes Solis, Patricia Cristina; de Lucena Ferretti-Rebustini, Renata Eloah; Martin Ramirez, Jeronimo; Matallana, Diana; Mbakile-Mahlanza, Lingani; Marques Ton, Alyne Mendonca; Tavares, Ronnielly Melo; Miotto, Eliane C.; Muniz-Terrera, Graciela; Munoz-Nevarez, Luis Arnoldo; Orozco, David; de Oliveira, Maira Okada; Piguet, Olivier; Caipa, Maritza Pintado; Pina Escudero, Stefanie Danielle; Schilling, Lucas Porcello; Rodrigues Palmeira, Andre Luiz; Yassuda, Monica Sanches; Manuel Santacruz-Escudero, Jose; Serafim, Rodrigo Bernardo; Smid, Jerusa; Slachevsky, Andrea; Serrano, Cecilia; Soto-Anari, Marcio; Takada, Leonel Tadao; Grinberg, Lea Tenenholz; Teixeira, Antonio Lucio; Barbosa, Maira Tonidandel; Trepel, Dominic; Ibanez, Agustin Article ISI Alzheimer's & Dementia (2021)
Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain Elisa Gorostieta-Salas , Daniel Moreno-Blas , Cristian Gerónimo-Olvera , Bulmaro Cisneros , Felipe A. Court and Susana Castro-Obregón Article OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)
New insights on the molecular mechanisms of collateral sprouting after peripheral nerve injury Dominique Lemaitre, Felipe A Court Article NEURAL REGENERATION RESEARCH (2021)
Ex Vivo Analysis of Axonal Degeneration Using Sciatic and Optic Nerve Preparations Rodrigo López-LealFelipe A. Court Article NEISSERIA MENINGITIDIS (2020)
Metformin protects from oxaliplatin induced peripheral neuropathy in rats N W Martinez , A Sánchez , P Diaz , R Broekhuizen , J Godoy , S Mondaca , A Catenaccio , P Macanas , B Nervi , M Calvo , F A Court Article (2020)
Axonal Degeneration in AD: The Contribution of A beta and Tau Salvadores, Natalia; Geronimo-Olvera, Cristian; Court, Felipe A. Article ISI FRONTIERS IN AGING NEUROSCIENCE (2020)
Collateral Sprouting of Peripheral Sensory Neurons Exhibits a Unique Transcriptomic Profile Lemaitre, Dominique; Llavero Hurtado, Maica; De Gregorio, Cristian; Onate, Maritza; Martinez, Gabriela; Catenaccio, Alejandra; Wishart, Thomas M.; Court, Felipe A. Article ISI MOLECULAR NEUROBIOLOGY (2020)
GERO Cohort Protocol, Chile, 2017-2022: Community-based Cohort of Functional Decline in Subjective Cognitive Complaint elderly Slachevsky, Andrea; Zitko, Pedro; Martinez-Pernia, David; Forno, Gonzalo; Court, Felipe A.; Lillo, Patricia; Villagra, Roque; Duran-Aniotz, Claudia; Parrao, Teresa; Assar, Rodrigo; Orellana, Paulina; Toledo, Carolina; Rivera, Rodrigo; Ibanez, Agustin; Parra, Mario A.; Gonzalez-Billault, Christian; Amieva, Helena; Thumala, Daniela Article ISI BMC GERIATRICS (2020)
Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates Garcia-Huerta, Paula; Troncoso-Escudero, Paulina; Wu, Di; Thiruvalluvan, Arun; Cisternas-Olmedo, Marisol; Henriquez, Daniel R.; Plate, Lars; Chana-Cuevas, Pedro; Saquel, Cristian; Thielen, Peter; Longo, Kenneth A.; Geddes, Brad J.; Lederkremer, Gerardo Z.; Sharma, Neeraj; Shenkman, Marina; Naphade, Swati; Sardi, S. Pablo; Spichiger, Carlos; Richter, Hans G.; Court, Felipe A.; Tshilenge, Kizito Tshitoko; Ellerby, Lisa M.; Wiseman, R. Luke; Gonzalez-Billault, Christian; Bergink, Steven; Vidal, Rene L.; Hetz, Claudio Article ISI ACTA NEUROPATHOLOGICA (2020)
Schwann Cell Reprogramming Into Repair Cells Increases Exosome-Loaded miRNA-21 Promoting Axonal Growth López-Leal R, Díaz-Viraqué F, Catalan RJ, Saquel C, Enright A, Iraola G, Court FA. Article JOURNAL OF CELL SCIENCE (2020)
The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease Onate, Maritza; Catenaccio, Alejandra; Salvadores, Natalia; Saquel, Cristian; Martinez, Alexis; Moreno-Gonzalez, Ines; Gamez, Nazaret; Soto, Paulina; Soto, Claudio.; Hetz, Claudio; Court, Felipe A. Article ISI SCOPUS CELL DEATH AND DIFFERENTIATION (2020)
The necroptosis pathway and its role in age-related neurodegenerative diseases: will it open up new therapeutic avenues in the next decade? Salvadores, Natalia; Court, Felipe A. Article ISI EXPERT OPINION ON THERAPEUTIC TARGETS (2020)
Altered mitochondrial bioenergetics are responsible for the delay in Wallerian degeneration observed in neonatal mice Kline, Rachel A.; Dissanayake, Kosala N.; Hurtado, Maica Llavero; Martinez, Nicolas W.; Ahl, Alexander; Mole, Alannah J.; Lamont, Douglas J.; Court, Felipe A.; Ribchester, Richard R.; Wishart, Thomas M.; Murray, Lyndsay M. Article ISI SCOPUS NEUROBIOLOGY OF DISEASE (2019)
c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling Escudero, C. A.; Cabeza, C.; Moya-Alvarado, G.; Maloney, M. T.; Flores, C. M.; Wu, C.; Court, F. A.; Mobley, W. C.; Bronfman, F. C. Article ISI SCOPUS SCIENTIFIC REPORTS (2019)
Compartmentalized necroptosis activation in excitotoxicity-induced axonal degeneration: a novel mechanism implicated in neurodegenerative disease pathology Arrazola, Macarena S.; Court, Felipe A. Article ISI SCOPUS NEURAL REGENERATION RESEARCH (2019)
Non-canonical function of IRE1 alpha determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics Carreras-Sureda, Amado; Jana, Fabian; Urra, Hery; Durand, Sylvere; Mortenson, David E.; Sagredo, Alfredo; Bustos, Galdo; Hazari, Younis; Ramos-Fernandez, Eva; Sassano, Maria L.; Pihan, Philippe; van Vliet, Alexander R.; Gonzalez-Quiroz, Matias; Torres, Angie K.; Tapia-Rojas, Cheril; Kerkhofs, Martijn; Vicente, Ruben; Kaufman, Randal J.; Inestrosa, Nibaldo C.; Gonzalez-Billault, Christian; Luke Wiseman, R.; Agostinis, Patrizia; Bultynck, Geert; Court, Felipe A.; Kroemer, Guido; Cesar Cardenas, J.; Hetz, Claudio Article ISI SCOPUS Nature Cell Biology (2019)
The p75(NTR) neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability Perez, Viviana; Bermedo-Garcia, Francisca; Zelada, Diego; Court, Felipe A.; Angel Perez, Miguel; Fuenzalida, Marco; Abrigo, Johanna; Cabello-Verrugio, Claudio; Moya-Alvarado, Guillermo; Carlos Tapia, Juan; Valenzuela, Vicente; Hetz, Claudio; Bronfman, Francisca C.; Pablo Henriquez, Juan Article ISI SCOPUS ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)
A dual role for Integrin alpha 6 beta 4 in modulating hereditary neuropathy with liability to pressure palsies Poitelon, Yannick; Matafora, Vittoria; Silvestri, Nicholas; Zambroni, Desiree; McGarry, Claire; Serghany, Nora; Rush, Thomas; Vizzuso, Domenica; Court, Felipe A.; Bachi, Angela; Wrabetz, Lawrence; Feltri, Maria Laura Article ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2018)
Axonal degeneration induced by glutamate excitotoxicity is mediated by necroptosis HernÃ¡ndez D.E.; Salvadores N.A.; Moya-Alvarado G.; CatalÃ¡n R.J.; Bronfman F.C.; Court, F. A. Article ISI SCOPUS Journal of Cell Science (2018)
In Vitro Analysis of the Role of Schwann Cells on Axonal Degeneration and Regeneration Using Sensory Neurons from Dorsal Root Ganglia Lopez-Leal, R; Diaz, P; Court, FA Article ISI SCOPUS NEISSERIA MENINGITIDIS (2018)
IRE1 alpha governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A Urra, Hery; Henriquez, Daniel R.; Canovas, Jose; Villarroel-Campos, David; Carreras-Sureda, Amado; Pulgar, Eduardo; Molina, Emiliano; Hazari, Younis M.; Limia, Celia M.; Alvarez-Rojas, Sebastian; Figueroa, Ricardo; Vidal, Rene L.; Rodriguez, Diego A.; Rivera, Claudia A.; Court, Felipe A.; Couve, Andres; Qi, Ling; Chevet, Eric; Akai, Ryoko; Iwawaki, Takao; Concha, Miguel L.; Glavic, Alvaro.; Gonzalez-Billault, Christian; Hetz, Claudio Article ISI SCOPUS Nature Cell Biology (2018)
Mitochondria and Calcium Regulation as Basis of Neurodegeneration Associated With Aging Mueller, Marioly; Ahumada-Castro, Ulises; Sanhueza, Mario; Gonzalez-Billault, Christian; Court, Felipe A.; Cardenas, Cesar Article ISI SCOPUS FRONTIERS IN NEUROSCIENCE (2018)
Teased Fiber Preparation of Myelinated Nerve Fibers from Peripheral Nerves for Vital Dye Staining and Immunofluorescence Analysis Catenaccio, A; Court, FA Article ISI SCOPUS NEISSERIA MENINGITIDIS (2018)
The inhibition of CTGF/CCN2 activity improves muscle and locomotor function in a murine ALS model Gonzalez, D; Rebolledo, DL; Correa, LM; Court, FA; Cerpa, W; Lipson, KE; van Zundert, B; Brandan, E Article ISI SCOPUS HUMAN MOLECULAR GENETICS (2018)
BAX inhibitor-1 regulates autophagy by controlling the IRE1 alpha branch of the unfolded protein response (vol 30, pg 4465, 2011) Castillo,Karen; Rojas-Rivera, Diego; Lisbona, Fernanda; Caballero, Benjamin; Nassif, Melissa;; Court, Felipe A.; Schuck, Sebastian; Ibar, Consuelo; Walter, Peter; Sierralta, Jimena.; Glavic, Alvaro.; Hetz, Claudio Article ISI EMBO JOURNAL (2017)
Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43(A315T) ALS/FTD mouse model Bargsted, L; Medinas, DB; Traub, FM; Rozas, P; Muñoz, N; Nassif, M; Jerez, C; Catenaccio, A; Court, FA; hetz, C; Matus, S Article ISI SCOPUS SCIENTIFIC REPORTS (2017)
Herpes Simplex Virus Type 1 Neuronal Infection Perturbs Golgi Apparatus Integrity through Activation of Src Tyrosine Kinase and Dyn-2 GTPase Martin, Carolina; Leyton, Luis; Hott, Melissa; Arancibia, Yennyfer; Spichiger, Carlos; McNiven, Mark A.; Court, Felipe A.; Concha, Margarita I.; Burgos, Patricia V.; Otth, Carola Article ISI SCOPUS Frontiers in Cellular and Infection Microbiology (2017)
Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration Catenaccio, Alejandra; Hurtado, Maica Llavero; Diaz, Paula; Lamont, Douglas J.; Wishart, Thomas M.; Court, Felipe A. Article ISI CELL DEATH & DISEASE (2017)
Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration Catenaccio, A; Hurtado, ML; Diaz, P; Lamont, DJ; Wishart, TM; Court, FA Article CELL DEATH & DISEASE (2017)
Molecular interaction between type 2 diabetes and Alzheimer's disease through cross-seeding of protein misfolding Moreno-Gonzalez, I; Edwards III, G; Salvadores, N; Shahnawaz, M; diaz-espinoza, R; Soto, C Article ISI SCOPUS MOLECULAR PSYCHIATRY (2017)
Resistance of leukemia cells to cytarabine chemotherapy is mediated by bone marrow stroma, involves cell-surface equilibrative nucleoside transporter-1 removal and correlates with patient outcome Macanas-Pirard, Patricia; Broekhuizen, Richard; Gonzalez, Alfonso; Oyanadel, Claudia; Ernst, Daniel; Garcia, Patricia; Montecinos, Viviana P.; Court, Felipe; Ocqueteau, Mauricio; Ramirez, Pablo; Nervi, Bruno Article ISI ONCOTARGET (2017)
Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury Onate, Maritza; Catenaccio, Alejandra; Martinez, Gabriela; Armentano, Donna; Parsons, Geoffrey; Kerr, Bredford; Hetz, Claudio; Court, Felipe A. Article ISI SCIENTIFIC REPORTS (2016)
Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury Onate, M; Catenaccio, A.; Martínez G.; Armentano, D; Parsons, G; Kerr B.; Hetz C.; Court FA. Article Scientific Reports (2016)
Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury Calvo M.; Richards, N.; Schmid A.B.; Barroso A.; Zhu, L; Ivulic D.; Zhu N.; Anwandter P.; Bhat, M. A.; Court, F. A.; McMahon S.B.; Bennett D.L.H. Article ISI SCOPUS ELIFE (2016)
Axons provide the secretory machinery for trafficking of voltage-gated sodium channels in peripheral nerve Gonzalez, Carolina; Canovas, Jose; Fresno, Javiera; Couve, Eduardo; Court, Felipe A.; Couve, Andres Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Axons provide the secretory machinery for trafficking of voltage-gated sodium channels in peripheral nerve González C; Canovas, J; Fresno, J; Couve E.; Court FA.; Couve A. Article Proceedings of the National Academy of Sciences of the United States of America (2016)
Bursting the unfolded protein response accelerate axonal regeneration Oñate M, Court FA, Hetz C. Article Neural Regeneration Research (2016)
Bursting the unfolded protein response accelerates axonal regeneration Onate, Maritza; Court, Felipe A.; Hetz, Claudio Article ISI NEURAL REGENERATION RESEARCH (2016)
Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic physiology Bodaleo, Felipe J.; Montenegro-Venegas, Carolina; Henriquez, Daniel R.; Court, Felipe A.; Gonzalez-Billault, Christian Article ISI SCIENTIFIC REPORTS (2016)
Origin of axonal proteins: Is the axon-schwann cell unit a functional syncytium? Lopez-Leal, Rodrigo; Alvarez, Jaime; Court, Felipe A. Article ISI CYTOSKELETON (2016)
Schwann Cell and Axon: An Interlaced Unit-From Action Potential to Phenotype Expression Court, FA; Alvarez, J Article ISI SCOPUS GLIAL CELLS IN HEALTH AND DISEASE OF THE CNS (2016)
ApoER2 and Reelin are expressed in regenerating peripheral nerve and regulate Schwann cell migration by activating the Rac1 GEF protein, Tiam1 Pasten, C; Cerda, J; Jausoro I.; Court, FA; Cáceres A.; Marzolo, MP Article ISI SCOPUS Molecular and Cellular Neuroscience (2015)
Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper Lener, Thomas; Gimona, Mario; Aigner, Ludwig; Boerger, Verena; Buzas, Edit; Camussi, Giovanni; Chaput, Nathalie; Chatterjee, Devasis; Court, Felipe A.; del Portillo, Hernando A.; O'Driscoll, Lorraine; Fais, Stefano; Falcon-Perez, Juan M.; Felderhoff-Mueser, Ursula; Fraile, Lorenzo; Gho, Yong Song; Goergens, Andre; Gupta, Ramesh C.; Hendrix, An; Hermann, Dirk M.; Hill, Andrew F.; Hochberg, Fred; Horn, Peter A.; de Kleijn, Dominique; Kordelas, Lambros; Kramer, Boris W.; Kraemer-Albers, Eva-Maria; Laner-Plamberger, Sandra; Laitinen, Saara; Leonardi, Tommaso; Lorenowicz, Magdalena J.; Lim, Sai Kiang; Lotvall, Jan; Maguire, Casey A.; Marcilla, Antonio; Nazarenko, Irina; Ochiya, Takahiro; Patel, Tushar; Pedersen, Shona; Pocsfalvi, Gabriella; Pluchino, Stefano; Quesenberry, Peter; Reischl, Ilona G.; Rivera, Francisco J.; Sanzenbacher, Ralf; Schallmoser, Katharina; Slaper-Cortenbach, Ineke; Strunk, Dirk; Tonn, Torsten; Vader, Pieter; van Balkom, Bas W. M.; Wauben, Marca; El Andaloussi, Samir; Thery, Clotilde; Rohde, Eva; Giebel, Bernd Article WOS-ESCI JOURNAL OF EXTRACELLULAR VESICLES (2015)
Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration Castillo, Valentina; Oate, Maritza; Woehlbier, Ute*; Rozas, Pablo; Andreu, Catherine; Medinas, Danilo; Valds, Pamela; Osorio, Fabiola; Mercado, Gabriela; Vidal, René L.; Kerr, Bredford; Court, Felipe A.; Hetz, Claudio; Gillingwater, Thomas H Article ISI SCOPUS PLOS ONE (2015)
Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling Rojas F.; González D; Cortes N.; Ampuero E.; Hernández DE; Fritz, E.; Abarzua S.; Martínez A; Elorza, AA; Alvarez A.; Court, F; van Zundert, B Article ISI SCOPUS FRONTIERS IN CELLULAR NEUROSCIENCE (2015)
Calcium Release from Intra-Axonal Endoplasmic Reticulum Leads to Axon Degeneration through Mitochondrial Dysfunction Villegas R, Martinez NW, Lillo J, Pihan P, Hernandez D, Twiss JL, Court FA Article ISI SCOPUS JOURNAL OF NEUROSCIENCE (2014)
Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1 Valdés P.; Mercado, G; Vidal, RL; Molina C.; Parsons, G; Court, FA; Martínez A; Galleguillos D; Armentano D.; Schneider, BL; hetz C. Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Emerging Roles of Extracellular Vesicles in the Nervous System Rajendran, L.; Bali, J.; Barr, M. M.; Court, F. A.; Kramer-Albers, E.-M.; Picou F.; Raposo G.; van der Vos, K. E.; van Niel G.; Wang J.; Breakefield, X. O. Article ISI SCOPUS JOURNAL OF NEUROSCIENCE (2014)
Sprouting of axonal collaterals after spinal cord injury is prevented by delayed axonal degeneration Collyer, E.; Catenaccio, A; Lemaitre D.; Díaz P; Valenzuela, V.; Bronfman, F; Court, F. A. Article ISI SCOPUS EXPERIMENTAL NEUROLOGY (2014)
The p75 neurotrophin receptor evades the endolysosomal route in neuronal cells, favouring multivesicular bodies specialised for exosomal release Escudero, CA; Lazo OM; Galleguillos, C; Parraguez JI; Lopez-Verrilli, MA; Cabeza, C; Leon, L.; Saeed U; Retamal, C; González A; Marzolo, MP; Carter BD; Court, FA; Bronfman, FC Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2014)
Measurement of autophagy flux in the nervous system in vivo Castillo, K; Valenzuela, V.; Matus, S; Nassif, M; Onate, M; Fuentealba Y.; Encina G.; Irrazabal T.; Parsons, G; Court, FA; Schneider, BL; Armentano D.; hetz C. Article ISI SCOPUS Cell Death and Disease (2013)
Schwann Cell-Derived Exosomes Enhance Axonal Regeneration in the Peripheral Nervous System Lopez-Verrilli, MA; Picou F.; Court, FA Article ISI SCOPUS GLIA (2013)
Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons Castillo, K; Nassif, M; Valenzuela, V.; Rojas F.; Matus, S; Mercado, G; Court, FA; van Zundert, B; hetz C. Article ISI SCOPUS Autophagy (2013)
A BAX/BAK and Cyclophilin D-Independent Intrinsic Apoptosis Pathway Zamorano S.; Rojas-Rivera, D; Lisbona, F; Parra, V; Court, F. A.; Villegas, R; Cheng E.H.; Korsmeyer S.J.; Lavandero S.; hetz C. Article ISI SCOPUS PLOS ONE (2012)
Activation of the unfolded protein response enhances motor recovery after spinal cord injury Valenzuela, V.; Collyer, E.; Armentano D.; Parsons G.B.; Court, F. A.; hetz C. Article ISI SCOPUS Cell Death and Disease (2012)
Diapause Formation and Downregulation of Insulin-Like Signaling via DAF-16/FOXO Delays Axonal Degeneration and Neuronal Loss Calixto, A; Jara J.S.; Court, F. A. Article ISI SCOPUS PLoS Genetics (2012)
Hypothyroidism in the Adult Rat Causes Incremental Changes in Brain-Derived Neurotrophic Factor, Neuronal and Astrocyte Apoptosis, Gliosis, and Deterioration of Postsynaptic Density Cortes C.; Eugenin, E; Aliaga, E; Carreño L.J.; Bueno, S. M.; González P.A.; Gayol S.; Naranjo, D; Noches, V; Marassi M.P.; Rosenthal, D; Jadue C.; Ibarra P.; Keitel C.; Wohllk N.; Court, F; Kalergis, A.M.; Riedel, C. A. Article ISI SCOPUS Thyroid (2012)
Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy Vidal R.L.; Figueroa, A; Court, F. A.; Thielen P; Molina C.; Wirth C.; Caballero, B; Kiffin, R; Segura-Aguilar, J; Cuervo A.M.; Glimcher L.H.; hetz C. Article ISI SCOPUS Human Molecular Genetics (2012)
Transfer of vesicles from Schwann cells to axons: a novel mechanism of communication in the peripheral nervous system Lopez-Verrilli M.A.; Court, F. A. Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2012)
Axonal Degeneration Is Mediated by the Mitochondrial Permeability Transition Pore Barrientos S.A.; Martinez, N.W.; Jara J.S.; Alvarez J.; Court, F. A.; Yoo S.; Zamorano S.; hetz C.; Twiss J.L. Article ISI SCOPUS Journal of Neuroscience (2011)
BAX inhibitor-1 regulates autophagy by controlling the IRE1 alpha branch of the unfolded protein response Castillo, K; Rojas-Rivera, D; Lisbona, F; Caballero, B; Nassif, M; Court, FA; Schuck, S; Ibar C.; Walter P.; Sierralta, J; Glavic A.; hetz C. Article ISI SCOPUS EMBO JOURNAL (2011)
BAX inhibitor-1 regulates autophagy by controlling the IRE1? branch of the unfolded protein response Castillo, K; Rojas-Rivera, D; Lisbona, F; Caballero B.N.; Nassif, M; hetz C.; Sierralta, J; Court, F. A.; Schuck, S; Walter P.; Ibar C.; Glavic A. Article EMBO JOURNAL (2011)
Chronic intermittent hypoxia-induced vascular enlargement and VEGF upregulation in the rat carotid body is not prevented by antioxidant treatment Del Rio R.; Munoz, C; Arias P.; Court, FA; Moya, EA; Iturriaga R. Article ISI SCOPUS American Journal of Physiology - Lung Cellular and Molecular Physiology (2011)
MMP2-9 Cleavage of Dystroglycan Alters the Size and Molecular Composition of Schwann Cell Domains Court, Felipe A.; Zambroni, Desiree; Pavoni, Ernesto; Colombelli, Cristina; Baragli, Chiara; Figlia, Gianluca; Sorokin, Lydia; Ching, William; Salzer, James L.; Wrabetz, Lawrence; Feltri, M. Laura Article ISI JOURNAL OF NEUROSCIENCE (2011)
Morphological Evidence for a Transport of Ribosomes from Schwann Cells to Regenerating Axons Court, FA; Midha, R; Cisterna, BA; Grochmal J.; Shakhbazau, A; Hendriks, WT; van Minnen, J Article ISI SCOPUS GLIA (2011)
A LAMININ-2, DYSTROGLYCAN, UTROPHIN AXIS IS REQUIRED FOR COMPARTMENTALIZATION AND ELONGATION OF MYELIN SEGMENTS Court, Felipe; Hewitt, Jane; Davies, Kay; Patton, Bruce; Uncini, Antonio; Wrabetz, Lawrence; Feltri, M. Article SCOPUS JOURNAL OF NEUROSCIENCE (2009)
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy hetz C.; Thielen P; Matus, S; Nassif, M; Court, F; Kiffin, R; Martinez, G; Cuervo, AM; Brown, RH; Glimcher, LH Article ISI SCOPUS GENES DEVELOPMENT (2009)
XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy hetz C.; Thielen P; Matus, S; Nassif, M; Court, F; Kiffin, R; Martinez, G; Cuervo, AM; Brown, RH; Glimcher, LH Article ISI SCOPUS AUTOPHAGY (2009)
?6?4 integrin and dystroglycan cooperate to stabilize the myelin sheath Nodari A.; Dati G.; Occhi S.; Court, F. A.; Colombelli C.; Zambroni D.; Wrabetz L.; Feltri M.L.; Previtali S.C.; Dina G.; Del Carro U.; Quattrini A.; Campbell K.P. Article JOURNAL OF NEUROSCIENCE (2008)
a6ß4 integrin and dystroglycan cooperate to stabilize the myelin sheath Nodari A.; Dati G.; Occhi S.; Court F.A.; Colombelli C.; Zambroni D.; Wrabetz L.; Feltri M.L.; Previtali S.C.; Dina G.; Del Carro U.; Quattrini A.; Campbell K.P. Article ISI SCOPUS JOURNAL OF NEUROSCIENCE (2008)
Identity, developmental restriction and reactivity of extralaminar cells capping mammalian neuromuscular junctions Court, FA; Gillingwater, TH; Melrose, S; Sherman, DL; Greenshields, KN; Morton, AJ; Harris, JB; Willison, HJ; Ribchester, RR Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2008)
Remodeling of motor nerve terminals in demyelinating axons of periaxin-null mice Court, FA; Brophy, PJ; Ribchester, RR Article ISI SCOPUS GLIA (2008)
Schwann Cell to Axon Transfer of Ribosomes: Toward a Novel Understanding of the Role of Glia in the Nervous System Court, FA; Hendriks, WTJ; MacGillavry, HD; Alvarez J.; van Minnen, J Article ISI SCOPUS JOURNAL OF NEUROSCIENCE (2008)
ABROGATION OF PROSTAGLANDIN E-2/EP4 SIGNALING IMPAIRS THE DEVELOPMENT OF RAG1(+) LYMPHOID PRECURSORS IN THE THYMUS OF ZEBRAFISH EMBRYOS Villablanca, Eduardo; Pistocchi, Anna; Court, Felipe; Cotelli, Franco; Bordignon, Claudio; Allende, Miguel; Traversari, Catia Article JOURNAL OF IMMUNOLOGY (2007)
Abrogation of prostaglandin E2/EP4 signaling impairs the development of rag1+ lymphoid precursors in the thymus of zebrafish embryos Villablanca, E. J.; Bordignon, C; Russo, V; Pistocchi, A; Cotelli, F; Court, F. A.; Allende, M.L.; Traversari, C Article SCOPUS JOURNAL OF IMMUNOLOGY (2007)
beta 1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelination Nodari, Alessandro; Zambroni, Desiree; Quattrini, Angelo; Court, Felipe A.; D'Urso, Alessandra; Recchia, Alessandra; Tybulewicz, Victor L. J.; Wrabetz, Lawrence; Feltri, M. Laura Article ISI JOURNAL OF CELL BIOLOGY (2007)
Basal lamina: Schwann cells wrap to the rhythm of space-time Court, Felipe A.; Wrabetz, Lawrence; Feltri, M. Laura Article ISI CURRENT OPINION IN NEUROBIOLOGY (2006)
Local regulation of the axonal phenotype, a case of merotrophism Court, FA; Alvarez J. Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2005)
Neurofascins are required to establish axonal domains for saltatory conduction Sherman, DL; Tait, S; Melrose, S; Johnson R.; Zonta, B; Court, FA; Macklin, WB; Meek, S; Smith, AJH; Cottrell, DF; Brophy, PJ Article ISI NEURON (2005)
Progressive abnormalities in skeletal muscle and neuromuscular junctions of transgenic mice expressing the Huntington's disease mutation Ribchester, RR; Thomson, D; Wood, NI; Hinks, T; Gillingwater, TH; Wishart, TM; Court, FA; Morton, AJ Article ISI EUROPEAN JOURNAL OF NEUROSCIENCE (2004)
Restricted growth of Schwann cells lacking Cajal bands slows conduction in myelinated nerves Court, FA; Sherman, DL; Pratt, T; Garry, EM; Ribchester, RR; Cottrell, DF; Fleetwood-Walker, SM; Brophy, PJ Article ISI NATURE (2004)
Neurons expressing the highest levels of gamma-synuclein are unaffected by targeted inactivation of the gene Ninkina, N; Papachroni, K; Robertson, DC; Schmidt, O; Delaney, L; O'Neill, F; Court, F; Rosenthal, A; Fleetwood-Walker, SM; Davies, AM; Buchman, VL Article ISI MOLECULAR AND CELLULAR BIOLOGY (2003)
Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene Mack, TGA; Reiner, M; Beirowski, B; Mi, WQ; Emanuelli, M; Wagner, D.; Thomson, D; Gillingwater, T; Court, F; Conforti, L; Fernando, FS; Tarlton, A; Andressen, C; Addicks, K; Magni, G; Ribchester, RR; Perry, VH; Coleman, MP Article ISI NATURE NEUROSCIENCE (2001)
Nerve regeneration in Wld(s) mice is normalized by actinomycin D Court, F; Alvarez J. Article ISI SCOPUS BRAIN RESEARCH (2000)


C-jun n-terminal kinase regulates P75 internalization leading to retrograde axonal transport of apoptotic signalling endosomes Bronfman, F; Escudero, c; Maloney, M; Flores C.; Court, F; Mobley, W Abstract ISI JOURNAL OF NEUROCHEMISTRY (2015)
Reelin, through its receptor ApoER2, regulates Schwann cell migration by activating Rac1; involvement of Tiam1 and Par3 Canales, MPM; Pasten, C; Cerda, J; Jausoro I.; Court, F; Cáceres A. Abstract ISI JOURNAL OF NEUROCHEMISTRY (2015)
AXONAL DEGENERATION IS ASSISTED CELL NON-AUTONOMOUSLY BY GLIAL CELLS Catenaccio, A; Silva P.; Court, F Abstract GLIA (2013)
Microtubule-associated protein 1B (MAP1B) regulates synaptic functions in mature neurons Bodaleo, F; Montenegro-Venegas, C; Court, F; Hartel, S; Gonzalez-Billault, C Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2013)
p75 neurotrophin receptor evades the endolysosomal route, favoring multivesicular bodies specialized for exosomal release in neuronal cells Escudero, c; Galleguillos, C; Parraguez, J; Lopez-Verrilli, M; Cabeza, C; Saeed U; Marzolo, M; Carter, B; Court, F; Bronfman, F Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2013)
ROLE OF SCHWANN CELL TO AXON TRANSFER OF VESICLES DURING AXONAL REGENERATION Court, F; Lopez-Verrilli, A; Picou F. Abstract GLIA (2013)
SCHWANN CELLS TRANSFER POLYRIBOSOMES TO REGENERATING AXONS Court, F; Hendriks, W; Verheijen, MHG; Midha, R; van Minnen, J Abstract JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM (2009)
Ribosome-like particles in sciatic nerve axons originate in Schwann cells, and associate with endoplasmic reticulum and cytoskeleton Alvarez J.; Court, F Abstract EUROPEAN JOURNAL OF NEUROSCIENCE (2000)
Sprouting, growth and regeneration: a novel model of the axon Alvarez J.; Court, F Abstract JOURNAL OF PHYSIOLOGY-LONDON (2000)


In Vitro Analysis of the Role of Schwann Cells on Axonal Degeneration and Regeneration Using Sensory Neurons from Dorsal Root Ganglia. López-Leal R, Diaz P, Court FA. BookSection (2018)
Purification of Exosomes from Primary Schwann Cells, RNA Extraction, and Next-Generation Sequencing of Exosomal RNAs De Gregorio C, Díaz P, López-Leal R, Manque P, Court FA. BookSection (2018)
Teased Fiber Preparation of Myelinated Nerve Fibers from Peripheral Nerves for Vital Dye Staining and Immunofluorescence Analysis. Catenaccio A, Court FA BookSection (2018)


Erratum to: IRE1? governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A (Nature Cell Biology, (2018), 20, 8, (942-953), 10.1038/s41556-018-0141-0) Urra H.; Henriquez D.R.; Cánovas J.; Villarroel-Campos D.; Carreras-Sureda A.; Pulgar E.; Molina E.; Hazari Y.M.; Limia C.M.; Alvarez-Rojas S.; Figueroa R.; Vidal R.L.; Rodriguez D.A.; Rivera C.A.; Court, F. A.; Couve A.; Qi L.; Chevet E.; Akai R.; Iwawaki T.; Concha, M. L.; Glavic Á.; Gonzalez-Billault C.; Hetz C. Errata ISI SCOPUS Nature Cell Biology (2018)
ApoER2 and reelin are expressed in regenerating peripheral nerve and regulate Schwann cell migration by activating the Rac1 GEF protein, Tiam1 (vol 69, pg 1, 2015) Pasten, C; Cerda, J; Jausoro I.; Court, F. A.; Cáceres A.; Marzolo M.-P. Errata ISI SCOPUS MOLECULAR AND CELLULAR NEUROSCIENCE (2016)


Investigating the role of caveolae-dependent mechanosensing in glial cells interaction with neurons PCI (ECOS170010) Proyecto 2018-2018 Inv. Principal
THE ROLE OF AXONAL DEGENERATION ON THE PATHOMECHANISM OF NEURODEGENERATIVE DISEASES FONDECYT (3170577) Proyecto 2017-2019 Inv. Patrocinante
Circuit formation by spatio-temporal control of mRNA translation The Israel Science Foundation (ISF), the Canadian Institutes of Health Research, the International Development Research Center and the Azrieli Foundation, Canada (n/a) Proyecto 2016-2018 Inv. Principal
GEROSCIENCE CENTER FOR BRAIN HEALTH AND METABOLISM FONDAP (15150012) Proyecto 2015-2020 Inv. Principal
TRANSFER OF RNA FROM SCHWANN CELL TO NEURONS MEDIATED BY EXOSOMES=> IMPACT UPON AXONAL REGENERATION AND NEURONAL SURVIVAL FONDECYT (1150766) Proyecto 2015-2019 Inv. Responsable
AXONAL DEGENERATION PROCEEDS BY PROGRAMMED NECROSIS FONDECYT (3140406) Proyecto 2013-2016 Inv. Patrocinante
Estimulación de la recuperación locomotora luego del daño a la medula espinal utilizando activadores vesiculares derivados de células gliales periféricas FONDEF (CA12i10120) Proyecto 2013-2015 Director(a)
“Iniciativa de red neuronal (IRN)=> Entendiendo las causas de la vulnerabilidad neuronal diferencial en enfermedades” PIA (ACT 1109) Proyecto 2013-2016 Director(a)
CALCIUM INCREASE IN THE AXOPLASM FROM INTRACELLULAR STORES IS THE FIRST EVENT LEADING TO MITOCHONDRIA DYSFUNCTION AND AXONAL DEGENERATION FONDECYT (3130610) Proyecto 2012-2015 Inv. Patrocinante
Role of Cellular Stress in locomotor recovery after Spinal cord injury Christopher and Dana Reeve Foundation (NA) Proyecto 2012-2012 Inv. Principal
ROLE OF RNA TRANSFER FROM GLIAL CELLS TO NEURONS DURING AXONAL REGENERATION. FONDECYT (3130527) Proyecto 2012-2015 Inv. Patrocinante
INTERFERON-GAMMA THERAPY FOR PROGRESSIVE CLINICAL FORMS OF MULTIPLE SCLEROSIS FONDECYT (1110523) Proyecto 2011-2014 Coinvestigador(a)
MECHANISMS INVOLVED IN THE AXONAL DEGENERATION PROGRAM=> ROLE OF OXIDATIVE STRESS AND MITOCHONDRIAL DYSFUNCTION FONDECYT (1110987) Proyecto 2011-2015 Inv. Responsable
MECHANISMS INVOLVED IN THE AXONAL DEGENERATION PROGRAM=> ROLE OF OXIDATIVE STRESS AND MITOCHONDRIAL DYSFUNCTION FONDECYT (1110987) Proyecto 2011-2015 Inv. Responsable
Role of UPR in locomotor recovery after Spinal cord injury NASS (North America Spine Society) (NA) Proyecto 2010-2012 Inv. Principal
SCHWANN CELL TO AXON TRANSFER OF MACROMOLECULES IS MEDIATED BY EXOSOMES FONDECYT (3110014) Proyecto 2010-2012 Inv. Patrocinante
ALTERED SUBCELLULAR DISTRIBUTION PATTERN OF FABP4 FROM VISCERAL ADIPOSE TISSUE IS INVOLVED IN OBESITY-INDUCED INSULIN RESISTANCE IN MICE. FONDECYT (1090230) Proyecto 2009-2011 Coinvestigador(a)
MILLENIUM NUCLEUS IN REGENERATIVE BIOLOGY (MINREB) FONDEF (RC120003) Proyecto 2009-2016 Director(a)
Botanic drug for the treatment of Insulin resistance and Diabetes type II and its evaluation in neurodegenerative diseases. FONDEF (D08I1031) Proyecto 2008-2011 Coinvestigador(a)
GLIA-TO-AXON TRANSFER OF RIBOSOMES=> PATHWAY AND REGULATORY MECHANISMS. FONDECYT (1070377) Proyecto 2007-2011 Inv. Responsable
GLIA-TO-AXON TRANSFER OF RIBOSOMES=> PATHWAY AND REGULATORY MECHANISMS. FONDECYT (1070377) Proyecto 2007-2011 Inv. Responsable


Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders Salvadores N.; Sanhueza M.; Manque P.; Court F.A. Review ISI SCOPUS FRONTIERS IN NEUROSCIENCE (2017)
Injury to the nervous system: A look into the ER Valenzuela, V; Onate, M; hetz, C; Court, FA Review ISI SCOPUS BRAIN RESEARCH (2016)
Schwann Cell Exosomes Mediate Neuron-Glia Communication and Enhance Axonal Regeneration Lopez-Leal, R; Court, F. A. Review ISI SCOPUS CELLULAR AND MOLECULAR NEUROBIOLOGY (2016)
Exosomes: mediators of communication in eukaryotes Lopez-Verrilli, María A; Court, Felipe A. Review ISI SCIELO SCOPUS Biological Research (2013)
Mitochondria as a central sensor for axonal degenerative stimuli Court, F. A.; Coleman M.P. Review ISI SCOPUS Trends in Neurosciences (2012)
Slow axoplasmic transport under scrutiny Court, Felipe A.; Alvarez, Jaime Review ISI SCIELO SCOPUS Biological Research (2011)

102

Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

Natalia Salvadores

Profesora Asistente

Centro de Resiliencia, Adaptación y Mitigación

Universidad Mayor de Chile

Temuco, Chile

Melissa Calegaro

Principal Investigator, head lab

Research Vice Presidency

Universidad Mayor

Santiago, Chile

Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Maria Matus

Principal Investigator

Fundacion Ciencia & Vida

Santiago, Chile

Francisca Bronfman

Full Professor

Instituto de Ciencias Biomédicas

Universidad Andrés Bello

Santiago, Chile

Karen Castillo

Académica Investigadora

,Centro de Investigación de Estudios Avanzados del Maule (CIEAM)

Universidad Catolica del Maule

Talca, Chile

Maria Paz Marzolo

Profesor Titular

Departamento de Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, FAC. CIENCIAS BIOLOGICAS, DEPTO. BIOLOGIA

Santiago, Chile

Miguel Allende

Director

Biología

FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

Alvaro Glavic

Associate Professor

Departamento de Biología

Universidad de Chile

Santiago, Chile

Washington

Postdoctoral Researcher

Fundación Ciencia y Vida

Santiago, Chile

Paula Diaz

PhD (c)

Departamento de Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

Pablo Rozas

Investigador

SymbiOx

Santiago, Chile

Alexis Martinez

Investigador postdoctoral senior

Facultad de medicina

Instituto de Neurcoeincia Biomedica

Santiago, Chile

Rodrigo Iturriaga

Chairman of the Department of Physiology

Physiology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

René Vidal

Profesor Asistente

Universidad Mayor

Santiago, Chile

Jimena Sierralta

Full Professor

Neuroscience

Faculty of Medicine, Universidad de Chile

Santiago, Chile

Agustin Ibanez

Profesor Titular

Psicologia

Universidad Adolfo Ibánez

Santiago, Chile

Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

Andrea Slachevsky

Associate Professor

ICBM

UNIVERSIDAD DE CHILE

Chile, Chile

Carolina Cabeza

Académica y Jefa de Centro de Investigación

Universidad Bernardo O'Higgins

Santiago , Chile

Maria Lisbona

Postdoctorado

Biología

Universidad de Chile

Santiago, Chile

Danilo Bilches

Staff Scientist

Instituto de Neurociencia Biomedica

Santiago, Chile

Philippe Pihán

Posdoctorado

Fisiología

Universidad de Chile

Santiago, Chile

Jose Parraguez

Investigador

Particular

Santiago, Chile

Mario Sanhueza

Regional Director of Research

Universidad Mayor

Temuco, Chile

Daniel Henriquez

Director Ciencia Transversal

Fundación Centro MERI

Santiago, Chile

Miguel Concha

Full Professor

Anatomy and Developmental Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

Carlos Spichiger

Profesor Adjunto

Facultad de Ciencias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Felix Diaz

Alvaro Elorza

FULL PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Graciela Muniz

Professor

Department of Social Medicine and Department of Primary Care

Ohio University

Ohio, Estados Unidos

JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

Johanna Ábrigo

Bioquímico

Centro de Bioinformática y Biología Integrativa

Santiago, Chile

Carlos Escudero

Full Professor

Basic Sciences Department

Universidad del Bio Bio

Chillan, Chile

Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

David González

Investigador postdoctoral

Institut des Neurosciences de Montpellier (INM)

Montpellier, Francia

Emiliano Molina

Estudiante de doctorado

Biología

Universidad de Chile

Santiago, Chile

Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

Yennyfer Arancibia

Docente-Investigadora

Ciencias Biológicas y Químicas

Universidad San Sebastián

Puerto Montt, Chile

Dinka Ivulic

MV., PhD. DCSAV

Universidad de Chile

Santiago, Chile

Viviana Pérez

Profesor Asistente

Fisiología

Universidad de Concepción

Concepcion, Chile

Cheril Tapia

Profesor Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

Vicente Valenzuela

Investigador postdoctoral

Instituto de Neurociencia Biomédica

Santiago, Chile

Carolina Martin

Docente Auxiliar

Sede Puerto Montt

UNIVERSIDAD AUSTRAL DE CHILE

Puerto Montt, Chile

Daniela Rebolledo

Académico

Centro de Excelencia en Biomedicina de Magallanes

Punta Arenas, Chile

Diego Rojas

Assistant Professor

Center for Integrative Biology

Universidad Mayor

Santiago, Chile

Daniel Ernst

Profesor Asistente

Hematología y Oncología

Pontificia Universidad Católica de Chile

Santiago, Chile

Julio Cardenas

Associated Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

Bruno Nervi

Associated Professor

Hematology - Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

Eduardo Couve

Francisco Rivera

Associate Professor in Integrative Neurobiology

Molecular and Integrative Biosciences Research Programme

University of Helsinki

Helsinki, Finlandia

Hans Richter

Profesor Titular

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

Celia Limia

N/A

N/A

Santiago, Chile

PATRICIA BURGOS

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

CAROLA OTTH

profesor titular

microbiologia clinica

UNIVERSIDAD AUSTRAL DE CHILE. FACULTAD DE MEDICINA. INSTITUTO DE MICROBIOLOGIA CLINICA

VALDIVIA, Chile

Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

Macarena Arrázola

Profesor Asistente

Centro de Biología Integrativa

Universidad Mayor

Santiago, Chile

Ute Wohlbier

Associate Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

Alejandra Catenaccio

Asistente de Investigación

Universidad Mayor

HUECHURABA, SANTIAGO, Chile

Valentina Castillo

Investigadora Postdoctoral

Instituto de Ingeniería Biológica y Médica

Pontificia Universidad Católica de Chile

Santiago, Chile

Esteban Aliaga

Profesor

Kinesiología

Universidad Católica el Maule

Talca, Chile

Valentina Valenzuela

Investigador adjunto

Universidad de Concepcion

Concepción, Chile

Felipe Bodaleo

Postdoctoral Researcher

Universidad de Chile

Santiago, Chile

Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Margarita Calvo

Profesor Asociado

Fisiologia

Pontificia Universidad Catolica de Chile

Santiago, Chile

Catherine Andreu

Estudiante de Doctorado

Escuela de Psicología

Pontificia Universidad Católica de Chile

Santiago, Chile

Nicole Cortés

Coordinadora de Estudios Clínicos

Laboratorio de Biología Celular, Molecular y Neurociencias, Corporación Centro Internacional de Biomedicina, ICC

Santiago, Chile

Marioly Muller

Académico

Tecnología Médica

Universidad de Chile

Santiago, Chile

Cristian De Gregorio

Postdoctoral fellow

medicine

Universidad del Desarrollo

Lo Barnechea, Chile

Fabiola Osorio

Associate Professor

Programa Disciplinario de Inmunologia

Universidad de Chile

Santiago, Chile

Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

Adolfo García

Investigador Asociado

Facultad de Humanidades

Universidad de Santiago de Chile

Santiago de Chile, Chile

Luis Leyton

Encargado I+D

Biotecom SpA

Santiago, Chile

Pedro Zitko

Jefe de Unidad

Dirección

Hospital Barros Luco Trudeau

Santiago, Chile

Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

MIGUEL PEREZ

Associate Professor

Pontificia Universidad Catolica de Valparaiso

VALPARAISO, Chile

Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

Pablo González

Associate Professor

Molecular Genetics and MIcrobiology

Pontificia Universidad Católica de Chile

Santiago, Chile

Daniela Thumala

Profesora Asociada - área Psicología Clínica

Departamento de Psicología

UNIVERSIDAD DE CHILE

Santiago, Chile

Andrea Calixto

Full professor

Neuroscience

Universidad de Valparaíso

Valparaiso, Chile

Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

Gonzalo Encina

Investigador

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Pedro Chana Cuevas

Profesor Titular

Facultad de Ciencias Medicas

Universidad de Santiago

Santiago, Chile

Alexis Kalergis

Full Professor

Microbiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

David Naranjo

Profesor titular

Neurociencia

Universidad de Valparaíso

VALPARAISO, Chile

Susan Bueno

Profesor Asociado

Genética Molecular y Microbiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Leandro Carreño

Profesor Asistente

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

Claudia Duran-Aniotz

Profesor Asociado

Escuela de Psicología

Universidad Adolfo Ibánez

Santiago, Chile

Carolina Toledo

Jefa de Departamento

Dirección de Atención Primaria

Servicio de Salud Metropolitano Occidente

Santiago, Chile

Paulina Troncoso

Bioquimica PhD

Laboratorio Clínico Banco de Sangre Anatomía Patológica

Clínica Alemana de Santiago

Santiago, Chile

Marisol Cisternas

PHD c

Universidad Mayor de Chile

Santiago, Chile

Felipe Alfredo Court Goldsmith

Líneas de Investigación

Educación

Bs. Biological Sciences, Catholic University of Chile. Chile, 1999

MSc, University of Edinburgh, UK. Reino Unido, 2001

PhD, University of Edinburgh, UK. Chile, 2004

Experiencia Académica

Associate Professor Full Time

EMBO Postdoctoral fellow Full Time

Full Professor Full Time

Experiencia Profesional

Director

Director Advance Microscopy Unit Part Time

Full Professor and Director Center for Integrative Biology Full Time

Chief Scientific Officer Other

Formación de Capital Humano

Article (85)

Abstract (9)

BookSection (3)

Errata (2)

Proyecto (21)

Investigating the role of caveolae-dependent mechanosensing in glial cells interaction with neurons

THE ROLE OF AXONAL DEGENERATION ON THE PATHOMECHANISM OF NEURODEGENERATIVE DISEASES

Circuit formation by spatio-temporal control of mRNA translation

GEROSCIENCE CENTER FOR BRAIN HEALTH AND METABOLISM

TRANSFER OF RNA FROM SCHWANN CELL TO NEURONS MEDIATED BY EXOSOMES=> IMPACT UPON AXONAL REGENERATION AND NEURONAL SURVIVAL

AXONAL DEGENERATION PROCEEDS BY PROGRAMMED NECROSIS

Estimulación de la recuperación locomotora luego del daño a la medula espinal utilizando activadores vesiculares derivados de células gliales periféricas

“Iniciativa de red neuronal (IRN)=> Entendiendo las causas de la vulnerabilidad neuronal diferencial en enfermedades”

CALCIUM INCREASE IN THE AXOPLASM FROM INTRACELLULAR STORES IS THE FIRST EVENT LEADING TO MITOCHONDRIA DYSFUNCTION AND AXONAL DEGENERATION

Role of Cellular Stress in locomotor recovery after Spinal cord injury

ROLE OF RNA TRANSFER FROM GLIAL CELLS TO NEURONS DURING AXONAL REGENERATION.

INTERFERON-GAMMA THERAPY FOR PROGRESSIVE CLINICAL FORMS OF MULTIPLE SCLEROSIS

MECHANISMS INVOLVED IN THE AXONAL DEGENERATION PROGRAM=> ROLE OF OXIDATIVE STRESS AND MITOCHONDRIAL DYSFUNCTION

MECHANISMS INVOLVED IN THE AXONAL DEGENERATION PROGRAM=> ROLE OF OXIDATIVE STRESS AND MITOCHONDRIAL DYSFUNCTION

Role of UPR in locomotor recovery after Spinal cord injury

SCHWANN CELL TO AXON TRANSFER OF MACROMOLECULES IS MEDIATED BY EXOSOMES

ALTERED SUBCELLULAR DISTRIBUTION PATTERN OF FABP4 FROM VISCERAL ADIPOSE TISSUE IS INVOLVED IN OBESITY-INDUCED INSULIN RESISTANCE IN MICE.

MILLENIUM NUCLEUS IN REGENERATIVE BIOLOGY (MINREB)

Botanic drug for the treatment of Insulin resistance and Diabetes type II and its evaluation in neurodegenerative diseases.

GLIA-TO-AXON TRANSFER OF RIBOSOMES=> PATHWAY AND REGULATORY MECHANISMS.

GLIA-TO-AXON TRANSFER OF RIBOSOMES=> PATHWAY AND REGULATORY MECHANISMS.

Review (6)