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jaime eduardo villegas olavarria

Profesor Asistente

Universidad Andrés Bello

Santiago, Chile

Mitochondrial ncRNAs in normal and malignant cell proliferation; Diagnostics and therapy of cancer

Ciencias Biológicas, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1988
Ciencias, mención Biología Celular y Molecular, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2000

Profesor Asistente Full Time

Universidad Andrés Bello

Ciencias de la Vida

Santiago, Chile

2019 - A la fecha

Investigador Senior Other

Andes Biotechnologies SpA

Santiago, Chile

2011 - 2019
Investigador Part Time

Grupo BIOS

Santiago, Chile

2008 - 2019

Tutor de una tesis doctoral, cinco tesis de magister, 10 tesis de pregrado, miembro comisión de 26 tesis de magíster, 18 tesis de doctorado, 8 tesis de pregrado.

Taller de Ingeniería Genética para Líderes de Opinión. Taller teórico-practico de tres días de duración. (2004, 2005, 2006, 2007,2012, 2014, 2018)
Taller Bio-class: Acercando el mundo científico a la comunidad escolar. (Invitado)

Distinción Académica: Premio Medalla “R. A. Phillipi

UNIVERSIDAD AUSTRAL DE CHILE

Chile, 1999

Premio a la mejor tesis de pregrado, patrocinado por la Dirección de Investigación de la UNiversidad
Premio Fundación científica Biovision

Fundación Científica Biovision

Francia, 2003

Premio en reconocimiento como uno de los científicos jóvenes más promisorio a nivel mundial
Premio “Emprendimiento Biotecnológico BIOTECH 2004

Red AMSUD-Pasteur

Uruguay, 2004

Premio a la mejor investigación en biotecnología en el campo de terapias antitumorales, otorgada por el Instituto Pasteur, filial Uruguay
Premio Fundación Científica Biovision

Fundación Científica Biovision

Francia, 2005

Premio en reconocimiento como uno de los científicos jóvenes más promisorio a nivel mundial
Premio Fundación Científica Biovision

Fundación Científica Biovision

Chile, 2007

Premio en reconocimiento como uno de los científicos jóvenes más promisorio a nivel mundial
Premio a la Investigación Científica Universitaria: Cura y Prevención del Cáncer

Santander Universidades y el Mercurio

Chile, 2013

Premio a la mejor investigación en desarrollo de nuevas metodologías de diagnostico y tratamiento del cáncer


Exosomes released upon mitochondrial ASncmtRNA knockdown reduce tumorigenic properties of malignant breast cancer cells Lobos-GonzÃ¡lez L.; Bustos R.; Campos A.; Silva V.; Silva V.; Jeldes E.; Salomon C.; Varas-Godoy M.; CÃ¡ceres-Verschae A.; Duran E.; Vera T.; Ezquer F.; Ezquer M.; Burzio, V.A.; Villegas J. Article SCOPUS SCIENTIFIC REPORTS (2020)
Gold nanoparticle based double-labeling of melanoma extracellular vesicles to determine the specificity of uptake by cells and preferential accumulation in small metastatic lung tumors Lara, Pablo; Palma-Florez, Sujey; Salas-Huenuleo, Edison; Polakovicova, Iva; Guerrero, Simon; Lobos-Gonzalez, Lorena; Campos, America; Munoz, Luis; Jorquera-Cordero, Carla; Varas-Godoy, Manuel; Cancino, Jorge; Arias, Eloisa; Villegas, Jaime; Cruz, Luis J.; Albericio, Fernando; Araya, Eyleen; Corvalan, Alejandro H.; Quest, Andrew F. G.; Kogan, Marcelo J. Article ISI SCOPUS JOURNAL OF NANOBIOTECHNOLOGY (2020)
Targeting antisense mitochondrial noncoding RNAs induces bladder cancer cell death and inhibition of tumor growth through reduction of survival and invasion factors Borgna, Vincenzo; Lobos-Gonzalez, Lorena; Guevara, Francisca; Landerer, Eduardo; Bendek, Maximiliano; Avila, Rodolfo; Silva, Veronica; Villota, Claudio; Araya, Mariela; Rivas, Alexis; Lopez, Constanza; Socias, Teresa; Castillo, Jorge; Alarcon, Luis; Burzio, Luis O.; Burzio, Veronica A.; Villegas, Jaime Article ISI SCOPUS JOURNAL OF CANCER (2020)
HPV-18 E2 protein downregulates antisense noncoding mitochondrial RNA-2, delaying replicative senescence of human keratinocytes Villota, Claudio; Varas-Godoy, Manuel; Jeldes, Emanuel; Campos, America; Villegas, Jaime; Borgna, Vincenzo; Burzio, Luis O.; Burzio, Veronica A. Article ISI SCOPUS AGING-US (2019)
Mitochondrial ncRNA targeting induces cell cycle arrest and tumor growth inhibition of MDA-MB-231 breast cancer cells through reduction of key cell cycle progression factors Fitzpatrick, Christopher; Bendek, Maximiliano F.; Briones, Macarena; Farfan, Nicole; Silva, Valeria A.; Nardocci, Gino; Montecino, Martin; Boland, Anne; Deleuze, Jean-Francois; Villegas, Jaime; Villota, Claudio; Silva, Veronica; Lobos-Gonzalez, Lorena; Borgna, Vincenzo; Barrey, Eric; Burzio, Luis O.; Burzio, Veronica A. Article ISI SCOPUS CELL DEATH & DISEASE (2019)
Cervical cancer, human papillomavirus and vaccines: assessment of the information retrieved from general knowledge websites in Chile Lopez, C.,; Krauskopf, E; Villota, C; Burzio, L.O; Villegas, J Article ISI SCOPUS Public Health (2017)
In vivo knockdown of antisense noncoding mitochondrial RNAs by a lentiviral-encoded shRNA inhibits melanoma tumor growth and lung colonization Manuel Varas-Godoy, Alvaro Lladser; Nicole Farfan, Claudio Villota; Jaime Villegas, Julio C. Tapia; Luis O. Burzio, Veronica A. Burzio Article Pigment Cell & Melanoma Research (2017)
Mitochondrial ASncmtRNA-1 and ASncmtRNA-2 as potent targets to inhibit tumor growth and metastasis in the RenCa murine renal adenocarcinoma model Borgna V, Villegas J; Burzio VA, Belmar S; Araya M, Jeldes E; Lobos-González L, Silva V; Villota C, Oliveira-Cruz L; Lopez C, Socias T; Castillo O, Burzio LO. Article Oncotarget (2017)
Assessment of the Expression of Long Noncoding Mitochondrial RNAs (lncmtRNAs) during cervical cancer progression and cervical carcinoma Komal Dadlani, Constanza Lopez, Fernando Gabler, Juan Carlos Roa, Claudio Villota, Luisa Lina-Villa, Enrique Boccardo, Eva Bustamante, Veronica Burzio, Luis O. Burzio and Jaime Villegas Olavarria1,2* Article Journal of Cancer Science and Therapy (2016)
Targeting antisense mitochondrial ncRNAs inhibits murine melanoma tumor growth and metastasis through reduction in survival and invasion factors Lorena Lobos-González, Verónica Silva, Mariela Araya, Franko Restovic, Javiera Echenique, Luciana Oliveira-Cruz, Christopher Fitzpatrick, Macarena Briones, Jaime Villegas, Claudio Villota, Soledad Vidaurre, Vincenzo Borgna, Miguel Socias, Sebastián Valenz Article Oncotarget (2016)
The Urgent Need for New Therapeutical Approaches for Renal and Bladder Cancer: Mitochondrial Non-Coding RNAs as Efficient Targets Vincenzo Borgna, Lorena Lobos-González, Verónica Silva, Constanza López, Mariela Araya, Emanuel Jeldes, Verónica Burzio, Teresa Socias, Luis O.Burzio and Jaime Villegas Article SM Journal of Urology (2015)
Down-regulation of the Antisense Mitochondrial Non-coding RNAs (ncRNAs) Is a Unique Vulnerability of Cancer Cells and a Potential Target for Cancer Therapy Vidaurre S.; Fitzpatrick, C; Burzio, VA; Briones, M.; Villota, C; Villegas, J; Echeñique J.; Oliveira-Cruz, L; Araya M.; Borgna, V; Socias, T; López C.; Ávila R.; Burzio, LO Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Long non-coding mitochondrial RNAs as potential targets for diagnosis and therapy of bladder cancer Villegas, J; Rivas, A; Ávila R.; Borgna, V; Lobos-Gonzales L.; Burzio V; López C.; Gomez, R; Landerer, E.; Velarde L.; Burzio L.O. Article SCOPUS International Journal of Cancer Research and Prevention (2014)
The Mitochondrial Antisense ncRNAs are Down-Regulated in Early Cervical Carcinoma Jaime Villegas, Komal Dadlani, Rodolfo Avila, Claudio Villota, Verónica Burzio, Constanza Lopez, Miguel Socias4, Luis Zapata and Luis O. Burzio Article Journal Cancer Science & Therapy (2013)
Determination of the differential expression of mitochondrial long non-coding RNAs as a noninvasive diagnosis of bladder cancer Rivas, A; Burzio V; Landerer, E.; Borgna, V; Gatica, S; Ávila R.; López C.; Villota, C; De La Fuente R.; Echeñique J.; Burzio L.O.; Villegas, J Article ISI SCOPUS BMC Urology (2012)
Expression of Mitochondrial Non-coding RNAs (ncRNAs) Is Modulated by High Risk Human Papillomavirus (HPV) Oncogenes Villota, C; Campos A.; Vidaurre S.; Oliveira-Cruz, L; Boccardo, E; Burzio, V.A.; Varas, M; Villegas, J; Villa L.L.; Valenzuela P.D.T.; Socias, M; Roberts, S.; Burzio L.O. Article ISI SCOPUS Journal of Biological Chemistry (2012)
Nuclear localization of the mitochondrial ncRNAs in normal and cancer cells Landerer, E.; Villegas, J; Burzio, VA; Oliveira L.; Villota, C; López C.; Restovic, F; Martínez R.; Castillo O.; Burzio, LO Article ISI SCOPUS Cellular Oncology (2011)
Expression of a family of noncoding mitochondrial RNAs distinguishes normal from cancer cells Burzio, VA; Villota, C; Villegas, J; Landerer, E.; Boccardo, E; Villa, LL; Martínez R.; López C.; Gaete, F; Toro V.; Rodríguez X; Burzio, LO Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Expression of a novel non-coding mitochondrial RNA in human proliferating cells Villegas, J; Burzio V; Villota, C; Landerer, E.; Martínez R.; Santander, M; Pinto, R; Vera, MI; Boccardo, E; Villa, LL; Burzio, LO Article ISI NUCLEIC ACIDS RESEARCH (2007)
The complete sequence of the mitochondrial genome of the Chinook salmon, Oncorhyncus tshawytscha Wilhelm, V; Villegas, J; Engel E.; Bernales S.; Valenzuela P.D.T.; Burzio L.O.; Miquel, A Article SCOPUS BIOLOGICAL RESEARCH (2003)
A putative RNA editing from U to C in a mouse mitochondrial transcript Villegas, J; Muller, I; Arredondo J.; Pinto, R; Burzio, LO Article ISI SCOPUS NUCLEIC ACIDS RESEARCH (2002)
Localization of the 16S mitochondrial rRNA in the nucleus of mammalian spermatogenic cells Villegas, J; Araya, P; Bustos-Obregon, E; Burzio, LO Article ISI SCOPUS MOLECULAR HUMAN REPRODUCTION (2002)
A novel chimeric mitochondrial RNA localized in the nucleus of mouse sperm Villegas, J; Zarraga, AM; Muller, I; Montecinos L.; Werner, E; Brito M.; Meneses M.; Burzio, LO Article ISI SCOPUS DNA and Cell Biology (2000)


Mitochondrial non-coding RNAs as therapeutic target in cervical cancer Ávila R.; Farfan, N; Lobos, L; Silva, V.; Villota, C; Burzio, LO; Villegas, J Abstract ISI FEBS JOURNAL (2014)
Non Coding Mitochondrial RNAs as Novel Teragnostic Molecular Tool in Cervix Cancer Villegas, J; Ávila R.; Dadlani, K; Socias, M; Zapata L.; Villota, C; Burzio V; Oliveira-Cruz, L; Bustamante, E; Burzio, LO Abstract ISI EUROPEAN JOURNAL OF CANCER (2012)
The antisense non-coding mitochondrial RNA as a molecular therapeutic target for a murine model of melanoma Burzio V; Vidaurre S.; Villegas, J; Villota, C; Echeñique J.; Burzio, LO Abstract ISI FEBS JOURNAL (2011)
A single FISH procedure for the detection of tumor cells: Bladder cancer as model Rivas, A; Landerer, E.; Burzio V; Gatica, S; López C.; Burzio, LO; Villegas, J Abstract ISI EJC SUPPLEMENTS (2010)
Sense and antisense noncoding mitochrondrial RNA differentiate normal from tumor cells Landerer, E.; Villegas, J; Burzio V; Villa, L.; Boccardo, E; Socias, M; Gaete, F; Toro V.; Burzio, L; Villota, C Abstract ISI ACTA CYTOLOGICA (2007)
Identification of a novel editing reaction in a mouse mitochondrial chimeric RNA Villegas, J; Muller, I; Arredondo J.; Burzio, LO Abstract ISI FASEB JOURNAL (2000)


Long Noncoding Mitochondrial RNAs (LncmtRNAs) as Targets for Cancer Therapy Jaime Villegas Olavarria, Verónica A. Burzio, Vincenzo Borgna, Lorena Lobos-Gonzalez, Mariela Araya, Francisca Guevara, Claudio Villota and Luis O. Burzio BookSection (2018)
Targeting Non-Coding Mitochondrial RNAs (ncmtRNAs) in Gynecological and Urinary Malignancies: Universal Targets for the Development of an Efficient Therapy? Vincenzo, Borgna, Lorena Lobos-González, Rodolfo Ávila, Mariela Araya, Verónica Burzio, Emmanuel Jeldes, Verónica Silva, Francisca Guevara, Constanza López, Claudio Villota, Eva Bustamante, Max Bendex, Cristopher Fitzpatrick, Luis Burzio, L.O. and Jaime V BookSection (2017)
Long non-coding mitochondrial RNAs as potential targets for diagnosis and therapy of bladder cancer. Jaime Villegas, Alexis Rivas, Rodolfo Ávila, Vincenzo Borgna, Lorena Lobos-Gonzales, Verónica Burzio, Constanza López, Reynaldo Gomez, Eduardo Landerer, Laura Velarde and L. O. Burzio BookSection (2014)
Biosíntesis de pegamentos de organismos marinos. Álvaro Miquel, Ilse Müller, Verónica Burzio, Juan Aguayo, Cristian Flores, Jaime Villegas, Arturo, Yudelevich y Luis O. Burzio BookSection (2009)
Piscirickettsia salmonis: un enfoque genómico para un problema de la salmonicultura Vivian Wilhelm, Esteban Engel, Álvaro Miquel, Adolfo Jamett, Juan Aguayo, Ilse Müller, Cristian Hernández, Cristian Soza, Jaime Villegas, Sebastián Bernales, Rodrigo Martínez, Mario Rosemblatt, Luis O. Burzio y Pablo D.T. Valenzuela BookSection (2009)


Long non coding mitochondrial RNAs as potential targets for diagnosis and therapy of bladder cancer Villegas, J; Rivas, A; Ávila R.; Borgna, V; Lobos-Gonzales L.; Burzio V; López C.; Gomez, R; Landerer, E.; Velarde L.; Burzio L.O. BookWhole SCOPUS Bladder Cancer: Risk Factors, Emerging Treatment Strategies and Challenges (2014)


Evaluation of antisense therapy in PDX models of advanced cervical cancer: Mitochondrial non-coding RNAs as target Jaime Villegas, Francisca Guevara, Lorena Lobos-Gonzales, Claudio Villota and Luis O. Burzio. RNA ConferencePaper (2018)


Antisense therapy against non-coding mitochondrial RNAs as potent therapy for prostate cancer Villegas, J; Guevara, F; Sandoval, E; Valenzuela, S, Socias, T; López, C; Lobos-Gonzales, L., Silva, V; Burzio, L.O ConferencePoster (2019)
La interferencia del RNA mitocondrial no codificante largo (RNAmtnc-AS) como un nuevo tratamiento para el cáncer renal humano Mariela Araya, Francisca Guevara, Jaime Villegas, Luis Alarcon, Luis Orlando Burzio, Vincenzo Borgna ConferencePoster (2019)
The antisense long non-coding Mitochondrial RNA (AS-NCMTRNA) interference with andes-1537 as a novel treatment for renal carcinoma M. Araya, F. Guevara, J. Villegas, L. Alarcón, L. Burzio, and V. Borgna. ConferencePoster (2019)
Evaluation in vivo of the efficacy of an antisense therapy in a patient derived xenograft model (PDX) of advanced cervical cancer Guevara, F, Silva V, Lobos-González L, Villota C, Sanhueza N, Reyes C, Castillo J, Bustamante E, Burzio L.O. and Villegas, J ConferencePoster (2018)
. Evaluation of the efficacy of antisense therapy in a patient derived xenograft model (PDX) of advanced cervical cancer Guevara F, Silva V, Lobos-Gonzalez L, Villota, C, Carrasco M, Sanhueza N, Reyes C, Castillo J, Bustamante E, Burzio L, Villegas, J ConferencePoster (2017)
Evaluation of the efficacy of antisense therapy in a patient derived xenograft model (PDX) of advanced cervical cancer Villegas, J., Guevara, F., Silva, V., Lobos-Gonzales, L., Villota, C, Carrasco, M., Sanhueza, N., Reyes, C., Castillo, J., Bustamante, E. and Burzio, L.O. ConferencePoster (2017)
HPV-18 E2 protein induces partial immortalization of human keratinocytes followed by replicative senescence and modulation of the mitochondrial SncmtRNA and the ASncmtRNAs Villota C, Varas-Godoy M, Campos A, Jeldes E, Villegas J, Burzio V, Burzio L O. ConferencePoster (2017)
Lactadherin and VE-cadherin Incorporated in to exosomes secreted postinterference of ASncmtRNA decrease tumorigenic property in breast cancer cell Lobos-Gonzalez Lorena, Bustos Rocio, Campos America, Silva Valeria, Silva Veronica, Varas-Godoy Manuel, Caceres-Verchae Albano, Villegas Jaime, Ezquer Fernando, Ezquer Marcelo, Burzio Veronica, Luis O. Burzio. ConferencePoster (2017)
Mitochondrial ASncmtRNA-1 and ASncmtRNA-2 as potent targets to inhibit tumor growth and metastasis in the RenCa murine renal adenocarcinoma model. Jaime Villegas, Vincenzo Borgna, Verónica A. Burzio, Sebastián Belmar, Mariela Araya, Emanuel Jeldes, Lorena Lobos-González, Verónica Silva, Claudio Villota, Luciana Oliveira-Cruz, Constanza Lopez, Teresa Socias, Octavio Castillo and Luis O. Burzio ConferencePoster (2017)
Targeting antisense mitochondrial ncRNAs inhibits murine melanoma tumor growth and metastasis through reduction in survival and invasion factors Lorena Lobos-González, Verónica Silva, Mariela Araya, Franko Restovic, Javiera Echenique, Luciana Oliveira-Cruz, Christopher Fitzpatrick, Macarena Briones, Jaime Villegas, Claudio Villota, Soledad Vidaurre, Vincenzo Borgna, Miguel Socias, Sebastián Valenz ConferencePoster (2017)
Long non-coding mitochondrial RNAs as therapeutic targets in gynecological cancers. Soledad Vidaurre, Rodolfo Avila, Karen Villota, Jaime Villegas, Gareth Owen and Verónica Burzio ConferencePoster (2016)
. Exosomes released upon knockdown of the antisense non-coding mitochondrial RNAs modulate tumorigenic properties of the human breast cancer cell line MDA -mb-231 Bustos R, Campos A, Varas-Godoy M, Carrasco M, Guevara F, Villegas J, Burzio V, Burzio L, Lobos-Gonzalez, L ConferencePoster (2016)
The antisense non-coding mitochondrial RNAs as therapeutic targets in cervical and ovarian cancer Vidaurre S, Avila R, Villota K, Villegas J, Owen G, Burzio V ConferencePoster (2016)
Knockdown of the mitochondrial antisense ncRNAs abolishes murine melanoma tumor growth and metastasis Burzio, Verónica., Lobos-Gonzalez, Lorena., Silva, Verónica., Araya, Mariela., Oliveira-Cruz, Luciana., Fitzpatrick, Christopher., Briones, Macarena., Villegas, Jaime., Villota, Claudio., Vidaurre, Soledad., Borgna, Vincenzo., Lopez, Constanza., Teresa, S ConferencePoster (2015)
Knockdown of the mitochondrial antisense ncRNAs induces complete inhibition of murine melanoma tumor growth and metastasis Lorena Lobos-González, Verónica Silva, Mariela Araya, Luciana Oliveira-Cruz, Christopher Fitzpatrick, Macarena Briones, Jaime Villegas, Claudio Villota, Soledad Vidaurre, Vincenzo Borgna, Constanza Lopez, Teresa Socias, Luis O. Burzio and Verónica A. Burz ConferencePoster (2015)
La interferencia del RNA mitocondrial no codificante antisentido (RNAmtnc-AS) suprime el crecimiento tumoral y aumenta la sobrevida en modelos ortotópicos de cáncer renal subcutáneo y ortotópico Borgna, V., Villegas, J., Belmar, S., Jeldes, E., Burzio, V., Fernandoise, P., Hernandez, S., Zamorano, A., Alarcón, L., araya, M. Burzio, L.O. ConferencePoster (2015)
Targeted inhibition of ASnc mtRNA promote apoptosis and inhibit tumorigenic properties in genitourinary cancer in vitro and in vivo. Borgna, V., Lobos-Gonzalez, L., Silva, V., Araya, M., Rivas, A., Ávila, R., López, C., Socias, T., Burzio, V, Burzio, L.O and Villegas, J ConferencePoster (2015)
The Antisense long non-coding mitochondrial RNA (AS-ncmtRNA) interference as a novel treatment for Renal carcinoma Borgna V., Villegas J., Oliveira-Cruz L., Socias T., Belmar S., Burzio V., Burzio L.O. ConferencePoster (2014)
Evaluation of the expression of a family of non-coding mitochondrial RNAs through the progression of cervical cancer: a novel tool for diagnosis K. Dadlani, C. Villota, R. Ávila, C. López, L. Zapata, JC. Roa, L.O. Burzio and J. Villegas ConferencePoster (2014)
Non-coding mitochondrial RNAs (ncmtRNAs) as therapeutic target of cervical cancer Villota C., Avila R., Farfan N., Burzio L.O. and Villegas J. ConferencePoster (2014)
Evaluation of a diagnostic method for cervical cancer: Non-coding mitochondrial RNAs as markers Dadlani, K., Avila, R., Villota, C., López, C., Zapata, L., Bustamante, E., Burzio, V., Burzio, L.O. and Villegas, J. ConferencePoster (2013)
Gene therapy against bladder cancer: A new strategy to fight the urothelial carcinoma Landerer, E., Bendek, M., Lobos, L., Avila, M., Rivas, A., Borgna, V. Gonzales, C. and Villegas, J ConferencePoster (2013)
Targeting non-coding mitochondrial RNA induces cell death of primary cultures of cervical cancer Villegas, J., Avila, R., Villota, C., Bustamante, E., Zapata, L., Oliveira-Cruz, L. and Burzio, L ConferencePoster (2013)
Targeting the antisense non-coding mitocondrial RNA (AsncmtRNA) inhibits neoplastic characteristic of human bladder cell lines Villegas, J., Borgna, V., Lobos, L., Avila, R., Rivas, A., Silva, V. and Burzio, L.O. ConferencePoster (2013)
Non-coding mitochondrial RNAs as novel theragnostic molecular tool in cervix cancer Villegas, J., Avila, R., Dadlani, K., Socias, M., Zapata, L., Villota, C., Burzio, V., Oliveira-Cruz, L., Bustamante, E. and Burzio, L.O ConferencePoster (2012)
Renal cell carcinoma: evaluation of the mitochondrial non-coding RNAs as potential targets for therapy Borgna, V., Rivas, A., Lobos-Gonzales, L., Peña, E., Fernandois, P., Landerer, E., Oliveira, L., Villegas, J. and Burzio, L.O ConferencePoster (2012)


Different cancers, same target? Villegas J.; Borgna V.; Burzio V.A. Editorial ISI SCOPUS AGING-US (2017)


Evaluación de una nueva terapia para el cáncer de próstata resistente a castración Villegas, Jaime Eduardo; Borgna, Vincenzo; 2. Valenzuela, Sebastián A.; Guevara, Francisca Proyecto (2019)
Validación de terapia antisentido para cáncer cervicouterino in vivo FONDEF - CONICYT (D10E1090) Proyecto 2016-2017 Director(a)
Preclinical animal studies required for the treatment of human cancer using oligonucleotides INNOVA-CORFO (12IEAT-16317) Proyecto 2013-2015 Inv. Principal
Developing a targeted therapy against cervical cancer FONDEF (D10i1090) Proyecto 2012-2014 Director(a)
Development of a prototype diagnostic kit for the detection and monitoring of bladder cancer from urine samples. INNOVA-CORFO (12IDL4-13358) Proyecto 2012-2014 Director(a)
Evaluation of a novel antisense mitochondrial RNA as an element of early cáncer diagnosis DID-UNAB (DI28-09/R) Proyecto 2009-2010 Inv. Responsable
DEVELOPMENT OF A HIGHLY EFFICIENT SYSTEM FOR IDENTIFICATION OF NEOPLASTIC CELLS IN BLADDER CANCER PATIENTS, BASED ON THE DIFFERENTIAL EXPRESSION OF A NOVEL FAMILY OF MITOCHONDRIAL RNAs. FONDECYT (1085210) Proyecto 2005-2008 Inv. Responsable
Development of new products for the diagnosis and therapy of cancer FONDEF (D04I1338) Proyecto 2005-2008 Inv. Principal
Development of new tools for the detection of viral pathogens in plants and their use in certified virus-free plants PIA (IPI30) Proyecto 2005-2008 Investigador(a)
Use of antisense oligonucleotides against a family of human mitochondrial chimeric RNAs=> potential use in diagnosis and therapy of cancer DID-UNAB (DI20-02) Proyecto 2005-2006 Inv. Principal
Human chimeric mitochondrial RNA=> Role in cell proliferation and apoptosis DID-UNAB (DI 20-02) Proyecto 2003-2004 Inv. Responsable
Translocation of mitochondrial RNAs to the nucleus of spermatogenetic cells FONDECYT (2960062) Proyecto 1996-1999 Inv. Responsable

jaime villegas

Profesor Asistente

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

Luis Burzio

Scientific Director

Andes Biotechnologies

FUNDACION CIENCIA PARA LA VIDA

Santiago, Chile

jaime villegas

Investigador Senior

Andes Biotechnologies

Fundación Ciencia para la Vida

Santiago, Chile

Claudio Villota

Profesor/investigador Asociado

Facultad de Salud

Universidad Bernardo O'Higgins

Santiago, Chile

Verónica Burzio

Investigadora Asociada

Fundacion Ciencia y Vida

Santiago, Chile

Alexis Rivas

Investigador Postdoctoral

Instituto de Neurociencias Biomédicas

Universidad de Chile

Santiago, Chile

Eduardo Landerer

ENCARGADO POSTGRADO UROLOGÍA HFB

UROLOGÍA

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

Vincenzo Borgna

Investigador

Inmuno-Oncología

FUNDACION CIENCIA VIDA

Santiago, Chile

MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

Ronny Martinez

Profesor Asociado

Ingenieria en Alimentos

UNIVERSIDAD DE LA SERENA

La Serena, Chile

Christopher Fitzpatrick

Postoctoral Researcher

Non coding RNAs

Fundación Ciencia y Vida

Santiago, Chile

Reynaldo Gomez

Jefe del Servicio de Urología

Departmento de urología

Hospital del Trabajador

Santiago, Chile

LAURA VELARDE

Uróloga

Departmento de urología

Hospital del Trabajador

Santiago, Chile

Maximiliano Bendek

ninguno

ninguna

Santiago, Chile

Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Gino Nardocci

Investigador / Profesor Asistente

Universidad de Los Andes

Santiago, Chile

Edison Salas

Director de laboratorio de nanotecnología

Aintech

Santiago, Chile

Franko Restovic

Manager

Bioeconomy

Fundación Fraunhofer Chile Research

Santiago, Chile

Erwin Krauskopf

Profesor Asociado

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Pablo Valenzuela

Founder and Scientific Director

Fundación Ciencia & Vida

Santiago, Chile

Ana Meneses

Académico

Universidad Diego Portales

Santiago, Chile

Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Jorge Cancino

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

ALEJANDRO CORVALAN

Principal Investigator

Hematology and Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

Sebastian Bernales

Founder

Merken Biotech

Santiago, Chile

Simon Guerrero

Investigador

Instituto de Investigación Interdisciplinar en Ciencias Biomédicas SEK

Universidad SEK

Santiago, Chile

Nicole Farfán

Asistente de investigación

instituto de ciencias biomedicas

Universidad del Desarrollo

Santiago, Chile

Eyleen Araya

Academic

Chemical Sciences

Universidad Andres Bello

santiago, Chile

Eduardo Ezquer

Director/Full Professor

Centro de Medicina Regenerativa

UNIVERSIDAD DEL DESARROLLO, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS

Santiago, Chile

pamela araya

JEFE DE SECCIÓN

BIOMEDICO

INSTITUTO DE SALUD PUBLICA DE CHILE

SANTIAGO, Chile

Enrique Werner

Académico

Ciencias Básicas

UNIVERSIDAD DEL BIO-BIO

Chillán, Chile

Francisca Sepúlveda

PhD(c)

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

jaime eduardo villegas olavarria

Líneas de Investigación

Educación

Ciencias Biológicas, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1988

Ciencias, mención Biología Celular y Molecular, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2000

Experiencia Académica

Profesor Asistente Full Time

Experiencia Profesional

Investigador Senior Other

Investigador Part Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

Distinción Académica: Premio Medalla “R. A. Phillipi

Premio Fundación científica Biovision

Premio “Emprendimiento Biotecnológico BIOTECH 2004

Premio Fundación Científica Biovision

Premio Fundación Científica Biovision

Premio a la Investigación Científica Universitaria: Cura y Prevención del Cáncer

Article (23)

Abstract (6)

BookSection (5)

BookWhole (1)

ConferencePaper (1)

ConferencePoster (26)

Editorial (1)

Proyecto (12)

Validación de terapia antisentido para cáncer cervicouterino in vivo

Preclinical animal studies required for the treatment of human cancer using oligonucleotides

Developing a targeted therapy against cervical cancer

Development of a prototype diagnostic kit for the detection and monitoring of bladder cancer from urine samples.

Evaluation of a novel antisense mitochondrial RNA as an element of early cáncer diagnosis

DEVELOPMENT OF A HIGHLY EFFICIENT SYSTEM FOR IDENTIFICATION OF NEOPLASTIC CELLS IN BLADDER CANCER PATIENTS, BASED ON THE DIFFERENTIAL EXPRESSION OF A NOVEL FAMILY OF MITOCHONDRIAL RNAs.

Development of new products for the diagnosis and therapy of cancer

Development of new tools for the detection of viral pathogens in plants and their use in certified virus-free plants

Use of antisense oligonucleotides against a family of human mitochondrial chimeric RNAs=> potential use in diagnosis and therapy of cancer

Human chimeric mitochondrial RNA=> Role in cell proliferation and apoptosis

Translocation of mitochondrial RNAs to the nucleus of spermatogenetic cells