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Francisca Soledad Sepúlveda Guevara

PhD(c)

Universidad del Desarrollo

Santiago, Chile

Vesículas extracelulares secretadas por adipocitos asociados a cáncer Terapia antisentido para cáncer Desarrollo modelos pre clínicos

Biotecnología, Universidad Andrés Bello. Chile, 2018
Ingeniero en Biotecnología, Universidad Andrés Bello. Chile, 2016
Ciencia e Innovación en Medicina, Universidad del Desarrollo. Chile, 2022
Ciencia e Innovación en Medicina, Universidad del Desarrollo. Chile

Asistente de Investigación Full Time

Andes Biotechnologies

Santiago, Chile

2017 - 2019
Asistente de Investigación Full Time

Merken Biotech SpA

Santiago, Chile

2019 - 2021
Monitor Científico Other

BioClass

Santiago, Chile

2018 - 2019
PhD (c) Other

Universidad del Desarrollo

Chile

2021 - A la fecha

Entrenamiento de tesistas en manejo de animales inmunosuprimidos

Presentación en congresos nacionales de la especialidad


Knockdown of Antisense Noncoding Mitochondrial RNA Reduces Tumorigenicity of Patient-Derived Clear Cell Renal Carcinoma Cells in an Orthotopic Xenograft Mouse Model Araya, Mariela; Sepulveda, Francisca; Villegas, Jaime; Alarcon, Luis; Burzio, Luis O.; Burzio, Veronica A.; Borgna, Vincenzo Article ISI CANCERS (2024)
Caveolin-1-dependent tenascin C inclusion in extracellular vesicles is required to promote breast cancer cell malignancy Campos, America; Burgos-Ravanal, Renato; Lobos-Gonzalez, Lorena; Huilcaman, Ricardo; Gonzalez, Maria Fernanda; Diaz, Jorge; Verschae, Albano Caceres; Acevedo, Juan Pablo; Carrasco, Macarena; Sepulveda, Francisca; Jeldes, Emanuel; Varas-Godoy, Manuel; Leyton, Lisette; Quest, Andrew F. G. Article ISI NANOMEDICINE (2023)
Increase in ADAR1p110 activates the canonical Wnt signaling pathway associated with aggressive phenotype in triple negative breast cancer cells Morales, Fernanda; Perez, Paola; Tapia, Julio C.; Lobos-Gonzalez, Lorena; Manuel Herranz, Jose; Guevara, Francisca; Rojas de Santiago, Pamela; Palacios, Esteban; Andaur, Rodrigo; Sagredo, Eduardo A.; Marcelain, Katherine; Armisen, Ricardo Article ISI GENE (2022)
Evaluation of the chemopreventive potentials of ezetimibe and aspirin in a novel mouse model of gallbladder preneoplasia Rosa, Lorena; Lobos-Gonzalez, Lorena; Munoz-Durango, Natalia; Garcia, Patricia; Bizama, Carolina; Gomez, Natalia; Gonzalez, Ximena; Wichmann, Ignacio A.; Saavedra, Nicolas; Guevara, Francisca; Villegas, Jaime; Arrese, Marco; Ferreccio, Catterina; Kalergis, Alexis M.; Miquel, Juan Francisco; Espinoza, Jaime A.; Roa, Juan C. Article ISI MOLECULAR ONCOLOGY (2020)
Targeting antisense mitochondrial noncoding RNAs induces bladder cancer cell death and inhibition of tumor growth through reduction of survival and invasion factors Borgna, Vincenzo; Lobos-Gonzalez, Lorena; Guevara, Francisca; Landerer, Eduardo; Bendek, Maximiliano; Avila, Rodolfo; Silva, Veronica; Villota, Claudio; Araya, Mariela; Rivas, Alexis; Lopez, Constanza; Socias, Teresa; Castillo, Jorge; Alarcon, Luis; Burzio, Luis O.; Burzio, Veronica A.; Villegas, Jaime Article ISI SCOPUS JOURNAL OF CANCER (2020)


Chapter 6: Non-Coding Mitochondrial RNAs (ncmtRNAs) in Gynecological and Urinary Malignancies: Universal Targets for Development of an Efficient Therapy? Borgna, Vincenzo; Lobos-González, Lorena-; Burzio, Verónica; Araya, Mariela; Ávila, Rodolfo; Jeldes, Emmanuel; Silva, Verónica; Briones, Macarena; Socías, Teresa; Guevara, Francisca.; López, Constanza; Villota, Claudio; Bustamante, Eva; Bendek, Maximiliano; Fitzpatrick, Christopher; Burzio, Luis O.; Villegas, Jaime; Hiroto S. Watanabe BookSection (2017)


Aptamers as a potential therapeutic tool for blocking Epithelial-Mesenchymal transition in triple negative breast cancer model Mayorga-Lobos, Cristina; Sepulveda, Francisca; Riveros, Ana; KOGAN, MARCELO; Lobos-Gonzalez, Lorena ConferencePoster (2024)
Aptámeros bloquean capacidades tumorogénicas promovidas por vesículas extracelulalres de cáncer de mama Mayorga-Lobos, Cristina; Sepulveda, Francisca; Lobos-Gonzalez, Lorena ConferencePoster (2023)
Functionalized gold nanoparticles blocking Lactadherin present in extracellular vesicles secreted by triple negative breast cancer cells diminished the migratory capacity in receptor cells Mayorga-Lobos, Cristina; Sepulveda, Francisca; Riveros, Ana; KOGAN, MARCELO; Lobos-Gonzalez, Lorena ConferencePoster (2023)
Searching for radioresistance-promotor miRNAs in breast cancer Sepulveda, Francisca; Mayorga-Lobos, Cristina; Arias, Robinson; Guzmán, Constanza; Marambio, Sandra; Duran-Jara, Eduardo; Lobos-Gonzalez, Lorena ConferencePoster (2023)
Blocking Lactadherin present in triple positive breast cancer BT474 cells exosomes with functionalized gold nanoparticles decrease EMT in breast epithelial cells MCF10A Mayorga-Lobos, Cristina; Sepulveda, Francisca; Riveros, Ana; KOGAN, MARCELO; Lobos-Gonzalez, Lorena ConferencePoster (2022)
Antisense therapy against non-coding mitochondrial RNAs as potent therapy for prostate cancer Villegas, Jaime; Sepulveda, Francisca; Sandoval, Erik; Valenzuela, Sebastian; Socias, Teresa; Lopez, Constanza; Lobos-Gonzalez, Lorena; Silva, Verónica; Burzio L.O. ConferencePoster (2019)
The antisense long non-coding mitocondrial RNA (AS-NCMTRNA) interference with ANDES- 1537 AS a novel treatment for renal carcinoma Araya, Mariela; Sepulveda, Francisca; Villegas, Jaime; Burzio L.O.; Borgna, Vincenzo ConferencePoster (2019)
Caveolin-1 containing extracelular vesicles promote malignant ascites formation in vitro an in vivo model of peritoneal carcinomatosis Campos, America; Lobos-Gonzalez, Lorena; Silva, Verónica; Carrasco, Macarena; Guevara, Francisca; Burgos, Renato; Diaz, Natalia; Varas-Godoy, Manuel; Quest, Andrew ConferencePoster (2018)
Evaluation in vivo of the efficacy of an antisense therapy in a patient derived xenograft model (PDX) of advanced cervical cancer Guevara, Francisca; Silva, Verónica; Lobos-Gonzalez, Lorena; Villota, Claudio; Sanhueza, Nicole; Reyes, Constanza; Castillo, J; Bustamante, Eva; Burzio L.O.; Villegas, Jaime ConferencePoster (2018)
Evaluation of antisense therapy in PDX models of advanced cervical cancer: Mitochondrial noncoding RNAs as target Villegas, Jaime; Guevara, Francisca; Lobos-Gonzalez, Lorena; Villota, Claudio; Burzio L.O. ConferencePoster (2018)
Primer modelo murino de lesiones preneoplásicas de la vesícula biliar asociado a litiasis inducida por dieta Rosa, Lorena; Lobos-Gonzalez, Lorena; Gómez, N.; Munoz-Durango, Natalia; Romero, D; De La Jara, N; Guevara, Francisca ConferencePoster (2018)
Development and characterization of the first lithiasis-associated gallbladder cancer model in mice Rosa, Lorena; Lobos-González, Lorena; Romero, Diego; Gómez, Natalia; Muñoz Durango, Natalia; De La Jara, Nathaly; Carrasco, Macarena; Guevara, Francisca.; García, Patricia; Kalergis, Alexis; Miquel, Juan Francisco; Roa, Juan Carlos ConferencePoster (2017)
Evaluation of the efficacy of antisense therapy in a patient derived xenograft model (PDX) of advanced cervical cancer Guevara, Francisca.; Silva, María Verónica.; Lobos-González, Lorena; Villota, Claudio.; Carrasco, Macarena.; Sanhueza, Nicole.; Reyes, Constanza.; Castillo, J.; Bustamante, Eva.; Villegas, Jaime. ConferencePoster (2017)
Exosomes released upon knockdown of the Antisense non-coding mitochondrial RNAs modulate tumorigenic properties of the human breast cancer cell line MDA-MB-231 Bustos, Rocio.; Campo, América.; Varas-Godoy, Manuel.; Carrasco, Macarena.; Guevara, Francisca.; Villegas, Jaime.; Burzio, Verónica.; Burzio, Luis.; Lobos-González, Lorena- ConferencePoster (2016)


EV-miRNA-Mediated Intercellular Communication in the Breast Tumor Microenvironment Sepulveda, Francisca; Mayorga-Lobos, Cristina; Guzman, Kevin; Duran-Jara, Eduardo; Lobos-Gonzalez, Lorena Review ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)