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Mauricio Javier Farfán Urzúa

Profesor Asociado

Universidad de Chile

Providencia, Chile

Interacción Bacteria-Hospedero; Diagnóstico Molecular; Farmacognética; Microbiota intestinal

Bioquímico, UNIVERSIDAD DE CHILE. Chile, 2012
Químico Farmacéutico, UNIVERSIDAD DE CHILE. Chile, 2015
Doctor en Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2016

Posdoctoral fellow Full Time

UNIVERSITY OF MARYLAND

School of Medicine

Baltimore, Estados Unidos

2006 - 2008
Profesor Asociado Full Time

UNIVERSIDAD DE CHILE

Facultad de Medicina

Santiago , Chile

2008 - A la fecha
Bioquimico Asesor Laboratorio de Biología Molecular Other

CLINICA LAS CONDES

Santiago, Chile

2014 - 2019

Postdoctoral fellow Full Time

University of Maryland

Baltimore, Chile

2006 - 2008
Profesor Asistente Full Time

Universidad de Chile

Santiago, Chile

2008 - 2014
Profesor Asociado Full Time

Universidad de Chile

Santiago, Chile

2014 - A la fecha
Jefatura Laboratorio de Biología Molecular Other

Hospital Dr. Luis Calvo Mackenna

Santiago, Chile

2008 - A la fecha
Bioqumico Asesor Laboratorio de Biología Molecular Other

Clinica Las Condes

Santiago, Chile

2014 - 2018

1.- Director de Tesis alumna Dominique Yañez Osorio, Licenciatura en Bioquimica, 2014
2.- Director de Tesis alumna Mariana Izquierdo Tramón, Licenciatura en Bioquimica, 2013
3.- Director de Tesis alumna Alejandra Vergara Arcos, Magister en Microbiología, 2013
4.- Director de Tesis alumna Lidia Cantero Almeyda, Magister en Microbiología, 2011
5.-Director de Tesis alumna Cristina Cananles Lopez, Licenciatura en Química y Farmacia, 2012
6.- Director de Tesis alumna Carolina Salas Palma, Magister en Bioquímica, 2010
7.- Director de Tesis alumna Alejandra Alvestegui Seelenfreund, Magister en Bioquimica, 2015
8.- Director de Tesis alumno Joan Galdamez, Licenciatura en Química y Farmacia, 2014
9.- Director de Tesis alumna Natalie Espinoza Giacomozzi, Magister en Bioquímica, 2016
10.- Director de Tesis alumno Pablo Gallardo, Licenciatura en Bioquimica, 2017
11-. Director de Tesis alumna Mariana Izquierdo Tramón, Doctorado en Ciencias Biomédicas, 2019
12-. Director de Tesis alumno Joaquin Lopez, Magister en Bioquímica, 2018
13-. Director de Tesis alumna Dominique Yañez Osorio, Magister en Bioquímica, en curso
14.- Director de Tesis alumno Claudio Girón, Magister en Bioquímica, en curso


A metagenomic approach to unveil the association between fecal gut microbiota and short-chain fatty acids in diarrhea caused by diarrheagenic Escherichia coli in children Gallardo, Pablo; Izquierdo, Mariana; Viver, Tomeu; Bustos-Caparros, Esteban; Piras, Dana; Vidal, Roberto M.; Harmsen, Hermie M. J.; Farfan, Mauricio J. Article ISI MICROBIAL CELL (2024)
Universal and Expanded Screening Strategy for Congenital Cytomegalovirus Infection: Is Pool Testing by a Rapid Molecular Test in Saliva a New Choice in Developing Countries? Izquierdo, Giannina; Guerra, Carolina; Reyes, Roberto; Araya, Leslie; Sepulveda, Belen; Cabrera, Camila; Medina, Pamela; Mardones, Eledier; Villavicencio, Leonel; Montecinos, Luisa; Tarque, Felipe; Acevedo, William; Barraza, Marlon; Farfan, Mauricio; Mendez, Jocelyn; Torres, Juan Pablo Article ISI VIRUSES-BASEL (2024)
Optimizing congenital cytomegalovirus detection by pool testing in saliva by a rapid molecular test Izquierdo, Giannina; Farfan, Mauricio J.; Villavicencio, Leonel; Montecinos, Luisa; Tarque, Felipe; Acevedo, William; Reyes, Roberto; Guerra, Carolina; Araya, Leslie; Sepulveda, Belen; Cabrera, Camila; Medina, Pamela; Mendez, Jocelyn; Mardones, Elieder; Torres, Juan P. Article ISI EUROPEAN JOURNAL OF PEDIATRICS (2023)
Secretory-IgA binding to intestinal microbiota attenuates inflammatory reactions as the intestinal barrier of preterm infants matures Mahdally, Sarah M.; Izquierdo, Mariana; Viscardi, Rose M.; Magder, Laurence S.; Crowley, Helena M.; Bafford, Andrea C.; Drachenberg, Cinthia B.; Farfan, Mauricio J.; Fasano, Alessio; Sztein, Marcelo B.; Salerno-Goncalves, Rosangela Article ISI CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2023)
Bacteria from gut microbiota associated with diarrheal infections in children promote virulence of Shiga toxin-producing and enteroaggregative <i>Escherichia coli</i> pathotypes Izquierdo, Mariana; Lopez, Joaquin; Gallardo, Pablo; Vidal, Roberto M.; Ossa, Juan C.; Farfan, Mauricio J. Article ISI FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)
Characterization of Adherent-Invasive Escherichia coli (AIEC) Outer Membrane Proteins Provides Potential Molecular Markers to Screen Putative AIEC Strains Saitz, Waleska; Montero, David A.; Pardo, Mirka; Araya, Daniela; De la Fuente, Marjorie; Hermoso, Marcela A.; Farfan, Mauricio J.; Ginard, Daniel; Rossello-Mora, Ramon; Rasko, Dave A.; Del Canto, Felipe; Vidal, Roberto M. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
CYP3A5 and UGT1A9 Polymorphisms Influence Immunosuppressive Therapy in Pediatric Kidney Transplant Recipients Krall, Paola; Yanez, Dominique; Rojo, Angelica; Delucchi, Angela; Cordova, Miguel; Morales, Jorge; Boza, Pia; de la Rivera, Alonso; Espinoza, Natalie; Armijo, Natalia; Castaneda, Luis E.; Farfan, Mauricio J.; Salas, Carolina Article ISI FRONTIERS IN PHARMACOLOGY (2021)
Landscapes and bacterial signatures of mucosa-associated intestinal microbiota in Chilean and Spanish patients with inflammatory bowel disease Chamorro, Nayaret; Montero, David A.; Gallardo, Pablo; Farfan, Mauricio; Contreras, Mauricio; De la Fuente, Marjorie; Dubois, Karen; Hermoso, Marcela A.; Quera, Rodrigo; Pizarro-Guajardo, Marjorie; Paredes-Sabja, Daniel; Ginard, Daniel; Rossello-Mora, Ramon; Vidal, Roberto Article ISI MICROBIAL CELL (2021)
Molecular detection of gastrointestinal pathogens among children under 5 years old with diarrhea in a hospital center for rotavirus sentinel surveillance in Chile Poulain, Carolina; Galeno, Hector; Loayza, Sergio; Vergara, Natalia; Valdivieso, Francisca; Coria, Paulina; Sotomayor, Viviana; Elvira Simian, Maria; Acevedo, Johanna; Farfan, Mauricio J. Article ISI REVISTA CHILENA DE INFECTOLOGIA (2021)
Performance of SARS-CoV-2 rapid antigen test compared with real-time RT-PCR in asymptomatic individuals Pena, Monica; Ampuero, Manuel; Garces, Carlos; Gaggero, Aldo; Garcia, Patricia; Soledad Velasquez, Maria; Luza, Ricardo; Alvarez, Pia; Paredes, Fabio; Acevedo, Johanna; Farfan, Mauricio J.; Solari, Sandra; Soto-Rifo, Ricardo; Valiente-Echeverria, Fernando Article ISI INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)
Gut Microbiota-Metabolome Changes in Children With Diarrhea by DiarrheagenicE. coli Gallardo, Pablo; Izquierdo, Mariana; Vidal, Roberto M.; Soto, Francisco; Ossa, Juan C.; Farfan, Mauricio J. Article ISI FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)
Norovirus compared to other relevant etiologies of acute gastroenteritis among families from a semirural county in Chile Lucero, Yalda; Lagomarcino, Anne J.; Espinoza, Monica; Kawakami, Nanami; Mamani, Nora; Huerta, Nicole; Canto, Felipe Del; Farfan, Mauricio; Sawaguchi, Yoshihiro; George, Sergio; Ryan, Miguel O. ' Article ISI INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)
Respiratory viral infections during episodes of fever in children undergoing hematopoietic stem cell transplantation Pablo Torres, Juan; Eugenia Castro-Moraga, Maria; Catalan, Paula; de la Maza, Veronica; Vergara, Alejandra; Valenzuela, Romina; Tapia, Lorena; Olivares-Morales, Mauricio; Farfan, Mauricio J.; Elena Santolaya, Maria Article ISI REVISTA CHILENA DE INFECTOLOGIA (2020)
Capacity to adhere to and invade human epithelial cells, as related to the presence of virulence genes in, motility of, and biofilm formation of Campylobacter jejuni strains isolated from chicken and cattle Farfan, M; Lartiga, N; Benavides, MB; Alegria-Moran, R; Saenz, L; Salcedo, C; Lapierre, L Article ISI SCOPUS CANADIAN JOURNAL OF MICROBIOLOGY (2019)
TLR4 Participates in the Inflammatory Response Induced by the AAF/II Fimbriae From Enteroaggregative Escherichia coli on Intestinal Epithelial Cells Alvestegui A.; Olivares-Morales M.; MuÃ±oz E.; Smith R.; Nataro J.P.; Ruiz-Perez F.; Farfan M.J. Article ISI SCOPUS FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2019)
Efficacy of pre-emptive versus empirical antifungal therapy in children with cancer and high-risk febrile neutropenia=> a randomized clinical trial. Santolaya ME, Alvarez AM; Acuña M, Avilés CL; Salgado C, Tordecilla J; Varas M, Venegas M; Villarroel M, Zubieta M; Farfán M, de la Maza V; Vergara A, Valenzuela R Article JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2018)
Intestinal Inflammation in Chilean Infants Fed With Bovine Formula vs. Breast Milk and Its Association With Their Gut Microbiota Ossa, Juan C.; Yanez, Dominique; Valenzuela, Romina; Gallardo, Pablo; Lucero, Yalda.; Farfan, Mauricio J. Article ISI SCOPUS FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2018)
Characterization of enterotoxigenic Escherichia coli strains isolated from the massive multi-pathogen gastroenteritis outbreak in the Antofagasta region following the Chilean earthquake, 2010 Montero, David; Vidal, Maricel; Pardo, Mirka; Torres, Alexia; Kruger, Eduardo; Farfán, Mauricio; O'Ryan, Miguel; Luo, Qingwei; Fleckenstein, James; Del Canto, Felipe; Vidal, Roberto Article ISI SCOPUS INFECTION GENETICS AND EVOLUTION (2017)
Distinctive Gut Microbiota Is Associated with Diarrheagenic Escherichia coli Infections in Chilean Children Gallardo P, Izquierdo M; Vidal RM, Chamorro-Veloso N; Rosselló-Móra R, O'Ryan M Article FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2017)
Efficacy and safety of withholding antimicrobial treatment in children with cancer, fever and neutropenia, with a demonstrated viral respiratory infection: a randomized clinical trial Santolaya, M.E.; Alvarez, A.M.; Acuña, M.; Avilés, C.L.; Salgado, C.; Tordecilla, J.; Varas, M.; Venegas, M.; Villarroel, M.; Zubieta, M.; Toso, A.; Bataszew, A.; Farfán, M.J.; de la Maza, V.; Vergara, A.; Valenzuela, R.; Torres, J.P. Article ISI SCOPUS CLINICAL MICROBIOLOGY AND INFECTION (2017)
Genomic Loads and Genotypes of Respiratory Syncytial Virus: Viral Factors during Lower Respiratory Tract Infection in Chilean Hospitalized Infants Espinosa, Yazmín; San Martín, Camila; Torres, Alejandro; Farfán, Mauricio; Torres, Juan; Avadhanula, Vasanthi; Piedra, Pedro; Tapia, Lorena Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
Helicobacter pylori cagA plus Is Associated with Milder Duodenal Histological Changes in Chilean Celiac Patients Lucero, Yalda; Oyarzún, Amaya; O'Ryan, Miguel; Quera, Rodrigo; Espinosa, Nelly; Valenzuela, Romina; Simian, Daniela; Alcalde, Elisa; Arce, Claudio; Farfán, Mauricio J.; Vergara, Alejandra F.; Gajardo, Iván; Mendez, Jocelyn; Carrasco, Jorge; Errázuriz, Germán; Gonzalez, Mónica; Ossa, Juan C.; Maiza, Eduardo; Perez-Bravo, Francisco; Castro, Magdalena; Araya, Magdalena Article ISI SCOPUS Frontiers in Cellular and Infection Microbiology (2017)
Detection of Helicobacter pylori by Real-Time PCR for 16s rRNA in Stools of NonInfected Healthy Children, Using ELISA Antigen Stool Test as the Gold Standard George, Sergio; Mamani, Nora; Lucero, Yalda; Torres, Juan Pablo; Farfán, Mauricio; Lagomarcino, Anne J; Orellana, Andrea; O'Ryan, Miguel Article ISI SCOPUS HELICOBACTER (2016)
Detection of Helicobacter pylori by Real-Time PCR for 16s rRNA in Stools of NonInfected Healthy Children, Using ELISA Antigen Stool Test as the Gold Standard. George S, Mamani N, Lucero Y, Torres JP, Farfán M, Lagomarcino AJ, Orellana A, O'Ryan M Article HELICOBACTER (2016)
Filmarray GI (TM) panel for detection of enteric pathogens in stool samples: preliminary experience Farfan, M; Piemonte, P; Labra, Y; Henriquez, J.; Candia, E.; Torres, JP Article ISI REVISTA CHILENA DE INFECTOLOGIA (2016)
Filmarray GI TM panel for detection of enteric pathogens in stool samples: preliminary experience Farfán M, Piemonte P, Labra Y, Henríquez J, Candía E, Torres JP. Article Revista Chilena de Infectologia (2016)
NPHS2 Mutation analysis study in children with steroid-resistant nephrotic syndrome Azocar M, Vega Á, Farfán M, Cano F Article Revista Chilena de Pediatria (2016)
Respiratory Viral Infections and Coinfections in Children With Cancer, Fever and Neutropenia Clinical Outcome of Infections Caused by Different Respiratory Viruses Torres, JP; Farfan, M; Mejias, A; Ramilo O; Santolaya, ME Article ISI SCOPUS PEDIATRIC INFECTIOUS DISEASE JOURNAL (2016)
Respiratory Viral Infections and Coinfections in Children With Cancer, Fever and Neutropenia: Clinical Outcome of Infections Caused by Different Respiratory Viruses. Torres JP, De la Maza V, Kors L, Villarroel M, Piemonte P, Izquierdo G, Salgado C, Tordecilla J, Contardo V, Farfán MJ, Mejías A, Ramilo O, Santolaya ME. Article Pediatric Infectious Disease (2016)
The human gut microbiome of Latin America populations: a landscape to be discovered. Magne F, O'Ryan ML, Vidal R, Farfan M. Article CURRENT OPINION IN INFECTIOUS DISEASES (2016)
The Role of Fibronectin in the Adherence and Inflammatory Response Induced by Enteroaggregative Escherichia coli on Epithelial Cells Yáñez, Dominique; Izquierdo, Mariana; Ruiz-Perez, Fernando; Nataro, James P.; Girón, Jorge A.; Vidal, Roberto M.; Farfan, Mauricio J. Article ISI SCOPUS FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2016)
Enterovirus D68 infection, Chile, Spring 2014 Torres JP, Farfan MJ, Izquierdo G, Piemonte P, Henriquez J, O'Ryan ML Article Emerging Infectious Disease (2015)
Etiologic diagnosis in meningitis and encephalitis molecular biology techniques Conca N, Santolaya ME, Farfan MJ, Cofré F, Vergara A, Salazar L, Torres JP Article Revista Chilena de Pediatria (2015)
Flagellin and GroEL mediates in vitro binding of an atypical enteropathogenic Escherichia coli to cellular fibronectin Moraes, CTP; Polatto, JM; Rossato, SS; Izquierdo, M; Munhoz, DD; Martins, FH; Pimenta, DC; Farfan MJ; Elias, WP; Barbosa, AS; Piazza, RMF Article ISI SCOPUS BMC Microbiology (2015)
Long polar fimbriae participates in the induction of neutrophils transepithelial migration across intestinal cells infected with enterohemorrhagic E. coli O157=>H7. Vergara AF, Vidal RM; Torres AG, Farfan MJ. Article FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2015)
Long polar fimbriae participates in the induction of neutrophils transepithelial migration across intestinal cells infected with enterohernorrhagic E. coli O157:H7 Vergara, AF; Vidal, RM; Torres, AG; Farfan, MJ Article FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2015)
TleA, a Tsh-Like Autotransporter Identified in a Human Enterotoxigenic Escherichia coli Strain Gutiérrez D.; PARDO, M; Montero D.; Oñate A.; Farfan MJ; Ruiz-Perez, F; Del Canto, F; Vidal, R Article ISI SCOPUS Infection and Immunity (2015)
TleA, a Tsh-like autotransporter identified in a human enterotoxigenic Escherichia coli strain Gutiérrez D, Pardo M, Montero D, Oñate A, Farfán MJ, Ruiz-Pérez F, Del Canto F, Vidal R Article Infection and Immunity (2015)
Identification of Cell Surface-Exposed Proteins Involved in the Fimbria-Mediated Adherence of Enteroaggregative Escherichia coli to Intestinal Cells Izquierdo, M; Navarro-Garcia, F; Nava-Acosta, R; NATARO, JP; Ruiz-Perez, F; Farfan MJ Article ISI SCOPUS INFECTION AND IMMUNITY (2014)
Identification of Cell Surface-exposed Proteins involved in the Fimbria-mediated adherence of Enteroagregative Escherichia coli to Intestinal Cells Izquierdo M; Nava -Acosta R; Nataro JP; Ruiz-Pérez F; Farfán MJ Article Infection and Immunity (2014)
Long Polar Fimbriae participates in the induction of neutrophils transepithelial migration across intestinal cells infected with enterohemorrhagic E. coli O157:H7. Vergara A.; Vidal R.; Torres A.G.; Farfan M.J. Article ISI SCOPUS Frontiers in Cellular and Infection Microbiology (2014)
Participation of integrin α5β1 in the fibronectin-mediated adherence of enteroaggregative Escherichia coli to intestinal cells. Izquierdo M, Alvestegui A; Nataro JP, Ruiz-Perez F Article BIOMED RESEARCH INTERNATIONAL (2014)
Participation of Integrin alpha 5 beta 1 in the Fibronectin-Mediated Adherence of Enteroaggregative Escherichia coli to Intestinal Cells Izquierdo, M; Alvestegui A.; NATARO, JP; Ruiz-Perez, F; Farfan MJ Article ISI SCOPUS BIOMED RESEARCH INTERNATIONAL (2014)
Participation of Integrin alpha 5 beta 1 in the Fibronectin-Mediated Adherence of Enteroaggregative Escherichia coli to Intestinal Cells Izquierdo M.; Alvestegui, A; Nataro, JP; Ruiz-Perez, F; Farfan, MJ Article BIOMED RESEARCH INTERNATIONAL (2014)
Prevalence of TPMT and ITPA gene polymorphisms and effect on mercaptopurine dosage in Chilean children with acute lymphoblastic leukemia Farfan MJ; Salas C.; Canales, C; Silva, F; Villarroel M.; Kopp, K; Torres, JP; Santolaya, ME; Morales J. Article ISI SCOPUS BMC CANCER (2014)
Prevalence of TPMT and ITPA gene polymorphisms and effect on mercaptopurine dosage in Chilean children with acute lymphoblastic leukemia Farfán MJ; Salas C; Canales C; Silva F; Villarroel M; Kopp K; Torres JP; Santolaya ME; Morales J Article BMC Cancer (2014)
Prospective validation of a risk prediction model for severe sepsis in children with cancer and high-risk febrile neutropenia Santolaya ME Article Pediatric Infectious Disease Journal (2013)
Prospective Validation of a Risk Prediction Model for Severe Sepsis in Children With Cancer and High-risk Febrile Neutropenia Santolaya, ME; Alvarez, AM; Aviles, CL; Becker, A; Venegas, M; O´Ryan, M; Salgado, C.; Topelberg S.; Tordecilla, J; Varas, M; Villarroel M.; Viviani T; Zubieta, M; De La Maza, V; Vergara A.; Farfan MJ; Torres, JP Article ISI SCOPUS Pediatric Infectious Disease Journal (2013)
The long polar fimbriae of STEC 0157:H7 induce expression of pro-inflammatory markers by intestinal epithelial cells Farfan MJ; Cantero, L; Vergara A.; Vidal, R; Torres, AG Article ISI SCOPUS Veterinary Immunology and Immunopathology (2013)
The long polar fimbriae os STEC O157: H7 induce expression of pro-inflammatory markers by intestinal epithelial cells. Farfán MJ; Cantero L; Vergara A; Vidal R; Torres AG Article Veterinary Immunology and Immunopathology (2013)
Encefalitis herpetica neonatal: Valor de la clínica versus la Biología Molecular Izquierdo G; Cofré J; Torres JP; Venegas G; Vergara V; Farfán M Article Revista Chilena de Infectología (2012)
Frequency and clinical outcome of respiratory viral infections and mixed viral-bacterial infections in children with cancer, fever and neutropenia Torres JP; Labraña Y; Ibañez C; Kasaneva P; Farfán MJ; De la Maza V; Villarroel M; Vergara I; Piemonte P; Zubieta M; Salgado C; Tordecilla J; Topelberg S; O´Ryan M; Santolaya ME Article Pediatric Infectious Disease Journal (2012)
Frequency and Clinical Outcome of Respiratory Viral Infections and Mixed Viral-bacterial Infections in Children With Cancer, Fever and Neutropenia Torres, J.P.; Labraña Y.; Ibáñez C; Kasaneva P.; Farfan M.J.; De La Maza, V; Villarroel M.; Vergara, I; Piemonte, P; Zubieta, M; Salgado, C.; Tordecilla, J; Topelberg S.; O'Rryan M.; Santolaya M.E. Article ISI SCOPUS PEDIATRIC INFECTIOUS DISEASE JOURNAL (2012)
Neonatal herpes simplex encephalitis: clinical profile versus molecular biology Izquierdo, G; Cofre J.; Torres, JP; Venegas G.; Vergara A.; Farfan, M Article ISI REVISTA CHILENA DE INFECTOLOGIA (2012)
Comparación de las técnicas de reacción de la polimerasa en cadena en tiempo real y antigenemia para la detección de citomegalovirus en sangre en niños sometidos a trasplantes Farfán MJ; Torres JP; Vergara A; Donoso G; Alba A; Paris C; Santolaya ME Article Revista Chilena de Infectología (2011)
Diagnosis of Bacteremia in Febrile Neutropenic Episodes in Children With Cancer Microbiologic and Molecular Approach Santolaya, ME; Farfan MJ; De La Maza, V; Cociña M; santelices F; Alvarez, AM; Aviles, CL; Becker, A; O´Ryan, M; Roman, P.; Salgado, C.; Silva P.; Topelberg S.; Tordecilla, J; Varas, M; Villarroel M.; Viviani T; Zubieta, M; Torres, JP Article ISI SCOPUS Pediatric Infectious Disease Journal (2011)
Diagnosis of Bacteremia in Febrile Neutropenic Episodes in children with cancer: Microbiologic and Molecular Approach Santolaya ME; Farfán MJ; De la Maza V; Álvarez A; Avilés C; Becker A; O´Ryan M; Román P; Salgado C; Silva P; Topelberg S; Tordecilla J; Varas M; Villarroel M; Viviani T; Zubieta M; Torres JP Article Pediatric Infectious Disease Journal (2011)
Long Polar Fimbriae of Enterohemorrhagic Escherichia coli O157:H7 Bind to Extracellular Matrix Proteins Farfan MJ; Cantero, L; Vidal, R; Botkin, DJ; Torres, AG Article ISI SCOPUS Infection and Immunity (2011)
Molecular mechanisms mediating colonization of Shiga toxin producing Escherichia coli strains Farfán MJ; Torres AG Article Infection and Immunity (2011)
Shigella enterotoxin - 2 is a type III effector that participates in Shigella induced interleukin 8 secretion by epithelial cells Farfán MJ; Toro CS; Barry EM; Nataro JP Article FEMS Immunol Med Microbiol (2011)
Shigella enterotoxin-2 is a type III effector that participates in Shigella-induced interleukin 8 secretion by epithelial cells Farfan MJ; Toro, CS; Barry, EM; NATARO, JP Article ISI SCOPUS FEMS Immunology and Medical Microbiology (2011)
The Long Polar Fimbriae of Enterohemorrhagic Escherichia Coli 0157:H7 binds to Extracellular Matrix proteins Farfán MJ; Cantero L; Vidal R; Botkin DJ; Torres AG Article Infection and Immnunity (2011)
A new multiplex PCR for differential identification of Shigella flexneri and Shigella sonnei and detection of Shigella virulence determinants Farfan MJ; Garay, TA; Prado, CA; Filliol, I; Ulloa, MT; Toro, CS Article ISI SCOPUS Epidemiology and Infection (2010)
A new multiplex PCR to identify Shigella differentiates S. flexneri from S. sonnei, and detects Shigella virulence determinants Farfán MJ; Garay T; Ulloa M; Toro C Article Epidemiology and Infection (2010)
Characterization of the most prevalent colonization factor antigens present in Chilean clinical enterotoxigenic Escherichia coli strains using a new multiplex polymerase chain reaction Vidal, RM; Valenzuela P.; Baker, K; Lagos R.; Esparza M.; Livio, S; Farfan, M; NATARO, JP; LEVINE, MM; PRADO, V Article ISI SCOPUS DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2009)
Multiplex PCRs for identification and characterizatrion of enterotoxigenic Escherichia coli: detecting colonization factor antigen genes Vidal R; Valenzuela P; Baker K; Lagos R; Esparza M; Livio S; Farfán M; Nataro J; Levine M; Prado V Article Diagnostic Microbiology and Infectious Disease (2009)
The major pilin subunit of the AAF/II fimbriae from enteroaggreegative E. coli mediates binding to extracellular matrix proteins Farfán MJ; Inman KG; Nataro JP Article Infection and Immunity (2008)
Solution structure of the novel dispersin protein of enteroaggregative Escherichia coli. Velarde JJ; Varney KM; Inman KG; Farfán MJ; Dudley E; Fletcher J; Weber DJ; Nataro JP Article Molecular Microbiology (2007)
Genetic analysis of antibiotic-resistance determinants in multidrug-resistant Shigella strains isolated from Chilean children Toro, CS; Farfan, M; Contreras, I; Flores, O; Navarro, N; Mora, GC; PRADO, V Article ISI SCOPUS EPIDEMIOLOGY AND INFECTION (2005)
Genetic analysis of antibiotic-resistance determinants in multidrug-resistant Shigella strains isolated from Chilean children Toro, CS; Farfan M.; Contreras, I; Flores, O; Navarro, N; Mora, GC; Prado, V Article EPIDEMIOLOGY AND INFECTION (2005)
Preliminary evaluation of DNA damage related with the smoking habit measured by the comet assay in whole blood cells Ellahuene, MF; Perez-Alzola, LP; Farfan-Urzua, M; Gonzalez-Hormazabal, P; Garay, M; Olmedo, MI; Last, JA Article CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2004)
Molecular characterization of resistance mechanisms to chloramphenicol in Shigella flexneri strains isolated from Chilean children with acute diarrhea Farfan M.; Flores, O; Navarro, N; Prado, V; Mora, G; Toro C. Article Revista médica de Chile (2002)
Molecular characterization of resistance mechanisms to chloramphenicol in Shigella flexneri strains isolated from Chilean children with acute diarrhea Farfan, M; Flores, O; Navarro, N; PRADO, V; Mora, G; Toro, C. Article ISI REVISTA MEDICA DE CHILE (2002)


Hybrid and potentially pathogenic Escherichia coli strains Garcia-Angulo V.A.; Farfan M.J.; Torres A.G. BookWhole SCOPUS From Molecules to Networks: An Introduction to Cellular and Molecular Neuroscience: Third Edition (2013)


Encefalitis herpética neonatal: valor de la clínica versusla biología molecular Izquierdo, G; Vergara A.; Farfan, M; Cofre J.; Torres, J.P.; Venegas G. CaseReport SCIELO SCOPUS REVISTA CHILENA DE INFECTOLOGIA (2012)


"Diagnóstico en medicina en la era de las ""omicas""" Mauricio J. Farfán; Juan Pablo Torres Editorial WOS-ESCI SCIELO SCOPUS Revista chilena de pediatría (2018)


Enterovirus D68 Infection, Chile, Spring 2014 Torres, JP; Farfan MJ; Izquierdo, G; Piemonte, P; Henriquez, J.; O'Ryan, ML Letter ISI SCOPUS Emerging Infectious Diseases (2015)


DEVELOPMENT OF NEW DIAGNOSTIC OPTIONS FOR ENTEROAGGREGATIVE ESCHERICHIA COLI AS AN IMPORTANT DIARRHEAL PATHOGEN PCI (ERANet17/H) Proyecto 2019-2021 Inv. Principal
PLATAFORMA INFORMÁTICA BASADA EN MACHINE LEARNING PARA OPTIMIZAR EL MANEJO DE LOS EPISODIOS DE FIEBRE Y NEUTROPENIA EN NIÑOS CON CÁNCER FONDEF (ID18I10293) Proyecto 2018-2020 Investigador(a)
VIRAL FACTORS, HOST IMMUNE RESPONSE AND NASOPHARYNGEAL MICROBIOTA AS DETERMINANTS OF THE SEVERITY OF RESPIRATORY VIRAL INFECTIONS IN CHILDREN WITH HEMATOPOIETIC STEM CELL TRANSPLANT FONDECYT (1171795) Proyecto 2017-2021 Coinvestigador(a)
BACTERIAL MICROBIOTA STRAINS ASSOCIATED WITH DIARRHEOGENIC E. COLI INFECTION PROMOTES FIMBRIAL-MEDIATED ADHERENCE AND INFLAMMATION INDUCTION OF ENTEROAGGREGATIVE AND SHIGA TOXIN-PRODUCING E. COLI TO INTESTINAL CELLS FONDECYT (1160426) Proyecto 2016-2020 Inv. Responsable
CHARACTERIZATION OF NEW GENETIC MARKERS ENCODED WITHIN AN UNDESCRIBED LOCUS OF ADHERENCE AND AUTOAGGREGATION (LAA) PRESENT IN EMERGING CLINICALLY RELEVANT SHIGA TOXIN-PRODUCING E.COLI STRAINS. FONDECYT (1161161) Proyecto 2016-2020 Coinvestigador(a)
GENETIC AND SYSTEMIC BIOMARKERS ASSOCIATED WITH SEVERITY OF INVASIVE FUNGAL DISEASE IN CHILDREN WITH CANCER, FEVER AND NEUTROPENIA=> A NEW INSIGHT FONDECYT (1161662) Proyecto 2016-2020 Coinvestigador(a)
IMPLEMENTACIÓN DE UNA PLATAFORMA DE ANÁLISIS DE BIOMARCADORES PARA LA INVESTIGACIÓN EN PEDIATRÍA FONDEQUIP (EQM150037) Proyecto 2016-2017 Director(a)
CLINICAL SEVERITY AND SPECIFIC GENE EXPRESSION PROFILE IN RESPIRATORY VIRAL INFECTIONS IN CHILDREN WITH CANCER, FEVER AND NEUTROPENIA=> A STEP FORWARD FONDECYT (11309011) Proyecto 2013-2016 Coinvestigador(a)
ASSOCIATION OF FIBRONECTIN WITH THE SECRETION OF PRO-INFLAMMATORY CYTOKIN ES BYINTESTINAL CELLS INFECTED WITH DIARRHEAGENIC E.COLI FONDECYT (1120809) Proyecto 2012-2016 Inv. Principal
ROL DE POLIMORFISMOS DE LA ENZIMA CYP3A5 EN EL METABOLISMO DE TACROLIMUS EN NIÑOS SOMETIDOS A TRASPLANTE RENAL SOCIEDAD CHILENA DE TRASPLANTE Proyecto 2012-2013 Coinvestigador(a)
TOWARDS A MORE RATIONAL APPROACH IN THE COMPREHENSIVE MANAGEMENT OF THE CHILD WITH CANCER, FEVER AND NEUTROPENIA=> FILLING THE GAPS. FONDECYT (1120800) Proyecto 2012-2016 Coinvestigador(a)
IDENTIFICACION OF IMMUNODOMINANT ANTIGENS IN SHIGATOXIN PRODUCING ESCHERICHIA COLI THAT PARTICIPATE IN ADHESION TO HUMAN INTESTINAL CELLS=> SEROLOGICAL CHARACTERIZATION AND POSSIBLE USE AS IMMUNOGENS FOR PROTECTIVE VACCINE DEVELOPMENT FONDECYT (1110260) Proyecto 2011-2015 Coinvestigador(a)
PERFILES TRANSCRIPCIONALES Y DIAGNOSTICO MICROBIOLOGICO MOLECULAR PARA AVANZAR EN EL DIAGNOSTICO DE SEPSIS Y EN LA IDENTIFICACION DEL MICROORGANISMO CAUSAL EN NIQOS CON CANCER, NEUTROPENIA Y FIEBRE FONDECYT (1090194) Proyecto 2009-2012 Personal técnico y/o de apoyo
PREVALENCIA DE POLIMORFISMOS EN LA ENZIMA TPMT EN PACIENTES PEDIATRICOS CON LEUCEMIA LINFOBLASTICA AGUDA EN EL HOSPITAL DR. LUIS CALVO MACKENNA FUNDACION NUESTROS HIJOS Proyecto 2009-2010 Coinvestigador(a)
FIBRONECTIN PARTICIPATION IN THE ADHESION OF DIARRHOEAGENIC E. COLI TO INTESTINAL CELLS FONDECYT (11080180) Proyecto 2008-2011 Inv. Responsable
VIRULENCE IN ENTEROAGGREGATIVE ESCHERICHIA COLI PROYECTO NATIONAL INSTITUTE OF HEALTH AI033096 Proyecto 2006-2008 Postdoctorado


Bacterial Gut Microbiota and Infections During Early Childhood George, Sergio; Aguilera, Ximena; Gallardo, Pablo; Farfan, Mauricio; Lucero, Yalda; Torres, Juan Pablo; Vidal, Roberto; O'Ryan, Miguel Review ISI FRONTIERS IN MICROBIOLOGY (2022)
Molecular Mechanisms That Mediate Colonization of Shiga Toxin-Producing Escherichia coli Strains Farfan M.J.; Torres A.G. Review ISI SCOPUS Infection and Immunity (2012)

Mauricio Farfán

Profesor Asociado

Departamento de Pediatria y Cirugia Infantil, Hospital Dr. Luis Calvo Mackenna, Facultad de Medicina, Universidad de Chile

Universidad de Chile

Providencia, Chile

roberto vidal

Head of Pathogenic Escherichia coli Laboratory

Director Microbiology and Mycology Program

UNIVERSIDAD DE CHILE

Santiago, Chile

Miguel O'Ryan

Profesor Titular

Programa de Microbiologia y Micologia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Veronica De la Maza

Profesor academico

Pediatra y Cirugía

Universidad de Chile

Santiago, Chile

Mariana Izquierdo

Profesor Asistente

Departamento de Pediatría y Cirugía Infantil Oriente

Universidad de Chile

Santiago, Chile

Milena Villarroel

JEFE CENTRO DE RESPONSABILIDAD

PEDIATRIA

HOSPITAL LUIS CALVO MACKENNA

Santiago, Chile

David Montero

Profesor Asistente

Microbiología

Universidad de Concepción

Concepción, Chile

Yalda Lucero

Profesor Asistente

Programa de Microbiología y Micología; Departamento de Pediatría y Cirugía infantil;

DIVISIÓN NORTE, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE, DEPARTAMENTO DE PEDIATRÍA Y CIRUGÍA INFANTIL-HOSPITAL LUIS CALVO MACKENNA

Santiago, Chile

Marjorie De la Fuente

Académico investigador

Facultad de Medicina

Universidad Finis Terrae

Santiago , Chile

Pablo Román

Profesor Asistente

Departamento de Ingeniería Informática

Universidad de Santiago de Chile

Santiago, Chile

Niurka Navarro

Gerente

Innovación y Desarrollo

Nutri-Omics SpA

Samtiago, Chile

Jorge Morales

Jefe de Farmacia y Servicios Farmaceuticos

Subdirección Médica

Hospital Dr. Luis Calvo Mackenna

Santiago, Chile

Felipe Del Canto

Profesor Asistente

Programa de Microbiologia y Micologia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Juan Pablo Torres

Jefe Unidad de Investigación Clínica

Pediatría y Cirugía Infantil Oriente

UNIVERSIDAD DE CHILE

Santiago, Chile

Juan Ossa

Profesor asistente

Pediatria y Cirugia Oriente

Universidad De Chile, Hospital Luis Calvo Mackenna

Santiago, Chile

Johanna Acevedo

Profesor asociado investigador

Instituto de Ciencias e Innovación en Medicina (ICIM)

Universidad del Desarrollo

Santiago, Chile

Ricardo Soto

PROFESOR ASOCIADO

FACULTAD DE MEDICINA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Daniela Gutiérrez

Encargada de laboratorio Ingeniería sanitaria

Ingeniería

Universidad de Santiago de Chile

Santiago, Chile

Guido Mora

Académico/Investigador

Facultad Ciencias de la Salud

Universidad SEK

Santiago, Chile

Tamara Garay

Profesor Asistente

Universidad de Santiago de Chile

Santiago, Chile

Leonardo Sáenz

Profesor Asociado

Ciencias Biológicas Animales

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS

Santiago, Chile

Sandra Solari

Profesor Clinico Asociado

Laboratorios Clinicos

Facultad de Medicina - PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Sergio George

Tesista Doctorado en Ciencias Médicas y Especialidad en Pediatría

Facultad de Medicina

Universidad de Chile

Santiago, Chile

Fernando Valiente

Profesor Asociado

ICBM

Universidad de Chile

Santiago, Chile

Romina Valenzuela

Enfermera

Cirugia y pediatria Oriente

universidad de chile

santiago, Chile

Felipe Santelices

Instructor Adjunto

Neonatología

Universidad Católica de Chile

Santiago, Chile

Lorena Tapia

Profesora Asociada

Departamento de Pediatría y Cirugía Infantil Norte

Universidad de Chile

Santiago, Chile

Maria Santolaya

Pediatra infectologa, Profesor titular

Pediatria, Campus Oriente

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, DEPARTAMENTO DE PEDIATRÍA ORIENTE

Santiago, Chile

Paola Krall

Profesor Auxiliar

Universidad Austral de Chile

Valdivia, Chile

Magdalena Castro

Coordinadora de Investigación

Medicina

Universidad Finis Terrae

Santiago, Chile

Luis Castañeda

Assistant Professor

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

Angel Onate

Profesor Titular

Microbiología

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Alonso De la Rivera

María Ulloa

Jefe de Laboratorio

Fundación COANIQUEM Avances Tecnológicos

Santiago, Chile

Aldo Gaggero

Académico. Profesor Asociado.

Virología

ICBM. FACULTAD DE MEDICINA. UNIVERSIDAD DE CHILE.

Santiago, Chile

Patricia García

Jefe de Laboratorio de Microbiologia

Escuela de Medicina

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, LABORATORIO DE MICROBIOLOGÍA

Santiago, Chile

Alberto Toso

Médico asistencial

Neonatología

Pontificia Universidad Católica de Chile

Santiago, Chile

Mauricio Javier Farfán Urzúa

Líneas de Investigación

Educación

Bioquímico, UNIVERSIDAD DE CHILE. Chile, 2012

Químico Farmacéutico, UNIVERSIDAD DE CHILE. Chile, 2015

Doctor en Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2016

Experiencia Académica

Posdoctoral fellow Full Time

Profesor Asociado Full Time

Bioquimico Asesor Laboratorio de Biología Molecular Other

Experiencia Profesional

Postdoctoral fellow Full Time

Profesor Asistente Full Time

Profesor Asociado Full Time

Jefatura Laboratorio de Biología Molecular Other

Bioqumico Asesor Laboratorio de Biología Molecular Other

Formación de Capital Humano

Article (73)

BookWhole (1)

CaseReport (1)

Editorial (1)

Letter (1)

Proyecto (16)

DEVELOPMENT OF NEW DIAGNOSTIC OPTIONS FOR ENTEROAGGREGATIVE ESCHERICHIA COLI AS AN IMPORTANT DIARRHEAL PATHOGEN

PLATAFORMA INFORMÁTICA BASADA EN MACHINE LEARNING PARA OPTIMIZAR EL MANEJO DE LOS EPISODIOS DE FIEBRE Y NEUTROPENIA EN NIÑOS CON CÁNCER

VIRAL FACTORS, HOST IMMUNE RESPONSE AND NASOPHARYNGEAL MICROBIOTA AS DETERMINANTS OF THE SEVERITY OF RESPIRATORY VIRAL INFECTIONS IN CHILDREN WITH HEMATOPOIETIC STEM CELL TRANSPLANT

BACTERIAL MICROBIOTA STRAINS ASSOCIATED WITH DIARRHEOGENIC E. COLI INFECTION PROMOTES FIMBRIAL-MEDIATED ADHERENCE AND INFLAMMATION INDUCTION OF ENTEROAGGREGATIVE AND SHIGA TOXIN-PRODUCING E. COLI TO INTESTINAL CELLS

CHARACTERIZATION OF NEW GENETIC MARKERS ENCODED WITHIN AN UNDESCRIBED LOCUS OF ADHERENCE AND AUTOAGGREGATION (LAA) PRESENT IN EMERGING CLINICALLY RELEVANT SHIGA TOXIN-PRODUCING E.COLI STRAINS.

GENETIC AND SYSTEMIC BIOMARKERS ASSOCIATED WITH SEVERITY OF INVASIVE FUNGAL DISEASE IN CHILDREN WITH CANCER, FEVER AND NEUTROPENIA=> A NEW INSIGHT

IMPLEMENTACIÓN DE UNA PLATAFORMA DE ANÁLISIS DE BIOMARCADORES PARA LA INVESTIGACIÓN EN PEDIATRÍA

CLINICAL SEVERITY AND SPECIFIC GENE EXPRESSION PROFILE IN RESPIRATORY VIRAL INFECTIONS IN CHILDREN WITH CANCER, FEVER AND NEUTROPENIA=> A STEP FORWARD

ASSOCIATION OF FIBRONECTIN WITH THE SECRETION OF PRO-INFLAMMATORY CYTOKIN ES BYINTESTINAL CELLS INFECTED WITH DIARRHEAGENIC E.COLI

ROL DE POLIMORFISMOS DE LA ENZIMA CYP3A5 EN EL METABOLISMO DE TACROLIMUS EN NIÑOS SOMETIDOS A TRASPLANTE RENAL

TOWARDS A MORE RATIONAL APPROACH IN THE COMPREHENSIVE MANAGEMENT OF THE CHILD WITH CANCER, FEVER AND NEUTROPENIA=> FILLING THE GAPS.

IDENTIFICACION OF IMMUNODOMINANT ANTIGENS IN SHIGATOXIN PRODUCING ESCHERICHIA COLI THAT PARTICIPATE IN ADHESION TO HUMAN INTESTINAL CELLS=> SEROLOGICAL CHARACTERIZATION AND POSSIBLE USE AS IMMUNOGENS FOR PROTECTIVE VACCINE DEVELOPMENT

PERFILES TRANSCRIPCIONALES Y DIAGNOSTICO MICROBIOLOGICO MOLECULAR PARA AVANZAR EN EL DIAGNOSTICO DE SEPSIS Y EN LA IDENTIFICACION DEL MICROORGANISMO CAUSAL EN NIQOS CON CANCER, NEUTROPENIA Y FIEBRE

PREVALENCIA DE POLIMORFISMOS EN LA ENZIMA TPMT EN PACIENTES PEDIATRICOS CON LEUCEMIA LINFOBLASTICA AGUDA EN EL HOSPITAL DR. LUIS CALVO MACKENNA

FIBRONECTIN PARTICIPATION IN THE ADHESION OF DIARRHOEAGENIC E. COLI TO INTESTINAL CELLS

VIRULENCE IN ENTEROAGGREGATIVE ESCHERICHIA COLI

Review (2)