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Ricardo Andrés Soto Rifo

PROFESOR ASOCIADO

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Virology; HIV; RNA Biology; Epitranscriptomics; Molecular Biology; Inflammation

Molecular and Cellular Biology, ECOLE NORMALE SUPERIEURE DE LYON. Francia, 2010
Molecular and Cellular Biology, UNIVERSITE CLAUDE BERNARD LYON-1. Chile, 2006
BIOCHEMIST, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 2004

ASSISTANT PROFESSOR Full Time

UNIVERSIDAD DE CHILE

FACULTAD DE MEDICINA

SANTIAGO, Chile

2013 - 2017
ASSOCIATE PROFESSOR Full Time

UNIVERSIDAD DE CHILE

FACULTAD DE MEDICINA

SANTIAGO, Chile

2017 - A la fecha

POST-DOC Full Time

INSERM

Lyon, Francia

2010 - 2012

Postdoctorantes

Dr. Daniela Toro Ascuy, Fondecyt post-doctoral grant Nº 3160091 “A landscape of the HIV-1 full-length unspliced mRNA nuclear export and translation initiation complexes” (2015-2018)

GRADUATE STUDENTS

1) Mr. Felipe León, Master Program in Biochemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile (2018-present)
2) Ms. Camila Pereira Montecinos, Graduate Program in Biomedical Sciences, Faculty of Medicine, University of Chile (2017-present)
3) Ms. Paulina Aguilera, Graduate Program in Microbiology, Faculty of Sciences, University of Chile (2017-present)
4) Mr. Sebastian Riquelme, Graduate Program in Microbiology, Faculty of Sciences, University of Chile (2017-present)
5) Mr. Bárbara Rojas, Graduate Program in Biochemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile ( 2017-present)
6) Mr. Francisco Garcia, Graduate Program in Microbiology, Faculty of Sciences, University of Chile (2014-2019)
7) Ms. Paulina Rubilar Guzmán, Master Research in Molecular and Cellular Biology, Université Claude Bernard Lyon-1, France (2010-2011)

UNDERGRADUATE STUDENTS

1) Mr. Eduardo Isla, Biochemistry, Universidad de Santiago de Chile (2018-present)
2) Mr. Alvaro Thadani Biotechnology Enginner, Universidad de Chile (2016-2018)
3) Ms. Alejandra Leyva, Biotechnology Enginner, Universidad de Chile (2016-2018)
4) Ms. Barbara Rojas, Biotechnology, Universidad Santo Tomás (2014-2016)
5) Mr Alvaro Frohlich, Biochemistry, Pontificia Universidad Católica de Valparaiso (2014-2015)

Científico Jóven del año

Sociedad de Biología Celular de Chile

Chile, 2018

Este premio lo otorga la Sociedad de Biología Celular de Chile junto a GrupoBios para reconocer al científico jóven del año (menor de 40 años). El año 2018 fue elegido entre más de 20 postulantes.


Differential neutralizing antibody responses elicited by CoronaVac and BNT162b2 against SARS-CoV-2 Lambda in Chile Acevedo, Monica L.; Gaete-Argel, Aracelly; Alonso-Palomares, Luis; de Oca, Marco Montes; Bustamante, Andres; Gaggero, Aldo; Paredes, Fabio; Cortes, Claudia P.; Pantano, Sergio; Martinez-Valdebenito, Constanza; Angulo, Jenniffer; Le Corre, Nicole; Ferres, Marcela; Navarrete, Marcelo A.; Valiente-Echeverria, Fernando; Soto-Rifo, Ricardo Article ISI NATURE MICROBIOLOGY (2022)
Epitranscriptomic regulation of HIV-1 full-length RNA packaging Pereira-Montecinos, Camila; Toro-Ascuy, Daniela; Ananias-Saez, Catarina; Gaete-Argel, Aracelly; Rojas-Fuentes, Cecilia; Riquelme-Barrios, Sebastian; Rojas-Araya, Barbara; Garcia-de-Gracia, Francisco; Aguilera-Cortes, Paulina; Chnaiderman, Jonas; Acevedo, Monica L.; Valiente-Echeverria, Fernando; Soto-Rifo, Ricardo Article ISI NUCLEIC ACIDS RESEARCH (2022)
Evaluation of the Immune Response Induced by CoronaVac 28-Day Schedule Vaccination in a Healthy Population Group Escobar, Alejandro; Reyes-Lopez, Felipe E.; Acevedo, Monica L.; Alonso-Palomares, Luis; Valiente-Echeverria, Fernando; Soto-Rifo, Ricardo; Portillo, Hugo; Gatica, Jimena; Flores, Ivan; Nova-Lamperti, Estefania; Barrera-Avalos, Carlos; Bono, Maria Rosa; Vargas, Leonardo; Simon, Valeska; Leiva-Salcedo, Elias; ; Vial, Cecilia; Hormazabal, Juan; Cortes, Lina Jimena; Valdes, Daniel; Sandino, Ana M.; Imarai, Monica; Acuna-Castillo, Claudio Article ISI FRONTIERS IN IMMUNOLOGY (2022)
Neutralizing antibody titers elicited by CoronaVac and BNT162b2 vaccines in health care workers with and without prior SARS-CoV-2 infection Wolff, Marcelo J.; Acevedo, Monica L.; Nunez, Maria Antonieta; Lafourcade, Monica; Gaete-Argel, Aracelly; Soto-Rifo, Ricardo; Valiente-Echeverria, Fernando Article ISI JOURNAL OF TRAVEL MEDICINE (2022)
Screening of Natural Products Inhibitors of SARS-CoV-2 Entry Gonzalez-Maldonado, Pamela; Alvarenga, Nelson; Burgos-Edwards, Alberto; Flores-Giubi, Ma. Eugenia; Barua, Javier E.; Romero-Rodriguez, Ma. Cristina; Soto-Rifo, Ricardo; Valiente-Echeverria, Fernando; Langjahr, Patricia; Cantero-Gonzalez, Guadalupe; Sotelo, Pablo H. Article ISI MOLECULES (2022)
Sustained Antibody-Dependent NK Cell Functions in Mild COVID-19 Outpatients During Convalescence Fuentes-Villalobos, Francisco; Garrido, Jose L.; Medina, Matias A.; Zambrano, Nicole; Ross, Natalia; Bravo, Felipe; Gaete-Argel, Aracelly; Oyarzun-Arrau, Aaron; Amanat, Fatima; Soto-Rifo, Ricardo; Valiente-Echeverria, Fernando; Ocampo, Renato; Esveile, Christian; Ferreira, Leonila; Cabrera, Johanna; Torres, Vivianne; Rioseco, Maria L.; Riquelme, Raul; Barria, Sebastian; Alvarez, Raymond; Pinos, Yazmin; Krammer, Florian; Calvo, Mario; Barria, Maria I.; COVID South Chile Grp Article ISI FRONTIERS IN IMMUNOLOGY (2022)
Accuracy of a RT-qPCR SARS-CoV-2 detection assay without prior RNA extraction Beltran-Pavez, Carolina; Alonso-Palomares, Luis A.; Valiente-Echeverria, Fernando; Gaggero, Aldo; Soto-Rifo, Ricardo; Barriga, Gonzalo P. Article ISI JOURNAL OF VIROLOGICAL METHODS (2021)
CBP80/20-dependent translation initiation factor (CTIF) inhibits HIV-1 Gag synthesis by targeting the function of the viral protein Rev Garcia-de-Gracia, Francisco; Gaete-Argel, Aracelly; Riquelme-Barrios, Sebastian; Pereira-Montecinos, Camila; Rojas-Araya, Barbara; Aguilera, Paulina; Oyarzun-Arrau, Aaron; Rojas-Fuentes, Cecilia; Acevedo, Monica L.; Chnaiderman, Jonas; Valiente-Echeverria, Fernando; Toro-Ascuy, Daniela; Soto-Rifo, Ricardo Article ISI RNA BIOLOGY (2021)
Early versus deferred anti-SARS-CoV-2 convalescent plasma in patients admitted for COVID-19: A randomized phase II clinical trial Balcells, Maria Elvira; Rojas, Luis; Le Corre, Nicole; Martinez-Valdebenito, Constanza; Ceballos, Maria Elena; Ferres, Marcela; Chang, Mayling; Vizcaya, Cecilia; Mondaca, Sebastian; Huete, Alvaro; Castro, Ricardo; Sarmiento, Mauricio; Villarroel, Luis; Pizarro, Alejandra; Ross, Patricio; Santander, Jaime; Lara, Barbara; Ferrada, Marcela; Vargas-Salas, Sergio; Beltran-Pavez, Carolina; Soto-Rifo, Ricardo; Valiente-Echeverria, Fernando; Caglevic, Christian; Mahave, Mauricio; Selman, Carolina; Gazitua, Raimundo; Briones, Jose Luis; Villarroel-Espindola, Franz; Balmaceda, Carlos; Espinoza, Manuel A.; Pereira, Jaime; Nervi, Bruno Article ISI PLOS MEDICINE (2021)
Escherichia coli HS and Enterotoxigenic Escherichia coli Hinder Stress Granule Assembly Velasquez, Felipe; Marin-Rojas, Josefina; Soto-Rifo, Ricardo; Torres, Alexia; Del Canto, Felipe; Valiente-Echeverria, Fernando Article ISI Microorganisms (2021)
Insights into neutralizing antibody responses in individuals exposed to SARS-CoV-2 in Chile Beltran-Pavez, Carolina; Riquelme-Barrios, Sebastian; Oyarzun-Arrau, Aaron; Gaete-Argel, Aracelly; Gonzalez-Stegmaier, Roxana; Cereceda-Solis, Karina; Aguirre, Adam; Travisany, Dante; Palma-Vejares, Ricardo; Barriga, Gonzalo P.; Gaggero, Aldo; Martinez-Valdebenito, Constanza; Le Corre, Nicole; Ferres, Marcela; Balcells, Maria Elvira; Fernandez, Jorge; Ramirez, Eugenio; Villarroel, Franz; Valiente-Echeverria, Fernando; Soto-Rifo, Ricardo Article ISI SCIENCE ADVANCES (2021)
N-6 -Methyladenosine Negatively Regulates Human Respiratory Syncytial Virus Replication Figueroa, Fabian; Vega-Gibson, Alonso; Catrileo, Joseline; Gaete-Argel, Aracelly; Riquelme-Barrios, Sebastian; Antonio Alonso-Palomares, Luis; Tapia, Lorena, I; Valiente-Echeverria, Fernando; Soto-Rifo, Ricardo; Acevedo, Monica L. Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
Performance of SARS-CoV-2 rapid antigen test compared with real-time RT-PCR in asymptomatic individuals Pena, Monica; Ampuero, Manuel; Garces, Carlos; Gaggero, Aldo; Garcia, Patricia; Soledad Velasquez, Maria; Luza, Ricardo; Alvarez, Pia; Paredes, Fabio; Acevedo, Johanna; Farfan, Mauricio J.; Solari, Sandra; Soto-Rifo, Ricardo; Valiente-Echeverria, Fernando Article ISI INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)
RNA Helicase DDX3: A Double-Edged Sword for Viral Replication and Immune Signaling Hernandez-Diaz, Tomas; Valiente-Echeverria, Fernando; Soto-Rifo, Ricardo Article ISI Microorganisms (2021)
Safety and Immunogenicity of an Inactivated Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine in a Subgroup of Healthy Adults in Chile Bueno, Susan M.; Abarca, Katia; Gonzalez, Pablo A.; Galvez, Nicolas M. S.; Soto, Jorge A; Duarte, Luisa F.; Schultz, Barbara M.; Pacheco, Gaspar A.; Gonzalez, Liliana A.; Vazquez, Yaneisi; Rios, Mariana; Melo-Gonzalez, Felipe; Rivera-Perez, Daniela; Iturriaga, Carolina; Urzua, Marcela; Dominguez, Angelica; Andrade, Catalina A.; Berrios-Rojas, Roslye, V; Canedo-Marroquin, Gisela; Covian, Camila; Moreno-Tapia, Daniela; Saavedra, Farides; Vallejos, Omar P.; Donato, Paulina; Espinoza, Pilar; Fuentes, Daniela; Gonzalez, Marcela; Guzman, Paula; Munoz Venturelli, Paula; Perez, Carlos M.; Potin, Marcela; Rojas, Alvaro; Fasce, Rodrigo A.; Fernandez, Jorge; Mora, Judith; Ramirez, Eugenio; Gaete-Argel, Aracelly; Oyarzun-Arrau, Aaron; Valiente-Echeverria, Fernando; Soto-Rifo, Ricardo; Weiskopf, Daniela; Sette, Alessandro; Zeng, Gang; Meng, Weining; Gonzalez-Aramundiz, Jose, V; Kalergis, Alexis M.; CoronaVac03CL Study Grp Article ISI CLINICAL INFECTIOUS DISEASES (2021)
Seroconversion and Abundance of IgG Antibodies against S1-RBD of SARS-CoV-2 and Neutralizing Activity in the Chilean Population Gonzalez-Stegmaier, R.; Cereceda, K.; Briones, J. L.; Beltran-Pavez, C.; Oyarzun-Arrau, A.; Riquelme-Barrios, S.; Selman, C.; Yarad, F.; Mahave, M.; Caglevic, C.; Morales, R.; Aguirre, A.; Valiente-Echeverria, F.; Soto-Rifo, R.; Marsiglia, H.; Gazitua, R.; Villarroel-Espindola, F. Article ISI JOURNAL OF IMMUNOLOGY RESEARCH (2021)
Surveillance of seasonal respiratory viruses among Chilean patients during the COVID-19 pandemic Alonso-Palomares, Luis A.; Caceres, C. Joaquin; Tapia, Rodrigo; Aguilera-Cortes, Paulina; Valenzuela, Santiago; Valiente-Echeverria, Fernando; Soto-Rifo, Ricardo; Gaggero, Aldo; Barriga, Gonzalo P. Article ISI HEALTH SCIENCE REPORTS (2021)
Tellurite Promotes Stress Granules and Nuclear SG-Like Assembly in Response to Oxidative Stress and DNA Damage Gaete-Argel, Aracelly; Velasquez, Felipe; Marquez, Chantal L.; Rojas-Araya, Barbara; Bueno-Nieto, Constanza; Marin-Rojas, Josefina; Cuevas-Zuniga, Miguel; Soto-Rifo, Ricardo; Valiente-Echeverria, Fernando Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
The Landscape of IFN/ISG Signaling in HIV-1-Infected Macrophages and Its Possible Role in the HIV-1 Latency Rojas, Masyelly; Luz-Crawford, Patricia; Soto-Rifo, Ricardo; Reyes-Cerpa, Sebastian; Toro-Ascuy, Daniela Article ISI CELLS (2021)
Bacterial Synthesis of Ternary CdSAg Quantum Dots through Cation Exchange: Tuning the Composition and Properties of Biological Nanoparticles for Bioimaging and Photovoltaic Applications Ordenes-Aenishanslins, Nicolas; Anziani-Ostuni, Giovanna; Pablo Monras, Juan; Tello, Alejandra; Bravo, Denisse; Toro-Ascuy, Daniela; Soto-Rifo, Ricardo; Prasad, Paras N.; Manuel Perez-Donoso, Jose Article ISI Microorganisms (2020)
Crosstalk between RNA Metabolism and Cellular Stress Responses during Zika Virus Replication Oyarzún-Arrau A, Alonso-Palomares L, Valiente-Echeverría F, Osorio F, Soto-Rifo R Article Pathogens (2020)
Meteorological impact on the COVID-19 pandemic: A study across eight severely affected regions in South America Zhu, Liting; Liu, Xiaobo; Huang, Haining; Avellan-Llaguno, Ricardo David; Lazo, Mauricio Manuel Llaguno; Gaggero, Aldo; Soto-Rifo, Ricardo; Patino, Leandro; Valencia-Avellan, Magaly; Diringer, Benoit; Huang, Qiansheng; Zhu, Yong-Guan Article ISI SCIENCE OF THE TOTAL ENVIRONMENT (2020)
DISC1 promotes translation maintenance during sodium arsenite-induced oxidative stress Fuentes-Villalobos, Francisco; Farkas P., Carlos; Riquelme-Barrios, Sebastian; Armijo, M.E.; Soto-Rifo, Ricardo; Pincheira, Roxana;; Castro, Ariel F. Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2019)
Inhibition of miR-378a-3p by Inflammation Enhances IL-33 Levels: A Novel Mechanism of Alarmin Modulation in Ulcerative Colitis Dubois-Camacho, Karen; Diaz-Jimenez, David; De la Fuente, Marjorie; Quera, Rodrigo; Simian, Daniela; Martinez, Maripaz; Landskron, Glauben; Olivares-Morales, Mauricio; Cidlowski, John A.; Xu, Xiaojiang; Gao, Guangping; Xie, Jun; Chnaiderman, Jonas; Soto-Rifo, Ricardo; Gonzalez, Maria-Julieta; Calixto, Andrea.; Hermoso, Marcela A. Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2019)
Salmon cells SHK-1 internalize infectious pancreatic necrosis virus by macropinocytosis Levicán?Asenjo, Jorge; Soto?Rifo, Ricardo; Aguayo, Francisco; Gaggero, Aldo; Leon, Oscar Article ISI SCOPUS JOURNAL OF FISH DISEASES (2019)
Strategies for Success. Viral Infections and Membraneless Organelles Aracelly Gaete-Argel; Chantal L. Márquez; Gonzalo P. Barriga; Ricardo Soto-Rifo; Fernando Valiente-Echeverría Article ISI SCOPUS FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2019)
A Rev–CBP80–eIF4AI complex drives Gag synthesis from the HIV-1 unspliced mRNA Toro-Ascuy, Daniela; Rojas-Araya, Bárbara; García-de-Gracia, Francisco; Rojas-Fuentes, Cecilia; Pereira-Montecinos, Camila; Gaete-Argel, Aracelly; Valiente-Echeverría, Fernando; Ohlmann, Théophile; Soto-Rifo, Ricardo Article ISI SCOPUS Nucleic Acids Research (2018)
Differences in the internalization of self-inactivating VSVG-pseudotyped murine leukemia virus-based vectors in human and murine cells Acevedo, Mónica Loreto; García-de Gracia, Francisco; Miranda-Cárdenas, Camila; Soto-Rifo, Ricardo; Aguayo, Francisco; León, Oscar Article ISI SCOPUS JOURNAL OF VIROLOGICAL METHODS (2018)
Emerging Roles of N-6-Methyladenosine on HIV-1 RNA Metabolism and Viral Replication Riquelme-Barrios, Sebastián; Pereira-Montecinos, Camila; Valiente-Echeverría, Fernando; Soto-Rifo, Ricardo Article ISI SCOPUS FRONTIERS IN MICROBIOLOGY (2018)
Epitranscriptomic regulation of viral replication Pereira-Montecinos, Camila; Valiente-Echeverría, Fernando; Soto-Rifo, Ricardo Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2017)
Infectious pancreatic necrosis virus enters CHSE-214 cells via macropinocytosis Levican J, Miranda C, Soto-Rifo R, Aguayo F, gaggero A, Leon O. Article ISI SCOPUS SCIENTIFIC REPORTS (2017)
microRNAs stimulate translation initiation mediated by HCV-like IRESes Mengardi, Chloe; Limousin, Taran; Ricci, Emiliano P.; Soto-Rifo, Ricardo; Decimo, Didier; Ohlmann, Theophile Article ISI NUCLEIC ACIDS RESEARCH (2017)
DEAD-box RNA helicase DDX3 connects CRM1-dependent nuclear export and translation of the HIV-1 unspliced mRNA through its N-terminal domain Fröhlich A.; Rojas-Araya B.; Pereira-Montecinos C.; Dellarossa A.; Toro-Ascuy, D.; Prades-Pérez Y.; García-de-Gracia F.; Garcés-Alday A.; Rubilar P.S.; Valiente-Echeverría F.; Ohlmann T.; Soto-Rifo, R Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2016)
Interactions between the HIV-1 Unspliced mRNA and Host mRNA Decay Machineries Toro-Ascuy, Daniela; Rojas-Araya, Bárbara; Valiente-Echeverría, Fernando; Soto-Rifo, Ricardo Article ISI SCOPUS VIRUSES-BASEL (2016)
Who Regulates Whom? An Overview of RNA Granules and Viral Infections Poblete-Durn, Natalia; Prades-Prez, Yara; Vera-Otarola, Jorge; Soto-Rifo, Ricardo; Valiente-Echeverra, Fernando Article ISI SCOPUS VIRUSES-BASEL (2016)
HIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA Lara Ajamian, Karen Abel, Shringar Rao, Kishanda Vyboh, Francisco García-de-Gracia, Ricardo Soto-Rifo, Andreas Kulozik, Niels Gehring, Andrew Mouland Article Biomolecules (2015)
RNA helicase DDX3: at the crossroad of viral replication and antiviral immunity Fernando Valiente-Echeverria, Marcela A. Hermoso and Ricardo Soto-Rifo Article Reviews in Medical Virology (2015)
Tobacco Smoke Activates Human Papillomavirus 16 p97 Promoter and Cooperates with High-Risk E6/E7 for Oxidative DNA Damage in Lung Cells Peña, Nelson; Carrillo, Diego; Muñoz, Juan P.; Chnaiderman, Jonás; Urzúa, Ulises; León, Oscar; Tornesello, Maria L.; Corvalán, Alejandro H.; Soto?Rifo, Ricardo; Aguayo, Francisco; Liu, Xuefeng Article ISI SCOPUS PLOS ONE (2015)
Translational control of the HIV unspliced genomic mRNA Bárbara Rojas-Araya, Théophile Ohlmann and Ricardo Soto-Rifo Article Viruses (2015)
HIV-2 genomic RNA accumulates in stress granules in the absence of active translation Soto-Rifo, R; Valiente-Echeverria, F; Rubilar, PS; Garcia-de-Gracia, F; Ricci, EP; Limousin, T; Decimo, D; Mouland AJ; Ohlmann T. Article ISI NUCLEIC ACIDS RESEARCH (2014)
miRNA repression of translation in vitro takes place during 43S ribosomal scanning Ricci, EP; Limousin, T; Soto-Rifo, R; Rubilar, PS; Decimo, D; Ohlmann T. Article ISI NUCLEIC ACIDS RESEARCH (2013)
The DEAD-box helicase DDX3 substitutes for the cap-binding protein eIF4E to promote compartmentalized translation initiation of the HIV-1 genomic RNA Soto-Rifo, R; Rubilar, PS; Ohlmann T. Article ISI SCOPUS Nucleic Acids Research (2013)
The roles of DDX3 in mRNA metabolism Soto-Rifo R, Ohlmann T. Article Wiley Interdiscip Rev RNA (2013)
Translation initiation is driven by different mechanisms on the HIV-1 and HIV-2 genomic RNAs de Breyne, S; Soto-Rifo, R; Lopez-Lastra, M; Ohlmann T. Article ISI VIRUS RESEARCH (2013)
DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs Soto-Rifo, R; Rubilar, PS; Limousin, T; de Breyne, S; Decimo, D; Ohlmann T. Article ISI EMBO JOURNAL (2012)
Different effects of the TAR structure on HIV-1 and HIV-2 genomic RNA translation Soto-Rifo, R; Limousin, T; Rubilar, PS; Ricci, EP; Decimo, D; Moncorge, O; Trabaud, MA; Andre, P; Cimarelli, A; Ohlmann T. Article ISI NUCLEIC ACIDS RESEARCH (2012)
Functional mechanisms of the cellular prion protein (PrPC) associated anti-HIV-1 properties Alais, S; Soto-Rifo, R; Balter, V; Gruffat, H; Manet, E; Schaeffer, L; Darlix, JL; Cimarelli, A; Raposo G.; Ohlmann T.; Leblanc, P Article ISI CELLULAR AND MOLECULAR LIFE SCIENCES (2012)
The Andes Hantavirus NSs Protein Is Expressed from the Viral Small mRNA by a Leaky Scanning Mechanism Vera-Otarola, J; Solís L.; Soto-Rifo, R; Ricci E.P.; Pino, K; Tischler, N. D.; Ohlmann T.; Darlix J.-L.; Lopez-Lastra, M Article ISI SCOPUS Journal of Virology (2012)
Activation of a microRNA response in trans reveals a new role for poly(A) in translational repression Ricci, EP; Limousin, T; Soto-Rifo, R; Allison R.; Poyry, T; Decimo, D; Jackson, RJ; Ohlmann T. Article ISI NUCLEIC ACIDS RESEARCH (2011)
The 3 ' Untranslated Region of the Andes Hantavirus Small mRNA Functionally Replaces the Poly(A) Tail and Stimulates Cap-Dependent Translation Initiation from the Viral mRNA Vera-Otarola, J; Soto-Rifo, R; Ricci, EP; Ohlmann T.; Darlix, JL; Lopez-Lastra, M Article ISI SCOPUS Journal of Virology (2010)
Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein Charnay, N; Ivanyi-Nagy, R; Soto-Rifo, R; Ohlmann T.; Lopez-Lastra, M; Darlix, JL Article ISI SCOPUS RETROVIROLOGY (2009)
Structural and functional diversity of viral IRESes Balvay, Laurent; Rifo, Ricardo Soto; Ricci, Emiliano P.; Decimo, Didier; Ohlmann, Theophile Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2009)
Lentiviral RNAs can use different mechanisms for translation initiation Ricci, Emiliano P.; Rifo, Ricardo Soto; Herbreteau, Cecile H.; Decimo, Didier; Ohlmann, Theophile Article ISI BIOCHEMICAL SOCIETY TRANSACTIONS (2008)
Back to basics: the untreated rabbit reticulocyte lysate as a competitive system to recapitulate cap/poly(A) synergy and the selective advantage of IRES-driven translation Soto Rifo, Ricardo; Ricci, Emiliano P.; Decimo, Didier; Moncorge, Olivier; Ohlmann, Theophile Article ISI NUCLEIC ACIDS RESEARCH (2007)
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility Dieterich, Klaus; Rifo, Ricardo Soto; Faure, Anne Karen; Hennebicq, Sylviane; Ben Amar, Baha; Zahi, Mohamed; Perrin, Julia; Martinez, Delphine; Sele, Bernard; Jouk, Pierre-Simon; Ohlmann, Theophile; Rousseaux, Sophie; Lunardi, Joel; Ray, Pierre F. Article ISI NATURE GENETICS (2007)


Millennium Institute in Immunology and Immunotherapy Kalergis, A.M.; Bueno, Susan; Carreno, Leandro J.; Gonzalez, Pablo A.; Lopez Lastra, Marcelo; Cáceres, Mónica; Owen, Gareth; Roa, Juan Carlos; Torres, Vicente; Riedel, Claudia; Quezada, Claudia; Alvarez, Alejandra; Simon, Felipe; Soto-Rifo, Ricardo Proyecto (2022)
Understanding liquid-liquid phase separation during the retroviral life cycle” Valiente-Echeverría, Fernando; Soto-Rifo, Ricardo Proyecto (2021)
Impact of the N6 methylation of adenosine on the switch between translation and encapsidation of HIV-1 genomic RNA Sargueil, Bruno; Soto-Rifo, Ricardo Proyecto (2019)
m6A switches as drivers of retroviral genomic RNA selection for packaging Soto Rifo, Ricardo; Valiente-Echeverría, Fernando; Acevedo, Monica L. Proyecto (2019)
RNAstasis during HIV-1 replication FONDECYT (1180798) Proyecto 2018-2021 Coinvestigador(a)
Desarrollo de un sistema de screening de alto rendimiento (HTS) para la identificación de inhibidores específicos de la expresión génica de VIH-1 FONDEF (ID16I10017) Proyecto 2016-2018 Director(a)
HIV gene expression in the RNA epigenetics era FONDECYT (1160176) Proyecto 2016-2019 Inv. Responsable
Molecular pathogenesis of emerging viruses PIA (ACT1408) Proyecto 2016-2018 Coinvestigador(a)
Understanding the role of the DEAD-box helicase DDX3 in viral and cellular messenger RNA metabolism PCI (C15B03) Proyecto 2016-2019 Inv. Responsable
A landscape of the HIV-1 full-length unspliced mRNA nuclear export and translation initiation complexes FONDECYT (3160091) Proyecto 2015-2018 Inv. Patrocinante
Infectious Pancreatic Necrosis Virus=> Characterization of the receptors and virus entry pathways FONDECYT (1151250) Proyecto 2015-2018 Coinvestigador(a)
The atlas of the HIV-1 genomic messenger ribonucleoprotein (mRNP) complex PCI (2013-0005) Proyecto 2013-2016 Director(a)
From the nucleus to the ribosome=> deciphering the role of DDX3 in linking nuclear export and translation of the HIV-1 genomic RNA FONDECYT (11121339) Proyecto 2012-2015 Inv. Principal
“Characterization of cellular factors involved in HIV-1 and HIV-2 genomic RNA translational control” PCI (C11S01) Proyecto 2012-2015 Investigador(a)
“Etude de la régulation de l’expression de l’ARNm génomique du virus de l’immunodéficience humaine de type I” ANRS (France) (NM/N°1616/CSS 2/AO 2010) Proyecto 2010-2013 Investigador(a)
Investigating and Targeting the mechanism of HIV-1 protein synthesis PCI (C05S01) Proyecto 2006-2008 Investigador(a)
IRES function ANR (France) (06BLANC-0290) Proyecto 2006-2009 Investigador(a)
ESTUDIO DEL MECANISMO DE TRADUCCION DE LAS PROTEINAS DEL VIRUS DE LA NECROSIS PANCREATICA INFECCIOSA FONDECYT (1040282) Proyecto 2004-2007 Investigador(a)


New Challenges of HIV-1 Infection: How HIV-1 Attacks and Resides in the Central Nervous System Rojas-Celis, V; Valiente-Echeverria, F; Soto-Rifo, R; Toro-Ascuy, D Review ISI CELLS (2019)
RNA helicase DDX3: at the crossroad of viral replication and antiviral immunity Valiente-Echeverria, F; Hermoso, MA; Soto-Rifo, R Review ISI SCOPUS Reviews in Medical Virology (2015)
Translational Control of the HIV Unspliced Genomic RNA Rojas-Araya, B; Ohlmann T.; Soto-Rifo, R Review ISI SCOPUS Viruses (2015)
The role of the DEAD-box RNA helicase DDX3 in mRNA metabolism Soto-Rifo, R; Ohlmann T. Review ISI SCOPUS Wiley Interdisciplinary Reviews: RNA (2013)

Ricardo Soto

PROFESOR ASOCIADO

FACULTAD DE MEDICINA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Fernando Valiente

Profesor Asociado

ICBM

Universidad de Chile

Santiago, Chile

Marcelo Lopez

Profesor Titular

Infectologia e Inmunologia Pediatrica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Daniela Toro

Profesor Asistente

facultad de ciencias de la salud

Universidad Autonoma de Chile

Santiago, Chile

Aldo Gaggero

Académico. Profesor Asociado.

Virología

ICBM. FACULTAD DE MEDICINA. UNIVERSIDAD DE CHILE.

Santiago, Chile

Monique Le Corre

Assistant Professor

Faculty of medicine, Pediatric division

Pontificia Universidad Catolica de Chile

Santiago, Chile

Francisco Aguayo

Profesor Asociado

Programa de Virología, Instituto de Ciencias Biomédicas (ICBM)

Universidad de Chile

Santiago, Chile

Jonas Chnaiderman

Profesor Asociado

Instituto de Ciencias Biomédicas

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Franz Villarroel

Jefe Laboratorio - PI

Departamento de Investigación del Cáncer

Fundación Arturo López Pérez

Santiago, Chile

Gonzalo Barriga

Profesor Asistente

Instituto de Ciencias Biomedicas

Universidad de Chile

Santiago, Chile

Marcela Ferres

Head of Department

Pediatric Infectious Diseases and Immunology

Pontificia Universidad Católica de Chile

Santiago, Chile

Aracelly Gaete

Tesista Doctoral

Universidad de Chile

Santiago, Chile

Francisco Fuentes

Profesor Asistente

Departamento de Microbiología

Universidad de Concepción

Concepción, Chile

Carolina Selman

Subdirectora

Unidades de Diagnóstico

Fundación Arturo Lopez Perez

Santiago, Chile

María Balcells

Associate Professor

Department of Infectious Diseases of the Adult

Pontificia Universidad Catolica de Chile

Santiago, Chile

Roxana Gonzalez

Investigador Senior

Fundación Arturo López Pérez

Santiago, Chile

María Domínguez

Profesora asistente adjunta

Departamento de Salud Pública

Pontificia Universidad Católica de Chile

Santiago, Chile

Farides Saavedra

Investigadora

Fundación Ciencia y Vida

Ñuñoa, Chile

Lorena Tapia

Profesora Asociada

Departamento de Pediatría y Cirugía Infantil Norte

Universidad de Chile

Santiago, Chile

Jenniffer Angulo

Asistente de Investigación

Pediatría e Inmunologia Pediátrica

Pontificia Universidad Católica de Chile

Santiago, Chile

Carmen Imarai

Profesor Titular

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Paula Muñoz

Clinical Research Center Director

Universidad del Desarrollo

Santiago, Chile

Jorge Soto

Profesor Asistente

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

Susan Bueno

Profesor Asociado

Genética Molecular y Microbiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Jose Garrido

Investigador asesor, part time

Universidad San Sebastián

Puerto Montt, Chile

Maria Barria

Investigador, Associate Professor

Universidad San Sebastián

Puerto Montt, Chile

MARIO CALVO

Profesor Asociado

Instituto de Medicina

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

SEBASTIAN REYES

Profesor Asistente

Centro de Genómica y Bioinformática

Universidad Mayor de Chile

Santiago, Chile

Sandra Solari

Profesor Clinico Asociado

Laboratorios Clinicos

Facultad de Medicina - PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Mauricio Farfán

Profesor Asociado

Departamento de Pediatria y Cirugia Infantil, Hospital Dr. Luis Calvo Mackenna, Facultad de Medicina, Universidad de Chile

Universidad de Chile

Providencia, Chile

Johanna Acevedo

Profesor asociado investigador

Instituto de Ciencias e Innovación en Medicina (ICIM)

Universidad del Desarrollo

Santiago, Chile

Felipe Reyes

Assistant professor

Universidad de S

Santiago de Chile, Chile

Claudio Acuña

Profesosr Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Juan Hormazabal

Investigador Postdoctoral

Facultad De Medicina

Universidad del Desarrollo

Santiago, Chile

Estefania Nova

Assistant Professor

Clinical Biochemistry & Immunology

University of Concepcion

Concepción , Chile

María Elena Ceballos

Profesor Asistente

Enfermedades Infecciosas del Adulto

Pontificia Universidad Católica de Chile

Santiago, Chile

Iván Flores

Post Doc

Progama de Inmunología

Universidad de Chile

Santiago, Chile

LINA CORTES

Investigadora Postdoctoral

Facultad de Medicina

Universidad del Desarrollo

Santiago, Chile

Maria Vial

Associate Professor/Profesor Asociado

Instituto de Ciencias e Innovación de Medicina

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

Dante Travisany

Profesor Asociado

Facultad de Ingeniería y Negocios

Universidad de Las Américas

Santiago, Chile

Carlos Farkas

PostDoctoral Fellow

CancerCare Manitoba

University of Manitoba

Winnipeg, Canada

Manuel Espinoza

Profesor Asociado

Salud Pública

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Carlos Barrera

Funcionario

Biología

Universidad de Santiago de Chile

Santiago, Chile

Jorge Fernandez

JEFE SUBDEPTO

BIOMEDICO NACIONAL Y DE REFERENCIA

INSTITUTO DE SALUD PUBLICA

santiago, Chile

Hugo Marsiglia

Director Relaciones Médicas Internacionales

Fundación Arturo López Pérez

Santiago, Chile

luis rojas

Profesor asistente

Medicina Interna

Pontificia Universidad católica de Chile. Facultad de Medicina, Escuela de Medicina

Santiago, Chile

carolina iturriaga

Sub Directora Laboratorio de inmunología y Alergia Traslacional UC

Pediatria

Pontificia Universidad Católica de Chile

santiago, Chile

Eugenio Ramírez

INSTITUTO DE SALUD PÚBLICA DE CHILE

Santiago, Chile

Marcelo Navarrete

Profesor Titular

Medicina

Universidad de Magallanes

Punta Arenas, Chile

Carolina Beltrán

Postdoc

Virología

Universidad de Chile

Santiago, Chile

FELIPE MELO

Profesor Asistente

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

KAREN DUBOIS

Postdoctoral fellow Fondef IDeA ID17I10064 IDI17

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

Diego Carrillo

Profesor auxiliar

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

Glauben Landskron

Academic Researcher

Escuela de Medicina

Universidad Finis Terrae

Santiago, Chile

Ana Rojas

Asistente de Investigación

Universidad Autónoma de Chile

Santiago, Chile

Maria González

Academico

FACULTAD DE MEDICINA - UNIVERSIDAD DE CHILE

Santiago, Chile

Gisela Canedo

Investigadora y Profesora

Facultad de Odontología

Universidad de Los Andes

Santiago, Chile

Alessandra Dellarossa

Asistente de Investigación

Laboratorio de Biología

Centro de Estudios Científicos

Valdivia, Chile

Sebastián Riquelme

Estudiante doctorado

Virología

Universidad de Chile

Santiago, Chile

Ariel Castro

Full Professor

Department of Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCION

concepciòn, Chile

Roxana Pincheira

Full Professor

Bioquímica y Biología Celular

Universidad de Concepcion

Concepción, Chile

Andrea Calixto

Full professor

Neuroscience

Universidad de Valparaíso

Valparaiso, Chile

Maria Nuñez

Directora Postítulo en Inmunohematología Avanzada

Universidad Diego Portales

Santiago, Chile

Alejandro Escobar

assistant professor

Institute for Research in Dental Sciences

UNIVERSIDAD DE CHILE

Santiago, Chile

Omar Vallejos

Lab Manager y Coordinador

Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

Marcela Hermoso

Full Professor

School of Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

ALEJANDRO CORVALAN

Principal Investigator

Hematology and Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

ULISES URZUA

Assistant Professor

ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

Matías Medina

Docente

Ciencias

Universidad San Sebastián

Puerto Montt, Chile

Patricia García

Jefe de Laboratorio de Microbiologia

Escuela de Medicina

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, LABORATORIO DE MICROBIOLOGÍA

Santiago, Chile

Nicole Zambrano

CEO / Investigador principal

Laboratorio MolecVET

Santiago, Chile

Christian Esveile

Médico adjunto

Hospital Clínico Herminda Martin

Chillan, Chile

Ricardo Andrés Soto Rifo

Líneas de Investigación

Educación

Molecular and Cellular Biology, ECOLE NORMALE SUPERIEURE DE LYON. Francia, 2010

Molecular and Cellular Biology, UNIVERSITE CLAUDE BERNARD LYON-1. Chile, 2006

BIOCHEMIST, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 2004

Experiencia Académica

ASSISTANT PROFESSOR Full Time

ASSOCIATE PROFESSOR Full Time

Experiencia Profesional

POST-DOC Full Time

Formación de Capital Humano

Premios y Distinciones

Científico Jóven del año

Article (55)

Proyecto (18)

RNAstasis during HIV-1 replication

Desarrollo de un sistema de screening de alto rendimiento (HTS) para la identificación de inhibidores específicos de la expresión génica de VIH-1

HIV gene expression in the RNA epigenetics era

Molecular pathogenesis of emerging viruses

Understanding the role of the DEAD-box helicase DDX3 in viral and cellular messenger RNA metabolism

A landscape of the HIV-1 full-length unspliced mRNA nuclear export and translation initiation complexes

Infectious Pancreatic Necrosis Virus=> Characterization of the receptors and virus entry pathways

The atlas of the HIV-1 genomic messenger ribonucleoprotein (mRNP) complex

From the nucleus to the ribosome=> deciphering the role of DDX3 in linking nuclear export and translation of the HIV-1 genomic RNA

“Characterization of cellular factors involved in HIV-1 and HIV-2 genomic RNA translational control”

“Etude de la régulation de l’expression de l’ARNm génomique du virus de l’immunodéficience humaine de type I”

Investigating and Targeting the mechanism of HIV-1 protein synthesis

IRES function

ESTUDIO DEL MECANISMO DE TRADUCCION DE LAS PROTEINAS DEL VIRUS DE LA NECROSIS PANCREATICA INFECCIOSA

Review (4)