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ALEJANDRA SAN MARTIN

Professor

Universidad Andrés Bello

Santiago, Chile

Líneas de Investigación


Molecular mechanisms of vascular smooth muscle cell (VSMC) phenotypic modulation and its role in vascular pathologies. Redox signaling Regulation of the cytoskeleton and migration Cellular and mitochondrial metabolism

Educación

  •  Biochemist, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1998
  •  Biologia Celular y Molecular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004

Experiencia Académica

  •   postdoctoral fellow Full Time

    EMORY UNIVERSITY

    Medicine

    Atlanta, Estados Unidos

    2004 - 2009

  •   Assistant Professor Full Time

    EMORY UNIVERSITY

    Medicine

    Atlanta, Estados Unidos

    2009 - 2017

  •   Associate Professor Full Time

    EMORY UNIVERSITY

    Medicine

    Atlanta, Chile

    2017 - 2022

  •   Adjunct Professor Other

    EMORY UNIVERSITY

    Medicine

    Atlanta, Chile

    2023 - A la fecha

  •   Professor Full Time

    UNIVERSIDAD ANDRES BELLO

    Medicine

    Santiago, Chile

    2023 - A la fecha

Experiencia Profesional

  •   Associate Professor Full Time

    Emory University

    Atlanta, Estados Unidos

    2017 - 2022

  •   Assistant Professor Full Time

    Emory University

    Atlanta, Chile

    2009 - 2017

  •   Postdoctoral fellow Full Time

    Emory University

    Atlanta, Estados Unidos

    2004 - 2009

Formación de Capital Humano


a. PhD Students Directly Supervised:

2006-2012 Holly William, Graduate Student, Molecular and Systems Pharmacology Program, Emory University
2010-2013 Minyoung Lee, Graduate Student, Molecular and Systems Pharmacology Program, Emory University
2020-2024 Bethany Bogan, Graduate Student, Molecular and Systems Pharmacology Program, Emory University
2021-present Claire Holden, Graduate Student, Molecular and Systems Pharmacology Program, Emory University

b. Post-doctoral Fellows Directly Supervised:

2008-2011 Abel Garrido
2009-2010 Zhen Yang
2010-2012 Hope Gole
2011-2012 Marcelo Montenegro
2011-2013 Candace Adamo
2013-2015 Charity Duran
2013-2018 Alejandra Valdivia
2014-2015 Gloria Torres
2015-2017 Kely Sheldon
2015-2021 Holly Williams
2016-2022 Felipe Paredes

c. Undergrad:

2008-2010 Mithunan Maheswaranathan, in 2-semester research project and honor thesis project. He graduated summa cum laude at Emory University
2011-2012 Isabel Fernandez, in 2-semester research project and honor thesis project at Emory University
2024 Stefano Migliorelli, in 2 semester research project to obtain the title of Biomedical engineering at Andres Bello University, Chile

d. Others

2015 Matthew Tillman, PhD student, Molecular and System Pharmacology program, laboratory rotation, Emory University
2018 Izabela Suster, PhD student, Biochemistry, Cell and Developmental Biology (BCDB) program, Emory University, laboratory rotation
2014 Felipe Paredes, PhD student, Biomedical Science program, laboratory rotation, University of Chile, Chile, laboratory rotation
2016 David Moncada-Ruff, PhD student, Biomedical Science program, University of Chile, Chile, laboratory rotation
2017 Fernanda Sanhueza-Olivares, Master student, Biomedical Science program, University of Chile, Chile, laboratory rotation
2017 Macarena Tejos, Research associate, Department of Neuroscience, University of Chile, Chile, laboratory rotation
2018 Karime França, Postdoctoral fellow, Universidade Federal do Paraná, Departamento de Patologia Básica Curitiba PR, Brazil, laboratory rotation
2018 Izabela Suster, PhD student, Biochemistry, Cell and Developmental Biology (BCDB) program, laboratory rotation Emory University
2023-2024 Nicolas Sales, Undergrad, Biomedical engineering, in a laboratory rotation, Andres Bello University, Chile


Difusión y Transferencia


Patents

International PCT Application No. PCT/US2023/037103
Title: Uses of Hydroimidazopyridopyrimidinone Derivatives for Managing Aneurysms or Other Vascular Conditions or Diseases

Lectureships, Seminar Invitations, and Visiting Professorships

2007 “NADPH oxidases in vascular pathology.” Faculty of Biological Science, Universidad Católica de Chile, Santiago, Chile
2008 “Mechanism of PDGF-induced migration in vascular smooth muscle.” University of Iowa Cardiovascular Research Center, Iowa City, Iowa, USA
2009 “Mechanism of PDGF-induced migration in vascular smooth muscle.” Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
2010 “Mechanism of vascular smooth muscle migration: role of SSH1L.” Department of Medicine, Division of Cardiology, Emory University
2011 “Role of SSH1L phosphatase in smooth muscle migration.” Faculty of Biological Science, Universidad Católica de Chile, Santiago, Chile
2012 “Redox-activated slingshot/cofilin pathway regulates actin dynamics and inflammatory gene expression in vascular smooth muscle cell.” Department of Bioengineering, Clemson University, Clemson, South Carolina, USA
2012 “Role of the actin binding protein cofilin in the VSMC response to mechanical stress.” Highlighted Research, Department of Medicine Research Day,Emory University
2012 “Redox-mediated signaling in vascular smooth muscle cell migration and cytoskeleton reorganization.” Smooth Muscle, Federation of American Societies for Experimental Biology (FASEB) meeting, Snowmass Village, Colorado, USA
2013 “Redox regulation of the cytoskeleton: attachment, mechanical transduction and inflammation.” Department of Medicine, Division of Digestive Diseases, Emory University
2013 “Redox regulation of the cytoskeleton: attachment, mechanical transduction and inflammation.” Department of Medicine, Division of Pulmonary and Critical Care,Emory University
2013 “The role of Nox proteins in the regulation of the cytoskeleton of the vascular smooth muscle cells.” Center of Molecular Studies of the Cell, Universidad de Chile, Santiago, Chile
2014 “Multiple roles of Poldip2 in the phenotypic modulation of vascular smooth muscle cells.” Advanced Center for Chronic Diseases, Universidad de Chile, Santiago, Chile
2015 “Multiple roles of Poldip2 in the phenotypic modulation of vascular smooth muscle cells.” Department of Cell Biology, Universidad Católica de Chile, Santiago, Chile
2015 “Cytoskeleton regulation and its role in vascular biology.” Chilean Society for Biochemistry annual meeting, Puerto Varas, Chile
2015 “Oxidative stress and inflammation in cardiovascular injury and protection.” Annual Scientific Sessions, American Heart Association, Orlando, USA
2016 “Redox regulation of the cytoskeleton in vascular smooth muscle cells.” Department of Physiology & Pharmacology, The University of Georgia, USA
2016 “Diverse roles of NADPH oxidases in the vascular smooth muscle cell phenotype.” Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA
2016 “Poldip2 regulates cellular metabolism under hypoxia.” Department of Medicine, University of Chile, Santiago, Chile
2016 “Control of actin cytoskeleton by NADPH oxidases.” Department of Medicine, Division of Cardiology, Emory University
2016 “Modulation of smooth muscle function by NADPH oxidases.” Program in Molecular and System Pharmacology, Emory University
2017 “Poldip2-mediated regulation of cell metabolism under hypoxia” Department of Medicine, Division of Cardiology, Emory University
2017 “Regulation of protein lipoylation by Poldip2 promotes metabolic adaptation to hypoxia.” Center for Molecular and Translational Medicine, Georgia State University, Atlanta, Georgia, USA
2017 “Regulation of mitochondrial function by Poldip2 supports hypoxia and cancer cell metabolic adaptation.” Advanced Center for Chronic Diseases, Universidad de Chile, Santiago, Chile
2018 “Identification of a novel pathway controlling cell metabolism” Department of Medicine Research Day, Emory University
2018 “Control of mitochondrial metabolism by Poldip2 regulates VSMC phenotype and vascular properties” International Society for Heart Research, Huilo-Huilo, Los Ríos Region, Chile
2019 “Poldip2 controls vascular smooth muscle cell phenotype” Department of Medicine, Division of Cardiology, Emory University
2021 “Metabolic Control of Smooth Muscle Phenotype”, Department of Medicine, The University of North Carolina at Chapel hill
2021 “Metabolic Control of Smooth Muscle Phenotype”, Centre for Cardiovascular Science, The University of Edinburgh
2020 "Mitochondrial druggable targets that control VSMC phenotype" Free Radical Biology and Medicine annual meeting, Orlando, USA
2023 “Role of the mitochondrial protease Clpp in the vasculature”, PNAM in Physiological Sciences, Puerto Varas, Chile

Society Memberships

2002-present Chilean Society for Cell Biology
2002-present American Heart Association, ATVB Council
2002-present Society for Redox Biology and Medicine (SFRBM)
2011-present The American Society for Biochemistry and Molecular Biology
2015-present The American Society for Cell Biology


Premios y Distinciones

  •   Merit Award for Young Investigator, Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB) Council, American Heart Association

    American Heart Association

    Estados Unidos, 2002

    International Award for a young investigator in the area of vascular diseases.

  •   Early Career Faculty Outstanding Citation Award

    EMORY UNIVERSITY

    Chile, 2012

    Annual award for the best publication in the department of medicine for a junior faculty member.

  •   Outstanding Citation Basic Scientific Citation Award

    EMORY UNIVERSITY

    Chile, 2018

    Annual award for the best publication in the department of medicine for a senior faculty member.

  •   Recognition for Excellent Teaching

    The Phi Beta Kappa Society

    Chile, 2012

    Recognition for my work as teacher and mentor by The Phi Beta Kappa Society (???), the oldest and most prestigious academic honor society in the United States.

  •   C. Dayton Riddle Distinguished Lecturer

    CLEMSON UNIVERSITY

    Chile, 2012

    Academic distinction from Clemson University for scholar achievements.

  •   Member of the Emory 1%

    EMORY UNIVERSITY

    Chile

    Distinction for investigators who have received study section scores in the top 1 percentile on a grant proposal from NIH.

  •   Promising Young Investigators

    Circulation journal

    Chile, 2016

    Highlighted by the Circulation journal (one of the most prestigious in the area of cardiovascular research IF 38).

  •   K99/R00 Fellow to Faculty transition award NIH

    NATIONAL INSTITUTE OF HEALTH

    Estados Unidos, 2008

    It is a highly competitive award from the NIH to fund your transition from your last years of fellowship to your first years as a junior faculty. 250k for 5 years.

  •   Beca Conicyt de Doctorado

    Conicyt

    Chile, 2001

    Beca para la realizacion del doctorado en Cs. Biologicas otogada por el gobierno de Chile.

  •   Travel Award, 9th Annual Meeting Society for Redox Biology and Medicine

    Society for Redox Biology and Medicine

    Estados Unidos, 2003

    Tavel award selected for abstract scoring

  •   Best Scientific Work, Annual Meeting

    Sociedad de Cardiologia de Chile

    Chile, 2003

    Annual meeting Award to the best scientific work presented that year.

  •   Cardiology Research Symposium Award

    EMORY UNIVERSITY

    Estados Unidos, 2007

    Award for the best scientific work during the annual symposium.


 

Article (45)

The mitochondrial protease ClpP is a druggable target that controls VSMC phenotype by a SIRT1-dependent mechanism
The Role of Fatty Acid Synthase in the Vascular Smooth Muscle Cell to Foam Cell Transition
Metabolic regulation of the proteasome under hypoxia by Poldip2 controls fibrotic signaling in vascular smooth muscle cells
Nox1-based NADPH oxidase regulates the Par protein complex activity to control cell polarization
Regulation of total LC3 levels by angiotensin II in vascular smooth muscle cells
Characterization of <i>Poldip2</i> knockout mice: Avoiding incorrect gene targeting
Metabolic adaptation in hypoxia and cancer
Mitochondrial Protein Poldip2 (Polymerase Delta Interacting Protein 2) Controls Vascular Smooth Muscle Differentiated Phenotype by O-Linked GlcNAc (N-Acetylglucosamine) Transferase-Dependent Inhibition of a Ubiquitin Proteasome System
Quiescin/sulfhydryl oxidase 1b (QSOX1b) induces migration and proliferation of vascular smooth muscle cells by distinct redox pathways
Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells
Angiotensin II-Regulated Autophagy Is Required for Vascular Smooth Muscle Cell Hypertrophy
The cofilin phosphatase slingshot homolog 1 restrains angiotensin II-induced vascular hypertrophy and fibrosis in vivo
Autophagy mediates tumor necrosis factor-alpha-induced phenotype switching in vascular smooth muscle A7r5 cell line
Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer
Poldip2 takes a central role in metabolic reprograming.
PPARγ Regulates Mitochondrial Structure and Function and Human Pulmonary Artery Smooth Muscle Cell Proliferation
Glucagon-like peptide-1 inhibits vascular smooth muscle cell dedifferentiation through mitochondrial dynamics regulation
HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol 1,4,5-trisphosphate receptor
Redox-Sensitive Regulation of Myocardin-Related Transcription Factor (MRTF-A) Phosphorylation via Palladin in Vascular Smooth Muscle Cell Differentiation Marker Gene Expression
Hic-5 Mediates TGFβ-Induced Adhesion in Vascular Smooth Muscle Cells by a Nox4-Dependent Mechanism
Nox4-dependent activation of cofilin mediates VSMC reorientation in response to cyclic stretching
Role of Subplasmalemmal Mitochondria in Angiotensin II-Mediated Contraction
The Role of Nox-Mediated Oxidation in the Regulation of Cytoskeletal Dynamics
Do endothelial cells eat tryptophan to die?
NADPH oxidases: progress and opportunities.
Transforming Growth Factor β Inhibits Platelet Derived Growth Factor-Induced Vascular Smooth Muscle Cell Proliferation via Akt-Independent, Smad-Mediated Cyclin D1 Downregulation
Role of Coronin 1B in PDGF-Induced Migration of Vascular Smooth Muscle Cells
NADPH oxidase 4 mediates TGF-β-induced smooth muscle α-actin via p38MAPK and serum response factor
Platelet-derived Growth Factor (PDGF) Regulates Slingshot Phosphatase Activity via Nox1-dependent Auto-dephosphorylation of Serine 834 in Vascular Smooth Muscle Cells
Vascular smooth muscle insulin resistance, but not hypertrophic signaling, is independent of angiotensin II-induced IRS-1 phosphorylation by JNK
PGC-1α Serine 570 Phosphorylation and GCN5-mediated Acetylation by Angiotensin II Drive Catalase Down-regulation and Vascular Hypertrophy
Insulin-Like Growth Factor-1 Receptor Expression Masks the Antiinflammatory and Glucose Uptake Capacity of Insulin in Vascular Smooth Muscle Cells
Mechanisms of Vascular Smooth Muscle NADPH Oxidase 1 (Nox1) Contribution to Injury-Induced Neointimal Formation
Dual regulation of cofilin activity by LIM kinase and Slingshot-1L phosphatase controls platelet-derived growth factor-induced migration of human aortic smooth muscle cells
Nox1-based NADPH oxidase-derived superoxide is required for VSMC activation by advanced glycation end-products
Reactive oxygen species-selective regulation of aortic inflammatory gene expression in Type 2 diabetes
Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice
Effect of Mediterranean and Occidental Diets, and Red Wine, on Plasma Fatty Acids in Humans: An Intervention Study
Wine, diet, antioxidant defenses, and oxidative damage
Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors
Differences in plasma antioxidants according to socioeconomic level in Chilean women
Spontaneous urinary chemiluminescence and diet. An intervention study in humans
A high-fat diet induces and red wine counteracts endothelial dysfunction in human volunteers
Plasma polyphenols and antioxidants, oxidative DNA damage and endothelial function in a diet and wine intervention study in humans.
HERPUD1 governs tumor cell mitochondrial function via inositol 1,4,5-trisphosphate receptor-mediated calcium signaling

Abstract (4)

Advanced glycated products induce the expression of iNOS in VSMC
Advanced glycation products induce VSMC activation by ROS-mediated mechanism
Homocysteine induces endotelial dysfunction by an oxidative stress dependent mechanism
Vascular smooth muscle cell phenotypic change and RAGE expression induced by advanced glycation end-products is mediated by reactive oxygen species generation

Letter (1)

New perspectives on the novel role of the Poldip2/ACSM1 axis in a functional mammalian lipoylation salvage pathway Reply

Proyecto (7)

Metabolic Control of Vascular smooth muscle cells
Role of Poldip2 in liver fibrosis
Role of Poldip2 in vascular mitochondrial dynamics
Mechanically stressed VSMC: A role for slingshot phosphatase in inflammation
Vascular Oxidases in Migration
Mechanism of SSH1L phosphatase activation in VSMC: role in vascular pathology
Molecular mechanism of PDGF induced migration in vascular smooth muscle cells

Review (2)

Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System
Redox Control of Vascular Smooth Muscle Migration
59
ALEJANDRA SAN MARTIN

Professor

Medicine

Universidad Andrés Bello

Santiago, Chile

5
oscar castillo

Director Escuela

Facultad de Medicina

Universidad Finis Terrae

Santiago, Chile

4
Fernanda Sanhueza

Bioquímica

Hospital Base San José de Osorno

Osorno, Chile

3
GLORIA TORRES

Investigadora Postdoctoral

CIIB

Universidad de Los Andes

Santiago, Chile

3
Ada Cuevas

Médico

Nutrición Clínica

CLINICA LAS CONDES

Santiago, Chile

3
Pablo Strobel

Prrofesional de laboratorio

Facultad Ciencias Veterinarias

Universidad Austral de Chile

Valdivia, Chile

3
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

2
Clara Quiroga

Profesor Asistente Adjunto

División de Enfermedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

2
SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

2
Olga Panes

Technical Director/ Associated Research

Hematology-Oncology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Ignacio Norambuena

Postdoctorado

Universidad de Chile

Santiago, Chile

2
Ines Urquiaga

Coordinador Cientifico

Escuela de Medicina

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Jaime Riquelme

Assistant Professor

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

1
Roberto Fuentealba

Docente investigador

Salud

Universidad Santo Tomás

Talca, Chile

1
Roberto Bravo

Assistant Professor

Institute of Nutrition and Food Technology (INTA), Universidad de Chile

Santiago, Chile

1
Rodrigo Troncoso

Associate Professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

1
Constanza Núñez

Investigadora

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Alvaro Martínez

Director Asociado de Propiedad Intelectual y Transferencia Tecnológica

FUNDACIÓN CIENCIA PARA LA VIDA (FCV)

Santiago, Chile

1
Paulina Villar

Tesista doctorado en bioquímica

Bioquímica

Universidad de Chile

Santiago, Chile

1
Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

1
MARIANNE BRENET

Investigador

SymbiOx Inc.

Macul, Chile

1
Jaime Pereira

Jefe

Hematología-Oncología

ESCUELA DE MEDICINA, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Roberto Ebensperger

Associate Professor

Pharmacy

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Macarena Tejos

Trainee (PhD Student)

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Diego Mezzano

Director

Hematology-Oncology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile