Diego Antonio Mezzano Abedrapo
Director
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile
Platelet Physiology and Pathophysiology; Platelet Tissue Factor; Platelet Pro-coagulant Activity; Mechanisms of Atherothrombosis; Primary Hemostasis Disorders; Functions of Neo-synthesized Proteins by Platelets; Platelet Aging in Circulation.
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Medical Doctor, Pontificia Universidad Católica de Chile. Chile, 1969
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Professor Full Time
Physician, Sótero del Río Hospital
Medicine
Santiago, Chile
1974 - A la fecha
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Medical Doctor Full Time
Hospital Sótero del Río
Medicine, P. Catholic University of Chile
Santiago, Chile
1972 - 1974
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Hematology Fellowship Full Time
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Medicine
Santiago, Chile
1974 - 1976
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National Institutes of Health, Fogarty Center, Research Fellowship Full Time
Blood Center of South-Eastern Milwaukee
Associated with Medical College of Wisconsin
Milwaukee, Estados Unidos
1978 - 1980
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Research fellowship Full Time
Blood Ctr. South-Eastern Milwaukee
Milwaukee, Estados Unidos
1978 - 1980
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Attending Physician, Internal Medicine Full Time
Hospital Sótero del Río
Santiago, Chile
1972 - 1974
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Internal Medicine Fellowship Full Time
School of Medicine, Catholic Univ of Chile
Santiago, Chile
1969 - 1972
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Hematology Fellowship Full Time
School of Medicine, Catholic Univ of Chile
Santiago, Chile
1974 - 1976
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Associate Editor Other
Journal of Thrombosis and Haemostasis
Leiden, Holanda
2014 - A la fecha
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Co-Chairman, Platelet Physiology Sub-Committee Other
International Society for Thrombosis and Haemostasis
Chapel Hill, Estados Unidos
2012 - A la fecha
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Member, Lectures and Awards Committee Other
International Society for Thrombosis and Haemostasis
Chapel Hill, Chile
2012 - A la fecha
Medical Students.
1997-2004: Director, Organizer and Lecturer in the course of Pathophysiology: Cellular and Molecular Basis of the Disease. For 3rd grade students of Medicine. First semester
2005-2009: Co-Direction of the Integrated Course "Functional and Morphological Pathology". First semester. Lecturer in this course until now.
1997-2006: Lectures and Bibliographic Seminars in the Course Molecular Biology of the Cell, for 2nd grade students of Medicine. First Semester.
1983-1985 and 1988-2009: Director of the chapter of Blood Physiology. Collaborator since 2010 in the same course, for 2nd grade students of Medicine.2nd Semester.
1976-2011: Lectures in Thrombosis, Hemostasis and Transfusion Medicine in the Chapter of Clinical Hematology in the Integrated Medical-Surgical Course for Medical Students, 4th grade.
1990-1999: Programmed Hematology, Hemostasis-Thrombosis and Transfusion Medicine Rounds with groups of students during their Internship.
1985-1989: Optative Course: Training Program in Blood Banking for Pre-Graduate Medical Students. 1 semester.
Pre-Graduate Students in other Health-Related Careers.
1983-1986: Coordinator of the Course Pathophysiology for Nursery Students. 2nd Semester.
1998-2014: Lectures in Hemostasis in the Course Introduction to Clinical Laboratory, for Biochemistry and Biology Students (Faculty of Biological Sciences)
1998-2014: Lectures in Hemostasis in the Course Introduction to Clinical Laboratory, for Chemistry and Pharmacy Students (Faculty of Chemistry)
2012-2014: Lectures in Pathophysiology of the Blood for Dentistry Students (Health Sciences Faculty)
Post-Graduate Students.
1997-2003: Director, Subspecialty Clinical and Laboratory Training in Hemostasis-Thrombosis and Transfusion Medicine. Duration: 1 year. or Hematologists, Pediatricians, Clinical Pathologists, Internists,
2004-2014: Director, Subspecialty Clinical and Laboratory Training in Hemostasis-Thrombosis, 1 year duration for Hematologists, Pediatricians, Clinical Pathologists, Internists,
1995-2014: Medical Sciences PhD Program: Lectures and Seminars in successive courses of this program: Integrative Physiology, Basic Biologic Processes in Human Diseases, Cell-cell interactions in disease: mechanisms and functions.
1997-2013: Magister of Nutrition. Lectures on pathophysiology of disorders related with nutrition and metabolism (atherosclerosis, thrombosis, hemostatic disorders associated with vitamin K deficiency, diabetes, homocysteine metabolism)
Tutorship of Pre-Graduate Students in the Hemostasis and Thrombosis Laboratory.
1992-2014: Pre-Graduate Students of Medical Technology (Internship), Biochemistry and Biology (Clinical Lab Courses) rotate permanently in our Laboratories. These include students of our and other Universities: Universidades Andrés Bello, Mayor, San Sebastián.
1985-2009: Tutorship of 31 Medical Students to help in teaching activities, consultative functions in the courses I directed.
1985-1996: Tutorship of 18 medical students to participate in specific areas of our research projects. Six of them are co-authors in our papers.
Tutorship of Post-Graduate Students in the Hemostasis and Thrombosis Laboratory.
1982-2014: more than 50 physicians, mainly hematologists and clinical pathologists, either during their specialty fellowships or for further training, have spent from 1 to 3 months of stay in our Laboratories for training. We receive fellows or hematologists from all along the country, and almost all the accredited Hematology Fellowship Programs are trained by us.
1982-2014: all the Hematology and Hematology-Oncology Fellows (Adults and Pediatricians) of our Institution are trained in Hemostasis and Thrombosis in our Laboratory
Thesis.
1982-2014: I have tutored or co-tutored the Pre-Graduate Thesis of 30 students of Biochemistry, Biology, Chemistry and Pharmacy, from other Faculties or Universities. The results of the Thesis of almost all of them have been presented in scientific meetings and most of them have co-authored the publications of our laboratory.
2007-2010: co-tutor of the PhD Thesis in Medical Sciences of Sebastián Cabrera,, from the University of Chile: “Transport of L-Arginina in Human Platelets. Role of platelet dysfunction in chronic renal failure".
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IV Latin-american Scientific Meeting of Medical Students
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Venezuela, 1991
I was the tutor of the students Mariela Torrente and Ignacio Campos. First Prize in Clinical Sciences. "Tubular Necrosis and Acute Renal Failure in Rats Treated with 5-Hydroxi tryptofan .
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X Chilean Congress of Hematology
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Chile, 1994
Prize to the Best Scientific Work: "Inhibition of fibrinolysis corrects the bleeding time (BT) in patients with terminal renal failure. Mezzano D, Tagle R, Downey P, Thambo S, González F, Mezzano S, Barja P, Pérez M, Panes O, Rodríguez MS, Muñoz B, Pereira J.
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Chilean Meeting of the Societies of Hypertension, Nephrology and Transplantation
Societies of Hypertension, Nephrology and Transplantation
Chile, 1994
Prize to the Best Scientific Work. Fibrinolysis inhibition corrects the bleeding time in most patients with terminal chronic renal failure" Tagle R, Downey P, González F, Pais E, Mezzano S, Thambo S, Barja P, Pérez M, Panes O, Pereira J, Mezzano D. La Serena, 1994.
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Faculty of Medicine Scientific Meeting of Residents and Fellows
Faculty of Medicine, P. Catholic University of Chile
Chile, 1995
First Prize to the Best Abstract. "Fibrinolysis inhibition corrects the bleeding time in most patients with terminal chronic renal failure" Fellow: Rodrigo Tagle, M.D. Tutor: D. Mezzano, M.D.
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IX Chilean Congress of Clinical Chemistry
Chilean Society of Clinical Chemistry
Chile, 1995
"Disorders of primary hemostasis can be the consequence of clotting and fibrinolysis activation in terminal chronic renal failure" O. Panes, B. Muñoz, M. Pérez, J. Pereira, D. Mezzano.
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Best Publication 1996
Sociedad Médica de Santiago
Chile, 1996
"Hemostatic disorder of uremia: the platelet defect, main determinant of the prolonged bleeding time, is correlated with indices of activation of coagulation and fibrinolysis". Thromb Haemostas 1996; 76: 312-321. Mezzano D, Tagle R, Panes O, Pérez M, Downey P, Muñoz B, Aranda E, Barja P, Thambo S, González F, Mezzano S, Pereira J.
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Best Professor 3rd Grade of Medicine, 1997
School of Medicine, P. Catholic University of Chile
Chile, 1997
Voted by the Students of 3rd Grade of Medicine
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Prize Araucaria Foundation on Coronary Artery Disease
Chilean Society of Cardiology and cardiovascular Surgery
Chile, 1998
“Coronary Heart Disease: asociation with C677T gene mutation of 5,10-methylen-tetrahydrofolate reductase and plasma levels of folic acid and homocysteine". Mezzano D, Guarda E, Villagrán C, Goycoolea M, Aranda E, Quiroga T, Fajuri A, Marchant E, Martínez A, Maiz A, Pereira J.
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Best Professor 3rd Grade Medicine 1998
School of Medicine, P. Catholic University of Chile
Chile, 1998
Voted by the 3rd Grade students
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Prize Senior Investigator 1999
Faculty of Medicine, P. Catholic University of Chile
Chile, 1999
Elected by the Faculty Council.
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Prize Second Best Publication XIII Congress Chilean Society of Hematology
Chilean Society of Hematology
Chile, 2000
Selected by the Scientific Committee and the Society Directors.
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Prize Best Professor 3rd Grade of Medicine 2000
School of Medicine, P. Catholic University of Chile
Chile, 2000
Voted by the 3rd Grade Students of Medicine.
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Prize Medical Society of Santiago 1999 to the Best Publication during 1999.
Medical Society of Santiago
Chile, 1999
“Complementary Benefits of Mediterranean diet and red wine on hemostatic factors with cardiovascular risk". Mezzano D, Martínez C, Marshall G, Muñoz B, Rodríguez S, San Martín A, Pereira J, Leighton F.
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Prize Academy of Medicine 2000 to a Research Career
Chilean Academy of Medicine
Chile, 2000
Physiology, Pathophysiology and Clinical Aspects of Primary Hemostasis", granted during the XXII Congress of the Chilean Congress of Internal Medicine.
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Prize Chilean Society of Clinical Chemistry to the Best Oral Presentacion.
Chilean Society of Clinical Chemistry
Chile, 2001
“Prevalence of heparin-induced anti-phospholipid and anti-platelet antibodies in patients on hemodialysis”. Palomo I, Pereira J, Jara E, Alarcón M, Espinoza M, Moore R, Hernández A, Hernández E, Díaz G, Quiroga G, Rojas P, Vásquez M, Mezzano D, Arce I.
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Prize Best Professor 3rd Grade 2002 of Medicine
School of Medicine, P. Catholic University of Chile
Chile, 2002
Voted by the 3rd Grade Students of Medicine.
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Prize Dr. Germán Ducach Grinberg 2003 to the Best Publication in Clinical Hematology.
Chilean Society of Internal Medicine
Chile, 2003
“Mediterranean diet, but not red wine, is associated with beneficial changes on primary haemostasis”. Mezzano D, Leighton F, Strobel P, Martínez C, Marshall G, Cuevas A, Castillo O, Panes O, Muñoz B, Rozowski J, Pereira J. Eur J Clin Nutr 2003; 57: 439-446.
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Prize Dr. Germán Ducach Grinberg 2005 to the Best Publication in Clinical Hematology.
Chilean Society of Internal Medicine
Chile, 2005
“Template bleeding time and PFA-100® have low sensitivity to screen patients with hereditary mucocutaneous haemorrhages: comparative study in 148 patients. Quiroga T, Goycoolea M, Muñoz B, Morales M, Aranda E, Panes O, Pereira J, Mezzano D. J Thromb Haemost 2004; 2: 892-8.
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Prize Medical Society of Santiago 2007 to the Best Scientific Work in the XXIX Congress of the Chilean Society of Internal Medicine
Medical Society of Santiago
Chile, 2007
Cerebral perfusion defects associated with hemostasis activation in chronic cocain consumers". Massardo T, Jaimovich R, Pallavicini J, Quintana JC, Panes O, Hidalgo P, Mezzano D, Sáez C, Pereira J.
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Prize Dr. Germán Ducach Grinberg 2009 to the Best Publication in Clinical Hematology
Chilean Society of Internal Medicine
Chile, 2009
“High prevalence of bleeders of unknown cause among patients with inherited mucocutaneous bleeding. Prospective study of 280 patients and 299 controls”. Quiroga T, Goycoolea M, Panes O, Aranda E, Martínez C, Belmont S, Muñoz B, Zúñiga P, Pereira J, Mezzano D. Haematologica 2007, 92:357-365.
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Prize Eduardo Bunster Montero 2012, Chilean Society of Hematology
Chilean Society of Hematology
Chile, 2012
Prize to the Professional Career, Elected by the Directors of the Chilean Society of Hematology. Plenary Conference 2012, Congress of the Chilean Society of Hematology.
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Prize Germán Ducach Grinberg 2014 to the Best Publication in Clinical Hematology.
Chilean Society of Internal Medicine
Chile, 2014
An adenine insertion in exon 6 of human GP6 generates a truncated protein associated with a bleeding disorder in 4 Chilean families. V. Matus, G. Valenzuela, C. G. Sáez, P. Hidalgo, M. Lagos, E. Aranda, O. Panes, J. Pereira, X. Pillois, A.T. Nurden and D. Mezzano. J Thromb Haemost 2013; 11(9):1751-9.
Blood Physiology. 1993 |
Transfusion Therapy. 1979 |
Mediterranean Food and Diets, Global Resource for the Control of Metabolic Syndrome and Chronic Diseases |
New oral anticoagulant drugs |
The Level of Laboratory Testing Required for Diagnosis or Exclusion of a Platelet Function Disorder Using Platelet Aggregation and Secretion Assays |