Redox regulation of proteins, intracellular calcium concentration, signal transduction, cell death, apoptosis, autophagy. Molecular mechanism of cardioprotection, Ischemia Reperfusion cardiac, mechanism of degradation of proteins, mitochondrial dynam

2005-2007
Student: Agustin Alvarado Osorio
Title: "Phosphorylation of Sarcoplasmic Reticulum Proteins by Preconditioning Tachycardia.",
Institution: UNIVERSIDAD DE CHILE, Master / Master / DEA

2008-2010
Student: Ernesto Muñoz
Title: "Activity of the Sarcoplasmic Reticulum Reticulum Calcium Pump and its Redox Modifications",
Institution: UNIVERSIDAD DE CHILE, Master

2008-2009
Student: Carolina Fernández Pérez
Title: "Participation of mitochondrial permeability transition pore (mPTP) in preconditioning by tachycardia",
Institution: UNIVERSIDAD DE CHILE, Master

2009-2012
Student: Mauricio Ibacache
Title: "Cardioprotection by dexmedetomedine in myocardial ischemia and reperfusion",
Institution: UNIVERSIDAD DE CHILE, PhD

2009-2010
Student: Julio Miranda Betancourt
Title: "S-glutathionylation of the ryanodine receptor in skeletal muscle of insulin-resistant mice.",
Institution: UNIVERSIDAD DE CHILE, Master

2012-2014
Student: Javier Pezoa
Title: "Degradation of RyR2 in rat hearts subjected to ischemia-reperfusion: role of calpains and proteosome",
Institution: UNIVERSIDAD DE CHILE, Master

2013-2017
Student: Quezada Catalán, Mauricio
Title: "Effect of ascorbic acid on the damage caused by reperfusion in an isolated heart infarct model of a rat",
Institution: UNIVERSIDAD DE CHILE, Master

2013-2015
Student: Jaime Riquelme
Title: "Role of the eNOS-nitric oxide-cGMP-dependent protein kinase pathway in the preconditioning cardiac effect of dexmedetomidine",
Institution: UNIVERSIDAD DE CHILE, PhD

2015-2016
Student: CHALMERS ESPINOZA, STEFANIE GRACE
Title: "Cardioprotective effect of n-acetylcysteine in the damage produced by ischemia, on the content of mitofusin 2, in isolated heart of rat",
Institution: UNIVERSIDAD DE CHILE, Master

2015-2017
Student: BERRIOS ZAMORA, DANIELA
Title: "Effect of the Proteasome Chymotrypsin Activity on the damage produced by ischemia in rat isolated heart",
Institution: UNIVERSIDAD ARTURO PRAT, Bachelor

2015-2018
Student: González, Jaime
Title: "Pharmacological prevention of myocardial damage due to reperfusion in acute myocardial infarction",
Institution: UNIVERSIDAD DE CHILE, PhD

2016-2017
Student: Conejeros Vasquez Carolina
Title: "Participation of Miro1 in hypertrophy in neonatal rat cardiomyocytes",
Institution: UNIVERSIDAD DE CHILE, Master

2016-2017
Student: Ahumada Cortes Xavier
Title: "Effect of the inhibition of the chymotrypsin activity of the proteasome during ischemia, in the mitochondrial structure of the rat isolated heart",
Institution: UNIVERSIDAD DE CHILE, Master

2016-2018
Student: Huechamil Iglesias Matias Ignacio
Title: " The use of iron chelators decreases diastolic dysfunction in an ex vivo model of ischemia and reperfusion due to the inhibition of titin redox status ",
Institution: UNIVERSIDAD DE CHILE, Master

2017-2018
Student: Inostroza Herrera Cristopher
Title: "Decreased myocardial damage by reperfusion in the Langendorff model by co-administration of Ascorbic Acid and Deferoxamine",
Institution: UNIVERSIDAD DE CHILE, Master

2017-2019
Student: Utreras Mendoza Yildy
Title: "" Identification of the signaling pathway of cardiac hypertrophy in C57BL / 6J mice fed a high-fat diet "",
Institution: UNIVERSIDAD DE CHILE, PhD

2018-2019
Student: Mujica Isidora
Title: "Effect of obesity produced by a high-fat diet on the cellular redox balance in the heart",
Institution: UNIVERSIDAD DE CHILE, Master

2017- 2019
Student: Gajardo, Abraham Isaac Jacob
Title: "Effect of" autonomic stress "on cardioprotection due to remote ischemic preconditioning: transferring ischemic conditioning from the laboratory to clinical practice",
Institution: UNIVERSIDAD DE CHILE, PhD

Patent of Invention
INAPI
registry number 56881
Headline: Universidad de Chile
Inventors:
Sánchez Vergara, Gina; Prieto Domínguez, Juan Carlos; Florenzano Urzúa, Fernando; Gormaz Araya, Juan Guillermo; Rodrigo Salinas, Ramón; Aguayo Nayle, Rubén.
Title:
Pharmaceutical injectable antioxidant composition comprising high dose ascorbic acid, N-acetyl cysteine ??and deferoxamine; use in the prevention of damage by perfusion in patients before, during and after angioplasty, acute myocardial infarction or reperfusion in cerebrovascular accident.

Application 2014-3326
Date of application: 05-12-2014
Award date: 04-10-2018
Date of granting registration number: 03-01-2019
Effective date: 05-12-2014
Expiry date: 05-12-2034