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Andrea Cristina Paula-Lima -

Profesora Asociada

UNIVERSIDAD DE CHILE

Santiago, Chile

Neurobiology of Alzheimer´s disease; Endoplasmic reticulum, Mitochondria & Neuronal Calcium Signaling; Neuroinflammation.

Biotechnologist, Federal Institute of Chemistry of Rio de Janeiro. Brasil, 1996
Pharmacist, Federal University of Rio de Janeiro. Brasil, 2003
PhD in Biological Chemistry, Federal University of Rio de Janeiro. Chile, 2007
University teaching, UNIVERSIDAD DE CHILE. Chile, 2012
Post Doctorate , UNIVERSIDAD DE CHILE. Chile, 2011

Assistant Professor Full Time

UNIVERSIDAD DE CHILE

Faculty of Medicine

Santiago, Chile

2010 - 2011
Associate Professor Full Time

UNIVERSIDAD DE CHILE

Faculty of Dentistry

Santiago, Chile

2011 - A la fecha
Associate Professor Part Time

UNIVERSIDAD DE CHILE

Faculty of Medicine

Santiago, Chile

2019 - A la fecha
Coordinadora de Postgrado Full Time

UNIVERSIDAD DE CHILE

Faculty of Dentistry

Santiago, Chile

2013 - 2018

Técnica de Laboratorio de Bacteriología Clínica Full Time

Fiocruz

Rio de Janeiro, Brasil

1996 - 1996
Asistente de Docencia en Laboratorio Part Time

Instituto Federal de Química do Rio de Janeiro

Rio de Janeiro, Chile

1995 - 1995


Astaxanthin Counteracts Excitotoxicity and Reduces the Associated Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation García F.; Lobos P.; Ponce A.; Cataldo K.; Meza D.; Farías P.; Estay C.; Oyarzún-Ampuero F.; Herrera-Molina R.; Paula Lima A.; Ardíles A.; Hidalgo C.; Adasme T.; Munoz P.C. Article ISI Marine Drugs (2020)
Differential navigational strategies during spatial learning in a new modified version of the Oasis maze Concha-Miranda, Miguel; More, Jamileth; Grinspun, Noemi; Sanchez, Cristian; Paula-Lima, Andrea; Valdés, José L. Article ISI SCOPUS Behavioural Brain Research (2020)
Redox modifications in synaptic components as biomarkers of cognitive status, in brain aging and disease Munoz P.C.; Ardiles A.; Pérez-Espinosa B.; Núñez-Espinosa C.; Paula-Lima A.; Gonzalez-Billaud C.; Epinosa-Parrilla Y. Article ISI Mechanisms of Ageing and Development (2020)
Calcium Release Mediated by Redox-Sensitive RyR2 Channels Has a Central Role in Hippocampal Structural Plasticity and Spatial Memory More, Jamileth Y.; Bruna, Barbara A.; Lobos, Pedro E.; Galaz, José L.; Figueroa, Paula L.; Namias, Silvia; Sánchez, Gina L.; Barrientos, Genaro C.; Valdés, José L.; Paula-Lima, Andrea C.; Hidalgo, Cecilia; Adasme, Tatiana Article ISI SCOPUS ANTIOXIDANTS & REDOX SIGNALING (2018)
Reactive oxygen species released from astrocytes treated with amyloid beta oligomers elicit neuronal calcium signals that decrease phospho-Ser727-STAT3 nuclear content Munoz, Y; Paula-Lima, AC; Nunez, MT Article ISI SCOPUS FREE RADICAL BIOLOGY AND MEDICINE (2018)
The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K Bruna, Barbara; Lobos, Pedro; Herrera-Molina, Rodrigo; Hidalgo, Cecilia; Paula-Lima, Andrea; Adasme ,Tatiana Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)
Contribution of Ca(2+) Release Channels to Hippocampal Synaptic Plasticity and Spatial Memory: Potential Redox Modulation. Paula-Lima, Andrea C; Adasme, Tatiana; Hidalgo, Cecilia Article Antioxidants & redox signaling (2014)
Amyloid beta-peptide oligomers, ryanodine receptor-mediated Ca(2+) release, and Wnt-5a/Ca(2+) signaling: opposing roles in neuronal mitochondrial dynamics? Paula-Lima, Andrea C; Hidalgo, Cecilia Article Frontiers in cellular neuroscience (2013)
Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease. Paula-Lima, Andrea C; Brito-Moreira, Jordano; Ferreira, Sergio T Article Journal of neurochemistry (2013)
Amyloid-beta oligomers induce differential gene expression in adult human brain slices. Sebollela, Adriano; Freitas-Correa, Leo; Oliveira, Fabio F; Paula-Lima, Andrea C; Saraiva, Leonardo M; Martins, Samantha M; Mota, Louise D; Torres, Cesar; Alves-Leon, Soniza; de Souza, Jorge M; Carraro, Dirce M; Brentani, Helena; De Felice, Fernanda G; Ferreira, Sergio T Article The Journal of biological chemistry (2012)
Sub-lethal levels of amyloid Î²-peptide oligomers decrease non-transferrin-bound iron uptake and do not potentiate iron toxicity in primary hippocampal neurons. SanMartín, C D; Paula-Lima, A C; Hidalgo, C; Núñez, M T Article Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine (2012)


Role of RyR2-mediated calcium release in synaptic plasticity, learning and memory in control and AD-model rats Hidalgo C.; More, J.; Valdes, I; SanMartin, C.; Muñoz P; Barrientos, G; Valdes, JL; Sánchez G; Paula Lima A. Abstract ISI JOURNAL OF NEUROCHEMISTRY (2015)


El serotipo b Aggregatibacter actinomycetemcomitans es parte del consorcio de bacterias periodontales que participan en la etiología de la enfermedad de Alzheimer Andrea Paula-Lima; Diaz-Zuniga, J. Proyecto (2020)
CANCER LEAVES A TRAIT OF DIMINISHED IMMUNE TOLERANCE THAT PROTECTS FROM ALZHEIMER’S DISEASE FONDECYT (324282) Proyecto 2019-2023 Coinvestigador(a)
UNVEILING HOW NEURONAL CALCIUM SIGNALS REACH THE NUCLEUS FOLLOWING SYNAPSE ACTIVATION PCI (BMBF180051) Proyecto 2019-2022 Coinvestigador(a)
ASOCIACIÓN ENTRE ENFERMEDAD PERIODONTAL Y ENFERMEDAD DE ALZHEIMER Facultad de Odontología (FioUch) Proyecto 2017-2019 Subdirector(a)
EXPERIMENTAL PERIODONTAL INFECTION INDUCED BY PORPHYROMONAS GINGIVALIS OR AGGREGATIBACTER ACTINOMYCETEMCOMITANS AND ITS ASSOCIATION WITH ALZHEIMER’S DISEASE. LOOKING FOR THE POTENTIAL RISK FACTOR. International Association for Dental research (171) Proyecto 2017-2019 Subdirector(a)
CM-BIOMEDICAL NEUROSCIENCE INSTITUTE Iniciativa Científica Milenium (BNI P09-015-F) Proyecto 2016-2021 Investigador(a)
DEFECTIVE CALCIUM/REDOX SIGNALING AND ANOMALOUS ELECTRICAL BRAIN ACTIVITY IN RATS INJECTED WITH AMYLOID BETA OLIGOMERS=> FUNCTIONAL AND BEHAVIORAL CORRELATES WITH ALZHEIMER´S PATIENTS. FONDECYT (1150736) Proyecto 2015-2019 Inv. Responsable
MICROSCOPIO DE CAMPO EVANESCENTE O TIRF FONDEQUIP (EQM140019) Proyecto 2014-2014 Coinvestigador(a)
MOTORIZED MICROSCOPE “CELL OBSERVER” WITH LED FLUORESCENCE SYSTEM FONDEQUIP (EQM140156) Proyecto 2014-2014 Coinvestigador(a)
System Storage and Advanced Biomedical Computing Services (SASIBA) FONDEQUIP (EQM140119) Proyecto 2014-2014 Coinvestigador(a)
ACQUISITION OF AN ULTRACENTRIFUGE WITH 4 ROTORS FONDEQUIP (EQM130155) Proyecto 2013-2013 Coinvestigador(a)
CONFOCAL MICROSCOPY PLATFORM FOR USE IN ADVANCED BIOMEDICAL RESEARCH FONDEQUIP (EQM130042) Proyecto 2013-2013 Coinvestigador(a)
ACQUISITION OF A SCANNING ELECTRON MICROSCOPE AND ANCILLARY EQUIPMENT (SEMEDX) (SEM-EDX) FOR ADVANCED RESEARCH IN DENTAL SCIENCES FONDEQUIP (EQM130076) Proyecto 2012-2012 Coinvestigador(a)
BIOMED-HPC=> RED DE BIOLOGÍA Y MEDICINA COMPUTACIONAL DE ALTO RENDIMIENTO. Programa U-redes Línea Domeyko 2. Fondequip (CONRED-2012-999) Proyecto 2012-2014 Coinvestigador(a)
ESTUDIO DE PATRONES OSCILATORIOS ANORMALES EN SUJETOS CON ENFERMEDAD DE ALZHEIMER INCIPIENTE Y EN ROEDORES INYECTADOS CON OLIGÓMEROS DEL PÉPTIDO BETA-AMILOIDE. Fondos Estratégicos BNI (Biomedical Neuroscience Institute) (BNI P-09-015F) Proyecto 2012-2013 Coinvestigador(a)
EPIFLUORESCENCE MICROSCOPE TO STIMULATE INTERDISCIPLINARY RESEARCH USING CELL BIOLOGY APPROACHES IN THE FACULTY OF DENTISTRY, UNIVERSIDAD DE CHILE. Universidad de Chile (VID2011) Proyecto 2011-2011 Coinvestigador(a)
UNRAVELING THE CALCIUM SIGNALING PATHWAYS THAT MEDIATE THE NEURONAL DYSFUNCTIONS INDUCED BY AMYLOID-BETA PEPTIDE OLIGOMERS. FONDECYT (11110322) Proyecto 2011-2014 Inv. Responsable
RENOVACIÓN ACADÉMICA PARA EL DESARROLLO DE LA MEDICINA MOLECULAR PAI (79090021) Proyecto 2010-2013 Inv. Principal
ROLE OF RYANODINE RECEPTORS ON NEURONAL CALCIUM SIGNALS AND SYNAPTIC PLASTICITY ALTERATIONS INDUCED BY THE BETA-AMYLOID PEPTIDE. FONDECYT (3085025) Proyecto 2007-2010 Inv. Responsable
ROLE OF RYANODINE RECEPTORS ON NEURONAL CALCIUM SIGNALS AND SYNAPTIC PLASTICITY ALTERATIONS INDUCED BY THE BETA-AMYLOID PEPTIDE. FONDECYT (3085025) Proyecto 2007-2010 Inv. Responsable