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CATALINA PÍA PRIETO SEITTER

Investigadora senior

Universidad de Chile

Santiago, Chile

Células troncales humanas, Células endoteliales, Reparación tisular, Diabetes gestacional, Disfunción endotelial, Células mesenquimales, Cordón umbilical, Medicina regenerativa

Doctorado en Ciencias Biológicas con mención en Cs. Fisiológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2012
Magíster en Ciencias Biológicas con mención en Cs. Fisiológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2010
Licenciatura en Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2006
Diplomado en Docencia en Educación Superior, Pontificia Universidad Católica de Chile. Chile, 2024

Postdoctor Full Time

UNIVERSIDAD DE CHILE

Ciencias

Santiago, Chile

2012 - 2013
Investigador responsable Full Time

UNIVERSIDAD DE CHILE

Ciencias

Santiago, Chile

2014 - 2015
Investigadora asociada Full Time

UNIVERSIDAD DE CHILE

Ciencias

Santiago, Chile

2015 - 2017
Docente Other

UNIVERSIDAD DE CHILE

Ciencias

Santiago, Chile

2024 - 2024

Ayudante Fisiología humana BIO 256M Other

Pontificia Universidad Católica de Chile

Santiago, Chile

2008 - 2008
Ayudante Laboratorio de Fisiología (BIO299c) Other

Pontificia Universidad Católica de Chile

Santiago, Chile

2006 - 2006
Ayudante Laboratorio de Química, Biología Celular (BIO297c) Other

Pontificia Universidad Católica de Chile

Santiago, Chile

2006 - 2006
Tesista pregrado Part Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2006 - 2006
Tesista Postgrado Full Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2007 - 2012
Ayudante Trabajo Experimental en Ecología (BIO298c) Other

Pontificia Universidad Católica de Chile

Chile

2005 - 2005
Directora de Innovación (CTO) Full Time

CellTech4U SpA

Santiago, Chile

2022 - 2024

Integrante de la Red de Investigadoras y Académicas Uchile (RIAC)

“The Y.W. Loke New Investigator Travel Award 2010”

The Placental Associations of America (PAA) and The Latin American Symposium on Fetal-Maternal Interaction and Placenta. (SLIMP)

Chile, 2010

In recognition of the excellence of his/her abstract submitted
La Sociedad Latino-Americana de Investigaciones Materno-Fetales y Placentarias Premio 2010

XVI International Federation of Placenta Association (IFPA), The Placental Associations of America (PAA) and The Latin American Symposium on Fetal-Maternal Interaction and Placenta. (SLIMP) 2010

Chile, 2010

In recognition of the best oral presentation


Efficacy of stem cell secretome loaded in hyaluronate sponge for topical treatment of psoriasis Carrillo, Daniela; Edwards, N; Arancibia-Altamirano D; Otarola, F.; Villarroel C; Prieto CP; Gabriela Villamizar-Sarmiento, Maria; Sauma D.; Valenzuela, F.; LATTUS J.; Oyarzun-Ampuero, F; Palma, V Article doi.org/10.1002/btm2.1044 Bioengineering & Traslational Medicine (2022)
Schizophrenia-derived hiPSC brain microvascular endothelial-like cells show impairments in angiogenesis and blood-brain barrier function Casas, Barbara S.; Vitoria, Gabriela; Prieto, Catalina P.; Casas, Mariana; Chacon, Carlos; Uhrig, Markus; Ezquer, Fernando; Ezquer, Marcelo; Rehen, Stevens K.; Palma, Veronica Article ISI MOLECULAR PSYCHIATRY (2022)
Downregulation of the Netrin-1 Receptor UNC5b Underlies Increased Placental Angiogenesis in Human Gestational Diabetes Mellitus Casas, Bárbara S.; Falcón, Paulina.; Villanueva, Andrea A.; Lois, Pablo.; Lattus, José. Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Hyperbaric Oxygen Increases Stem Cell Proliferation, Angiogenesis and Wound-Healing Ability of WJ-MSCs in Diabetic Mice Pena-Villalobos, I; Casanova-Maldonado, I; Lois, P; Prieto, C; Pizarro, C; Lattus, J; Osorio, G; Palma, V Article ISI FRONTIERS IN PHYSIOLOGY (2018)
Epigenetic Signatures at the RUNX2-P1 and Sp7 Gene Promoters Control Osteogenic Lineage Commitment of Umbilical Cord-Derived Mesenchymal Stem Cells Sepulveda, Hugo; Aguilar, Rodrigo; Prieto, Catalina P.; Bustos, Francisco; Aedo, Sócrates; Lattus, José; van Zundert, Brigitte; Palma, Verónica; Montecino, Martin Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2017)
Netrin-1 acts as a non-canonical angiogenic factor produced by human Wharton's jelly mesenchymal stem cells (WJ-MSC) Prieto C.P., Ortiz M.C., Villanueva A.A., Villarroel C., Edwards S., Elliott M., Aedo, S., Lattus J., Meza D., Lois P., Palma V Article ISI SCOPUS Stem Cell Research and Therapy (2017)
Runt-Related Transcription Factor 2 Induction During Differentiation of Wharton's Jelly Mesenchymal Stem Cells to Osteoblasts Is Regulated by Jumonji AT-Rich Interactive Domain 1B Histone Demethylase Bustos F.; Sepúlveda H.; Prieto C.P.; Carrasco M.; Díaz L.; Palma J.; LATTUS J.; Montecino M.; Palma V. Article ISI SCOPUS STEM CELLS (2017)
Sonic hedgehog (SHH) signaling improves the angiogenic potential of Wharton's jelly-derived mesenchymal stem cells (WJ-MSC) Zavala G.; Prieto C.P.; Villanueva A.A.; Palma V. Article ISI SCOPUS STEM CELL RESEARCH & THERAPY (2017)
Sonic hedgehog (SHH) signaling improves the angiogenic potential of Wharton's jelly-derived mesenchymal stem cells (WJ-MSC). Zavala G, Prieto CP, Villanueva AA, Palma V. Article Stem Cell Res Ther. (2017)
Functional analysis reveals angiogenic potential of human mesenchymal stem cells from Wharton's jelly in dermal regeneration Edwards, SS; Zavala, G; Prieto CP; Elliott M.; Martínez, S.; Egana, JT; Bono, MR.; Palma, V Article ISI SCOPUS ANGIOGENESIS (2014)
Functional analysis reveals angiogenic potential of human mesenchymal stem cells from Wharton's jelly in dermal regeneration. Edwards SS, Zavala G; Prieto CP, Elliott M; Martínez S, Egaña JT; Bono MR, Palma V. Article Angiogenesis (2014)
Role of arginase-2 and eNOS in the differential vascular reactivity and hypoxia-induced endothelial response in umbilical arteries and veins Krause BJ, Prieto CP; Muñoz-Urrutia E, San Martín S; Sobrevia L, Casanello P Article Placenta (2012)
Role of arginase-2 and eNOS in the differential vascular reactivity and hypoxia-induced endothelial response in umbilical arteries and veins Krause, B. J.; Prieto C.P.; Munoz-Urrutia, E; San Martin, S; Sobrevia L.; Casanello, P Article ISI SCOPUS Placenta (2012)
Hypoxia-reduced nitric oxide synthase activity is partially explained by higher arginase-2 activity and cellular redistribution in human umbilical vein endothelium Prieto CP, Krause BJ; Quezada C, San Martin R; Sobrevia L, Casanello P Article Placenta (2011)
Hypoxia-reduced nitric oxide synthase activity is partially explained by higher arginase-2 activity and cellular redistribution in human umbilical vein endothelium Prieto CP; Krause, BJ; Quezada C.; San Martín R.; Sobrevia L.; Casanello, P Article ISI SCOPUS Placenta (2011)
Reduced L-Arginine Transport and Nitric Oxide Synthesis in Human Umbilical Vein Endothelial Cells from Intrauterine Growth Restriction Pregnancies is Not Further Altered by Hypoxia Casanello, P; Krause, B; Torres E.; Gallardo V.; Gonzalez, M.; Prieto, C; Escudero, c; Farias M.; Sobrevia L. Article ISI SCOPUS PLACENTA (2009)
Reduced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelial cells from intrauterine growth restriction pregnancies is not further altered by hypoxia Casanello P, Krause B; Torres E, Gallardo V; González M, Prieto C; Escudero C, Farías M Article Placenta (2009)
Processes regulating early post-settlement habitat use in a subtidal assemblage of brachyuran decapods Pardo, LM; Palma, AT; Prieto, C; Sepúlveda P.; Valdivia, I; Ojeda, FP Article ISI SCOPUS JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY (2007)
Processes regulating early post-settlement habitat use in a subtidal assemblage of brachyuran decapods Pardo LM, Palma AT; Prieto C, Sepúlveda P; Valdivia I, Ojeda FP Article Journal of Experimental Marine Biology and Ecology (2007)


INCREASED SPROUTING IN GESTATIONAL DIABETES MELLITUS COULD RESULT FROM DOWNREGULATION OF THE NETRIN-1'S ANTI-ANGIOGENIC RECEPTOR, UNC5B Prieto, CP; Villanueva, AA; Falcon, P; Alvarez, F ; Enriquez, P; Lattus, J; Aedo, S; Palma, V Abstract ISI PLACENTA (2017)
RhoA/ROCK Signaling Pathway Is Not Implicated in the Regulation of eNOS Activation and arginase-2 Expression in Human Umbilical Vein Endothelial Cells Exposed to Hypoxia. Prieto CP; Krause, BJ; Sobrevia L.; Casanello, P Abstract ISI REPRODUCTIVE SCIENCES (2012)
Abnormal Expression of L-Arginine/NO-Related Enzymes in HUVEC Is Associated with Altered Vascular Reactivity of Umbilical Vein from IUGR Placentae Krause, BJ; Muñoz E; Prieto CP; Sobrevia L.; Casanello, P Abstract ISI JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2011)
Hypoxia-Reduced eNOS Activity Could Be Explained by Higher Arginase II Activity and Cellular Redistribution in Human Umbilical Vein Endothelial Cells Prieto CP; Krause, B; Sobrevia L.; Casanello, P Abstract ISI REPRODUCTIVE SCIENCES (2010)
PARTICIPATION OF ARGINASES IN THE VASCULAR TONE IN UMBILICAL VEIN FROM IUGR PLACENTAE: ROLE OF THE ENDOTHELIUM AND HYPOXIA Muñoz E; Krause, B; Prieto, C; Lavin C.; Sobrevia L.; Casanello, P Abstract ISI PLACENTA (2010)
RHOA/ROCK SIGNALLING PATHWAY IS NOT IMPLICATED IN ENOS INACTIVATION BY HYPOXIA IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS Prieto CP; Sobrevia L.; Casanello, P Abstract ISI PLACENTA (2010)
Role of Arginase II in the Vascular Function of Umbilical Arteries and Veins: Effect of Hypoxia Krause, B; Prieto, C; Sobrevia L.; Casanello, P Abstract ISI REPRODUCTIVE SCIENCES (2010)
Upregulation of Arginase II in Hypoxia Counteracts Nitric Oxide Synthesis in Human Umbilical Vein Endothelial Cells Prieto, C; Krause, B; Torres E.; Sobrevia L.; Casanello, P Abstract ISI REPRODUCTIVE SCIENCES (2009)
Hypoxia upregulates the expression of arginase II in human umbilical vein endothelial cells. Regulating the nitric oxide synthase activity Prieto CP; Krause, BJ; Torres E.; Sobrevia L.; Casanello, P Abstract ISI PLACENTA (2008)
Lower activity of L-arginine-nitric oxide pathway is related to PKCA activation in human umbilical vein endothelium from intruterine growth restriction. Casanello, P; Prieto, C; Escudero, c; Sobrevia L. Abstract ISI PLACENTA (2007)
Inhibition of L-arginine transport and nitric oxide activity in human umbilical vein endothelium of newborn with intrauterine growth restriction: role of hypoxia and PKC Casanello, P; Gallardo V.; Prieto, C; Sobrevia L. Abstract ISI EARLY HUMAN DEVELOPMENT (2006)


Finalización del desarrollo preclínico de un parche biológicamente activo, elaborado en base a una matriz de colágeno o celulosa que contiene células humanas de la gelatina de Wharton (hWJ-MSC), para la realización futura de ensayos clínicos en pacientes con pie diabético Palma Verónica Proyecto (2015)
ANGIOGENESIS NO CANONICA INDUCIDA POR LA VIA NETRINA-RHOA/ROCK EN UN MODELO ENTRE CELULAS TRONCALES DE LA GELATINA DE WHARTON (WJ-MSC) Y CELULAS ENDOTELIALES DE LA VENA UMBILICAL HUMANA (HUVEC) EN ALTA GLUCOSA Prieto Catalina ; Verónica Palma Proyecto (2014)
Non-canonical angiogenesis induced by Netrin-RhoA/ROCK pathway in a gestational diabetes model=> Interaction between stem cells from Wharton's jelly (WJ-MSC) and human umbilical vein endothelial cells (HUVEC) in high glucose. FONDECYT (3140368) Proyecto 2014-2015 Inv. Responsable
Develop technologies for the production and potential use of mesenchymal stem cells derived from Wharton's jelly for the treatment of vascular lesions caused by chronic limb ischemia FONDEF (D09I1047) Proyecto 2011-2013 Investigador(a)
Characterization of the pathohysiological mechanisms, and detection of common therapeutic targets in placental dysfunction in pathologies of the human pregnancy PIA (Anll.ACT73) Proyecto 2010-2011 Personal técnico y/o de apoyo
Role of arginases I and II in endothelial dysfunction in the feto-placenta unit in pregnancies with intrauterine growth restriction and hypoxia FONDECYT (1080534) Proyecto 2008-2012 Personal técnico y/o de apoyo
CARACTERIZACION DE LAS VIAS DE SEÑALIZACION INVOLUCRADAS EN LA DISMINUCION DE LA ACTIVIDAD DE LA RUTA L-ARGININA/OXIDO NITRICO ENDOTELIAL EN RESTRICCION DEL CRECIMIENTO INTRAUTERINO E HIPOXIA Casanello, Paola Proyecto (2007)
Participación de las arginasas en la disfunción endotelial característica de la hipertensión arterial. Apoyo en investigación. Pontificia Universidad Católica de Chile (VRAID BM14/2007) Proyecto 2007-2008 Personal técnico y/o de apoyo
Regulation of L-Arginine/Nitric Oxide pathway signaling in human umbilical vein endothelium from intrauterine growth restriction (IUGR). FONDECYT (1030607) Proyecto 2003-2007 Personal técnico y/o de apoyo