Man

Bernardo Javier Krause Leyton

Associate Professor

Universidad de O'Higgins

Rancagua, Chile

Líneas de Investigación


Vascular physiology; Immune System; Fetal programming; Epigenetics; Hypoxia; Obesity; Early Life Stress;

Educación

  •  Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2012
  •  Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009
  •  Biochemist, UNIVERSIDAD DE CHILE. Chile, 2004

Experiencia Académica

  •   Assistant Professor of Chemistry Other

    UNIVERSIDAD DEL BIO-BIO

    Health and Food Sciences

    Chillán, Chile

    2007 - 2007

  •   Assistant Professor of Physiology Other

    UNIVERSIDAD DE CHILE

    Health and Food Sciences

    Chillán, Chile

    2007 - 2007

  •   Ajunct Researcher Other

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    Santiago, Chile

    2010 - 2010

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    Santiago, Chile

    2017 - 2020

  •   Assistant Professor Full Time

    Universidad de O'Higgins

    Instituto de Ciencias de la Salud

    Rancagua, Chile

    2020 - 2021

  •   Profesor Asociado Full Time

    Universidad de O'Higgins

    Instituto de Ciencias de la Salud

    Rancagua, Chile

    2021 - A la fecha

Experiencia Profesional

  •   Welcome Trust Fellow Research Full Time

    Fetal and Developmental Physiology Laboratory, Faculty of Medicine, Universidad de Chile.

    Santiago, Chile

    2004 - 2007

  •   Fellow Research Full Time

    Faculty of Medicine Pontificia Universidad Católica de Chile

    Santiago, Chile

    2007 - 2007

  •   Secretary Other

    International Society for Developmental Origins of Health and Disease - Latin American Chapter

    Reino Unido

    2016 - 2020

  •   Coordinator of Research and Scientific Excellence Other

    International Society for Developmental Origins of Health and Disease - Latin American Chapter

    Reino Unido

    2020 - A la fecha

  •   Vice-president Ethics and Scientific Committee of Animal Welfare Other

    Pontificia Universidad Catolica de Chile

    Santiago, Chile

    2019 - Sin Información

Formación de Capital Humano


Postdoctoral mentorship, Dr. Alejandro González Candia, Insitituto de Ciencias de la Salud, Universidad de O'Higgins, 2020 (in progress).

Postdoctoral mentorship, Dr. Francisca Salas Perez, Insitituto de Ciencias de la Salud, Universidad de O'Higgins, 2020 - 2021.

Co-Director PhD in Biological Sciences. Pontificia Universidad Católica de Chile. Student: German Arenas. Title:“Efecto de la hipoxia en la expresión de PIEZO1 y su contribución en la respuesta vasodilatadora dependiente de endotelio”. (2019 - in progress)

Lecturer in the VI Workshop on Maternal-Fetal Interaction, University of São Paulo, October 2019, São Paulo, Brasil

Director Biochemist thesis, Pontificia Universidad Católica de Valparaíso. Student: Adolfo Paz Ferreira. Title: “Participación de vías de síntesis de H2S en la prevención de la disfunción vascular en embriones de Gallus gallus con restricción de crecimiento inducido por hipoxia” March 2019 - January 2020

Director Biochemist thesis, Pontificia Universidad Católica de Chile. Student: Estefanía Peñaloza Pezoa. Title: Micro-RNAs 21 y 126 en la respuesta a hypoxia en células endoteliales de arteria umbilical (Micro-RNA 21 and 126 in the response to hypoxia in HUAEC). September 2016- October 2017

Director PhD in Biomedical Science. Pontificia Universidad Católica de Chile. Student: Fabián Vega. Title: EFECTO DE LA REGULACIÓN DE LA VÍA mTOR SOBRE LA PROGRAMACIÓN FUNCIONAL EN MONOCITOS DE HIJOS DE MADRES CON OBESIDAD PREGESTACIONAL. 2017 - 2020

Director Nutritionist thesis, Pontificia Universidad Católica de Chile. Student: Isidora Lefever Medina. Title: Efecto in vitro de la leptina recombinante en la respuesta inflamatoria de macrófagos derivados de monocitos del cordón umbilical de recién nacidos de madres obesas (In vitro effect of leptin on the inflammatory response in monocyte-derived macrophages from neonates born to obese mothers). March - December 2016

Director Nutritionist thesis, Pontificia Universidad Católica de Chile. Student: Catalina Letelier. Title: Efecto in vitro de la leptina recombinante en la respuesta inflamatoria de macrófagos derivados de monocitos del cordón umbilical de recién nacidos de madres obesas (In vitro effect of leptin on the inflammatory response in monocyte-derived macrophages from neonates born to obese mothers). March - December 2016

Director Biochemist thesis, Pontificia Universidad Católica de Chile. Student: Francisca Cifuentes Zuñiga. Title: EFECTO DE LA OBESIDAD MATERNA SOBRE LA EXPRESIÓN DE MEDIADORES INFLAMATORIOS EN MACRÓFAGOS FETALES: POTENCIAL PROGRAMACIÓN DE LA FUNCIÓN INMUNE (Effect of maternal obesity on the expression of inflammatory mediators in fetal macrophages). July 2015-June 2016

Co-director Medical Veterinary thesis, University of Chile. Student: René Alegría. Title: CARACTERIZACIÓN DE LA FUNCIÓN VASCULAR DE UN MODELO DE RESTRICCIÓN DE CRECIMIENTO INTRA-UTERINO POR OCLUSIÓN PROGRESIVA DE ARTERIAS UTERINAS EN COBAYAS (Vascular function characterization in a guinea pig model of intrauterine growth restriction by gradual uterine artery occlusion) March - December 2014.

Lecturer on the III Workshop on Maternal Fetal Interaction - University of São Paulo, February 2013, São Paulo, Brasil

Tutorial. Molecular Cell Biology. Faculty of Odontology, Pontificia Universidad Católica de Chile. First semester 2010.


Difusión y Transferencia


Patents
- METHOD FOR THE ENANTIOSELECTIVE SYNTHESIS OF 2(S)-AMINO-6-BORONOHEXANOIC ACID (ABH) AND PURIFICATION. Presented in August 20th, 2015. PCT/CL2015/050035
- PHARMACEUTICAL COMBINATION FOR THE TREATMENT AND PREVENTION OF ARTERIAL HYPERTENSION AND VASCULAR DYSFUNCTION. Presented in November 18th, 2016. PCT/CL2016/050062

Invited Speaker
- Programación funcional y epigenética de la función vascular. XX Reunión Internacional de Ciencias Médicas, 2020. Mexico
- Vascular Programming Of Gasotransmitter Vasodilators Resulting From Hypoxia And Epigenetic Interactions. 55º Congresso Anual SBFIS, 2020. Brasil.
- Functional and epigenetic programming of cardiovascular disease. 2019 DOHaD international meeting. Melbourne, Australia.
- DESCUBRIENDO LOS ORÍGENES EPIGENÉTICOS DE LA DISFUNCIÓN VASCULAR ADULTA ASOCIADA A LA RESTRICCIÓN DEL CRECIMIENTO FETAL Y SU RELACIÓN CON EL ESTRÉS OXIDATIVO INTRAUTERINO. XL CONGRESO ANUAL DE LA SOCIEDAD DE FARMACOLOGÍA DE CHILE, 2018. Santa Cruz, Chile.
- Targeting the maternal oxidative stress in fetal growth restriction: preventing the early origins of vascular dysfunction. 3rd Meeting of Ibero-American DOHaD chapter 2018. Cancun, Mexico.
- The Impact of Obesity on Placenta and Intrauterine Growth. Annual Scientific Meeting - Society for Reproductive Investigation 2018. San Diego, USA.
- Introducción a la epigenética: función endotelial en la Restricción de Crecimiento Intrauterino como modelo de estudio. Jornada de Investigación de la División de Pediatría (PUC) 2017. Santiago, Chile
- "Epigenetic programming of the vascular function". DOHaD Seminar Chile 2016. Santiago, Chile
-"Fetal programming of endothelial function by epigenetic mechanisms: interaction with nitric oxide" XXXVIII Reunión Anual de la Sociedad de Bioquímica y Biología Molecular, 2015. Pucon, Chile.

Invited reviewer of manuscripts for the following ISI journals
- American Journal of Physiology.
- Biochemical Pharmacology.
- British Journal of Pharmacology.
- Free Radical Biology & Medicine
- Frontiers in Physiology.
- Gynecologic and Obstetric Investigation.
- International Journal of Obesity.
- Journal of Developmental Origins of Health and Disease.
- Journal of Herbal Medicine.
- Journal of Physiology.
- Obesity.
- Obesity Research and Clinical Practice.
- Pediatric Research.
- Placenta.
- Plos One
- Reproductive Sciences.

Outreach activities
- Biographic interview "Rockstart" (June 2022) https://soundcloud.com/txsplus/rockstars-con-gabriel-leon-y-dr-bernardo-krause-24-de-junio-del-2022?utm_source=clipboard&utm_campaign=wtshare&utm_medium=widget&utm_content=https%253A%252F%252Fsoundcloud.com%252Ftxsplus%252Frockstars-con-gabriel-leon-y-dr-bernardo-krause-24-de-junio-del-2022
- Radio Interview "Radio Sensasion" (May 2022) "Niñez vulnerable y enfermedades crónicas" https://www.youtube.com/watch?v=2p_GOU9bE-s (minutes 1 - 35)
- Radio Interview "Radio USACH" (August 2021) "El Estrés Postraumático y El Impacto de la Salud de los Padres en hijos" https://www.youtube.com/watch?v=OVOcVJKeYSw (minutes 34 - 55)
- News paper article (June 2021) "EL ORIGEN FETAL DE LAS ENFERMEDADES DEL ADULTO". https://lanoticia.cl/academico-uoh-participo-en-seminario-internacional-sobre-el-origen-fetal-de-las-enfermedades-del-adulto/
- News paper article (May 2021) "Investigador aclara la relación entre el asma y haber nacido de una madre con obesidad" https://www.litoralpress.cl/sitio/Prensa_Texto?LPKey=PB2KCE4EBKYH3EEMMVQBUJW2ORVSSHBNAQWZ26MILHWRYIBZDVAQ
- Radio Invertiew "Radio DUNA" (April 2021) "Mecanimos epigenéticos en los orígenes de la salud y enfermedad" https://www.duna.cl/programa/aire-fresco/2021/04/27/dr-bernardo-krause-e-investigacion-en-la-epigenetica-viene-a-reafirmar-la-importancia-de-proteger-los-primeros-anos-de-vida-beneficiando-la-lactancia-materna-y-toda-accion-de-cuidado-del-recien/
- TV interview "TVN Chile" (April 2021) "Obesidad en embarazo aumenta riesgo de asma en el hijo" https://www.youtube.com/watch?v=7p5hU8eeIAI
- "Epigenética en enfermedades crónicas y envejecimiento". Academia Chilena de Ciencias (2020) (http://www.academiadeciencias.cl/invitan-a-charla-sobre-la-epigenetica-humana-y-enfermedades-cronicas-o-envejecimiento/). Santiago, Chile.
- Radio Invertiew "Radio ADN" (September 2015) "La Placenta y La Salud" (https://drive.google.com/file/d/0B1QFpxiGXZ0rVUVtSE1pQUtnZVU/view?usp=sharing)
- Advocacy seminars (2017 -2019), Colegio Santo Domingo, La Reina, Santiago, Chile.


Premios y Distinciones

  •   Undergrade Fellowship

    UNIVERSIDAD DE CHILE

    Chile, 1997

    Academic performance based scholarship for undergraduate studies.

  •   Internship Fellowship

    European Union, Alfa Project Nº II-0379-FCD

    Francia, 2005

    Fellowship for reasearch visit to University of Milano. Training in proteomic analysis

  •   Meeting atendance Fellowship

    SOCIEDAD CHILENA DE CIENCIAS FISIOLOGICAS

    Chile, 2006

    Meeting atendance Fellowship

  •   Internship Fellowship.

    Alfa Project Nº II-0379-FCD, European Union.

    Francia, 2006

    Research exchange program.

  •   Meeting atendance Fellowship

    SOCIEDAD CHILENA DE CIENCIAS FISIOLOGICAS

    Chile, 2007

    Meeting atendance Fellowship

  •   Y.W. Loke New Investigator Travel Award

    International Federation of Placenta Associations

    Australia, 2009

    For support for New Investigators in Placentology to attend IFPA meetings.The awards are based on a review of abstracts submitted for an IFPA-designated meeting.

  •   Young Investigator Travel Award

    International Society for Developmental Origins of Health and Disease (DOHaD)

    Estados Unidos, 2011

    Meeting atendance Fellowship for Junior Investigators are merit-based awards given to the primary authors (all countries) of accepted abstracts (oral and poster)

  •   Y.W. Loke New Investigator travel award

    International Federation of Placenta Associations

    Francia, 2014

    Scientific merit based award for young investigator in Placental Physiology

  •   Premio Investigación Cientifica Universitaria

    Banco Santander

    Chile, 2018

    Con el objetivo de apoyar y difundir los mejores estudios sobre “Envejecimiento en la Población Chilena”, el jurado de la sexta versión del Premio a la Investigación Científica Universitaria de Banco Santander y El Mercurio se reunió para dirimir a los ganadores de esta convocatoria. “Orígenes epigenéticos de la disfunción vascular en el adulto”, del Dr. Bernardo Krause ganó el segundo lugar en la categoría Investigador Joven

  •   Programa Ciencia de Frontera

    ACADEMIA CHILENA DE CIENCIAS

    Chile, 2019

    El objetivo de este último premio es reconocer la excelencia y potencialidad de científicos jóvenes en diferentes áreas de las ciencias, además de promover el contacto del grupo de jóvenes que participan en programas similares en otros países (Academia Internacional de Científicos Jóvenes, TWAS, NAS u otras) y vincularlos a las actividades de la Academia.

  •   Coordinator of Research and Scientific Excellence

    International Society for Developmental Origins of Health and Disease

    Reino Unido, 2020

    The International Society for Developmental Origins of Health and Disease was set up to promote research into the fetal and developmental origins of disease and involves scientists from many backgrounds.


 

Article (49)

Dynamic DNA methylation changes in early versus late adulthood suggest nondeterministic effects of childhood adversity: a meta-analysis
Endothelial cell regulation of systemic haemodynamics and metabolism acts through the HIF transcription factors
Maternal and perinatal outcomes in pregnant women with confirmed severe and mild COVID-19 at one large maternity hospital in Chile
Maternal Obesity Is Associated With Higher Cord Blood Adipokines in Offspring Most Notably in Females
Novel insights for the role of nitric oxide in placental vascular function during and beyond pregnancy
Specific arterio-venous transcriptomic and ncRNA-RNA interactions in human umbilical endothelial cells: A meta-analysis
The asthma predictive index as a surrogate diagnostic tool in preschoolers: Analysis of a longitudinal birth cohort
Epigenetic mechanisms activated by childhood adversity
Leptin in Cord Blood Associates with Asthma Risk at Age 3 in the Offspring of Women with Gestational Obesity
Maternal obesity is associated with a sex-specific epigenetic programming in human neonatal monocytes
MiR-21-5p directly contributes to regulating eNOS expression in human artery endothelial cells under normoxia and hypoxia
Nonsyndromic orofacial clefts in Chile: LINE-1 methylation and MTHFR variants
PPARGC1A Gene Promoter Methylation as a Biomarker of Insulin Secretion and Sensitivity in Response to Glucose Challenges
Stim-activated TRPC-ORAI channels in pulmonary hypertension induced by chronic intermittent hypoxia
The challenge of spreading DOHaD concept throughout Latin America
Adult vascular dysfunction in foetal growth-restricted guinea-pigs is associated with a neonate-adult switching in Nos3 DNA methylation
Premature Vascular Aging in Guinea Pigs Affected by Fetal Growth Restriction
Chronic Intermittent Hypoxia-Induced Vascular Dysfunction in Rats is Reverted by N-Acetylcysteine Supplementation and Arginase Inhibition
LGA-newborn from patients with pregestational obesity present reduced adiponectin-mediated vascular relaxation and endothelial dysfunction in fetoplacental arteries
Mechanical characterization of arteries affected by fetal growth restriction in guinea pigs (Cavia porcellus).
Progressive uterine artery occlusion in the Guinea pig leads to defects in placental structure that relate to fetal growth
Fetal Growth Restriction Induces Heterogeneous Effects on Vascular Biomechanical and Functional Properties in Guinea Pigs (Cavia porcellus).
IL-10 Expression in Macrophages from Neonates Born from Obese Mothers Is Suppressed by IL-4 and LPS/INFγ.
N-Acetylcysteine, a glutathione precursor, reverts vascular dysfunction and endothelial epigenetic programming in intrauterine growth restricted guinea pigs.
Arginase-2 is cooperatively up-regulated by nitric oxide and histone deacetylase inhibition in human umbilical artery endothelial cells
Assessment of in vivo fetal growth and placental vascular function in a novel intrauterine growth restriction model of progressive uterine artery occlusion in guinea pigs
Cardiovascular function in term fetal sheep conceived, gestated and studied in the hypobaric hypoxia of the Andean altiplano
Markers of early endothelial dysfunction in intrauterine growth restriction-derived human umbilical vein endothelial cells revealed by 2D-DIGE and mass spectrometry analyses
Pre-gestational overweight in guinea pig sows induces fetal vascular dysfunction and increased rate of large and small fetuses
Arginase-endothelial nitric oxide synthase imbalance contributes to endothelial dysfunction during chronic intermittent hypoxia
Micro-RNAs Let7e and 126 in Plasma as Markers of Metabolic Dysfunction in 10 to 12 Years Old Children
Oxidative stress as common trait of endothelial dysfunction in chorionic arteries from fetuses with IUGR and LGA
The placental pursuit for an adequate oxidant balance between the mother and the fetus
Conceptual basis for prescriptive growth standards from conception to early childhood: present and future
Endothelial eNOS/arginase imbalance contributes to vascular dysfunction in IUGR umbilical and placental vessels
Role of DNA methyltransferase 1 on the altered eNOS expression in human umbilical endothelium from intrauterine growth restricted fetuses
Role of arginase-2 and eNOS in the differential vascular reactivity and hypoxia-induced endothelial response in umbilical arteries and veins
Hypoxia-reduced nitric oxide synthase activity is partially explained by higher arginase-2 activity and cellular redistribution in human umbilical vein endothelium
Role of nitric oxide in placental vascular development and function.
Differential expression of functional nucleoside transporters in non-differentiated and differentiated human endothelial progenitor cells
Long-term exposure to high-altitude chronic hypoxia during gestation induces neonatal pulmonary hypertension at sea level
Epigenetics: New Concepts of Old Phenomena in Vascular Physiology
Reduced L-Arginine Transport and Nitric Oxide Synthesis in Human Umbilical Vein Endothelial Cells from Intrauterine Growth Restriction Pregnancies is Not Further Altered by Hypoxia
TGF-beta 1 inhibits expression and activity of hENT1 in a nitric oxide-dependent manner in human umbilical vein endothelium
Evidence of a role for melatonin in fetal sheep physiology: direct actions of melatonin on fetal cerebral artery, brown adipose tissue and adrenal gland
High D-Glucose reduces SLC29A1 promoter activity and adenosine transport involving specific protein 1 in human umbilical vein endothelium
Microtubule proteins and their post-translational forms in the cerebrospinal fluid of patients with paraparesis associated with HTLV-I infection and in SH-SY5Y cells: An in vitro model of HTLV-I-induced disease
Sildenafil reverses hypoxic pulmonary hypertension in highland and lowland newborn sheep
Evolving in thin air - Lessons from the llama fetus in the altiplano

Abstract (31)

EFFECT OF FETAL GROWTH RESTRICTION ON THE BIOMECHANICAL AND STRUCTURAL PROPERTIES IN HUMAN UMBILICAL AND CHORIONIC ARTERIES
Novel Gasotransmitter Protection against Fetal Origins of Vascular Disease: The Role of Hydrogen Sulphide.
PROGRESSIVE UTERINE ARTERY OCCLUSION IN GUINEA PIGS INCREASES OXIDATIVE STRESS LEVELS AND DISRUPTS GLYCOGEN METABOLISM IN THE MATERNAL DECIDUA
DNA Methylation of nos3 Promoter in IUGR Guinea Pig Fetuses Does Not Predict Endothelial Function and DNA Methylation Later in Life
Role of Leptin in M1 Programming of Monocyte-Derived Macrophages from Newborns of Obese Mothers.
ADIPONECTIN RECEPTOR 1 EXPRESSION IN HUMAN UMBILICAL ARTERY ENDOTHELIAL CELLS (HUAEC) FROM LARGE FETUSES (LGA) OF OBESE WOMEN IS RELATED TO eNOS ACTIVATION
EPIGENETICS AND ENDOTHELIAL HETEROGENEITY IN THE UMBILICOPLACENTAL UNIT: A LANDSCAPE FOR EPIGENETIC PROGRAMMING OF VASCULAR FUNCTION
INTRAUTERINE GROWTH RESTRICTION IN GUINEA PIG IMPAIRS UMBILICAL AND SYSTEMIC VASCULAR FUNCTION
FOETAL AND UMBILICAL VASCULAR REACTIVITY IN A MODEL OF IUGR THROUGH GRADUAL UTERINE ARTERY OCCLUSION IN GUINEA PIGS
HISTONE DEACETYLASE ACTIVITY AND NITRIC OXIDE CONTROL THE EXPRESSION OF ENOS AND ARGINASE-2 IN HUMAN UMBILICAL ARTERY ENDOTHELIUM IN INTRAUTERINE GROWTH RESTRICTION
ROLE OF OXIDATIVE STRESS STATUS ON THE IMPAIRED ENOS-DEPENDENT RELAXATION IN PLACENTAL CHORIONIC ARTERIES OF INTRAUTERINE GROWTH RESTRICTED (IUGR) AND MACROSOMIC FETUSES FROM OBESE MOTHERS (FMOM)
Epigenetic mechanisms implicated in endothelial programming associated to IUGR: Insights from umbilical endothelium
RhoA/ROCK Signaling Pathway Is Not Implicated in the Regulation of eNOS Activation and arginase-2 Expression in Human Umbilical Vein Endothelial Cells Exposed to Hypoxia.
The Hypoxic Phenotype of IUGR Placental Endothelial Cells Is Reverted by DNMT1 Silencing. Evidence for Altered Epigenetic Vascular Programming.
Abnormal Expression of L-Arginine/NO-Related Enzymes in HUVEC Is Associated with Altered Vascular Reactivity of Umbilical Vein from IUGR Placentae
Altered Expression of L-Arginine/NO-Related Enzymes in Cultured Endothelial Cells from IUGR Placenta Is Accompanied by Specific DNA Methylation Changes
ADENOSINE TRANSPORT IS MEDIATED BY DIFFERENT NUCLEOSIDE TRANSPORTERS IN NON-DIFFERENTIATED AND DIFFERENTIATED HUMAN ENDOTHELIAL PROGENITOR CELLS
Hypoxia-Reduced eNOS Activity Could Be Explained by Higher Arginase II Activity and Cellular Redistribution in Human Umbilical Vein Endothelial Cells
PARTICIPATION OF ARGINASES IN THE VASCULAR TONE IN UMBILICAL VEIN FROM IUGR PLACENTAE: ROLE OF THE ENDOTHELIUM AND HYPOXIA
Role of Arginase II in the Vascular Function of Umbilical Arteries and Veins: Effect of Hypoxia
THE REDUCED NOS-DEPENDENT VASODILATION IN IUGR CHORIONIC ARTERIES IS IMPROVED BY ARGINASE INHIBITION
Upregulation of Arginase II in Hypoxia Counteracts Nitric Oxide Synthesis in Human Umbilical Vein Endothelial Cells
Hypoxia upregulates the expression of arginase II in human umbilical vein endothelial cells. Regulating the nitric oxide synthase activity
Persistent pulmonary hypertension of the newborn even following transient exposure of the pregnancy to high altitude
Preeclampsia is associated with increased adenosine transport via the human equilibrative nucleoside transporter 2 in placental microvascular endothelial cells.
Cardiovascular responses to acute hypoxemia in low altitude(LA)and high altitude (HA) fetal sheep (FS)
Differential femoral and pulmonary adrenergic vascular reactivity in high and low altitude newborn lambs
Hemoxygenase expression in lung tissue from high and low altitude newborn lambs
Melatonin blocks noradrenaline-induced vasoconstriction in middle cerebral artery in lowland fetal sheep
Melatonin restrains cortisol production in sheep fetal adrenal in late gestation
The ET-1 system in the pulmonary circulation from newborn lambs submitted to chronic hypoxia

Actualizacion (1)

Programación epigenética placentaria en restricción del crecimiento intrauterino

BookSection (2)

Epigenetic Programming of Cardiovascular Disease by Perinatal Hypoxia and Fetal Growth Restriction
LA ALIMENTACIÓN DE LA MADRE, EL BEBÉ Y EL NIÑO

Proyecto (18)

Time-course modeling of the vascular epigenetic programming by fetal growth restriction=> role of endothelial-derived miRNAs on hypoxia- and oxidative stress-induced responses
Biomechanical Behaviour of Arteries from Chronic Hypoxic Animals: Experiments, Modelling, Numerical Simulation and Validation
Biomechanical Behaviour of Arteries from Chronic Hypoxic Animals=> Experiments, Modelling, Numerical Simulation and Validation
Fetal programming of inflammatory responses and body fat by maternal obesity: Role of DHA in the modulation of epigenetic markers of obesity and metabolic disease
Fetal programming of inflammatory responses and body fat by maternal obesity=> Role of DHA in the modulation of epigenetic markers of obesity and metabolic disease
N-acetyl cysteine and the hypoxia induced vascular dysfunction in chick embryo
EARLY RISK OF ASTHMA IN CHILDREN EXPOSED TO IN-UTERO MATERNAL OBESITY. AN EPIGENETIC-MEDIATED PROGRAMMING OF IMMUNE FUNCTION
EARLY RISK OF ASTHMA IN CHILDREN EXPOSED TO IN-UTERO MATERNAL OBESITY. AN EPIGENETIC-MEDIATED PROGRAMMING OF IMMUNE FUNCTION
Modeling the epigenetic programming of vascular dysfunction by oxidative stress in the intrauterine growth restricted fetus: role of prenatal antioxidants in preventing long-term vascular dysfunction
MODELING THE EPIGENETIC PROGRAMMING OF VASCULAR DYSFUNCTION BY OXIDATIVE STRESS IN THE INTRAUTERINE GROWTH RESTRICTED FETUS=> ROLE OF PRENATAL ANTIOXIDANTS IN PREVENTING LONG-TERM VASCULAR DYSFUNCTION
Nueva formulación farmacológica para el tratamiento y la prevención de la hipertensión arterial y disfunciónvascular: Respuesta integrada a una patología multifactorial
Nueva formulación farmacológica para el tratamiento y la prevención de la hipertensión arterial y disfunciónvascular=> Respuesta integrada a una patología multifactorial
INTRAUTERINE PROGRAMMING OF HIPOXIA- AND OXIDATIVE STRESS-INDUCED VASCULAR RESPONSES IN PLACENTAL ENDOTHELIUM FROM IUGR AND MACROSOMIC FETUSES=> EARLY EVIDENCE FOR EPIGENETIC-DRIVEN VASCULAR DYSFUNCTION.
PAPEL DE ARGINASAS I Y II EN LA DISFUNCION ENDOTELIAL DE LA UNIDAD FETO-PLACENTARIA EN EMBARAZOS CON RESTRICCION DEL CRECIMIENTO INTRAUTERINO Y EN HIPOXIA
EL ORIGEN FETAL DE LA HIPERREACTIVIDAD VASCULAR PULMONAR Y DE LA HIPERTENSION PULMONAR POSTNATAL.
Effects of chronic hipoxia on fetal cardiovascular and endocrine functions in the sheep
INTRAUTERINE PROGRAMMING OF HIPOXIA- AND OXIDATIVE STRESS-INDUCED VASCULAR RESPONSES IN PLACENTAL ENDOTHELIUM FROM IUGR AND MACROSOMIC FETUSES: EARLY EVIDENCE FOR EPIGENETIC-DRIVEN VASCULAR DYSFUNCTION
N-acetyl cysteine and the hypoxia induced vascular dysfunction in chick embryo

Review (3)

Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic
Endothelial heterogeneity in the umbilico-placental unit: DNA methylation as an innuendo of epigenetic diversity
Role of nitric oxide in placental vascular development and function
99
Bernardo Krause

Associate Professor

Insituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

42
Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

21
Emilio HERRERA

Full Professor

Faculty of Medicine, ICBM

Universidad de Chile

Santiago, Chile

10
Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

10
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

5
Jorge Llanos

PROFESOR TITULAR

FISIOPATOLOGÍA

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

5
Víctor Reyes

Profesor Asociado

Instituto de Ciencias Biomédicas

UNIVERSIDAD DE CHILE - FACULTA DE MEDICINA

Santiago, Chile

4
CATALINA PRIETO

Investigadora senior

Biología

Universidad de Chile

Santiago, Chile

4
German Ebensperger

PROFESOR ASISTENTE

INSTITUTO DE CIENCIAS BIOMEDICAS

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

3
Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Fabián Vega

Investigador postdoctoral

Oftalmología

Universidad de Chile

Santiago, Chile

3
Claudia Torres

Full Professor

Instituto de Anatomía, Histología y Patología

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

3
ivo carrasco

Investigador

Universidad San Sebastián

Santiago, Chile

2
Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

2
Sebastian San Martin

Profesor Titular

Anatomía

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

2
Enrique Guzman

Profesor Asistente

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

2
Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

2
Carlos Escudero

Full Professor

Basic Sciences Department

Universidad del Bio Bio

Chillan, Chile

2
Rodrigo Iturriaga

Chairman of the Department of Physiology

Physiology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Claudio Aguayo

Profesor Asociado

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

2
Carlos Puebla

Assistant Professor

Universidad de O'Higgins

Santiago, Chile

2
José Suazo

Profesor Asociado

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

1
Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Andrea Vecchiola

Profesor Asistente

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Jose Luis Vega

Profesor Asociado

Biomedico

Universidad de Antofagasta

Antofagasta, Chile

1
Salesa Barja

Médico Nutrióloga pediátrica

Gastroenterología y Nutrición Pediátrica

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Jorge Carvajal

Chief of Department

Obstetrics

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Camila Corvalan

Assistant Professor

UNIVERSIDAD DE CHILE, INTA

SANTIAGO, Chile

1
Juan Kusanovic

Jefe CIMAF

Obstetricia y Ginecología

SERV. DE SALUD METROPOLITANA SUR ORIENTE, HOSPITAL SOTERO DEL RIO

Santiago, Chile

1
Francisco Valenzuela

Academico

Ciencias Básicas

UNIVERSIDAD DEL BÍO BÍO

Chillan, Chile

1
Claudia Quezada

Full Professor

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

1
Rody San Martín

Professor

Sciences Faculty

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Jose Castro

Profesor Asociado

Cardiologia y Neumologia Pediatrica

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Liliana Lamperti

Vicedecana

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE FARMACIA

Concepción, Chile

1
Julio Alarcón

Docente

Ciencias Básicas

UNIVERSIDAD DEL BÍO-BÍO

Chillan, Chile

1
Estefania Nova

Assistant Professor

Clinical Biochemistry & Immunology

University of Concepcion

Concepción , Chile

1
Jose Suazo

Profesor Asociado

Instituto de Investigación en Ciencias Odontológicas

Facultad de Odontologia, Universidad de Chile

Santiago, Chile

1
Rodrigo Valenzuela

Postdoctorado

Oftalmología

Universidad de Chile

Santiago, Chile

1
Carlos Salomón

Academic

University of Concepcion

Concepcion, Chile

1
Francisca Salas

Asistant Professor

Instituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile