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Fabian Alberto Salazar Lizama

Postdoctoral Research Fellow

MRC Centre for Medical Mycology, University of Exeter

Exeter, Reino Unido

Role of C-type lectin receptors in innate and adaptive immunity to fungi. Role of C-type lectin receptos in dendritic cell phenotype and function.

PhD in Immunology, UNIVERSITY OF NOTTINGHAM. Reino Unido, 2016
Magister en Bioquimica, mencion Proteinas y Biotecnologia, UNIVERSIDAD DE CHILE. Chile, 2010
Bioquimico, UNIVERSIDAD DE CHILE. Chile, 2010
Licenciatura en Bioquimica, UNIVERSIDAD DE CHILE. Chile, 2008

Postdoctoral Research Fellow Full Time

MRC Centre for Medical Mycology at the University of Aberdeen

Aberdeen, Reino Unido

2016 - 2019
Research Associate Part Time

University of Nottingham, School of Life Sciences, Immunology

Nottingham, Reino Unido

2014 - 2016
Research Associate Full Time

Fundacion Ciencia y Tecnologia para el Desarrollo

Santiago, Chile

2010 - 2012
Postdoctoral Research Fellow Full Time

MRC Centre for Medical Mycology at the University of Exeter

Exeter, Reino Unido

2019 - A la fecha

- Co-supervisor of PhD students (University of Exeter, 2019 to date).
- Co-Supervisor of intern students (Hons and MSc) (University of Aberdeen, 2016-2019).
- Bench supervisor of intern students (BMedSci and MSc) (University of Nottingham, 2012-2016).
- Lecture about innate immunity as part of the UG course ‘Immunology’ at the University of Chile (2010-2011).
- Made tutorial, marked exam/reports of the UG course ‘Immunology’ at the University of Chile (2009).
- Teaching skill courses: Demonstrating in laboratory practicals, Introduction to teaching and Small groups teaching.

CONFERENCE ATTENDANCE:
- Salazar, F., Dambuza, I., Speakman, E. & Brown, G. D. (2019). Novel dendritic cell-expressed C-type lectin receptors modulate adaptive immune responses during Candida infection. Gordon Research Conference and Seminar Immunology of Fungal Infections. 12-18 January 2019, Galveston, Texas, USA.
- Salazar, F., Hall, L., Negm, O.H., Tighe, P.J., Shakib, F. & Ghaemmaghami, A.M. (2015). Mannose receptor negatively regulates the TLR4-AhR-IDO axis in DCs with implication in allergic responses. 4th European Congress of Immunology. 6-9 September 2015, Vienna, Austria.
- Salazar, F., Hall, L., Negm, O.H., Tighe, P.J., Shakib, F. & Ghaemmaghami, A.M. (2015). The role of mannose receptor in modulating the TLR4-IDO axis in allergy. MACS Allergy Day. 19th May 2015, London, UK. (PRIZE BEST ORAL PRESENTATION).
- Salazar, F., Hall, L., Shakib, F. & Ghaemmaghami, A.M. (2014). Differential regulation of indoleamine 2,3-dioxygenase by TLRs and CLRs in human DCs, the role of aryl-hydrocarbon receptor. 13th International Symposium on Dendritic Cells. 14-18 September 2014, Tours, France.
- Salazar, F., Shakib, F. & Ghaemmaghami, A.M. (2013). Differential regulation of IDO by TLRs and CLRs in human DCs. 27th Annual Conference of the European Macrophage and Dendritic Cell Society. 10-12 October 2013, Erlangen, Germany.
- Salazar, F., Shakib, F. & Ghaemmaghami, A.M. (2013). Differential regulation of indoleamine 2,3-dioxygenase in human airway epithelial cells and dendritic cells. Joint Respiratory Research Day. 4th September 2013, Loughborough, UK.
- Salazar, F., Nova, E., Manubens, A., Cachicas, V., De Ioannes, A. & Becker, M. I. (2009). Innate immunity of marine invertebrates: search of antimicrobial peptides with potential biotechnological applications. 9th Latin American Congress of Immunology. 3-7 November 2009, Valparaiso, Chile.

Early Researcher of Excellence Award

UNIVERSITY OF NOTTINGHAM

Reino Unido, 2015

Awarded by the School of Life Sciences Postgraduate Research Committee in recognition for outstanding research contributions.
Becas Chile Doctorado en el Extranjero

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2010

Beca que financia estudios de doctorado en el extranjero.
Beca de Magister Facultad de Ciencias Quimicas y Farmeceuticas

UNIVERSIDAD DE CHILE

Chile, 2008

Beca que financia estudios de Magister
Becas Chile Post-doctorado en el Extranjero

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2017

Beca que financia estudios de post-doctorado en el extranjero.


T Cell Antifungal Immunity and the Role of C-Type Lectin Receptors Speakman, Emily A.; Dambuza, Ivy M.; Salazar, Fabian; Brown, Gordon D. Article ISI TRENDS IN IMMUNOLOGY (2020)
The Cross-Talk between miR-511-3p and C-Type Lectin Receptors on Dendritic Cells Affects Dendritic Cell Function Awuah, Dennis; Alobaid, Meshal; Latif, Arsalan; Salazar, Fabian; Emes, Richard D.; Ghaemmaghami, Amir M. Article ISI JOURNAL OF IMMUNOLOGY (2019)
TLR4, but Neither Dectin-1 nor Dectin-2, Participates in the Mollusk Hemocyanin-Induced Proinflammatory Effects in Antigen-Presenting Cells From Mammals Jimenez, Jose M.; Salazar, Michelle L. ; Arancibia, Sergio; Villar, Javiera; Salazar, Fabian; Brown, Gordon D.; Lavelle, Ed C.; Martinez-Pomares, Luisa; Ortiz-Quintero, Jafet; Lavandero, Sergio; Manubens, Augusto; Ines Becker, Maria Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2019)
A friendly danger Immune cell receptor DNGR-1 limits inflammatory tissue damage Salazar, Fabian; Brown, Gordon D. Article ISI SCIENCE (2018)
Antifungal Innate Immunity: A Perspective from the Last 10 Years Salazar, Fabian; Brown, Gordon D. Article ISI JOURNAL OF INNATE IMMUNITY (2018)
Generation of anti-inflammatory macrophages for implants and regenerative medicine using self-standing release systems with a phenotype-fixing cytokine cocktail formulation Kzhyshkowska, Julia; Barthes, Julien; Riabov, Vladimir; Knopf-Marques, Helena; Htwe, Su Su; Kluter, Harald; Schmuttermaier, Christina; Ghaemmaghami, Amir M.; Gudima, Alexandru; Vrana, Nihal Engin; Salazar, Fabian Article ISI Acta Biomaterialia (2017)
The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs Salazar, Fabián; Awuah, Dennis; Negm, Ola H.; Shakib, Farouk; Ghaemmaghami, Amir M. Article SCIENTIFIC REPORTS (2017)
Expression and regulation of immune-modulatory enzyme Indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation Ghaemmaghami, Amir M.; Sewell, Herb F.; Aldajani, Wejdan A.; Knox, Alan; Salazar, Fabian Article ISI ONCOTARGET (2016)
The impact of surface chemistry modification on macrophage polarisation Hassan M. Rostam, Sonali Singh; Fabian Salazar, Peter Magennis; Andrew Hook, Taranjit Singh; Nihal E. Vrana, Morgan R. Alexander Article Immunobiology (2016)
The mannose receptor negatively modulates the Toll-like receptor 4-aryl hydrocarbon receptor-indoleamine 2,3-dioxygenase axis in dendritic cells affecting T helper cell polarization Fabian Salazar, Laurence Hall; Ola H. Negm, Dennis Awuah; Patrick J. Tighe, Farouk Shakib Article The Journal of Allergy and Clinical Immunology (2016)
Immunocompetence of breeding females is sensitive to cortisol levels but not to communal rearing in the degu (Octodon degus) Luis A. Ebensperger, Cecilia León; Juan Ramírez-Estrada, Sebastian Abades; Loren D. Hayes, Esteban Nova; Fabián Salazar, Joydeep Bhattacharjee Article Physiology and Behaviour (2015)
Immunocompetence of breeding females is sensitive to cortisol levels but not to communal rearing in the degu (Octodon degus) Ebensperger, L.A.; Leon, C.; Ramirez-Estrada, J; Abades S.; Hayes L.D.; NOVA, E; Salazar F.; Bhattacharjee J.; Becker, M.I Article ISI SCOPUS PHYSIOLOGY & BEHAVIOR (2015)
A novel immunomodulatory hemocyanin from the limpet Fissurella latimarginata promotes potent anti-tumor activity in melanoma Sergio Arancibia, Cecilia Espinoza; Fabian Salazar, Miguel Del Campo; Ricardo Tampe, Ta-Ying Zhong; Pablo De Ioannes, Bruno Moltedo; Jorge Ferreira, Ed C. Lavelle; Augusto Manubens, Alfredo E. De Ioannes Article PLoS One (2014)
A Novel Immunomodulatory Hemocyanin from the Limpet Fissurella latimarginata Promotes Potent Anti-Tumor Activity in Melanoma Arancibia S.; Espinoza, C.; Salazar F.; del Campo, M; Tampe, R; Zhong, TY; De Ioannes, P; Moltedo, B; Ferreira J.; Lavelle EC; Manubens, A; De Ioannes, AE; Becker, MI Article ISI SCOPUS PLOS ONE (2014)
Immunocompetent 3D model of human upper airway for disease modeling and in vitro drug evaluation Helen Harrington, Paul Cato; Fabian Salazar, Malcolm Wilkinson; Alan Knox, John W. Haycock; Felicity Rose, Jon W. Aylott Article Molecular Pharmaceutics (2014)
Allergen recognition by innate immune cells=> critical role of dendritic and epithelial cells Fabian Salazar, Amir M. Ghaemmaghami Article Frontiers in Immunology (2013)
The role of lectins in allergic sensitization and allergic disease Fabian Salazar, Herb F. Sewell; Farouk Shakib, Amir M. Ghaemmaghami Article The Journal of Allergy and Clinical Immunology (2013)
Enhanced structural stability of Concholepas hemocyanin increases its immunogenicity and maintains its non-specific immunostimulatory effects Sergio Arancibia, Miguel Del Campo; Esteban Nova, Fabian Salazar Article European Journal of Immunology (2012)
Enhanced structural stability of Concholepas hemocyanin increases its immunogenicity and maintains its non-specific immunostimulatory effects Arancibia S.; Campo M.D.; NOVA, E; Salazar F.; Becker, M.I Article ISI SCOPUS European Journal of Immunology (2012)
Hemocyanins as immunostimulants del Campo, M; Arancibia S.; NOVA, E; Salazar F.; González A; Moltedo, B; De Ioannes, P; Ferreira J.; Manubens, A; Becker, MI Article ISI REVISTA MEDICA DE CHILE (2011)
Hemocyanins as immunostimulants Miguel Del Campo, Sergio Arancibia; Esteban Nova, Fabian Salazar; Andrea Gonzalez, Bruno Moltedo; Pablo De Ioannes, Jorge Ferreira; Augusto Manubens, Maria Ines Becker Article Revista Medica de Chile (2011)
Hemocyanins as immunostimulants Hemocianinas, una herramienta inmunológica de la biomedicina actual del Campo, M; Arancibia S.; NOVA, E; Salazar F.; González A; Moltedo, B; De Ioannes, P; Becker, M.I; Ferreira J.; Manubens, A Article SCOPUS Revista Medica de Chile (2011)
Concholepas hemocyanin biosynthesis takes place in the hepatopancreas, with hemocytes being involved in its metabolism Manubens, A; Salazar F.; Haussmann, D.; Figueroa J.; del Campo, M; Pinto, JM; Huaquin, L; Venegas A.; Becker, MI Article ISI SCOPUS Cell and Tissue Research (2010)
Concholepas hemocyanin biosynthesis takes place in the hepatopancreas, with hemocytes being involved in its metabolism Augusto Manubens, Fabian Salazar; Denise Haussmann, Jaime Figueroa; Miguel Del Campo, Jonathan Martinez Pinto; Laura Huaquin, Alejandro Venegas Article Cell and Tissue Research (2010)


Novel hemocyanin from the Fissurella latimarginata exhibits an outstanding immunogenicity and non-specific immunomodulatory effects in a melanoma model Becker, M; Arancibia S.; Cecilia, E; Salazar F.; del Campo, M; Born R.; Ferreira J.; Manubens, A; De Ioannes, A. Abstract ISI JOURNAL OF IMMUNOLOGY (2012)
Exceptional Immunological and Anticancer Properties of a New Hemocyanin from Fissurella Latimarginata (FLH) Arancibia S.; Espinoza, C.; del Campo, M; Salazar F.; Becker, MI Abstract ISI JOURNAL OF IMMUNOTHERAPY (2010)


Mollusk hemocyanins as natural immunostimulants in biomedical applications Becker, M.I., Arancibia, S., Salazar, F., Del Campo, M. & De Ioannes, A.E.; Thien Duc G BookSection (2014)
Hemocyanins in the Immunotherapy of Superficial Bladder Cancer. 2. Arancibia, S., Salazar, F. & Becker, M.I.; Canda, A. BookSection (2012)


Extracto de hemocitos de Loco -Concholepas concholepas- con actividad antimicrobiana, composición, procedimiento de preparación y sus usos Salazar & Becker Patent (2018)


C-type lectins in anti Fungal Immunity Wellcome Trust UK Proyecto 2016-2019 Postdoctorado
Mollusk hemocyanins as immunomodulatory proteins with beneficial clinical outcomes=> Elucidating the role of C-type lectin receptors in these effects FONDECYT (1151337) Proyecto 2015-2018 Personal técnico y/o de apoyo
Pilot Study to Assess the Use of an Immunocompetent 3D Model of Human Upper Airway for Comparing the Impact of Different Proteins in Different Matrices Unilever UK Proyecto 2014-2015 Investigador(a)
Local immunomodulation around implants by innovative auxiliary hydrogel-based systems encapsulating autologous and phenotype controlled macrophages European Union's Seventh Framework Programme (602694) Proyecto 2013-2017 Investigador(a)
Immunological basis involved in the immunomodulatory effects of mollusk hemocyanins in the immune system of mammals FONDECYT (1110651) Proyecto 2011-2014 Personal técnico y/o de apoyo
Identificación y caracterización de péptidos bioactivos de hemocianina de Loco y Lapas chilenas, con aplicaciones biotecnológicas. COPEC PUC (CQ057) Proyecto 2009-2012 Investigador(a)


Hemocianinas, una herramienta inmunológica de la biomedicina actual Del Campo, Miguel; Arancibia, Sergio; Nova, Esteban; Salazar, Fabián.; Gonzalez, Andrea; Moltedo, Bruno; De Ioannes, Pablo; Ferreira, Jorge; Manubens, Augusto; Becker, María Inés Review SCIELO REVISTA MEDICA DE CHILE (2011)