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Pablo Emilio De Ioannes Fernandez

Associate research scientist

NYU Medical Center

NEW YORK, Estados Unidos

Mechanisms in which gene silencing complexes impact chromatin structure and repress transcription. I use a combination of structural biology approaches, including x-ray crystallography and electron microscopy, coupled with biochemical assays

Biophysics and Structural Biology, MOUNT SINAI SCHOOL OF MEDICINE. Estados Unidos, 2012
Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2000
Biochemistry , PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1996

Postdoctoral Fello Full Time

NEW YORK UNIVERSITY SCHOOL OF MEDICINE

NEW YORK, Estados Unidos

2019 - 2019

Research Scientist Full Time

Biosonda S.A.

Santiago, Chile

2000 - 2002


Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination Valencia-Sanchez, Marco Igor; De Ioannes, Pablo; Wang, Miao; Vasilyev, Nikita; Chen, Ruoyu; Nudler, Evgeny; Armache, Jean-Paul; Armache, Karim-Jean Article ISI MOLECULAR CELL (2019)
Structure and function of the Orc1 BAH-nucleosome complex De Ioannes, Pablo; Leon, Victor A.; Kuang, Zheng; Wang, Miao; Boeke, Jef D.; Hochwagen, Andreas; Armache, Karim-Jean Article ISI NATURE COMMUNICATIONS (2019)
Structure and Dynamics of an Intrinsically Disordered Protein Region That Partially Folds upon Binding by Chemical-Exchange NMR Charlier, Cyril; Bouvignies, Guillaume; Pelupessy, Philippe; Walrant, Astrid; Marquant, Rodrigue; Kozlov, Mikhail; De Ioannes, Pablo; Bolik-Coulon, Nicolas; Sagan, Sandrine; Cortes, Patricia; Aggarwal, Aneel K.; Carlier, Ludovic; Ferrage, Fabien Article ISI JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
A Novel Immunomodulatory Hemocyanin from the Limpet Fissurella latimarginata Promotes Potent Anti-Tumor Activity in Melanoma Arancibia S.; Espinoza, C.; Salazar F.; del Campo, M; Tampe, R; Zhong, TY; De Ioannes, P; Moltedo, B; Ferreira J.; Lavelle EC; Manubens, A; De Ioannes, AE; Becker, MI Article ISI SCOPUS PLOS ONE (2014)
Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs Malu, Shruti; De Ioannes, Pablo; Kozlov, Mikhail; Greene, Marsha; Francis, Dailia; Hanna, Mary; Pena, Jesse; Escalante, Carlos R.; Kurosawa, Aya; Erdjument-Bromage, Hediye; Tempst, Paul; Adachi, Noritaka; Vezzoni, Paolo; Villa, Anna; Aggarwal, Aneel K.; Cortes, Patricia Article ISI JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Structural Basis of DNA Ligase IV-Artemis Interaction in Nonhomologous End-Joining De Ioannes, Pablo; Malu, Shruti; Cortes, Patricia; Aggarwal, Aneel K. Article ISI CELL REPORTS (2012)
Hemocyanins as immunostimulants del Campo, M; Arancibia S.; NOVA, E; Salazar F.; González A; Moltedo, B; De Ioannes, P; Ferreira J.; Manubens, A; Becker, MI Article ISI REVISTA MEDICA DE CHILE (2011)
Hemocyanins as immunostimulants Hemocianinas, una herramienta inmunológica de la biomedicina actual del Campo, M; Arancibia S.; NOVA, E; Salazar F.; González A; Moltedo, B; De Ioannes, P; Becker, M.I; Ferreira J.; Manubens, A Article SCOPUS Revista Medica de Chile (2011)
Structures of apo IRF-3 and IRF-7 DNA binding domains: effect of loop L1 on DNA binding De Ioannes, Pablo; Escalante, Carlos R.; Aggarwal, Aneel K. Article ISI NUCLEIC ACIDS RESEARCH (2011)
Immunodominant role of CCHA subunit of Concholepas hemocyanin is associated with unique biochemical properties Becker, MI; Fuentes, A.; del Campo, M; Manubens, A; NOVA, E; Oliva, H; Faunes F.; Valenzuela, MA.; Campos-Vallette, M; Aliaga A.; Ferreira J.; De Ioannes, AE; De Ioannes, P; Moltedo, B Article ISI SCOPUS INTERNATIONAL IMMUNOPHARMACOLOGY (2009)
Immunotherapeutic effect of concholepas hemocyanin in the murine bladder cancer model: Evidence for conserved antitumor properties among hemocyanins Moltedo, B; Faunes F.; Haussmann, D.; De Ioannes, P; De Ioannes, AE; Puente J.; Becker, MI Article ISI SCOPUS JOURNAL OF UROLOGY (2006)
A direct interaction between the RAG2 C terminus and the core histones is required for efficient V(D)J recombination West, KL; Singha, NC; De Ioannes, P; Lacomis, L; Erdjument-Bromage, H; Tempst, P; Cortes, P Article ISI IMMUNITY (2005)
Hemocyanin of the molluscan Concholepas concholepas exhibits an unusual heterodecameric array of subunits De Ioannes, P; Moltedo, B; Oliva, H; Pacheco R.; Faunes F.; De Ioannes, AE; Becker, MI Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Characterization of an alpha-L-arabinofuranosidase gene (abf1) from Penicillium purpurogenum and its expression Carvallo, M; De Ioannes, P; Navarro, C.; Chavez, R; Peirano, A.; Bull, P; Eyzaguirre, J Article ISI SCOPUS MYCOLOGICAL RESEARCH (2003)
Monoclonal antibodies to molluskan hemocyanin from Concholepas concholepas demonstrate common and specific epitopes among subunits Oliva, H; Moltedo, B; De Ioannes, P; Faunes F.; De Ioannes, AE; Becker, MI Article ISI HYBRIDOMA AND HYBRIDOMICS (2002)
An alpha-L-arabinofuranosidase from Penicillium purpurogenum: production, purification and properties De Ioannes, P; Peirano, A.; Steiner J.; Eyzaguirre, J Article ISI SCOPUS JOURNAL OF BIOTECHNOLOGY (2000)


Biochemical and Immunomodulatory Properties From Concholepas Hemocyanin (CCH) and Their Isolated Subunits Becker, MI; del Campo, M; Manubens, A; NOVA, E; Campos-Vallete, M; Ferreira J.; De Ioannes, P; Moltedo, B; De Joannes, AE Abstract ISI JOURNAL OF IMMUNOTHERAPY (2008)


Hemocianinas, una herramienta inmunológica de la biomedicina actual Del Campo, Miguel; Arancibia, Sergio; Nova, Esteban; Salazar, Fabián.; Gonzalez, Andrea; Moltedo, Bruno; De Ioannes, Pablo; Ferreira, Jorge; Manubens, Augusto; Becker, María Inés Review SCIELO REVISTA MEDICA DE CHILE (2011)
The endoxylanases from family 11: computer analysis of protein sequences reveals important structural and phylogenetic relationships Sapag, A; Wouters, J; Lambert, C.; De Ioannes, P; Eyzaguirre, J; Depiereux, E Review ISI SCOPUS JOURNAL OF BIOTECHNOLOGY (2002)