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Jaime Adolfo Valderrama Guerrero

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Quinone Chemistry; Bioactive Natural Products; Medicinal Chemistry; QuÃmica de Quinonas; QuÃmica HeterocÃclica; QuÃmica MÃ©dica


Inhibition of cell proliferation and migration by oxidative stress from ascorbate-driven juglone redox cycling in human bladder-derived T24 cells Kviecinski M.R.; Pedrosa R.C.; Felipe K.B.; Farias M.S.; Glorieux C.; Valenzuela,M.; Sid, B.; Benites, J.; Valderrama, J.A.; Verrax J.; Buc Calderon, P. Article ISI SCOPUS Biochemical and Biophysical Research Communications (2012)
An in vitro comparative study with furyl-1,4-quinones endowed with anticancer activities Benites, J.; VALDERRAMA, JA; Taper, H.; CALDERON, PB Article ISI SCOPUS Investigational New Drugs (2011)
Gastroprotective Effect and Cytotoxicity of Labdeneamides with Amino Acids Schmeda-Hirschmann, G; Rodríguez, J. A.; Theoduloz, C; Valderrama, J.A. Article ISI SCOPUS Planta Medica (2011)
Redox-Active Quinones and Ascorbate: An Innovative Cancer Therapy That Exploits the Vulnerability of Cancer Cells to Oxidative Stress Verrax J.; Beck R.; Dejeans N.; Glorieux C.; Sid, B.; Calderon P.B.; Pedrosa R.C.; Benites, J.; Vásquez D.; Valderrama, J.A. Article ISI SCOPUS Anti-Cancer Agents in Medicinal Chemistry (2011)
Studies on quinones. Part 47. Synthesis of novel phenylaminophenanthridinequinones as potential antitumor agents VALDERRAMA, JA; Ibacache, A.; Rodriguez JA.; Theoduloz, C; Benites, J. Article ISI SCOPUS EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
The solar-chemical photo-Friedel-Crafts heteroacylation of 1,4-quinones Benites, J.; Rios, D.; Díaz P; Valderrama, J.A. Article ISI SCOPUS Tetrahedron Letters (2011)
Biological evaluation of donor-acceptor aminonaphthoquinones as antitumor agents Benites, J.; VALDERRAMA, JA; Bettega, K; Pedrosa, RC; CALDERON, PB; Verrax J. Article ISI SCOPUS EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
Studies on quinones. Part 46. Synthesis and in vitro antitumor evaluation of aminopyrimidoisoquinolinequinones Vásquez D.; Rodriguez JA.; Theoduloz, C; CALDERON, PB; VALDERRAMA, JA Article ISI SCOPUS EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
Part 2: Influence of 2-Euryfuryl-1,4-naphthoquinone and Its peri-Hydroxy Derivatives on Both Cell Death and Metabolism of TLT Cells, a Murine Hepatoma Cell Line. Modulation of Cytotoxicity by Vitamin C Benites, J.; VALDERRAMA, JA; Taper, H.; CALDERON, PB Article ISI SCOPUS CHEMICAL PHARMACEUTICAL BULLETIN (2009)
Regiochemical control in the amination reaction of phenanthridine-7,10-quinones VALDERRAMA, JA; Ibacache, JA Article ISI SCOPUS TETRAHEDRON LETTERS (2009)
Studies on quinones. Part 45: Novel 7-aminoisoquinoline-5,8-quinone derivatives with antitumor properties on cancer cell lines VALDERRAMA, JA; Ibacache, JA; Arancibia, V; Rodriguez J.; Theoduloz, C Article ISI SCOPUS BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Synthesis and antitumor evaluation of 8-phenylaminopyrimido[4,5-c]isoquinolinequinones Vásquez D.; Rodriguez JA.; Theoduloz, C; Verrax J.; CALDERON, PB; VALDERRAMA, JA Article ISI SCOPUS BIOORGANIC MEDICINAL CHEMISTRY LETTERS (2009)
Synthesis and Antitumor Evaluation of Thiophene Analogs of Kigelinone VALDERRAMA, JA; Espinoza O.; Rodriguez J.; Theoduloz, C Article ISI SCOPUS Letters in Organic Chemistry (2009)
Design and synthesis of angucyclinone AB-pyrido[2,3-d] pyrimidine analogues VALDERRAMA, JA; Vásquez D. Article ISI SCOPUS TETRAHEDRON LETTERS (2008)
Part 1: Effect of vitamin C on the biological activity of two euryfurylbenzoquinones on TLT, a murine hepatoma cell line Benites, J.; Rojo L.; VALDERRAMA, JA; Taper, H.; CALDERON, PB Article ISI SCOPUS EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2008)
Studies on quinones. Part 42: Synthesis of furylquinone and hydroquinones with antiproliferative activity against human tumor cell lines Benites, J.; VALDERRAMA, JA; Rivera, F; Rojo L.; Campos N.; Pedro, M; Nascimento, MSJ Article ISI SCOPUS BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Studies on quinones. Part 43: Synthesis and cytotoxic evaluation of polyoxyethylene-containing 1,4-naphthoquinones VALDERRAMA, JA; Leiva, H; Rodriguez JA.; Theoduloz, C; Schmeda-Hirshmann, G Article ISI SCOPUS BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Studies on quinones. Part 44: Novel angucyclinone N-heterocyclic analogues endowed with antitumoral activity VALDERRAMA, JA; Colonelli, P; Vásquez D.; GONZALEZ, MF; Rodriguez JA.; Theoduloz, C Article ISI SCOPUS BIOORGANIC & MEDICINAL CHEMISTRY (2008)


Molecular Chaperone Hsp90 as a Target for Oxidant-Based Anticancer Therapies Beck R.; Dejeans N.; Glorieux C.; Calderon P.B.; Verrax J.; Pedrosa R.C.; Vosquez D.; Valderrama, J.A. Review ISI CURRENT MEDICINAL CHEMISTRY (2011)

Jaime Valderrama

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Julio Benites

Profesor Titular

Química y Farmacia

Universidad Arturo Prat

Iquique, Chile

Pedro Buc

Profesor titular

Quimica y Farmacia

Universidad Arturo Prat

Iquique, Chile

David Vásquez

Profesor Asistente

Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE

Santiago, Chile

Juana Ibacache

académico

Ciencias del ambiente

Universidad de Santiago de Chile

Santiago, Chile

Leonel Rojo

Profesor Asociado

Departamento de Biología

Universidad de Santiago de Chile

Estación Central, Chile

Guillermo Schmeda

Profesor Titular

UNIVERSIDAD DE TALCA

Talca, Chile

Veronica Arancibia

Profesor horas

Quimica Inorganica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Patricia Diaz

Academic

University of Connecticut Health Center

Farmington, CT, Estados Unidos

Jaime Adolfo Valderrama Guerrero

Líneas de Investigación

Article (18)

Inhibition of cell proliferation and migration by oxidative stress from ascorbate-driven juglone redox cycling in human bladder-derived T24 cells

An in vitro comparative study with furyl-1,4-quinones endowed with anticancer activities

Gastroprotective Effect and Cytotoxicity of Labdeneamides with Amino Acids

Redox-Active Quinones and Ascorbate: An Innovative Cancer Therapy That Exploits the Vulnerability of Cancer Cells to Oxidative Stress

Studies on quinones. Part 47. Synthesis of novel phenylaminophenanthridinequinones as potential antitumor agents

The solar-chemical photo-Friedel-Crafts heteroacylation of 1,4-quinones

Biological evaluation of donor-acceptor aminonaphthoquinones as antitumor agents

Studies on quinones. Part 46. Synthesis and in vitro antitumor evaluation of aminopyrimidoisoquinolinequinones

Part 2: Influence of 2-Euryfuryl-1,4-naphthoquinone and Its peri-Hydroxy Derivatives on Both Cell Death and Metabolism of TLT Cells, a Murine Hepatoma Cell Line. Modulation of Cytotoxicity by Vitamin C

Regiochemical control in the amination reaction of phenanthridine-7,10-quinones

Studies on quinones. Part 45: Novel 7-aminoisoquinoline-5,8-quinone derivatives with antitumor properties on cancer cell lines

Synthesis and antitumor evaluation of 8-phenylaminopyrimido[4,5-c]isoquinolinequinones

Synthesis and Antitumor Evaluation of Thiophene Analogs of Kigelinone

Design and synthesis of angucyclinone AB-pyrido[2,3-d] pyrimidine analogues

Part 1: Effect of vitamin C on the biological activity of two euryfurylbenzoquinones on TLT, a murine hepatoma cell line

Studies on quinones. Part 42: Synthesis of furylquinone and hydroquinones with antiproliferative activity against human tumor cell lines

Studies on quinones. Part 43: Synthesis and cytotoxic evaluation of polyoxyethylene-containing 1,4-naphthoquinones

Studies on quinones. Part 44: Novel angucyclinone N-heterocyclic analogues endowed with antitumoral activity

Review (1)

Molecular Chaperone Hsp90 as a Target for Oxidant-Based Anticancer Therapies

Jaime Valderrama

Julio Benites

Pedro Buc

David Vásquez

Juana Ibacache

Leonel Rojo

Guillermo Schmeda

Veronica Arancibia

Patricia Diaz