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Sebastian Esteban Brauchi Ulloa

Associate Professor

Universidad Austral de Chile

Valdivia, Chile

Líneas de Investigación


Ion Channel Biophysics Microscopy Single Molecule Studies

Educación

  •  PhD in Sciences, Universidad Austral de Chile. Chile, 2006
  •  Biochemist, PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2001

Experiencia Académica

  •   Postdoctoral Investigator Full Time

    HARVARD UNIVERSITY

    Medicine

    Boston, Estados Unidos

    2006 - 2008

  •   Assistant Professor Full Time

    Universidad Austral de Chile

    Medicine

    Valdivia, Chile

    2008 - 2014

  •   Associate Professor Full Time

    UNIVERSIDAD AUSTRAL DE CHILE

    Medicine

    Valdivia, Chile

    2015 - A la fecha

Experiencia Profesional

  •   Academico (Categoria III) Full Time

    Universidad Austral de Chile

    Valdivia, Chile

    2008 - 2014

  •   Academico (Categoria II) Full Time

    Universidad Austral de Chile

    Valdivia, Chile

    2015 - A la fecha

Formación de Capital Humano


DOCTORADO

Carlos Toro, UNIVERSIDAD AUSTRAL DE CHILE
Study of the dynamics and cell surface expression of the cold receptor TRPM8 in response to agonists.
Patrocinante
2013

Ximena Steinberg, UNIVERSIDAD AUSTRAL DE CHILE
Diseño racional de una enzima aminoacil-tRNA Sintetasa que permita la incorporación de aminoácidos no naturales fluorescentes en proteínas expresadas por células HEK293T.
Patrocinate
2015

Pamela Sotelo, UNIVERSIDAD AUSTRAL DE CHILE
Expresion y funcion de canales termosensibles en el tejido dental.
Patrocinante
2017

Deny Cabezas, UNIVERSIDAD AUSTRAL DE CHILE
Función del dominio TRP en la integración y comunicación de estímulos a la compuerta en canales TRP
Patrocinante
En Curso

Ella Matamala, Rol fisiológico y fisiopatológico de la familia de canales TTYH en la homeostasis ionica lisosomal.
Patrocinante
En Curso

Lisandra Flores, Estudio de la fase rapida de inactivacion de los canales TRPV5 y TRPV6
Patrocinante
En Curso

PRE-GRADO

Sebastian Garcia-Meza, Bioquimica, UNIVERSIDAD AUSTRAL DE CHILE
Funcion y expresion de canales TRPM8 en celulas de cancer de mama.
Patrocinante
En curso

Jose Vicente Gonzalez, Bioquímica, UNIVERSIDAD AUSTRAL DE CHILE
Caracterización de la mecánica del acoplamiento entre compuerta y sensor de mentol en el receptor TRPM8
Patrocinante
2015

Macarena Solis, Bioquímica, UNIVERSIDAD AUSTRAL DE CHILE
Expresión y función de transportadores de lactato en modelos de enfermedad de Huntington
Informante
2012

Luis Veliz, Ing Informatica, UNIVERSIDAD AUSTRAL DE CHILE
Seguimiento de partículas individuales en imágenes de microscopía de campo de evanescencia aplicado a la dinámica de membranas celulares.
Patrocinante
2011

Magdalena Esparza, Bioquímica, UNIVERSIDAD AUSTRAL DE CHILE
Estudio de la disponibilidad del transportador de ácido ascórbico, SVCT2, en la membrana plasmática
Co-Patrocinante
2011

Juan Pablo Vivar, Bioquímica, UACh
Monitoreo del potencial de membrana vesicular mediante un sistema híbrido entre proteínas fluorescentes y moléculas sintéticas
Patrocinante
2011

Pamela Sotelo, Bioquímica, UNIVERSIDAD AUSTRAL DE CHILE
Señales de localización y exportación nuclear como determinantes de la localización sub-celular del canal de iones TRPM1
Patrocinante
2012

Luis Arias, Bioquímica, UNIVERSIDAD AUSTRAL DE CHILE
Canales Iónicos TRP en el alga unicelular (Chlamydomonas Reinhardtii)
Patrocinante
2010


Difusión y Transferencia


Dissemination to general public.
May 2017. Conferencia Cafe Conciencia, Club de la Union. Organizer: Facultad de Ciencias, UACh, Valdivia.
September 2010. The Cafe Scientifique Conference. Organizer: Faculty of Medicine, UBC. Vancouver, Canada.

Dissemination within the scientific community:
Meeting/Symposium organizer:
Jan. 2015 Meeting organizer. CiSNe Summer Symposium in Biophysics and Neurobiology, UACh, Valdivia, Chile.
Feb. 2012 Platform Chair. 56th Biophysical Society Meeting, TRP channels Platform.
Oct. 2011 Symposium organizer. “From molecules to neural networks. Neurophysiology remixes on sensing and integration”. Chilean Physiological Society, annual meeting.
Oct. 2009 Meeting organizer. “A Convergence of Young Minds: Symposium for Early Career Investigators in Neuroscience and Biophysics”. UACh, Valdivia, Chile.

Service to scientific community:
Reviewer for scientific journals: eLife, Nature Neuroscience; Nature Communications, Proceedings of the National Academy of Science USA; Biophysical Journal; Journal of General Physiology; PLoS ONE; PLOS Biology; Structure; Journal of Biological Chemistry; Journal of Membrane Biology; The Journal of Neuroscience; Scientific Reports; The Plant Cell.

Grant Reviewer/panellist: National evaluator: CONICYT study sections as ad hoc reviewer: PIA, FONDECYT, PCI (2007-to date). Standing member FONDECYT study section in Biology (Physiology and Biophysics) 2012-2014. External evaluator: French National Research Agency (ANR) (2013-2014); US-Israel Binational Science Foundation (2013), Czech Science Foundation (GACR) (2013-2015); Belgium National Fund for Scientific Research (FNRS) (2013); Biotechnology and Biological Sciences Research Council (BBSRC), UK (2015).


Premios y Distinciones

  •   LSI Visiting Scientist Award

    UNIVERSITY OF BRITISH COLUMBIA

    Canada, 2012

    Every year the Life Science Institute at UBC name one international young scientist as distinguished scholar. I was named the visiting scientist of the year 2012.

  •   PEW Fellow in biomedical sciences

    PEW LATIN AMERICAN FELLOWS PROGRAM IN BIOMEDICAL SCIENCES

    Estados Unidos, 2006

    The Pew Latin American Fellows Program in the Biomedical Sciences provides support for young scientists from Latin America to receive postdoctoral training in the United States. The program gives these individuals an opportunity to further their scientific knowledge, promotes exchange and collaboration between investigators in the U.S. and Latin America, and advances research in Latin America

  •   Academic Merit Award

    UNIVERSIDAD AUSTRAL DE CHILE

    Chile, 2007

    Estudiante de mejor productividad en la generacion 2006 del programa de doctorado en ciencias.

  •   Visiting Scientist

    Janelia Research Campus, HHMI

    Estados Unidos, 2018

    Visiting Scientist


 

Article (35)

Gating and calcium-sensing mechanisms of TRPA1 channels revealed.
Imaging the electrical activity of organelles in living cells.
Evolutionary analyses reveal independent origins of gene repertoires and structural motifs associated to fast inactivation in calcium-selective TRPV channels.
Wheat germ agglutinin-conjugated fluorescent pH sensors for visualizing proton fluxes
Chalcone derivatives as non-canonical ligands of TRPV1
Fluorescent Labeling and 2-Photon Imaging of Mouse Tooth Pulp Nociceptors
RCAN1 Knockdown Reverts Defects in the Number of Calcium-Induced Exocytotic Events in a Cellular Model of Down Syndrome
The Integration of Electrical Signals Originating in the Root of Vascular Plants
Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid
Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1
A Transient Receptor Potential Ion Channel in Chlamydomonas Shares Key Features with Sensory Transduction-Associated TRP Channels in Mammals
A TRP conductance modulates repolarization after sensory-dependent depolarization in Chlamydomonas reinhardtii
Agonist-Dependent Modulation of Cell Surface Expression of the Cold Receptor TRPM8
Beyond the redox imbalance: Oxidative stress contributes to an impaired GLUT3 modulation in Huntington's disease
Cloning, Identification and Functional Characterization of Bovine Free Fatty Acid Receptor-1 (FFAR1/GPR40) in Neutrophils
Modulating the surface expression of cold receptors
The Different Roles of The Channel-Kinases TRPM6 and TRPM7
Delphinidin Activates NFAT and Induces IL-2 Production Through SOCE in T Cells
A cell- free assay to determine the stoichiometry of plasma membrane proteins
A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington's disease in mice
Design and synthesis of conformationally restricted capsaicin analogues based in the 1, 3, 4-thiadiazole heterocycle reveal a novel family of transient receptor potential vanilloid 1 (TRPV1) antagonists
Structurally conserved C-RFa revealed prolactin releasing activity in vitro and gene expression changes in pituitary of seasonally acclimatized carp
Near-Membrane Dynamics and Capture of TRPM8 Channels within Transient Confinement Domains
TRPM1 FORMS ION CHANNELS ASSOCIATED WITH MELANIN CONTENT IN MELANOCYTES
Ascorbic acid participates in a general mechanism for concerted glucose transport inhibition and lactate transport stimulation
Intrinsic electrostatic potential in the BK channel pore: Role in determining single channel conductance and block
TRPM7 FACILITATES CHOLINERGIC VESICLE FUSION WITH THE PLASMA MEMBRANE
Apoptosis Induced by Prolonged Exposure to Odorants in Cultured Cells from Rat Olfactory Epithelia
Dissection of the components for PIP(2) activation and thermosensation in TRP channels
Thermo TRP channels as modular proteins with allosteric gating
A hot-sensing cold receptor: C-terminal domain determines thermosensation in transient receptor potential channels
Apoptosis induced by prolonged exposure to odorants in cultured cells from rat olfactory epithelium
Kinetics, molecular basis, and differentiation of L-lactate transport in spermatogenic cells
Clues to understanding cold sensation: Thermodynamics and electrophysiological analysis of the cold receptor TRPM8
Dynamics of extracellular polymeric substances in UASB and EGSB reactors treating medium and low concentrated wastewaters

Abstract (2)

Beyond the REDOX imbalance: contributes to an oxidative stress modulation GLUT3 impaired in huntington's disease
An impaired expression of ascorbic acid transporter (SVCT2) at cellular surface would contribute to oxidative stress in Huntington's disease.

BookSection (1)

Mutagenesis and Temperature-Sensitive Little Machines

Review (6)

A structural view of ligand-dependent activation in thermoTRP channels
A Cool Channel in Cold Transduction
Sub-Cellular Distribution and Translocation of TRP Channels
A metabolic switch in brain: glucose and lactate metabolism modulation by ascorbic acid
Structure-functional intimacies of transient receptor potential channels
Large conductance Ca2+-activated K+ (BK) channel: Activation by Ca2+ and voltage
46
Sebastian Brauchi

Associate Professor

Physiology

Universidad Austral de Chile

Valdivia, Chile

12
ramon latorre

Profesor

Instituto de Neurociencia

Universidad de Valparaíso

5, Chile

5
Maite Castro

Professor

Faculty of Sciences

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

3
Felipe Beltrán

Gestor Tecnológico

I+D

Consorcio Apícola

Valdivia, Chile

3
Patricio Orio

Profesor Titular

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

3
ximena steinberg

Colaborador Docente

Bioquímica y Biologpia Molecular

Universidad de Concepción

Concepcion, Chile

2
Ivan Alfaro

Associate Professor, Director of Innovation and Technology Development

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

2
Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

2
Christian Cea

Profesor Asistente

Escuela de Medicina

Universidad de Santiago de Chile

Santiago, Chile

2
Rafael Burgos

FULL PROFESSOR

PHARMACOLOGY AND MORPHOPHYSIOLOGY

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

2
MARIA HIDALGO

Associate professor

Pharmacology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

2
Ilona Concha

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

2
Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

2
Daniel Bustos

Auxiliar Professor

Vicerrectoría de Investigación y Postgrado

Universidad Católica del Maule

Talca, Chile

1
Rodolfo Madrid

Full Professor

Departamento de Biología

UNIVERSIDAD DE SANTIGO DE CHILE

Santiago, Chile

1
Carmen Cea

ninguno

fruticultura

universidad de Chile

Santiago, Chile

1
Adriana Covarrubias

Profesor Ad Honorem- Investigador Asociado

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Evelyn Jara

Docente/Investigador

Ciencias Básicas

Universidad Santo Tomás

Temuco, Chile

1
Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

1
Pablo Caviedes

Full professor

ICBM

PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA, ICBM, FAC. DE MEDICINA, U. DE CHILE

Santiago, Chile

1
Javier Canales

Profesor Auxilliar

UNIVERSIDAD AUSTRAL DE CHILE

Chile

1
Rolando Chamy

Director

Núcleo Biotecnología Curauma

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
María Rauch

ACADEMICO

INSTITUTO DE BIOQUÍMICA Y MICROBIOLOGIA

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Jorge Farias

Full Professor

Chemical Engineering

Universidad de La Frontera

Temuco, Chile

1
Julio Caballero

Full Professor

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

1
Melissa Alegría

Académico Asociado

Facultad de Ingeniería y Negocios

Universidad de Las Américas

Santiago, Chile

1
Jaime Figueroa

Profesor Titular

Bioquimica y Microbiologia

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Ingrid Carvacho

Assistant Professor

Medicina Traslacional

Universidad Católica del Maule

Talca, Chile

1
Bruna Benso

Profesora Asistente

Facultad de Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

1
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Carolina Mascayano

Académico

Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGIA

santiago, Chile

1
María Miró

Académico

Facultad de Salud

Universidad Santo Tomás

Valdivia, Chile

1
Ana Cárdenas

Professor

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Rolando Chamy

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile