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María Pertusa Pastor

Profesor Asociado

UNIVERSIDAD DE SANTIAGO DE CHILE. FACULTAD QUÍMICA Y BIOLOGÍA

Santiago, Chile

Determinantes moleculares del tráfico y función de canales TRP

Licenciado en Bioquímica, Universidad Autónoma de Barcelona. España, 2002
PhD in Neuroscience, Universidad Miguel Hernández. España, 2010

Profesor Asociado Full Time

UNIVERSIDAD DE SANTIAGO DE CHILE

Química y Biología

Santiago, Chile

2021 - A la fecha
Profesor Asistente Full Time

UNIVERSIDAD DE SANTIAGO DE CHILE

Química y Biología

Santiago, Chile

2015 - 2020

Becario

Instiuto de Investigaciones Biomédicas de Barcelona

Barcelona, España

2003 - 2005
Becario Full Time

Instituto de Neurociencias de Alicante

Alicante, España

2005 - 2010
Investigador Postdoctoral

Universidad de Santiago de Chile

Santiago, Chile

2010 - 2013
Investigador Asociado

Universidad de Santiago de Chile

Santiago, Chile

2013 - 2014

Thesis director

2011 - 2013 Paulina Hardy Bioquímica Universidad de Santiago de Chile

2013 - 2014 Bastián Rivera Bioquímica Universidad de Santiago de Chile

2014 - 2015 Jeremy Salas Bioquímica Universidad de Santiago de Chile

2016 - 2017 Boris Lavanderos Bioquímica Universidad de Santiago de Chile

2016 - 2018 Katherine Valdebenito Bioquímica Universidad de Santiago de Chile

2016 - 2018 Bastián Rivera Doctorado en Neurociencia Universidad de Santiago de Chile

2018 - 2019 Claudio Moreno Bioquímica Universidad de Santiago de Chile

2022 - Victoria Flores Bioquímica Universidad de Santiago de Chile

Symposia / Lectures (Organizer / Invited speaker)

- SYMPOSIUM. Ion channels in Pain Neurophysiology. Annual meeting of the Chilean Society for Neuroscience, 2023, La Serena, Chile. Organizer.

- IBRO COURSE: Molecular and Cellular Mechanisms of Sensory Transduction. Universidad Autónoma de México, México, 2023. Keynote Speaker.

- SYMPOSIUM: TRP channels in cell physiology and physiopathology. Annual meeting of the Chilean Society for Neuroscience, 2019, La Serena, Chile. Organizer.

- SYMPOSIUM: Canales Iónicos y Neurociencias. LXI Congreso Nacional de la Sociedad Mexicana de Ciencias Fisiológicas, 2018, Colima, México. Speaker.

- SYMPOSIUM: Exploring key molecular determinants in cold sensing and neuropathic pain. Annual meeting of the Chilean Society for Neuroscience 2018. Puerto Varas, Chile. Speaker.

- SYMPOSIUM: Jornadas de Investigación básica - XI International meeting of the Asociación Chilena para el estudio del dolor (ACHED) IASP, Santiago, Chile. Speaker.

- SYMPOSIUM: Second Meeting of Proyecto Anillo: Physiological TRP channels in thermal sensory transduction and synaptic plasticity, Santiago, Chile. 2014. Universidad de Santiago de Chile. Speaker.

Talks by invitation

- Faculty of Sciences, University of Chile, 2010

- Instituto de Neurociencias de Alicante, Spain, 2015

- Faculty of Medicine, University of Chile, 2016

- Instituto de Neurociencias de Alicante, Spain, 2017

- Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 2018.

- Faculty of Medicine, University of Chile, 2019

- Faculty of Sciences, University of Chile, 2019

- Instituto de Neurociencias de Alicante, Spain, 2019

Website:

www.minicad.cl

www.minuspain.cl

Special Young Neuroscientists Symposium

Sociedad Chilena de Neurociencia

Chile, 2011

Award to Young Neuroscientists from the Chilean Society for Neuroscience.


Molecular determinants of TRPM8 function: key clues for a cool modulation Pertusa, MarÍa; Solorza, Jocelyn; Madrid, Rodolfo Article ISI FRONTIERS IN PHARMACOLOGY (2023)
Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons Arredondo, Cristian; Cefaliello, Carolina; Dyrda, Agnieszka; Jury, Nur; Martinez, Pablo; Diaz, Ivan; Amaro, Armando; Tran, Helene; Morales, Danna; Pertusa, Maria; Stoica, Lorelei; Fritz, Elsa; Corvalan, Daniela; Abarzua, Sebastian; Mendez-Ruette, Maxs; Fernandez, Paola; Rojas, Fabiola; Kumar, Meenakshi Sundaram; Aguilar, Rodrigo; Almeida, Sandra; Weiss, Alexandra; Bustos, Fernando J.; Gonzalez-Nilo, Fernando; Otero, Carolina; Tevy, Maria Florencia; Bosco, Daryl A.; Saez, Juan C.; Kahne, Thilo; Gao, Fen-Biao; Berry, James D.; Nicholson, Katharine; Sena-Esteves, Miguel; Madrid, Rodolfo; Varela, Diego; Montecino, Martin; Brown, Robert H.; Van Zundert, Brigitte Article ISI NEURON (2022)
Constitutive Phosphorylation as a Key Regulator of TRPM8 Channel Function Rivera, Bastian; Moreno, Claudio; Lavanderos, Boris; Hwang, Ji Yeon; Fernandez-Trillo, Jorge; Park, Kang-Sik; Orio, Patricio; Viana, Felix; Madrid, Rodolfo; Pertusa, Maria Article ISI JOURNAL OF NEUROSCIENCE (2021)
Negative Modulation of TRPM8 Channel Function by Protein Kinase C in Trigeminal Cold Thermoreceptor Neurons Rivera, Bastián; Campos, Matías; Orio, Patricio; Madrid, Rodolfo; Pertusa, María Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Non-conventional Axonal Organelles Control TRPM8 Ion Channel Trafficking and Peripheral Cold Sensing Cornejo, Víctor Hugo; González, Carolina; Campos, Matías; Vargas-Saturno, Leslie; Juricic, María de los Ángeles; Miserey-Lenkei, Stéphanie; Pertusa, María; Madrid, Rodolfo; Couve, Andrés Article ISI CELL REPORTS (2020)
Critical role of the pore domain in the cold response of TRPM8 channels identified by ortholog functional comparison Pertusa, Maria; Rivera, Bastian; Gonzalez, Alejandro; Ugarte, Gonzalo; Madrid, Rodolfo Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Non-invasive Neurite Mechanics in Differentiated PC12 Cells Gárate, Fernanda; Pertusa, María; Arana, Yahaira; Bernal, Roberto Article ISI SCOPUS FRONTIERS IN CELLULAR NEUROSCIENCE (2018)
IKD current in cold transduction and damage-triggered cold hypersensitivty González, Alejandro; Herrera, Gaspar; Ugarte, Gonzalo; Piña, Ricardo; Pertusa, María; Orio, Patricio; Madrid, Rodolfo Article ISI Advance In Experimental Medicine and Biology (2017)
Role of the Excitability Brake Potassium Current I-KD in Cold Allodynia Induced by Chronic Peripheral Nerve Injury González, Alejandro; Ugarte, Gonzalo; Restrepo, Carlos; Herrera, Gaspar; Piña, Ricardo; Gómez-Sánchez, José Antonio; Pertusa, María; Orio, Patricio; Madrid, Rodolfo Article ISI SCOPUS JOURNAL OF NEUROSCIENCE (2017)
Targeted overexpression of tumor necrosis factor-alpha increases cyclin-dependent kinase 5 activity and TRPV1-dependent Ca2+ influx in trigeminal neurons Rozas P.; Lazcano, P; Piña R.; Cho A.; Terse A.; Pertusa, M.; Madrid R.; Gonzalez-Billault C.; Kulkarni A.B.; Utreras, E Article ISI SCOPUS PAIN (2016)
Time-resolved neurite mechanics by thermal fluctuation assessments Garate F.; Betz, T; Pertusa, M.; Bernal, R Article ISI SCOPUS PHYSICAL BIOLOGY (2015)
Bidirectional Modulation of Thermal and Chemical Sensitivity of TRPM8 Channels by the Initial Region of the N-terminal Domain Pertusa, M.; González A; Hardy P.; Madrid R.; Viana, F. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Intimacies and Physiological Role of the Polymodal Cold-Sensitive Ion Channel TRPM8 Madrid R.; Pertusa, M. Article SCOPUS Current Topics in Membranes (2014)
N-Glycosylation of TRPM8 Ion Channels Modulates Temperature Sensitivity of Cold Thermoreceptor Neurons Pertusa, M.; Madrid R.; Morenilla-Palao, C; Belmonte, C; Viana, F. Article ISI SCOPUS Journal of Biological Chemistry (2012)
Differential Role of the Menthol-Binding Residue Y745 in the Antagonism of Thermally Gated TRPM8 Channels Malkia, Annika; Pertusa, María; Fernández-Ballester, Gregorio; Ferrer-Montiel, Antonio; Viana, Félix Article ISI Molecular Pain (2009)
Lipid Raft Segregation Modulates TRPM8 Channel Activity Morenilla-Palao, Cruz; Pertusa, María; Meseguer, Víctor; Cabedo, Hugo; Viana, Félix Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Expression of GDNF transgene in astrocytes improves cognitive deficits in aged rats Pertusa, M.; García-Matas, S.; Mammeri, H.; Adell, A.; Rodrigo, T.; Mallet, J.; Cristòfol, R.; Sarkis, C.; Sanfeliu, C. Article ISI NEUROBIOLOGY OF AGING (2008)
Astrocytes aged in vitro show a decreased neuroprotective capacity Pertusa, M.; García-Matas, S.; Rodríguez-Farré, E.; Sanfeliu, C.; Cristòfol, R. Article ISI JOURNAL OF NEUROCHEMISTRY (2007)
Transcriptional Control of Cholesterol Biosynthesis in Schwann Cells by Axonal Neuregulin 1 Pertusa, Maria; Morenilla-Palao, Cruz; Carteron, Christelle; Viana, Felix; Cabedo, Hugo Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Carboxyl-terminal fragment of amyloid precursor protein and hydrogen peroxide induce neuronal cell death through different pathways Sebastià, J.; Pertusa, M.; Vílchez, D.; Planas, A. M.; Verbeek, R.; Rodríguez-Farré, E.; Cristòfol, R.; Sanfeliu, C. Article ISI Journal of neural transmission (Vienna, Austria : 1996) (2006)
Down's syndrome astrocytes have greater antioxidant capacity than euploid astrocytes Sebastià, Jordi; Cristòfol, Rosa; Pertusa, Maria; Vílchez, David; Torán, Núria; Barambio, Santiago; Rodríguez-Farré, Eduard; Sanfeliu, Coral Article ISI EUROPEAN JOURNAL OF NEUROSCIENCE (2004)
Neurotoxic effects of trimethyltin and triethyltin on human fetal neuron and astrocyte cultures: A comparative study with rat neuronal cultures and human cell lines Cristòfol, Rosa M; Gassó, Sergi; Vílchez, David; Pertusa, MarÍa; Rodríguez-Farré, Eduard; Sanfeliu, Coral Article ISI TOXICOLOGY LETTERS (2004)


Modulation of TRP channels by N-glycosylation and Phosphorylation. Pertusa, María; Madrid, Rodolfo BookSection (2015)
TRP channels in cold transduction. In the book TRP channels in Sensory Transduction González, Alejandro; Ugarte, Gonzalo; Piña, Ricardo; Pertusa, María; Madrid, Rodolfo BookSection (2015)
Mutagenesis and temperature-sensitive little machines Pertusa, María; Moldenhauer, Hans; Brauchi, Sebastián; Latorre, Ramón; Madrid, Rodolfo; Orio, Patricio BookSection (2012)


TRPM8 phosphorylation as a critical modulator of cold sensing Madrid, Rodolfo; Cerda, Oscar; Victor Hugo Cornejo Proyecto (2024)
Millenium Nucleus of Ion Channels-Associated Diseases (MiNICAD) Iniciativa Científica Milenio, Ministerio de Enconomía (NC160011) Proyecto 2017-2020 Coinvestigador(a)
Functional unbalance of Kv1 channels and cold-sensitive TRP channels as a mechanism of cold hypersensitivity in orofacial neuropathic pain. FONDECYT (1161733) Proyecto 2016-2019 Coinvestigador(a)
CELLULAR AND MOLECULAR DETERMINANTS OF THE ABNORMAL COLD SENSITIVITY OF PRIMARY SENSORY NEURONS IN RESPONSE TO AXONAL DAMAGE. FONDECYT (1131064) Proyecto 2013-2016 Coinvestigador(a)
MOLECULAR DETERMINANTS OF COLD SENSITIVITY OF TRPM8 ION CHANNEL FONDECYT (11130144) Proyecto 2013-2016 Inv. Responsable
ROLE OF GABAA CHANNELS IN THE AXON INITIAL SEGMENT IN EPILEPSY FONDECYT (1130904) Proyecto 2013-2016 Coinvestigador(a)
Evolutionary adaptions of voltage-dependent potassium channels from an antartic organism. INACH (RT15-12) Proyecto 2012-2015 Coinvestigador(a)
Study of the physiological role of TRP channels in thermal transduction and synaptic plasticity PIA (ACT-1113) Proyecto 2012-2015 Coinvestigador(a)
PAPEL DEL DOMINIO N-TERMINAL EN LA OLIGOMERIZACION, TRAFICO Y FUNCION DEL CANAL IONICO TRPM8. FONDECYT (3110128) Proyecto 2010-2013 Inv. Responsable