Man

Constanza Cárdenas Carvajal

Associate Researcher

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

Líneas de Investigación


Molecular modeling; Fish Immunology; Immunological Markers; Aquatic Organisms; Bioinformatics; Peptide Synthesis, peptide design, genomic sequence analysis

Educación

  •  Chemistry, Universidad Nacional de Colombia. Colombia, 2005
  •  Chemistry, Universidad Nacional de Colombia. Colombia, 1990

Experiencia Académica

  •   postdoctoral fellowship Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

    Valparaiso, Chile

    2006 - 2009

  •   Docente Part Time

    Universidad Andres Bello

    Ingeniería en Biotecnologia

    Viña del Mar, Chile

    2011 - 2013

  •   Docente Other

    PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

    Doctorado en Biotecnología

    Valparaíso, Chile

    2007 - A la fecha

Experiencia Profesional

  •   Associate Researcher Full Time

    Pontificia Universidad católica de Valparaíso

    Valparaiso, Chile

    2010 - A la fecha

  •   Researcher Part Time

    Fraunhofer Chile Research center

    Valparaiso, Chile

    2012 - 2017

  •   Postdoctoral fellowship Full Time

    Pontificia Universidad Católica de Valparaíso

    Valparaiso, Chile

    2006 - 2009

  •   Docente Full Time

    Universidad de Pamplona

    Pamplona, Colombia

    2005 - 2006

  •   Researcher Full Time

    Fundación Instituto de Inmunología de Colombia

    Bogotá, Chile

    2001 - 2005

  •   researcher Full Time

    Instituto de Inmunología

    Bogotá, Colombia

    1997 - 2001

Formación de Capital Humano


co-tutora
Tesis Nicolás Ojeda “Estudio del mecanismo de fusión del virus ISA a la célula: influencia de la región HPR de HE, rol de la proteína F1 y desarrollo de péptidos interferentes”. Cotutora.
Tesis Alvaro Sequeida: “Aplicación de efectores del tipo activadores de la transcripción (TALE) para el incremento de la expresión de IL-8 en un modelo celular de infección con Piscirickettsia salmonis”. Cotutora.

Asesoría en la tesis de las alumnas Bárbara Nerea Jugo y Loreto Rocha, de Ingeniería Comercial de la Universidad Adolfo Ibáñez, en el marco del convenio con FCR.



 

Article (56)

First Insights about Antiparasitic and Action Mechanisms of the Antimicrobial Peptide Hepcidin from Salmonids against Caligus rogercresseyi
Improving 2-Chlorotrityl Chloride (2-CTC) Resin Activation
Ongoing diversification of the global fish pathogen <i>Piscirickettsia salmonis</i> through genetic isolation and transposition bursts
Peptides, solid-phase synthesis and characterization: Tailor-made methodologies
Protocol for Facile Synthesis of Fmoc-N-Me-AA-OH Using 2-CTC Resin as Temporary and Reusable Protecting Group
A Sporothrix spp. enolase derived multi-epitope vaccine confers protective response in BALB/c mice challenged with Sporothrix brasiliensis
Arginine Homopeptide of 11 Residues as a Model of Cell-Penetrating Peptides in the Interaction with Bacterial Membranes
Effect of Fish Stock Density on Hormone Genes Expression from Brain and Gastrointestinal Tract of Salmo salar
Relationship between type II polyproline helix secondary structure and thermal hysteresis activity of short homopeptides
Serum-isolated exosomes from Piscirickettsia salmonis-infected Salmo salar specimens enclose bacterial DnaK, DnaJ and GrpE chaperones
Immune characterization of a Colombian family cluster with SARS-CoV-2 infection
NK-lysin peptides ameliorate viral encephalopathy and retinopathy disease signs and provide partial protection against nodavirus infection in European sea bass
Tea bags for fmoc solid-phase peptide synthesis: An example of circular economy
Water-holding capacity of enzymatic protein hydrolysates: A study on the synergistic effects of peptide fractions
Bio-organometallic Peptide Conjugates: Recent Advances in Their Synthesis and Prospects for Biomedical Application
Bovine skin gelatin hydrolysates as potential substitutes for polyphosphates: The role of degree of hydrolysis and pH on water‐holding capacity
Collagen as a source of bioactive peptides: A bioinformatics approach
Cyanobacteria and Eukaryotic Microalgae as Emerging Sources of Antibacterial Peptides
Exploring small cationic peptides of different origin as potential antimicrobial agents in aquaculture
Expression of DC-SIGN-like C-Type Lectin Receptors in Salmo salar
Interaction of the Amino-Terminal Domain of the ISAV Fusion Protein with a Cognate Cell Receptor
Synthetic Peptides as a Promising Alternative to Control Viral Infections in Atlantic Salmon
The tea-bag protocol for comparison of Fmoc removal reagents in solid-phase peptide synthesis
Identification of Antimicrobial Peptides from the Microalgae Tetraselmis suecica (Kylin) Butcher and Bactericidal Activity Improvement
Molecular features associated with the adaptive evolution of Infectious Salmon Anemia Virus (ISAV) in Chile
Chemical Synthesis and Functional Analysis of VarvA Cyclotide
Immobilization of lipases in hydrophobic chitosan for selective hydrolysis of fish oil: The impact of support functionalization on lipase activity, selectivity and stability
An updated proposal for classification of infectious salmon anemia virus strains
Identification of a type I nitroreductase gene in non-virulent Trypanosoma rangeli
Structure-activity relationships on the study of beta-galactosidase folding/unfolding due to interactions with immobilization additives: Triton X-100 and ethanol
Chemical Synthesis and In Vitro Evaluation of a Phage Display-Derived Peptide Active against Infectious Salmon Anemia Virus.
Deprotection Reagents in Fmoc Solid Phase Peptide Synthesis=> Moving Away from Piperidine?
Effect of secondary anchor amino acid substitutions on the immunogenic properties of an HLA-A*0201-restricted T cell epitope derived from the Trypanosoma cruzi KMP-11 protein
Antimicrobial activity of trout hepcidin.
Coexistence in field samples of two variants of the infectious salmon anemia virus: a putative shift to pathogenicity.
Design and Activity of Novel Lactoferrampin Analogues Against O157:H7 Enterohemorrhagic Escherichia coli
Molecular characterization of calcineurin B from the non-virulent Trypanosoma rangeli kinetoplastid indicates high gene conservation
CLONING AND EXPRESSION ANALYSIS OF ALLOGRAFT INFLAMMATORY FACTOR TYPE 1 IN COELOMOCYTES OF ANTARCTIC SEA URCHIN (STERECHINUS NEUMAYERI)
Denaturing Gradient Gel Electrophoresis (DGGE) as a Powerful Novel Alternative for Differentiation of Epizootic ISA Virus Variants
Development of a new antibody for detecting natural killer enhancing factor (NKEF)-like protein in infected salmonids
Novel Strategy to Evaluate Infectious Salmon Anemia Virus Variants by High Resolution Melting
A natural peptide and its variants derived from the processing of infectious pancreatic necrosis virus (IPNV) displaying enhanced antimicrobial activity: A novel alternative for the control of bacterial diseases
Characterization of a functional toxin-antitoxin module in the genome of the fish pathogen Piscirickettsia salmonis
ISPsa2, the first mobile genetic element to be described and characterized in the bacterial facultative intracellular pathogen Piscirickettsia salmonis
Reactivation of immobilized penicillin G acylase: Influence of cosolvents and catalytic modulators
Molecular modeling of class I and II alleles of the major histocompatibility complex in Salmo salar
A novel antifungal peptide designed from the primary structure of a natural antimicrobial peptide purified from Argopecten purpuratus hemocytes
A wave function analysis of MHC-Peptide interactions
Wave function analysis of MHC-peptide interactions.
A theoretical analysis of HLA-DR beta 1*0301-CLIP complex using the first three multipolar moments of the electrostatic field
A comparative study of MHC Class-II HLA-DR beta 1*0401-Col II and HLA-DR beta 1*0101-HA complexes: a theoretical point of view
Allele effects in MHC-peptide interactions: a theoretical analysis of HLA-DRbeta1*0101-HA and HLA-DRbeta1*0401-HA complexes.
Quantum chemical analysis explains hemagglutinin peptide-MHC Class II molecule HLA-DRbeta1*0101 interactions.
Constructing a useful tool for characterizing amino acid conformers by means of quantum chemical and graph theory indices.
Plasmodium falciparum AMA-1 erythrocyte binding peptides implicate AMA-1 as erythrocyte binding protein.
Leishmania panamensis: a 44bp deletion in gp63 gene is found in cDNA and genomic libraries

Abstract (2)

Antibacterial activity of short cationic model peptides
Evaluation of immunogenic peptides derived from a highly protective antigenic protein of Piscirickettsia salmonis as a potential source for vaccine development

BookWhole (1)

Methods in Biocomputational Chemistry: A Lesson from the Amino Acids

Proyecto (13)

Development of antiviral peptides as therapeutic alternatives in the treatment of animals grown in confinement
Role of C-type lectin receptors in the infective process of salmo salar by the infectious salmon anemia virus=> implications for strain-specific virulence and fish susceptibility
“Estatus inmune de Salmo salar en condiciones de campo y su relación con la infección por P. salmonis=> Bases para la incorporación de péptidos inmunomoduladores en dieta como nuevos medicamentos contra el patógeno y el SRS
Estudio integral de las bases biológicas y moleculares del ciclo de vida de piscirickettsia salmonis en el contexto de una aproximación epidemiológica para desarrollar estrategias que permitan su control.
First approach for purification and characterization of antimicrobial peptides (AMPS) from microalgae
Desarrollo de un sistema diagnóstico de alta sensibilidad para el virus de la anemia infecciosa del salmón (ISAV) capaz de discriminar entre distintas variantes virales
Desarrollo de kits moleculares para la detección sintomática y asintomática de todas las variantes epizoóticas de Piscirickettsia salmonis en peces salmonídeos cultivados en Chile
CHARACTERIZATION OF TYPE IV SECRETION SYSTEMS (TIVSS) GENES IN PISCRICKETTSIA SALMONIS AND THEIR ASSOCIATION WITH BACTERIAL PATHOGENESIS
Péptidos sintéticos diseñados y dirigidos contra el ensamblaje del virus de la necrosis pancreática infecciosa IPNV.
Proyecto de instalación de centro de excelencia en Chile=> Fraunhofer Chile Research-Center for Systems Biotechnology
Péptidos antimicrobianos de bacterias antárticas síntesis y optimización contra bacterias patógenas de la industria alimentaria.
Selección de alelos del Complejo Mayor de Histocompatibilidad (MHC) como marcadores base para el desarrollo de productos de determinación rápida y predictiva de resistencia y susceptibilidad a Piscirickettsia salmonis en especies salmonídeas en cultivo=> un modelo con proyección a otros agentes patógenos.
Desarrollo de la bioinformática en la Pontificia Universidad Católica de Valparaíso=> adscripción a las actividades de docencia de pre y postgrado de la Universidad desde el Instituto de Biología
58
Constanza Cárdenas

Associate Researcher

Nucleo Biotecnologia Curauma

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

19
Fanny Guzman

Investigador Senior

Núcleo de Biotecnología Curauma

Pontificia Universidad Católica de Valparaiso

Valparaiso, Chile

13
Sergio Marshall

PROFESSOR

BIOLOGY INSTITUTE

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

6
LUIS MERCADO

Profesor Titular

Instituto de Biología

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

5
Vitalia Henríquez

Profesor Titular

Instituto deBiología

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

5
Claudio Alvarez

Profesor Asistente

Acuicultura

Universidad Católica del Norte

Coquimbo, Chile

4
Tanya Román

Estudiante de Postgrado

Nucleo de Biotecnología de Curauma

PUCV

Valparaíso, Chile

3
Fernando Gómez

Associate Proffesor

Instituto de Biologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

3
Vitalia Henriquez

DIrectora

Facultad de Ciencias

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

3
Nicolas Ojeda

Investigador Post-Doctoral

Instituto de Biología

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

3
María Rojas

Profesor adjunto

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

2
Claudia Bernal

Academica

Departamento de Química

Universidad de La Serena

La Serena, Chile

2
Marisela Carmona

Post-Doctorado

Aquaculture

Fraunhofer Chile Research

Valparaiso, Chile

2
Lorena Wilson

ESCUELA DE INGENIERIA BIOQUIMICA, PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Valparaiso, Chile

2
Andrés Illanes

Profesor Títular

Escuela de Ingeniería Bioquímica

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

2
Pedro Valencia

Research Associate

Chemical Engineering

UNIVERSIDAD TÉCNICA FEDERICO SANTA MARÍA

Valparaíso, Chile

1
Claudio Alvarez

Investigador Titular

Laboratorio FIGEMA

Centro de Estudios Avanzados en Zonas Aridas

Coquimbo, Chile

1
Paula Santana

Profesora Asistente e Investigadora

Facultad de Ingeniería

Universidad Autónoma de Chile

Santiago, Chile

1
LORENA ALVAREZ

INVESTIGADOR

CENTRO REGIONAL DE ESTUDIOS EN ALIMENTOS SALUDABLES

VALPARAISO, Chile

1
Jorge González

Jefe de Departamento

Departamento Científico

INSTITUTO ANTÁRTICO CHILENO

Punta Arenas, Chile

1
Paulina Urrutia

Profesor Asociado

Ingeniería Bioquímica

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Jose Gallardo

Profesor Adjunto

Facultad de Ciencias del Mar y Geografía

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Paulina Schmitt

Assistant Professor

Biology

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Valparaiso, Chile

1
Pablo Conejeros

Profesor Adjunto

Universidad de Valparaiso

Valparaiso, Chile

1
Jorn Bethke

CTO

AQUIT

Viña del mar, Chile

1
Claudio Jofré

Gerente General

Innovacell

Santiago, Chile

1
Suleivys Nuñez

Investigador en Proyecto Anillo

Departamento de Ingeniería Química y Ambiental

Universidad Técnica Federico Santa María

Valparaíso, Chile

1
Cristián Muñoz

Encargado de Laboratorio

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Claudia Pareja

Investigadora de Postdoctorado

Departamento de Hematología-Oncología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Yunesky Masip

Profesor ADJUNTO

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Quilpue, Chile

1
Carolina Salazar

Profesor agregado

Biología

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Jaime Figueroa

Profesor Titular

Bioquimica y Microbiologia

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile