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Evelyn Pardo Huguet

Investigadora Independiente

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

SANTIAGO , Chile

Líneas de Investigación


Neuroinmunología; Galectinómica; Neurociencia; Metabolismo celular; Inmunología; Autoinmunidad; Tráfico de proteínas

Educación

  •  Ciencias Biológicas m/Biología Celular y Molecular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2013
  •  Ciencias Biológicas , PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
  •  Bioquímico, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009
  •  Ciencias Biológicas , PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004

Experiencia Académica

  •   Doctorante Other

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biológicas

    SANTIAGO , Chile

    2008 - 2013

  •   Investigadora Other

    UNIVERSIDAD DE CHILE

    Medicina

    SANTIAGO , Chile

    2016 - 2017

  •   Post Doctorado Full Time

    Consejo Nacional de Investigación (CNR)

    Nápoles, Italia

    2014 - 2015

  •   Investigadora Independiente Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biológicas

    SANTIAGO, Chile

    2018 - 2018

Experiencia Profesional

  •   Profesora de Catedra y Labotatorio Part Time

    Universidad Pedro de Valdivia

    SANTIAGO , Chile

    2010 - 2012

  •   Profesora Instructor Biología Celular Part Time

    Pontificia Universidad Católica de Chile

    SANTIAGO , Chile

    2018 - 2018

Formación de Capital Humano


Tutora Tesis de pregrado Lucas Vicuña y Cristobal Curkovic.
Biol Res. 2013;46(3):275-80. doi: 10.4067/S0716-97602013000300008. Galectin-8 binds to LFA-1, blocks its interaction with ICAM-1 and is counteracted by anti-Gal-8 autoantibodies isolated from lupus patients. Vicuña L, Pardo E, Curkovic C, Döger R, Oyanadel C, Metz C, Massardo L, González A, Soza A.


Premios y Distinciones

  •   Microscopy training Fellowship

    CONSIGLIO NAZIONALE DELLE RICERCHE

    Italia, 2013

    Microscopy training Fellowship (2014-2015), Funded by Consiglio Nazionale Delle Ricerche (CNR) (Italy Government)

  •   Beca Postdoctorado

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2012

    Postdoctoral Fellowship Program (2012-2013), Funded by Comisión Nacional de Investigación Científica y Tecnólogica (CONICYT), Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) (Chilean Government).

  •   Beca Estudios de Doctorado

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2006

    CONICYT Scholarship to perform graduate studies (PhD) 2006-2009. Chilean Government

  •   Beca Estudios de Doctorado. PUC

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2009

    Scholarship for extends graduate studies (PhD) 2009-2010. Vicerrectoría Adjunta de Investigación y Doctorado (VRAID). PUC.

  •   Beca de viaje. CONICYT

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2007

    CONICYT Travel Award. Society for Neuroscience 2007, San Diego, USA.


 

Article (17)

GALECTIN-8 Is a Neuroprotective Factor in the Brain that Can Be Neutralized by Human Autoantibodies

Pardo, E.; Barake F; Tapia C.; Soza A.; Gonzalez, A

Article ISI SCOPUS
MOLECULAR NEUROBIOLOGY  (2019)

MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca2+ communication: a dead end in cancer cells

Ahumada-Castro, U; Silva-Pavez, E; Lovy, A; Pardo, E; Molgo, J; Cardenas, C

Article ISI SCOPUS
AUTOPHAGY  (2019)

Galectin-8 induces partial epithelial-mesenchymal transition with invasive tumorigenic capabilities involving a FAK/EGFR/proteasome pathway in Madin-Darby canine kidney cells

Oyanadel, Claudia; Holmes, Christopher; Pardo, Evelyn; Retamal, Claudio; Shaughnessy, Ronan; Smith, Patricio; Cortés, Priscilla; Bravo-Zehnder, Marcela; Metz, Claudia.; Feuerhake, Teo; Romero, Diego; Roa, Juan Carlos; Montecinos, Viviana; Soza, Andrea; González, Alfonso; Yamashita, Yukiko

Article ISI SCOPUS
MOLECULAR BIOLOGY OF THE CELL  (2018)

Galectin-8 as an immunosuppressor in experimental autoimmune encephalomyelitis and a target of human early prognostic antibodies in multiple sclerosis

Pardo, Evelyn; Cárcamo, Claudia; Uribe-San Martín, Reinaldo; Ciampi, Ethel; Segovia-Miranda, Fabián; Curkovic-Peña, Cristobal; Montecino, Fabián; Holmes, Christopher; Tichauer, Juan Enrique; Acuña, Eric; Osorio-Barrios, Francisco; Castro, Marjorie; Cortes, Priscilla; Oyanadel, Claudia; Valenzuela, David M.; Pacheco, Rodrigo; Naves, Rodrigo; Soza, Andrea; González, Alfonso; Klein, Robyn S

Article ISI SCOPUS
PLOS ONE  (2017)

Galectin-8 binds to LFA-1, blocks its interaction with ICAM-1 and is counteracted by anti-Gal-8 autoantibodies isolated from lupus patients

Vicuña, Lucas; Pardo, Evelyn; Curkovic, Cristóbal; Doger, Remziye; Oyanadel, Claudia; Metz, Claudia.; Massardo, Loreto; Gonzalez, Alfonso; Soza, Andrea

Article ISI SCIELO SCOPUS
Biological Research  (2013)

Galectin-8 binds to LFA-1, blocks its interaction with ICAM-1 and is counteracted by anti-Gal-8 autoantibodies isolated from lupus patients.

Vicuña, Lucas; Pardo, Evelyn; Curkovic, Cristóbal; Döger, Remziye; Oyanadel, Claudia; Metz, Claudia; Massardo, Loreto; González, Alfonso; Soza, Andrea

Article
Biological research  (2013)

UTP Controls Cell Surface Distribution and Vasomotor Activity of the Human P2Y(2) Receptor through an Epidermal Growth Factor Receptor-transregulated Mechanism

Norambuena A.; Palma, F; Poblete MI; Donoso, MV; Pardo E.; González A; Huidobro-Toro, JP

Article ISI SCOPUS
Journal of Biological Chemistry  (2010)

UTP controls cell surface distribution and vasomotor activity of the human P2Y2 receptor through an epidermal growth factor receptor-transregulated mechanism.

Norambuena, Andrés; Palma, Francisco; Poblete, M Inés; Donoso, M Verónica; Pardo, Evelyn; González, Alfonso; Huidobro-Toro, J Pablo

Article
The Journal of biological chemistry  (2010)

Autoantibodies against galectin-8: their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation

Massardo, L; Metz, C; Pardo E.; Mezzano, V; Babul, M.; Jarpa E.; guzman AM; Andre, S; Kaltner, H; Gabius, HJ; Jacobelli, S.; González A; Soza A.

Article ISI SCOPUS
LUPUS  (2009)

Autoantibodies against galectin-8: their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation.

Massardo, L; Metz, C; Pardo, E; Mezzano, V; Babul, M; Jarpa, E; Guzmán, A M; André, S; Kaltner, H; Gabius, H J; Jacobelli, S; González, A; Soza, A

Article
Lupus  (2009)

Galectin-8 Induces Apoptosis in Jurkat T Cells by Phosphatidic Acid-mediated ERK1/2 Activation Supported by Protein Kinase A Down-regulation

Norambuena A.; Metz, C; Vicuña L.; Silva, A; Pardo E.; Oyanadel, C; Massardo, L; González A; Soza A.

Article ISI SCOPUS
JOURNAL OF BIOLOGICAL CHEMISTRY  (2009)

Galectin-8 induces apoptosis in Jurkat T cells by phosphatidic acid-mediated ERK1/2 activation supported by protein kinase A down-regulation.

Norambuena, Andrés; Metz, Claudia; Vicuña, Lucas; Silva, Antonia; Pardo, Evelyn; Oyanadel, Claudia; Massardo, Loreto; González, Alfonso; Soza, Andrea

Article
The Journal of biological chemistry  (2009)

[Antibodies against galectin-8 in patients with systemic lupus erythematosus].

Pardo, Evelyn; Cárcamo, Claudia; Massardo, Loreto; Mezzano, Verónica; Jacobelli, Sergio; González, Alfonso; Soza, Andrea

Article
Revista meÌ�dica de Chile  (2006)

Antibodies against galectin-8 in patients with systemic lupus erythematosus

Pardo E.; Carcamo, C; Massardo, L; Mezzano, V; Jacobelli, S.; González A; Soza A.

Article ISI
REVISTA MEDICA DE CHILE  (2006)

Autoanticuerpos anti-galectina-8 en pacientes con lupus eritematoso sistémico

Pardo, Evelyn; carcamo, claudia; Massardo, Loreto; Mezzano, Veronica; Jacobelli, Sergio; Gonzalez, Alfonso; Soza G, Andrea

Article SCIELO
REVISTA MEDICA DE CHILE  (2006)

Galectin-8 binds specific beta 1 integrins and induces polarized spreading highlighted by asymmetric lamellipodia in Jurkat T cells

Carcamo, C; Pardo E.; Oyanadel, C; Bravo-Zehnder, M; Bull, P; Cáceres M.; Martinez, J.; Massardo, L; Jacobelli, S.; González A; Soza A.

Article ISI SCOPUS
EXPERIMENTAL CELL RESEARCH  (2006)

Galectin-8 binds specific beta1 integrins and induces polarized spreading highlighted by asymmetric lamellipodia in Jurkat T cells.

Cárcamo, Claudia; Pardo, Evelyn; Oyanadel, Claudia; Bravo-Zehnder, Marcela; Bull, Paulina; Cáceres, Mónica; Martínez, Jorge; Massardo, Loreto; Jacobelli, Sergio; González, Alfonso; Soza, Andrea

Article
Experimental cell research  (2006)

Abstract (5)

Galectin 8 autoantibodies are associated with relapsing remitting phenotype of multiple sclerosis and with higher disability scores

Ciampi, E; Uribe R.; Carcamo, C; Pardo E.; Curkovic, C; Cortes P.; Soza A.; González A

Abstract ISI
MULTIPLE SCLEROSIS JOURNAL  (2015)

Galectin-8 enhances B cell antigen presentation

Yuseff, MI; Pardo E.; Lennon-Dumenil, AM; Gozalez, A; Soza A.

Abstract ISI
FEBS JOURNAL  (2012)

Galectin-8 knockout mice have sex-dependent altered homeostasis of T and B lymphocytes and autoimmune features.

Pardo E.; Curkovic, C; Valenzuela, D; González A; Soza A.

Abstract ISI
MOLECULAR BIOLOGY OF THE CELL  (2012)

Galectin-8 induces apoptotic signaling through a link between phospholipase D, PKA and ERK pathways in Jurkat cells

Norambuena A.; Metz, C; Vicuña L.; Pardo E.; Silva, A; Carcamo, C; Andre, S; Gabius, HJ; González A; Soza A.

Abstract ISI
FEBS JOURNAL  (2007)

Autoantibodies against galectin-8 block adhesion and lamellipodia formation induced by galectin-8 in Jurkat cells

Carcamo, C; Soza A.; Pardo E.; Bull, P; Massardo, L; Jacobelli, S.; González A

Abstract ISI
MOLECULAR BIOLOGY OF THE CELL  (2004)

Patent (1)

Method and kit diagnose individuals with relapsing remitting Multiple Sclerosis and poor prognosis

Pardo, E.; Uribe, R; Ciampi E.; Gonzalez, A; Carcamo, C.; Soza A.

Patent
 

18
Evelyn Pardo

Investigadora Independiente

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

SANTIAGO , Chile

13
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

7
Maria Massardo

Docente Investigador

Medicina

Universidad San Sebastián

Santiago, Chile

6
Andrea Soza

Profesor Asociado

Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

5
CLAUDIA CARCAMO

Profesor Asociado

neurology

PONTIFICIA UNIVERSIDADA CATÓLICA DE CHILE. DEPARTAMENTO DE NEUROLOGÍA

Santiago, Chile

4
Claudia Oyanadel

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Claudia Metz

Docente Investigador

Universidad San Sebastián

Santiago, Chile

2
Jorge Martinez

Profesor Titular

Laboratorio de Biología Celular

INSTITUTO DE NUTRICIÓN Y TECNOLOGÍA DE ALIMENTOS (INTA), UNIVERSIDAD DE CHILE

Santiago, Chile

1
Rodrigo Naves

Associate Professor

Program of Immunology

Universidad de Chile

Santiago, Chile

1
Reinaldo Uribe

Instructor Adjunto

Neurología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Alenka Lovy

Assistant Professor

Science

Universidad Mayor de Chile

Santiago, Chile

1
Fabian Montecino

Asistente de investigación

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Patricio Smith

Profesor Asociado

Odontología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Christopher Holmes

Estudiante de doctorado

Ingeniería Biomédica

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Rodrigo Pacheco

Associate Investigator; Head of the Laboratory of Neuroimmunology

Fundación Ciencia para la Vida

Santiago, Chile

1
Ethel Ciampi

Instructor Adjunto

Neurología

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Cheril Tapia

Profesor Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

1
Eduardo Silva

Investigador Postdoctoral

Universidad Mayor

Santiago, Chile

1
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Monica Caceres

Profesor asociado

Instituto de ciencias biomedicas

Universidad de Chile

Santiago, Chile

1
Fabián Segovia

Associate professor

Department of Cell Biology

Universidad de Concepción

Concepción, Chile

1
María Barake

Becaria Postdoctoral

Facultad de Medicina y ciencia

Universidad San Sebastián

Santiago, Chile

1
Ana Guzman

MÉDICO JEFE LABORATORIO

LABORATORIO CLÍNICO

PONTIFICIA UNIVERSIDAD CATÓLICA

SANTAIGO, Chile