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Helga Lorena Weber Rascheya

Investigador

Universidad de la Frontera

Temuco, Chile

Gallbladder Cancer Stem Cells, Metabolic pathways involved in gallbladder cancer; Cancer-specific therapies for gallbladder cancer; Oncolytic Viruses in pancreatic cancer

Doctor Biología Celular y Molecular Aplicada, UNIVERSIDAD DE LA FRONTERA. Chile, 2010
Ingeniero Agrónomo, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2001

Investigador Post Doctoral Other

UNIVERSIDAD DE LA FRONTERA

Vicerrectoría de Investigación y Post Grado

Temuco, Chile

2012 - 2016
Investigador Full Time

UNIVERSIDAD DE LA FRONTERA

Vicerrectoría de Investigación y Postgrado

Temuco, Chile

2017 - A la fecha

Becario Doctoral Full Time

Fundación Instituto Leloir

Buenos Aires, Argentina

2010 - 2010
Investigador Post Doctoral Full Time

Universidad Adolfo Ibáñez

Santiago, Chile

2011 - 2011
Becario Post Doctoral Full Time

Institute for Biomedical Research Georg Speyer Haus

Frankfurt, Alemania

2012 - 2013
Investigador Post Doctoral Full Time

Universidad de La Frontera

Temuco, Chile

2012 - 2016
Investigador Full Time

Universidad de La Frontera

Temuco, Chile

2017 - A la fecha

Comités de Tesis de Pre- Grado

2020 Isabela Antonia Navarra Pérez Núñez. Silenciamiento del gen glipican 1 (gpc1) en las líneas celulares de cáncer de vesícula biliar Clon 1 y TGBC-2. Work to apply for the Biotechnology degree. Universidad de La Frontera. Temuco-Chile. Tutor.

2019 Joaquin Ignacio Sepúlveda Hafemann. Effect of the inhibitor surmanin in cell lines of gallbladder cancer. Work to apply for the Biotechnology degree. Universidad de La Frontera. Temuco-Chile. Internal evaluator.

2015 Natalia Paz Badilla Vidal. Determination of tumor markers in samples of bovine ovarian tissue for potential determination in patients of fertility preservation programs. Work to apply for the Biochemistry degree. Universidad de La Frontera. Temuco-Chile. Internal evaluator.

Comités de Tesis de Post- Grado

2019 Rodrigo Antonio Salazar Celedón. Determination of photoprotective activity of melanin from Antarctic bacteria Streptomyces fildesensis on human epidermal cells. Doctoral thesis. Doctoral Program in Science in Applied Molecular and Cell Biology. Universidad de La Frontera. Temuco, Chile. Internal evaluator.

2019 María Elena De Lourdes Reyes Rebolledo. Role of chemokines of the CC subfamily in the promotion of resistance to cisplatin mediated by paracrine / autocrine regulation in gastric cancer cell lines. Doctoral thesis. Doctoral Program in Science in Applied Molecular and Cell Biology. Universidad de La Frontera. Temuco, Chile. Internal evaluator.

2019 Katterin Pamela Bobadilla Fernández. Effect of stabilized copper nanoparticles on the release of proangiogen factors in human keratinocits and their role in angiogenesis. Doctoral Program in Science in Applied Molecular and Cell Biology. Universidad de La Frontera. Temuco, Chile. Internal evaluator.


Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor Garcia, Patricia; Bizama, Carolina; Rosa, Lorena; Espinoza, Jaime A.; Weber, Helga; Cerda-Infante, Javier; Sanchez, Marianela; Montecinos, Viviana P.; Lorenzo-Bermejo, Justo; Boekstegers, Felix; Davila-Lopez, Marcela; Alfaro, Francisca; Leiva-Acevedo, Claudia; Parra, Zasha; Romero, Diego; Kato, Sumie; Leal, Pamela; Lagos, Marcela; Carlos Roa, Juan Article ISI SCIELO BIOLOGICAL RESEARCH (2020)
Hippo-YAP1 Is a Prognosis Marker and Potentially Targetable Pathway in Advanced Gallbladder Cancer García, Patricia; Rosa, Lorena; Vargas, Sergio; Weber, Helga; Espinoza, Jaime A.; Suárez, Felipe; Romero-Calvo, Isabel; Elgueta, Nicole; Rivera, Vanessa; Nervi, Bruno; Obreque, Javiera; Leal, Pamela; Viñuela, Eduardo; Aguayo, Gloria; Muñiz, Sabrina; Sagredo, Alfredo; Roa, Juan C.; Bizama, Carolina Article ISI SCOPUS Cancers (2020)
Mucin 5B, carbonic anhydrase 9 and claudin 18 are potential theranostic markers of gallbladder carcinoma Espinoza, Jaime A.; Riquelme, Ismael; Sagredo, Eduardo A.; Rosa, Lorena; Garcia, Patricia; Bizama, Carolina; Apud-Bell, Maria; Leal, Pamela; Weber, Helga; Benavente, Felipe; Vargas, Sergio; Romero, Diego; Kalergis, Alexis M; Carlos Roa, Juan Article ISI SCOPUS HISTOPATHOLOGY (2019)
Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer Weber, H; Valbuena, JR; Barbhuiya, MA; Stein, S; Kunkel, H; García, P; Bizama, C; Riquelme, I; Espinoza, JA; Kurtz, SE; Tyner, J; Calderon, JF; Corvalán, AH; Grez, M; Pandey, A; Leal-Rojas, P; Roa, JC Article ISI SCOPUS ONCOTARGET (2017)
Low expression of equilibrative nucleoside transporter 1 is associated with poor prognosis in chemotherapy-naive pT2 gallbladder adenocarcinoma patients Espinoza, J.A; Garcia P.; Bizama, C; Leal J.L.; Riquelme I.; Weber, H; Macanas, P.; Aguayo, G; Viñuela E.; Roa, J.C; Nervi, B Article ISI SCOPUS HISTOPATHOLOGY (2016)
A Novel CDC25B Promoter-Based Oncolytic Adenovirus Inhibited Growth of Orthotopic Human Pancreatic Tumors in Different Preclinical Models Weber, HL; Gidekel, M.; Werbajh, S; Salvatierra E; Rotondaro, C; Sganga, L; Haab, GA; Curiel, DT; Cafferata, EG; Podhajcer, OL Article ISI SCOPUS Clinical Cancer Research (2015)
Activating c-KIT mutations confer oncogenic cooperativity and rescue RUNX1/ETO-induced DNA damage and apoptosis in human primary CD34+hematopoietic progenitors Wichmann C.; Quagliano-Lo Coco I.; Yildiz O.; Chen-Wichmann L.; Weber, H; Syzonenko T.; Doring C.; Brendel C.; Ponnusamy K.; Kinner A.; Brandts C.; Henschler R.; Grez, M Article ISI SCOPUS LEUKEMIA (2015)
Effects of c-FLIPL Knockdown in Cervical Uterine Carcinoma Cell Lines Ili CG; Brebi P.; Garcia P.; Leal P.; Lopez, J.; Tapia O.; Letelier P; Weber, H; Castillo J.; Roa, JC Article ISI SCIELO INTERNATIONAL JOURNAL OF MORPHOLOGY (2015)
Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy Riquelme I.; Saavedra, K; Espinoza, JA; Weber, H; Garcia P.; Nervi, B; Garrido M.; Corvalyn, AH; Roa, JC; Bizama, C Article ISI SCOPUS Oncotarget (2015)
Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice Weber, H; Leal P.; Stein S; Kunkel H; Garcia P.; Bizama, C; Espinoza, JA; Riquelme I.; Nervi, B; Araya, JC; Grez, M; Roa, JC Article ISI SCOPUS Oncotarget (2015)
The PI3K/AKT/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance Oscar Tapia; Ismael, Riquelme; Pamela Leal; Alejandra Sandoval; Susana Aedo; Helga Weber; Pablo Letelier; Enrique Bellolio; Miguel Villaseca; Patricia Garcia; Juan Carlos Roa Article ISI Virchows Arch (2014)
The PI3K/AKT/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance Tapia O, Riquelme I; Leal P, Sandoval A; Aedo S, Weber H; Letelier P, Bellolio E; Villaseca M, Garcia P Article VIRCHOWS ARCHIV (2014)
AKT/mTOR substrate P70S6K is frequently phosphorylated in gallbladder cancer tissue and cell lines Leal P.; Garcia P.; Sandoval A.; Buchegger, K; Weber, H; Tapia O.; Roa, J.C Article ISI SCOPUS OncoTargets and Therapy (2013)


HSP90 Expression and Antitumoral Activity of Geldanamicin and Its Analog in Gallbladder Carcinoma Valbuena J.; Weber, H; Leal P.; Garcia P.; Bizama, C; Espinoza J.; Roa, J Abstract ISI LABORATORY INVESTIGATION (2015)
mTOR/P70S6K signaling pathway as a potential target for advanced gallbladder cancer therapy Roa, JC; Leal P.; Weber, H; Garcia P.; Sandoval A.; Buchegger, K; Tapia O.; Nervi, B; Grez, M Abstract ISI JOURNAL OF CLINICAL ONCOLOGY (2014)
New Insights Into the Therapeutic Efficacy of the Pancreatic Cancer-Targeted AV25CDC Oncolytic Adenovirus Weber, H; Gidekel, M.; Werbajh, S; Salvatierra E; Rotondaro, C; Sganga, L; Curiel, DT; Cafferata, E; Podhajcer, OL Abstract ISI MOLECULAR THERAPY (2014)
Expression Analysis of AKT/mTOR Signaling Pathway in Primary Tumors and Cell Lines Derived from Gallbladder Cancer Roa, JC; Leal P.; Garcia P.; Tapia O.; Weber, H Abstract ISI LABORATORY INVESTIGATION (2013)


Pharmaceutical kit and method for treating cancer Osvaldo Podhajcer; Manuel Gidekel,; Eduardo Cafferata,; Helga Weber Patent Dr Helga Weber was incorporated as an co-author of the patent through an amendment in year 2014 (08/28/2014). (2014)
Extracts of Deschampsia antarctica Desv. with antineoplastic activity GIDEKEL, MANUEL; Weber, Helga; Cabrera, Gustavo; Gutiérrez, Ana; Osorio, Jennifer; Podhajcer, Osvaldo; Cafferta, Eduardo; Sunkel, Carlos; Mihovilovic, Ivan Patent


Connecting molecular subtypes of colorectal cancer with extracellular vesicles heterogeneity in patient-derived organoids Leal-Rojas P.A.; Roa, J.C; Weber, Helga Proyecto (2020)
Immunotherapy targeting cancer stem-like cells=> A promising new approach for gallbladder cancer treatment. (año término 2021) FONDECYT (11180987) Proyecto 2018-2020 Inv. Principal
PROTEOMIC SIGNATURE OF GALLBLADDER CANCER SECRETED EXOSOMES=> A DYNAMIC APPROACH TO DELINEATE THEIR POTENTIAL ROLE DURING MALIGNANT PROGRESSION AND THEIR CLINICAL RELEVANCE AS NOVEL RESERVOIR OF CIRCULATING BIOMARKERS. FONDECYT (1151008) Proyecto 2015-2019 Personal técnico y/o de apoyo
In vivo evaluation of the therapeutic efficacy of AZD8055 and Rapamycin in a subcutaneous tumor model in nude mice gallbladder cancer (NIH Swiss mice Athymic Nude). FONDECYT (74130031) Proyecto 2012-2013 Inv. Responsable
Validation of mTOR metabolic pathway inactivation for gallbladder cancer targeted therapy FONDECYT (1090171) Proyecto 2010-2012 Postdoctorado
EL FACTOR GM-CSF GATILLA UN AUMENTO DEL TRANSPORTE DE HEXOSAS Y DE VITAMINA C MEDIADO POR LOS TRANSPORTADORES FACILITATIVOS DE HEXOSAS (GLUTS) EN ESPERMATOZOIDES DE MAMIFEROS. FONDECYT (1990994) Proyecto 1999-2002 Tesista


Targeting specific molecular pathways holds promise for advanced gallbladder cancer therapy Bizama, C; Garcia P.; Espinoza, JA; Weber, H; Leal P.; Nervi, B; Roa, JC Review ISI SCOPUS Cancer Treatment Reviews (2015)