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CESAR ANTONIO RAMIREZ SARMIENTO

Assistant Professor

Pontificia Universidad Catolica de Chile

Santiago, Chile

Biophysics, evolution and function of gene-regulating metamorphic proteins (FoxP, RfaH, KaiB); enzyme discovery & engineering of novel biocatalysts for plastic degradation; development of open-source kits for molecular detection of SARS-CoV-2

Molecular Biology, Cellular Biology and Neurosciences, UNIVERSIDAD DE CHILE. Chile, 2014
Sciences with Honors in Biology, UNIVERSIDAD DE CHILE. Chile, 2007
Teaching in Higher Education, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2018

Assistant Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Institute for Biological and Medical Engineering

Santiago, Chile

2016 - A la fecha
Researcher Full Time

UNIVERSIDAD DE CHILE

Facultad de Ciencias

Santiago, Chile

2015 - 2016
Postdoctoral Researcher Full Time

UNIVERSIDAD DE CHILE

Facultad de Ciencias

Santiago, Chile

2013 - 2015
Visiting Graduate Student Full Time

UNIVERSITY OF CALIFORNIA-SAN DIEGO

San Diego, Estados Unidos

2011 - 2012
Teaching Assistant Part Time

UNIVERSIDAD DE CHILE

Facultad de Ciencias

Santiago, Chile

2007 - 2010

Assistant Professor Full Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2016 - A la fecha
Scientific Advisor Other

DICTUC S.A. & Ango Science SpA

Santiago, Chile

2017 - A la fecha
Researcher Full Time

Universidad de Chile

Santiago, Chile

2015 - 2016
Postdoctoral Researcher Full Time

Universidad de Chile

Santiago, Chile

2013 - 2015
Grader for SIMCE Other

INGEMAS LTDA

Santiago, Chile

2007 - 2007
Grader's Supervisor for SIMCE Other

INGEMAS LTDA

Santiago, Chile

2007 - 2007

Hans Neurath Oustanding Promise Travel Award

The Protein Society

Estados Unidos, 2017

The purpose of the awards is to showcase future protein science leaders--students and early-career protein scientists whose research has demonstrated exceptional potential--and to enable them to attend and present their abstracts at The Protein Society annual meeting
Biophysical Society International Meeting Grant

The Biophysical Society

Chile, 2017

The Society's International Relations Committee provides grants of up to $2500 to promote and facilitate the organization of and attendance at biophysical meetings and courses in countries experiencing financial need. Funds are provided for workshops and meetings organized by current Society members, which are held in countries in need or in nearby countries where organizers will use the funds to help students from countries in need attend the meeting. Granted for organizing the conference 2nd Protein Biophysics at the End of the World
PABMB Funding 2017

Panamerican Association for Biochemistry and Molecular Biology

Canada, 2017

PABMB support to Plenary Lectures and support to young scientists to attend scientific meetings, courses and workshops. Granted for organizing the conference 2nd Protein Biophysics at the End of the World
PROLAB Fellowship 2016

Panamerican Association for Biochemistry and Molecular Biology

Chile, 2016

Promoting Research Opportunities for Latin American Biochemists (PROLAB) Fellowship. Granted by the American Society for Biochemistry and Molecular Biology (ASBMB), the International Union of Biochemistry and Molecular Biology (IUBMB) and the Panamerican Association for Biochemistry and Molecular Biology (PABMB) for a short-term research visit to Ohio State University


Developing and Implementing Cloud-Based Tutorials That Combine Bioinformatics Software, Interactive Coding, and Visualization Exercises for Distance Learning on Structural Bioinformatics Engelberger, Felipe; Galaz-Davison, Pablo; Bravo, Graciela; Rivera, Maira; Ramírez-Sarmiento, César A. Article ISI JOURNAL OF CHEMICAL EDUCATION (2021)
An Evolutionary Marker of the Ribokinase Superfamily Is Responsible for Zinc-Mediated Regulation of Human Pyridoxal Kinase Ramírez-Sarmiento, César A.; Engelberger, Felipe; Guixé, Victoria Article CATALYSTS (2020)
Differential Local Stability Governs the Metamorphic Fold Switch of Bacterial Virulence Factor RfaH Galaz-Davison, P; Molina, JA; Silletti, S; Komives, EA; Knauer, SH; Artsimovitch, I; Ramirez-Sarmiento, CA Article ISI BIOPHYSICAL JOURNAL (2020)
Intrinsically Disordered Regions of the DNA-Binding Domain of Human FoxP1 Facilitate Domain Swapping Medina, Exequiel; Villalobos, Pablo; Hamilton, George L.; Komives, Elizabeth A.; Sanabria, Hugo; Ramirez-Sarmiento, Cesar A.; Babul, Jorge Article ISI JOURNAL OF MOLECULAR BIOLOGY (2020)
PKD2/polycystin-2 induces autophagy by forming a complex with BECN1 Pena-Oyarzun, Daniel; Rodriguez-Pena, Marcelo; Burgos-Bravo, Francesca; Vergara, Angelo; Kretschmar, Catalina; Sotomayor-Flores, Cristian; Ramirez-Sarmiento, Cesar A.; De Smedt, Humbert; Reyes, Montserrat; Perez, William; Torres, Vicente A.; Morselli, Eugenia; Altamirano, Francisco; Wilson, Christian A. M.; Hill, Joseph A; Lavandero, Sergio; Criollo, Alfredo Article ISI AUTOPHAGY (2020)
Role of Autophagy in the Microenvironment of Oral Squamous Cell Carcinoma Pena-Oyarzun, Daniel; Reyes, Montserrat; Hernandez-Caceres, Maria Paz; Kretschmar, Catalina; Morselli, Eugenia; Ramirez-Sarmiento, Cesar A.; Lavandero, Sergio; Torres, Vicente A.; Criollo, Alfredo Article ISI FRONTIERS IN ONCOLOGY (2020)
Tuning of Conformational Dynamics Through Evolution-Based Design Modulates the Catalytic Adaptability of an Extremophilic Kinase Zamora, Ricardo A.; Ramirez-Sarmiento, Cesar A.; Castro-Fernandez, Victor; Villalobos, Pablo; Maturana, Pablo; Herrera-Morande, Alejandra; Komives, Elizabeth A.; Guixe, Victoria Article ISI ACS CATALYSIS (2020)
Polycystin-1 Assembles With Kv Channels to Govern Cardiomyocyte Repolarization and Contractility Altamirano F.; Schiattarella G.G.; French K.M.; Kim S.Y.; Engelberger F.; Kyrychenko S.; Villalobos E.; Tong D.; Schneider J.W.; Ramirez-Sarmiento C.A.; Lavandero S.; Gillette, T. G.; Hill J.A. Article ISI SCOPUS CIRCULATION (2019)
Protein engineering of carotenoid cleavage dioxygenases to optimize beta-ionone biosynthesis in yeast cell factories Werner N.; Ramirez-Sarmiento C.A.; Agosin E. Article ISI SCOPUS FOOD CHEMISTRY (2019)
The protonation state of an evolutionarily conserved histidine modulates domainswapping stability of FoxP1. Medina, Exequiel; Villalobos, Pablo; Coñuecar, Ricardo; Ramírez-Sarmiento, César A; Babul, Jorge Article Scientific reports (2019)
Active Site Flexibility as a Hallmark for Efficient PET Degradation by I.Â sakaiensis PETase. Fecker, Tobias; Galaz-Davison, Pablo; Engelberger, Felipe; Narui, Yoshie; Sotomayor, Marcos; Parra, Loreto P; Ramírez-Sarmiento, César A Article Biophysical journal (2018)
Hydrogen-deuterium exchange mass spectrometry reveals folding and allostery in protein-protein interactions. Ramirez-Sarmiento, Cesar A; Komives, Elizabeth A Article Methods (San Diego, Calif.) (2018)
Identifying the interactions between natural, non-caloric sweeteners and the human sweet receptor by molecular docking. Acevedo, Waldo; Ramírez-Sarmiento, César A; Agosin, Eduardo Article Food chemistry (2018)
Protein topology determines substrate-binding mechanism in homologous enzymes. Herrera-Morande, Alejandra; Castro-Fernández, Victor; Merino, Felipe; Ramírez-Sarmiento, Cesar A; Fernández, Francisco J; Vega, M Cristina; Guixé, Victoria Article Biochimica et biophysica acta. General subjects (2018)
Relevance of Local Flexibility Near the Active Site for Enzymatic Catalysis: Biochemical Characterization and Engineering of Cellulase Cel5A From Bacillus agaradherans Saavedra, Juan M.; Azócar, Mauricio A.; Rodríguez, Vida; Ramírez-Sarmiento, César A.; Andrews, Barbara A.; Asenjo, Juan A.; Parra, Loreto P. Article ISI SCOPUS BIOTECHNOLOGY JOURNAL (2018)
Riddle Me This: Substrate Channeling Solves the Paradigms of cAMP-Dependent Activation of PKA Ramírez-Sarmiento, César A. Article ISI SCOPUS BIOPHYSICAL JOURNAL (2017)
Second ISCB Latin American Student Council Symposium (LA-SCS) 2016. Monzon, Alexander Miguel; Hasenahuer, Marcia A; Mancini, Estefanía; Coimbra, Nilson; Cravero, Fiorella; Cáceres-Molina, Javier; Ramírez-Sarmiento, César A; Palopoli, Nicolas; Meysman, Pieter; Parra, R Gonzalo Article F1000Research (2017)
Unusual dimerization of a BcCsp mutant leads to reduced conformational dynamics Carvajal, Alonso I.; Vallejos, Gabriel; Komives, Elizabeth A.; Castro-Fern?ndez, V?ctor; Leonardo, Diego A.; Garratt, Richard C.; Ram?rez-Sarmiento, C?sar A.; babul, jorge Article ISI SCOPUS FEBS JOURNAL (2017)
Discovery, Molecular Mechanisms, and Industrial Applications of Cold-Active Enzymes Santiago, Margarita; Ramírez-Sarmiento, César A.; Zamora, Ricardo A.; Parra, Loreto P. Article ISI SCOPUS FRONTIERS IN MICROBIOLOGY (2016)
Model of the Ankyrin and SOCS Box Protein, ASB9, E3 Ligase Reveals a Mechanism for Dynamic Ubiquitin Transfer Schiffer, Jamie M.; Malmstrom, Robert D.; Parnell, Jonathan; Ramirez-Sarmiento, Cesar; Reyes, Javiera; Amaro, Rommie E.; Komives, Elizabeth A. Article ISI SCOPUS STRUCTURE (2016)
Three-Dimensional Domain Swapping Changes the Folding Mechanism of the Forkhead Domain of FoxP1 Medina, E; Cordova, C; Villalobos, P.; Reyes, J; Komives E.A.; Ramírez-Sarmiento C.A.; Babul, J. Article ISI SCOPUS BIOPHYSICAL JOURNAL (2016)
Dissecting the functional roles of the conserved NXXE and HXE motifs of the ADP-dependent glucokinase from Thermococcus litoralis Abarca-Lagunas, MJ; Rivas-Pardo, JA; Ramirez-Sarmiento, CA; Guixe, V Article ISI SCOPUS FEBS Letters (2015)
Identifying Sequential Substrate Binding at the Single-Molecule Level by Enzyme Mechanical Stabilization Rivas-Pardo, JA; Alegre-Cebollada, J; Ramirez-Sarmiento, CA; Fernandez, JM; Guixe, V Article ISI SCOPUS ACS Nano (2015)
Interdomain Contacts Control Native State Switching of RfaH on a Dual-Funneled Landscape Ramirez-Sarmiento, CA; Noel, JK; Valenzuela SL; Artsimovitch I. Article ISI SCOPUS PLoS Computational Biology (2015)
The Folding Unit of Phosphofructokinase-2 as Defined by the Biophysical Properties of a Monomeric Mutant Ramirez-Sarmiento, CA; Baez, M; Zamora, RA; Balasubramaniam, D; Babul, J.; Komives, EA; Guixe, V Article ISI SCOPUS Biophysical Journal (2015)
Emergence of pyridoxal phosphorylation through a promiscuous ancestor during the evolution of hydroxymethyl pyrimidine kinases Castro-Fernandez, Victor; Bravo-Moraga, Felipe; Ramirez-Sarmiento, Cesar A; Guixe, Victoria Article ISI SCOPUS FEBS LETTERS (2014)
A Ribokinase Family Conserved Monovalent Cation Binding Site Enhances the MgATP-induced Inhibition in E. coli Phosphofructokinase-2 Baez, M; Cabrera, R; Pereira, HM; Blanco A.; Villalobos, P.; Ramirez-Sarmiento, CA; Caniuguir, A; Guixe, V; Garratt, RC; Babul, J. Article ISI SCOPUS BIOPHYSICAL JOURNAL (2013)
Catalytic and regulatory roles of species involved in metal-nucleotide equilibriums in human pyridoxal kinase Navarro, F; Ramirez-Sarmiento, CA; Guixe, V Article ISI SCOPUS BIOMETALS (2013)
Knotting pathways in proteins Sulkowska, JI; Noel, JK; Ramirez-Sarmiento, CA; Rawdon, EJ; Millett, KC; Onuchic, JN Article ISI SCOPUS Biochemical Society Transactions (2013)
Observation of Solvent Penetration during Cold Denaturation of E. coli Phosphofructokinase-2 Ramirez-Sarmiento, CA; Baez, M; Wilson, CAM; Babul, J.; Komives, EA; Guixe, V Article ISI SCOPUS BIOPHYSICAL JOURNAL (2013)
Expanded Monomeric Intermediate upon Cold and Heat Unfolding of Phosphofructokinase-2 from Escherichia coli Baez, M; Wilson, C.A.M.; Ramirez-Sarmiento, C.A.; Guixe, V; Babul, J. Article ISI SCOPUS BIOPHYSICAL JOURNAL (2012)


Breaking Down Protein Metamorphosis: Primary Drivers Behind the Structural Transformation of the Bacterial Virulence Factor RfaH Ramirez-Sarmiento, CA; Galaz-Davison, P; Komives, EA; Artsimovitch, I Abstract ISI PROTEIN SCIENCE (2017)
Characterization of the domain swapping mechanism of the forkhead domain of human FoxP1 at a single-molecule level Babul, J; Medina, E; Sanabria, H; Ramirez-Sarmiento, CA Abstract ISI PROTEIN SCIENCE (2017)
Cold-Adapted ADP-Dependent Sugar Kinase: Biophysical and Evolutionary Study of its Flexibility. Guixe, V; Zamora, RA; Ramirez-Sarmiento, CA; Castro-Fernandez, V; Villalobos, P; Komives, E Abstract ISI PROTEIN SCIENCE (2017)
Biophysical and evolutionary study of the structural flexibility of ADP-dependent sugar kinases from mesophilic and psychrophilic archaea Zamora, R; Castro-Fernandez, V; Ramirez-Sarmiento, CA; Komives, EA; Guixe, V Abstract ISI FEBS JOURNAL (2016)
Elucidating the domain swapping mechanism of the forkhead domain of human FoxP1 Medina, E; Cordova, C; Villalobos, P; Reyes, J; Komives, EA; Ramirez-Sarmiento, CA; Babul, J Abstract ISI FEBS JOURNAL (2016)
Domain swapping of the DNA-binding domain of human FoxP1 is facilitated by its low folding stability Medina, E; Valenzuela SL; Cordova, C; Ramirez-Sarmiento, CA; Babul, J. Abstract ISI PROTEIN SCIENCE (2015)
Folding topology determines substrate binding order in the ribokinase superfamily Herrera-Morande, A; Castro-Fernandez, V; Merino F.; Ramirez-Sarmiento, C; Fernandez F.; Vega, C; Guixe, V Abstract ISI PROTEIN SCIENCE (2015)
Direct Observation Of Solvent Penetration During Cold Denaturation Of Pfk-2 By Amide Hydrogen/Deuterium (H/H-2) Exchange Mass Spectrometry Ramirez-Sarmiento, C; Baez, M; Babul, J.; Komives, E; Guixe, V Abstract ISI PROTEIN SCIENCE (2012)


Research and Training in Structural Genomics and Molecular Biophysics for the characterization and design of proteins and enzymes Ramírez-Sarmiento, César A.; DÍez, Beatriz; Garratt, Richard C.; Pereira, Humberto M. Proyecto (2020)
Unveiling the evolutionary information for specifying a functional fold-switch in proteins Ramírez-Sarmiento, César A. Proyecto (2020)
Biofisica e Ingenieria de Proteinas del Regulador del Reloj Circadiano KaiABC de Cianobacteria FONDECYT (3190731) Proyecto 2019-2022 Inv. Patrocinante
Caracterización estructural, funcional e ingeniería de enzimas antárticas como potenciales biocatalizadores de la degradación de polietileno de tereftalato (PET) INACH (DG_11_18) Proyecto 2019-2020 Inv. Patrocinante
International Cooperation Network for the start-up, installation and training of human capital in mass spectrometry for interdisciplinary research in Chile PCI (REDI170624) Proyecto 2018-2019 Inv. Principal
BIOPHYSICAL AND EVOLUTIONARY ASSESSMENT OF THE EMERGENCE OF DOMAIN SWAPPING WITHIN THE FOX FAMILY OF TRANSCRIPTION FACTORS FONDECYT (1170701) Proyecto 2017-2020 Coinvestigador(a)
Unveiling the potential PET-degrading activity of Antarctic cutinases via protein engineering Instituto Antártico Chileno (RG_47_16) Proyecto 2017-2019 Inv. Principal
YEAST PLATFORMS FOR THE BIOTECHNOLOGICAL BIOSYNTHESIS OF APOCAROTENOID BIOACTIVE COMPOUNDS FONDECYT (1170745) Proyecto 2017-2020 Coinvestigador(a)
BIOPHYSICAL CHARACTERIZATION OF STRUCTURAL REARRANGEMENTS DURING NATIVE STATE SWITCHING IN FKH1/FKH2 AND RFAH TRANSCRIPTION FACTORS FONDECYT (11140601) Proyecto 2014-2017 Inv. Responsable