PDI - Resultado de Búsqueda

David Mauricio Ramirez Sanchez

Profesor Asistente

Universidad de Concepción

Concepcion, Chile

Multi-target Drug Design, Medicinal Chemistry, Molecular Simulation, Computer-aided Drug Design, Pharmacology, Pharmacoinformatics, Systems pharmacology

Licenciatura en Química, UNIVERSIDAD DISTRITAL FRANCISCO JOSE DE CALDAS. Colombia, 2009
Doctorado en Ciencias Aplicadas, UNIVERSIDAD DE TALCA. Chile, 2017
Farmacia, UNIVERSIDAD NACIONAL DE COLOMBIA. Colombia, 2012
Químico Farmacéutico, UNIVERSIDAD NACIONAL DE COLOMBIA. Colombia, 2012
Licenciado en Química, UNIVERSIDAD DISTRITAL FRANCISCO JOSE DE CALDAS. Colombia, 2009
Inteligenica Artifical, Universidad Catolica de Murcia. España, 2023

Profesor asistente Part Time

UNIVERSIDAD AUTONOMA DE CHILE

Facultad de Ciencias de la Salud

Talca, Chile

2016 - 2017
Asistente de investigación Part Time

UNIVERSIDAD DE TALCA

Facultad de Ingeniería

Talca, Chile

2015 - 2016
Postdoctoral fellow Full Time

WORCESTER POLYTECHNIC INSTITUTE

Worcester, Estados Unidos

2017 - 2018
Postdoctorado Part Time

UNIVERSIDAD DE TALCA

Facultad de Ingenieria

Talca, Chile

2016 - 2017
Profesor asistente Part Time

UNIVERSIDAD AUTONOMA DE CHILE

Facultad de Ciencias de la Salud

Santiago, Chile

2019 - A la fecha
Profesor Asistente Full Time

UNIVERSIDAD DE CONCEPCION

Facultad de Ciencias Biológicas

Concepción, Chile

2021 - A la fecha

Químico Farmacéutico de Producción Full Time

Unidossis

Bogotá, Colombia

2012 - 2013
Químico Farmacéutico Full Time

Hospital Universitario Mayor MEDERI

bogotá, Colombia

2013 - 2013
Asistente de investigación Part Time

Universidad de Talca

Talca, Chile

2015 - 2016
Postdoctoral fellow Full Time

Worcester Polytechnic Institute

Worcester, Estados Unidos

2017 - 2018

GRADUATE THESIS ADVISOR
• 2020 – current: José Carlos Márquez. PhD in Sciences, Universidad de Talca. Consensual local anesthetic binding site among atrial fibrillation relevant ion channels.
• 2023 – current: Jessica Valero. PhD in Chemistry, Universidad de Concepción.
• 2023 – current: Kevin Cobos. PhD in Molecular Physical Chemistry, Universidad Andrés Bello. Interacción entre Oligómeros de Beta-Amiloide y el Péptido KLVFF.
• 2023 – current: Paulina Valenzuela. Master in Biochemistry and Bioinformatics, Universidad de Concepción. Diseño de ligandos multitarget, una estrategia alternativa para tratar la enfermedad de Alzheimer
• 2023 – current: Laura Pacheco. Master in Biochemistry and Bioinformatics, Universidad de Concepción. Desarrollo de sulfonamidas como moduladores alostéricos positivos del receptor de glicina ?3: una alternativa terapéutica potencial para el tratamiento del dolor crónico.
• 2023 – current: Victoria Oviedo. Master in Neurobiology, Universidad de Concepción.
• 2023 – current: Alejandro Amaya. Master in Artificial Intelligence. Pontificia Universidad Javeriana. Identificación de ligándoselas multitarget como pontencial alternativa terapéutica para el tratamiento de la enfermedad de Alzheimer: Una aproximación desde Machine Learning
• 2023: Jazmina Bongain. Master. Universidad de Chile. Identification of key protein targets by which mesenchymal stem cell-derived secretome repair perinatal asphyxia damage: A bioinformatics approach.
• 2023: Javiera Armijo. Master in Neurosciences, Universidad Autónoma de Chile. Diseño de péptidos inhibidores de la formación y agregación de la placa de ?-amiloide (A?).
• 2023: Alexis Sepúlveda. Master in Neurosciences, Universidad Autónoma de Chile. Ejercicio físico como posible tratamiento preventivo no farmacológico de la enfermedad de Alzheimer basado en la interacción proteína-proteína de una red farmacológica.
• 2021. Lily Arrué. Master in Neurosciences, Universidad Autónoma de Chile. Targeting Alzheimer's disease through computational polypharmacology.

UNDERGRADUATE THESIS ADVISOR
• 2022 – current: Sebastian Fuentes. Faculty of Pharmacy. Universidad de Concepción. Diseño de péptidos inhibidores de la agregación del péptido ?-amiloide asistido por computadora.
• 2022 – current: Francisca Estuardo. Faculty of Pharmacy. Universidad de Concepción. Rol neuroprotector de cannabinoides presentes en un aceite cannábico enriquecido en CBD en modelos celulares de neurodegeneración.
• 2023: Claudia Martínez. Faculty of Pharmacy. Universidad Nacional de Colombia. Identificación de nuevos compuestos
con potencial actividad frente al canal TMC1 para tratar o prevenir la sordera mediante métodos quimioinfomáticos
• 2022: Brian Fell. Faculty of Chemistry. Universidad de Concepción. Diseño de moduladores alostéricos positivos para
el receptor nicotinico de acetilcolina ?7 humano mediante metodos de farmacoinformatica y machine learning.
• 2022: Victoria Oviedo. Department of Pharmacy. Universidad Autónoma de Chile.
• 2022: Alexandra Cigna. Department of Pharmacy. Universidad Autónoma de Chile. Diseño de compuestos con perfil
polifarmacológico para el tratamiento de la enfermedad de Alzheimer mediante el uso de farmacoinformática.
• 2022: Jordán Alegría. Department of Pharmacy. Universidad Autónoma de Chile. Study of polypharmacological profiles in key targets against Alzheimer disease.
• 2018: Laura Sánchez. Department of Chemistry, Universidad del Quindío. Study and identification of novel ROP18 modulators with potential therapeutic activity against Toxoplasma gondii.
• 2017: Carlos Peña. Bioinformatics Engineer School. Universidad de Talca. Thesis: Structural analysis of the blocker A1899 pathway to the binding site in TASK1 potassium channels.

- 2023: Sociedad de Bioinformática Chilena. Vicepresidente

Bachelor thesis Distinguished with meritorious mention

UNIVERSIDAD DISTRITAL FRANCISCO JOSE DE CALDAS

Colombia, 2009

Bachelor thesis: "Experimental and theoretical exploration of synthesis’ routes to obtain analogous to natural rubber" Distinguished with meritorious mention
Scholarship for Ph.D. studies

UNIVERSIDAD DE TALCA

Chile, 2013

Scholarship for Ph.D. studies from 2013 to 2017
Research internship grant

UNIVERSIDAD DE TALCA

Chile, 2016

“Estadías de estudiantes de postgrado dirigidas a prospectar innovaciones en el area de alimentos saludables, en entidades de nivel internacional” Framed in the “Convenio de desempeño para el apoyo a la innovación en la educación superior”
Top 2% most cited Scientist (position 332.071) in 2020

UNIVERSIDAD AUTONOMA DE CHILE

Estados Unidos, 2020

Top 2% most cited Scientist (position 332.071) in 2020 according to Stanford University study published in Plos Biology.


Antibacterial and Antiviral Properties of Chenopodin-Derived Synthetic Peptides Feijoo-Coronel, Marcia L.; Mendes, Bruno; Ramirez, David; Pena-Varas, Carlos; de los Monteros-silva, Nina Q. E.; Proano-Bolanos, Carolina; de Oliveira, Leonardo Camilo; Livio, Diego Fernandes; da Silva, Jose Antonio; da Silva, Jose Mauricio S. F.; Pereira, Marilia Gabriella A. G.; Rodrigues, Marina Q. R. B.; Teixeira, Mauro M.; Granjeiro, Paulo Afonso; Patel, Ketan; Vaiyapuri, Sakthivel; Almeida, Jose R. Article ISI ANTIBIOTICS-BASEL (2024)
Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase Rojas-Prats, Elisa; Martinez-Gonzalez, Loreto; Gil, Carmen; Ramirez, David; Martinez, Ana Article ISI JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2024)
Anti-Inflammatory Effect of Izalpinin Derived from <i>Chromolaena leivensis</i>: λ-Carrageenan-Induced Paw Edema and In Silico Model Mancipe, Juan C.; Vargas-Pinto, Pedro; Rodriguez, Oscar E.; Borrego-Munoz, Paola; Londono, Iovana Castellanos; Ramirez, David; Pineros, Luis G.; Mejia, Maria Camila; Pombo, Luis M. Article ISI MOLECULES (2023)
Design of β-Keto Esters with Antibacterial Activity: Synthesis, In Vitro Evaluation, and Theoretical Assessment of Their Reactivity and Quorum-Sensing Inhibition Capacity Martinez-Cifuentes, Maximiliano; Soto-Tapia, Emmanuel; Linares-Pipón, Camila; Bradshaw, Ben; Valenzuela-Hormazabal, Paulina; RAMIREZ-SANCHEZ, DAVID MAURICIO; Muñoz-Torres, Patricio; Parra, Claudio Article ISI SCOPUS Pharmaceuticals (2023)
Iridoid esters from<i> Valeriana</i><i> pavonii</i> Poepp. & Endl. as GABAA modulators: Structural insights in their binding mode and structure-activity relationship Giraldo, Sara E.; Bedoya, Mauricio; Pena-Varas, Carlos; Santana, Paula A.; Bazzocchi, Isabel L.; Jimenez, Ignacio A.; Marder, Mariel; Vergel, Nadezdha E.; Guerrero, Mario F.; Ramirez, David Article ISI JOURNAL OF PHARMACY AND PHARMACOGNOSY RESEARCH (2023)
Network pharmacology and topological analysis on tibolone metabolites and their molecular mechanisms in traumatic brain injury Barreto, George E.; Gonzalez, Janneth; Ramirez, David Article ISI BIOMEDICINE & PHARMACOTHERAPY (2023)
Trends and challenges in chemoinformatics research in Latin America Miranda-Salas, Jazmín; Peña-Varas, Carlos; Valenzuela Martínez, Ignacio; Olmedo, Dionisio A.; Zamora, William J.; Chávez-Fumagalli, Miguel Angel; Azevedo, Daniela Q.; Castilho, Rachel Oliveira; Maltarollo, Vinicius G.; Ramírez, David; Medina-Franco, José L. Article SCOPUS (2023)
Common Structural Pattern for Flecainide Binding in Atrial-Selective K<sub>v</sub>1.5 and Na<sub>v</sub>1.5 Channels: A Computational Approach Mazola, Yuliet; Montesinos, Jose C. E. Marquez; Ramirez, David; Zuniga, Leandro; Decher, Niels; Ravens, Ursula; Yarov-Yarovoy, Vladimir; Gonzalez, Wendy Article ISI PHARMACEUTICS (2022)
Crystal structure, Hirshfeld surface analysis, and molecular dynamics simulations of two isostructural N-propargyl-4-(2-oxopyrrolidin-1-yl)-1,2,3,4-tetrahydroquinolines Guiza, Fausto M.; Rodriguez-Nunez, Yeray A.; Ramirez, David; Romero Bohorquez, Arnold R.; Antonio Henao, Jose; Toro, Robert A.; Miguel Delgado, Jose; Diaz de Delgado, Graciela Article ISI JOURNAL OF MOLECULAR STRUCTURE (2022)
Identification of HMGCR, PPGARG and prohibitin as potential druggable targets of dihydrotestosterone for treatment against traumatic brain injury using system pharmacology McGoverna, Andrew; González, Janneth; Ramírez, David; Barreto, George E. Article INTERNATIONAL IMMUNOPHARMACOLOGY (2022)
Network pharmacology reveals multitarget mechanism of action of drugs to be repurposed for COVID-19 Alegria-Arcos, Melissa; Barbosa, Tabata; Sepulveda, Felipe; Combariza, German; Gonzalez, Janneth; Gil, Carmen; Martinez, Ana; Ramirez, David Article ISI FRONTIERS IN PHARMACOLOGY (2022)
New Drug Design Avenues Targeting Alzheimer's Disease by Pharmacoinformatics-Aided Tools Arrue, Lily; Cigna-Mendez, Alexandra; Barbosa, Tabata; Borrego-Munoz, Paola; Struve-Villalobos, Silvia; Oviedo, Victoria; Martinez-Garcia, Claudia; Sepulveda-Lara, Alexis; Millan, Natalia; Marquez Montesinos, Jose C. E.; Munoz, Juana; Santana, Paula A.; Pena-Varas, Carlos; Barreto, George E.; Gonzalez, Janneth; Ramirez, David Article ISI PHARMACEUTICS (2022)
Selective TASK-1 Inhibitor with a Defined Structure-Activity Relationship Reduces Cancer Cell Proliferation and Viability Arevalo, Barbara; Bedoya, Mauricio; Kiper, Aytug K.; Vergara, Fernando; Ramirez, David; Mazola, Yuliet; Bustos, Daniel; Zuniga, Rafael; Cikutovic, Rocio; Cayo, Angel; Rinne, Susanne; Teresa Ramirez-Apan, M.; Sepulveda, Francisco, V; Cerda, Oscar; Lopez-Collazo, Eduardo; Decher, Niels; Zuniga, Leandro; Gutierrez, Margarita; Gonzalez, Wendy Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2022)
Structural Insights into the Substrate Transport Mechanisms in GTR Transporters through Ensemble Docking Pena-Varas, Carlos; Kanstrup, Christa; Vergara-Jaque, Ariela; Gonzalez-Avendano, Mariela; Crocoll, Christoph; Mirza, Osman; Dreyer, Ingo; Nour-Eldin, Hussam; Ramirez, David Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy Nozal, Vanesa; Martinez Gonzalez, Loreto; Gomez-Almeria, Marta; Gonzalo-Consuegra, Claudia; Santana, Paula; Chaikuad, Apirat; Pérez-Cuevas, Eva; Knapp, Stefan; Lietha, Daniel; Ramírez, David; Petralla, Sabrina; Monti, Barbara; Gil, Carmen; Martín-Requero, Ángeles; Palomo, Valle; de Lago, Eva; Martinez, Ana Article JOURNAL OF MEDICINAL CHEMISTRY (2022)
Tibolone Pre-Treatment Ameliorates the Dysregulation of Protein Translation and Transport Generated by Palmitic Acid-Induced Lipotoxicity in Human Astrocytes: A Label-Free MS-Based Proteomics and Network Analysis Vesga-Jimenez, Diego J.; Martín?Jiménez, Cynthia; Rodríguez, Adriana; Aristizábal?Pachón, Andrés; Pinzón, Andrés; Barreto, George E.; Ramírez, David; González, Janneth Article INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
5-(Indol-2-yl)pyrazolo[3,4-b]pyridines as a New Family of TASK-3 Channel Blockers: A Pharmacophore-Based Regioselective Synthesis Ramirez, David; Mejia-Gutierrez, Melissa; Insuasty, Braulio; Rinne, Susanne; Kiper, Aytug K.; Platzk, Magdalena; Mueller, Thomas; Decher, Niels; Quiroga, Jairo; De-la-Torre, Pedro; Gonzalez, Wendy Article ISI MOLECULES (2021)
Antimicrobial properties of novel ionic liquids derived from imidazolium cation with phenolic functional groups Guzman, Luis; Parra-Cid, Cristobal; Guerrero-Munoz, Etiennette; Pena-Varas, Carlos; Polo-Cuadrado, Efrain; Duarte, Yorley; Castro, Ricardo I.; Nerio, Luz Stella; Araya-Maturana, Ramiro; Asefa, Tewodros; Echeverria, Javier; Ramirez, David; Forero-Doria, Oscar Article ISI BIOORGANIC CHEMISTRY (2021)
Application of ensemble pharmacophore-based virtual screening to the discovery of novel antimitotic tubulin inhibitors Gallego-Yerga, Laura; Ochoa, Rodrigo; Lans, Isaias; Pena-Varas, Carlos; Alegria-Arcos, Melissa; Cossio, Pilar; Ramirez, David; Pelaez, Rafael Article ISI COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2021)
From Kinase Inhibitors to Multitarget Ligands as Powerful Drug Leads for Alzheimer's Disease using Protein-Templated Synthesis Nozal, Vanesa; Garcia-Rubia, Alfonso; Cuevas, Eva P.; Perez, Concepcion; Tosat-Bitrian, Carlota; Bartolome, Fernando; Carro, Eva; Ramirez, David; Palomo, Valle; Martinez, Ana Article ISI ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)
Host-Directed FDA-Approved Drugs with Antiviral Activity against SARS-CoV-2 Identified by Hierarchical In Silico/In Vitro Screening Methods Ginex, Tiziana; Garaigorta, Urtzi; Ramirez, David; Castro, Victoria; Nozal, Vanesa; Maestro, Ines; Garcia-Carceles, Javier; Campillo, Nuria E.; Martinez, Ana; Gastaminza, Pablo; Gil, Carmen Article ISI PHARMACEUTICALS (2021)
Identification of a critical binding site for local anaesthetics in the side pockets of K(v)1 channels Kiper, Aytug K.; Bedoya, Mauricio; Stalke, Sarah; Marzian, Stefanie; Ramirez, David; de la Cruz, Alicia; Peraza, Diego A.; Vera-Zambrano, Alba; Marquez Montesinos, Jose C. E.; Arevalo Ramos, Barbara A.; Rinne, Susanne; Gonzalez, Teresa; Valenzuela, Carmen; Gonzalez, Wendy; Decher, Niels Article ISI BRITISH JOURNAL OF PHARMACOLOGY (2021)
PSC-db: A Structured and Searchable 3D-Database for Plant Secondary Compounds Valdes-Jimenez, Alejandro; Pena-Varas, Carlos; Borrego-Munoz, Paola; Arrue, Lily; Alegria-Arcos, Melissa; Nour-Eldin, Hussam; Dreyer, Ingo; Nunez-Vivanco, Gabriel; Ramirez, David Article ISI MOLECULES (2021)
Screening for Interacting Proteins with Peptide Biomarker of Blood-Brain Barrier Alteration under Inflammatory Conditions Vargas-Sanchez, Karina; Losada-Barragan, Monica; Mogilevskaya, Maria; Novoa-Herran, Susana; Medina, Yehidi; Buendia-Atencio, Cristian; Lorett-Velasquez, Vaneza; Martinez-Bernal, Jessica; Gonzalez-Reyes, Rodrigo E.; Ramirez, David; Petry, Klaus G. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Screening for Interacting Proteins with Peptide Biomarker of Blood–Brain Barrier Alteration under Inflammatory Conditions Vargas-Sanchez, Karina; Losada-Barragán, M; Mogilevskaya, Maria; Novoa-Herrán, S; Medina, Y; Buendía-Atencio, C; Lorett-Velásquez, V; Martínez-Bernal, J; Gonzalez-Reyes, R; Ramírez, David; Petry, K Article ISI, SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral Rojas-Prats, Elisa; Martinez-Gonzalez, Loreto; Gonzalo-Consuegra, Claudia; Liachko, Nicole F.; Perez, Concepcion; Ramirez, David; Kraemer, Brian C.; Martin-Requero, Angeles; Perez, Daniel, I; Gil, Carmen; de Lago, Eva; Martinez, Ana Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
Analysis of theZonula occludensToxin Found in the Genome of the Chilean Non-toxigenicVibrio parahaemolyticusStrain PMC53.7 Perez-Reytor, Diliana; Pavon, Alequis; Lopez-Joven, Carmen; Ramirez-Araya, Sebastian; Pena-Varas, Carlos; Plaza, Nicolas; Alegria-Arcos, Melissa; Corsini, Gino; Jana, Victor; Pavez, Leonardo; del Pozo, Talia; Bastias, Roberto; Blondel, Carlos J.; Ramirez, David; Garcia, Katherine Article ISI FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)
COVID-19: Drug Targets and Potential Treatments Gil, Carmen; Ginex, Tiziana; Maestro, Inés; Nozal, Vanesa; Barrado-Gil, Lucía; Cuesta-Geijo, Miguel Ángel; Urquiza, Jesús; Ramírez, David; Alonso, Covadonga; Campillo, Nuria E.; Martinez, Ana Article JOURNAL OF MEDICINAL CHEMISTRY (2020)
Elucidating the Structural Basis of the Intracellular pH Sensing Mechanism of TASK-2 K2P Channels Bustos, Daniel; Bedoya, Mauricio; Ramirez, David; Concha, Guierdy; Zuniga, Leandro; Decher, Niels; Hernandez-Rodriguez, Erix W.; Sepulveda, Francisco V.; Martinez, Leandro; Gonzalez, Wendy Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Identification of Mycobacterium tuberculosis CtpF as a target for designing new antituberculous compounds Santos, Paola; Lopez-Vallejo, Fabian; Ramírez, David; Caballero, Julio; Mata Espinosa, Dulce; Hernández-Pando, Rogelio; Soto, Carlos Y. Article ISI SCOPUS BIOORGANIC & MEDICINAL CHEMISTRY (2020)
Structural and functional computational analysis of nicotine analogs as potential neuroprotective compounds in Parkinson disease Becerra, Gina Paola; Rojas-Rodriguez, Felipe; Ramirez, David; Loaiza, Alix E.; Tobar-Tosse, Fabian; Mejia, Sol M.; Gonzalez, Janneth Article ISI COMPUTATIONAL BIOLOGY AND CHEMISTRY (2020)
Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening Ramirez, David; Concha, Guierdy; Arevalo, Barbara; Prent-Penaloza, Luis; Zuniga, Leandro; Kiper, Aytug K.; Rinne, Susanne; Reyes-Parada, Miguel; Decher, Niels; Gonzalez, Wendy; Caballero, Julio Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine Ramirez, David; Bedoya, Mauricio; Kiper, Aytug K.; Rinne, Susanne; Morales-Navarro, Samuel; Hernandez-Rodriguez, Erix W.; Sepulveda, Francisco V.; Decher, Niels; Gonzalez, Wendy Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
TASK Channels Pharmacology: New Challenges in Drug Design Bedoya, Mauricio; Rinne, Susanne; Kiper, Aytug K.; Decher, Niels; Gonzalez, Wendy; Ramirez, David Article ISI SCOPUS JOURNAL OF MEDICINAL CHEMISTRY (2019)
The interplay of the metallosensor CueR with two distinct CopZ chaperones defines copper homeostasis in Pseudomonas aeruginosa Novoa-Aponte, Lorena; Ramirez, David; Arguello, Jose M. Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
The molecular basis for an allosteric inhibition of K+-flux gating in K-2P channels Rinne, S; Kiper, AK; Vowinkel, KS; Ramirez, D; Schewe, M; Bedoya, M; Aser, D; Gensler, I; Netter, MF; Stansfeld, PJ; Baukrowitz, T; Gonzalez, W; Decher, N Article eLife (2019)
Theoretical and Experimental Approaches Aimed at Drug Design Targeting Neurodegenerative Diseases Morales-Navarro, Samuel; Prent-Penaloza, Luis; Rodriguez Nunez, Yeray A.; Sanchez-Aros, Laura; Forero-Doria, Oscar; Gonzalez, Wendy; Campilllo, Nuria E.; Reyes-Parada, Miguel; Martinez, Ana; Ramirez, David Article ISI SCOPUS PROCESSES (2019)
An important role for periplasmic storage in Pseudomonas aeruginosa copper homeostasis revealed by a combined experimental and computational modeling study Parmar, Jignesh H.; Quintana, Julia; Ramirez, David; Laubenbacher, Reinhard; Arguello, Jose M.; Mendes, Pedro Article ISI MOLECULAR MICROBIOLOGY (2018)
Computational Studies of Snake Venom Toxins Ojeda, Paola G.; Ramirez, David; Alzate-Morales, Jans; Caballero, Julio; Kaas, Quentin; Gonzalez, Wendy Article ISI SCOPUS TOXINS (2018)
HCN Channels=> New Therapeutic Targets for Pain Treatment Rami&#769, rez; David, Zú n&#771, iga; Rafael, Concha; Guierdy, Zú n&#771, iga Article MOLECULES (2018)
Is It Reliable to Take the Molecular Docking Top Scoring Position as the Best Solution without Considering Available Structural Data? Ramírez, David; Caballero, Julio Article ISI SCOPUS MOLECULES (2018)
Novel Alkylimidazolium Ionic Liquids as an Antibacterial Alternative to Pathogens of the Skin and Soft Tissue Infections Forero-Doria, Oscar; Castro, Ricardo; Gutierrez, Margarita; González, Diego; Santos, Leonardo; Ramírez, David; Guzman, Luis Article MOLECULES (2018)
Exploring and understanding the functional role, and biochemical and structural characteristics of an acidic phospholipase A(2), ApITx-I, purified from Agkistrodon piscivorus leucostoma snake venom Resende L.M.; Almeida J.R.; Schezaro-Ramos R.; Collaço R.C.O.; Simioni L.R.; Ramírez D.; González W.; Soares A.M.; Calderon L.A.; Marangoni S.; da Silva S.L. Article ISI SCOPUS TOXICON (2017)
Origin and evolution of transporter substrate specificity within the NPF family Morten Egevang Jørgensen; Deyang Xu; Christoph Crocoll; David Ramírez; Mohammed Saddik Motawia; Carl Erik Olsen; Hussam Hassan Nour-Eldin; Barbara Ann Halkier Article SCOPUS eLife (2017)
Side Fenestrations Provide an "Anchor" for a Stable Binding of A1899 to the Pore of TASK-1 Potassium Channels Ramírez, David; Arévalo, Bárbara; Martínez, Gonzalo; Rinné, Susanne; Sepúlveda, Francisco V.; Decher, Niels; González, Wendy Article ISI SCOPUS MOLECULAR PHARMACEUTICS (2017)
Structure-Based Discovery of Potential Two-Pore-Domain Potassium Channel Task-3 (K(2P)9.1) Modulators Ramírez, David; Caballero, Julio; Zúñiga, Leandro; Arévalo, Bárbara; Kiper, Aytug; Rinne, Susanne; Decher, Niels; Gonzalez, Wendy Article ISI BIOPHYSICAL JOURNAL (2017)
CoaTx-II, a new dimeric Lys49 phospholipase A(2) from Crotalus oreganus abyssus snake venom with bactericidal potential: Insights into its structure and biological roles Almeida, J.R.; Lancellotti, M.; Soares, A.M.; Calderon, L.A.; Ramírez, D.; González, W.; Marangoni, S.; Da Silva, S.L. Article ISI SCOPUS TOXICON (2016)
Computational methods applied to rational drug design Ramirez, D Article SCOPUS Open Medicinal Chemistry Journal (2016)
Functional mutagenesis screens reveal the 'cap structure' formation in disulfide-bridge free TASK channels Goldstein M.; Rinne, S; Kiper, AK; Ramirez, D; Netter, MF; Bustos, D; Ortiz-Bonnin, B; Gonzalez, W; Decher, N Article ISI SCOPUS SCIENTIFIC REPORTS (2016)
Is It Reliable to Use Common Molecular Docking Methods for Comparing the Binding Affinities of Enantiomer Pairs for Their Protein Target? Ramirez, D; Caballero, J Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)
Novel N-allyl/propargyl tetrahydroquinolines: Synthesis via Three-component Cationic Imino Diels-Alder Reaction, Binding Prediction, and Evaluation as Cholinesterase Inhibitors Rodríguez, Yeray A.; Gutiérrez, Margarita; Ramírez, David; Alzate-Morales, Jans; Bernal, Cristian C.; Güiza, Fausto M.; Romero Bohórquez, Arnold R. Article ISI SCOPUS CHEMICAL BIOLOGY & DRUG DESIGN (2016)
Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea? Kiper, AK; Rinne, S; Rolfes, C; Ramirez, D; Seebohm, G.; Netter, MF; Gonzalez, W; Decher, N Article ISI SCOPUS Pflugers Archiv European Journal of Physiology (2015)
Computational Insights of the Interaction among Sea Anemones Neurotoxins and Kv1.3 Channel Sabogal-Arango, Angélica; Barreto, George; Ramírez, David; González, Juan; Barreto, Viviana; Morales, Ludis; González, Janneth Article Bioinformatics and Biology Insights (2014)
Theoretical and Experimental Exploration of Organic Synthesis Routes to Obtain Natural Rubber Analogues David Ramírez; Danilo González; Pablo Ramos; Luis-Carlos Garcia Article Journal of Materials Science and Engineering A (2014)


Let’s talk pharmacology!!! Ramirez, David; Jara, Evelyn Liliana; Romina Rojas P; Daza, Claudia; Bruna, Carola Eugenia BookSection (2023)
Targeting Alzheimer’s Disease Through Pharmacoinformatics: New Challenges in Drug Design. Ramirez, David; Reyes Parada, Miguel; Arrue, Lily BookSection (2021)


Development of an infectious process-activated protide with therapeutic potential for control of fish farming diseases Santana, Paula; Ramírez, David Proyecto (2023)
Interdisciplinary generation of highly specific peptidic blockers of TASK-3 channel with antitumoral effect and targeting moiety for nanotherapeutics. Zuniga, Leandro; Ramírez, David Proyecto (2023)
Ligand and structure-based polypharmacology of K+ channels from the nociceptive primary sensory neurons: an alternative in pain treatment Gonzalez, Wendy; Ramírez, David Proyecto (2023)
Multidisciplinary center for biotecnology and molecular biology for climate change adaptative in forest resources (cebioclif) Herrera, Raul; Ramírez, David Proyecto (2023)
Open Chemoinformatics Ramírez, David; Salas, Alexis Marcelo Proyecto (2023)
Ori-tanpakushitsu: creación de modelos tridimensionales para la comprensión de las fuerzas intermoleculares involucradas en la acción farmacológica Salas, Alexis Marcelo; Ramírez, David Proyecto (2023)
Uso de un Escape Room como recurso docente en las asignaturas de Farmacología Jara, Evelyn Liliana; Ramírez, David Proyecto (2023)
Let's talk about pharmacology!!! Ramirez, David Proyecto (2022)
Towards systems pharmacology to design multi-target directed ligands as therapeutic alternatives for Alzheimer’s disease. Ramírez, David; Salas, Alexis Marcelo; Gutierrez, Margarita; Reyes Parada, Miguel Proyecto (2022)
Development of novel therapeutic alternatives for alcohol-use disorders: a multidisciplinary approach. Karahanian, Eduardo; Ramirez, David Proyecto (2021)
Identificación de moduladores del canal iónico TMC1 como alternativa terapéutica para el tratamiento de la sordera. Ramirez, David Proyecto (2021)
Reposicionamiento de medicamentos para tratamiento de la pandemia por coronavirus (COVID-19) Ramirez, David; Reyes-Parada, Miguel; Renard, Georgina; Ampuero, Estibaliz Proyecto (2020)
Multi-target drug design against neurodegenerative diseases. Ramirez, David; Ortiz, Fernando; Reyes-Parada M.; Gonzalez, W; Corsini, Gino R. Proyecto (2019)
Scholarship Programme for Young Professors and Researchers from Latin American Universities Coimbra Group (2019) Proyecto 2019-2019 Inv. Responsable
Structural insights into the substrate specificity and transport mechanisms in the Nitrate/Peptide Transporter (NPF) Family. FONDECYT (11180604) Proyecto 2018-2021 Inv. Principal
Análisis metabolómico de los efectos neuroprotectores de la tibolona en un modelo astrocitico humano de lipotoxicidad con ácido palmítico Conciencias (120377757268) Proyecto 2017-2020 Investigador(a)
Development of a novel protocol to predict what class of secondary metabolite is transported by a specific plant transporter Universidad de Talca (RU-915-2016) Proyecto 2016-2016 Inv. Principal
STRUCTURAL AND FUNCTIONAL UNDERSTANDING OF ION CHANNELS OF THE ALMT (ALUMINUM ACTIVATED MALATE TRANSPORTER) FAMILY FONDECYT (1150054) Proyecto 2015-2019 Personal técnico y/o de apoyo
UNDERSTANDING THE STRUCTURAL MECHANISM OF SELECTIVE BLOCKERS OF PH-GATED K2P CHANNELS FONDECYT (1140624) Proyecto 2014-2018 Personal técnico y/o de apoyo
Development and functional evaluation of synthetic molecules as TASK-3 potassium channel inhibitors for treatramnt of solid tumors FONDEF (CA13I10223) Proyecto 2013-2014 Personal técnico y/o de apoyo
Identificación de reacciones controladoras de lipotoxicidad inducida por ácido palmítico en un modelo computacional multiómico astrocitario. González, Janneth; Ramirez, D; Pinzón, A Proyecto (0)
InSecTr – International Network to Study Secondary Metabolite Transport in Plants Dreyer, I; Ramirez, D; Vergara-Jaque, A; Goznalez, W Proyecto (0)


Conotoxins as Tools to Understand the Physiological Function of Voltage-Gated Calcium (Ca-V) Channels Ramirez, D; Gonzalez, W; Fissore, RA; Carvacho, I Review ISI SCOPUS MARINE DRUGS (2017)
K-2P channels in plants and animals González, Wendy; Valdebenito, Braulio; Caballero, Julio; Riadi, Gonzalo; Riedelsberger, Janin; Martínez, Gonzalo; Ramirez, David; Zúñiga, Leandro; Sepúlveda, Francisco V.; Dreyer, Ingo; Janta, Michael; Becker, Dirk Review ISI SCOPUS Pflugers Archiv European Journal of Physiology (2015)

David Ramirez

Profesor Asistente

Facultad de Ciencias Biológicas

Universidad de Concepción

Concepcion, Chile

Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

Julio Caballero

Full Professor

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

Bárbara Arévalo

Investigador

Investigación

Centro de Estudios de Alimentos Procesados

Talca, Chile

Daniel Bustos

Auxiliar Professor

Vicerrectoría de Investigación y Postgrado

Universidad Católica del Maule

Talca, Chile

Mauricio Bedoya

Profesor Auxiliar

CIEAM

Universidad Católica del Maule

Talca, Chile

Leandro Zuñiga

Profesor Asociado

Medicine

Universidad de Talca

Talca, Chile

Melissa Alegría

Académico Asociado

Facultad de Ingeniería y Negocios

Universidad de Las Américas

Santiago, Chile

Ingo Dreyer

Professor Titular

Bioinformatica

Universidad de Talca

Talca, Chile

Francisco Sepúlveda

Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

Erix Hernández

Full Professor/Departamento de Medicina Traslacional, Académico-Investigador

Departamento de Medicina Traslacional

Universidad Católica del Maule

Talca, Chile

Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

Paula Santana

Profesora Asistente e Investigadora

Facultad de Ingeniería

Universidad Autónoma de Chile

Santiago, Chile

Samuel Morales

Académico Conferenciante

Universidad de Talca

Talca, Chile

Leonardo Pavez

Profesor Asociado

Instituto de Ciencias Naturales

Universidad de Las Américas

Santiago, Chile

Diliana Pérez

Docente con grado de doctor

Universidad Autónoma de Chile

Santiago, Chile

Carlos Blondel

Profesor Asistente

Instituto de Ciencias Biomédicas

Universidad Andrés Bello

Santiago, Chile

Roberto Bastías

Profesor

Facultad de Ciencias

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

Oscar Forero

Investigador

Instituto de Química de Recursos Naturales

Universidad de Talca

Talca, Chile

Gonzalo Riadi

Assistant Professor

Bioinformatics

Universidad de Talca

Talca, Chile

Gino Corsini

Director Instituto Ciencias Biomédicas

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

Braulio Valdebenito

TALCA, Chile

Ana Martinez

Research Professor

Centro Investigaciones Biológicas (CIB)

Consejo Superior de Investigaciones Científicas (CSIC)

Madrid, Chile

Talia del Pozo

Académico Investigador

FAVA

Universidad de Las Américas

Santiago, Chile

Ingrid Carvacho

Assistant Professor

Medicina Traslacional

Universidad Católica del Maule

Talca, Chile

MARIA CARMEN LOPEZ

Assistant professor

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Gabriel Nuñez

Jefe de Carrera, Ingeniería Civil Informática

Ciencias Naturales y Tecnología

Universidad de Aysén

Coyhaique, Chile

Ricardo Castro

investigador

Instituto de ciencias químicas aplicadas

Universidad Autonomade Chile

Talca, Chile

Yeray Rodríguez

Investigador

Universidad de Talca

talca, Chile

Paola Ojeda

Profesor Adjunto

Ciencias Pre-clinicas

Universidad Católica del Maule

Talca, Chile

Janin Riedelsberger

Profesora Asistente

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

Luis Guzman

Profesor Asistente

Departamento Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

Nicolás Plaza

Profesor

Ciencias de la Salud

Universidad Autónoma de Chile

Santiago, Chile

Oscar Cerda

Associate Professor

Molecular and Cellular Biology

Universidad de Chile

Santiago, Chile

Angel Cayo

ACADÉMICO INVESTIGADOR

MEDICINA TRASLACIONAL

Universidad Católica del Maule

TALCA, Chile

Javier Echeverría

Profesor Asistente e Investigador

Departamento de Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago de Chile, Chile

Efrain Polo

Docente

Universidad de Talca

Talca, Chile

David Mauricio Ramirez Sanchez

Líneas de Investigación

Educación

Licenciatura en Química, UNIVERSIDAD DISTRITAL FRANCISCO JOSE DE CALDAS. Colombia, 2009

Doctorado en Ciencias Aplicadas, UNIVERSIDAD DE TALCA. Chile, 2017

Farmacia, UNIVERSIDAD NACIONAL DE COLOMBIA. Colombia, 2012

Químico Farmacéutico, UNIVERSIDAD NACIONAL DE COLOMBIA. Colombia, 2012

Licenciado en Química, UNIVERSIDAD DISTRITAL FRANCISCO JOSE DE CALDAS. Colombia, 2009

Inteligenica Artifical, Universidad Catolica de Murcia. España, 2023

Experiencia Académica

Profesor asistente Part Time

Asistente de investigación Part Time

Postdoctoral fellow Full Time

Postdoctorado Part Time

Profesor asistente Part Time

Profesor Asistente Full Time

Experiencia Profesional

Químico Farmacéutico de Producción Full Time

Químico Farmacéutico Full Time

Asistente de investigación Part Time

Postdoctoral fellow Full Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

Bachelor thesis Distinguished with meritorious mention

Scholarship for Ph.D. studies

Research internship grant

Top 2% most cited Scientist (position 332.071) in 2020

Article (54)

BookSection (2)

Proyecto (22)

Scholarship Programme for Young Professors and Researchers from Latin American Universities

Structural insights into the substrate specificity and transport mechanisms in the Nitrate/Peptide Transporter (NPF) Family.

Ana&#769;lisis metabolo&#769;mico de los efectos neuroprotectores de la tibolona en un modelo astrocitico humano de lipotoxicidad con a&#769;cido palmi&#769;tico

Development of a novel protocol to predict what class of secondary metabolite is transported by a specific plant transporter

STRUCTURAL AND FUNCTIONAL UNDERSTANDING OF ION CHANNELS OF THE ALMT (ALUMINUM ACTIVATED MALATE TRANSPORTER) FAMILY

UNDERSTANDING THE STRUCTURAL MECHANISM OF SELECTIVE BLOCKERS OF PH-GATED K2P CHANNELS

Development and functional evaluation of synthetic molecules as TASK-3 potassium channel inhibitors for treatramnt of solid tumors

Review (2)

Análisis metabolómico de los efectos neuroprotectores de la tibolona en un modelo astrocitico humano de lipotoxicidad con ácido palmítico