Man

Jimena Cuenca Moreno

Investigador/profesor

Universidad de Los Andes

Santiago, Chile

Líneas de Investigación


Cell Therapy; Immunomodulatory effects of Mesenchymal Stem Cells; Autoimmune Diseases; Mechanisms in Autoimmune Diseases; Inflammation/miRNA; Molecular and Cellular Biology; Bioprocessing and Cellular Manufacturing

Educación

  •  Bioquímica , UNIVERSIDAD DE CHILE. Chile, 2002
  •  Bioquimica y Biologia Molecular, Universidad Complutense de Madrid. España, 2006

Experiencia Académica

  •   Investigador/profesor Full Time

    Universidad de los Andes

    Facultad de Medicina

    Santiago, Chile

    2011 - A la fecha

Experiencia Profesional

  •   Investigador/profesor Full Time

    Universidad de los Andes

    Chile

    2011 - A la fecha

  •   Investigador Full Time

    Instituto Investigaciones Biomédicas Alberto Sols (IIBM), Consejo Superior de Investigaciones Científicas (CSIC) y de la Universidad Autónoma de Madrid (UAM)

    Madrid, España

    2008 - 2010

  •   Investigador Full Time

    Universidad Complutense de Madrid

    Madrid, España

    2007 - 2008

Formación de Capital Humano


2012-present Miembro del cuerpo académico del Programa de Doctorado en Biomedicina, Universidad de los Andes
2016-presente Evaluador ANID
2017-2023 Carmen Hidalgo (PhDc, Doctorado en Biomedicina, Universidad de los Andes). Co-tutor de Tesis
2018 Dirección Practica Profesional. Carrera Biología, mención Bioprocesos. Estudiante: Manuel Ramirez Contador (Pontificia Universidad Católica de Chile) Finalizada
2016 Dirección Practica Profesional.Carrera Ingeniería Biológica, Diseño e Innovación de Bioproductos (Université de Technologie (UTC) de Compiègne, Francia)


Difusión y Transferencia


Inventor Patente: (EN) METHOD FOR OBTAINING A COMPOSITION CONTAINING A SPECIFIC POPULATION OF UMBILICAL CORD MESENCHYMAL CELLS AND USES THEREOF (WO/2019/051623). Inventores:MAROUN, Khoury; FIGUEROA, Fernando;ESPINOZA, Francisco;BARTOLUCCI, Jorge;CASTRO, Diego;MONTOYA, Paula;GONZÁLEZ, Paz; CUENCA, Jimena


Premios y Distinciones

  •   Beca predoctoral: "Cátedra Severo Ochoa"

    Consejo Superior de Investigaciones Científicas-BSCH

    España, 2002

    Beca para realización de estudios conducentes a obtención de grado de doctor.

  •   Beca predoctoral: “CNIC-BanCaja”

    CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES

    España, 2004

    Beca para realización de estudios conducentes a obtención de grado de doctor.


 

Article (24)

A Phase I Dose-Escalation Clinical Trial to Assess the Safety and Efficacy of Umbilical Cord-Derived Mesenchymal Stromal Cells in Knee Osteoarthritis
A novel porous hydrogel based on hybrid gelation for injectable and tough scaffold implantation and tissue engineering applications
A Psychrophilic GelMA: Breaking Technical and Immunological Barriers for Multimaterial High-Resolution 3D Bioprinting
Safety and efficacy of clinical-grade, cryopreserved menstrual blood mesenchymal stromal cells in experimental acute respiratory distress syndrome
Delivery of affordable and scalable encapsulated allogenic/autologous mesenchymal stem cells in coagulated platelet poor plasma for dental pulp regeneration
Current Status of Cell-Based Therapies for Respiratory Virus Infections: Applicability to COVID-19
Exosomes on the border of species and kingdom intercommunication
Stem cell exosomes inhibit angiogenesis and tumor growth of oral squamous cell carcinoma
The Reparative Abilities of Menstrual Stem Cells Modulate the Wound Matrix Signals and Improve Cutaneous Regeneration
Antimicrobial Activity of Mesenchymal Stem Cells: Current Status and New Perspectives of Antimicrobial Peptide-Based Therapies
Safety and Efficacy of the Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Patients With Heart Failure A Phase 1/2 Randomized Controlled Trial (RIMECARD Trial [Randomized Clinical Trial of Intravenous Infusion Umbilical Cord Mesenchymal Stem Cells on Cardiopathy])
Characterization of menstrual stem cells: angiogenic effect, migration and hematopoietic stem cell support in comparison with bone marrow mesenchymal stem cells
Chorion Mesenchymal Stem Cells Show Superior Differentiation, Immunosuppressive, and Angiogenic Potentials in Comparison With Haploidentical Maternal Placental Cells
Combination therapy of menstrual derived mesenchymal stem cells and antibiotics ameliorates survival in sepsis
MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers
Novel approaches to lupus drug discovery using stem cell therapy. Role of mesenchymal-stem-cell-secreted factors.
Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors
Multiple imputation procedures allow the rescue of missing data: An application to determine serum tumor necrosis factor (TNF) concentration values during the treatment of rheumatoid arthritis patients with anti-TNF therapy
The -308 polymorphism in the promoter region of the tumor necrosis factor-alpha (TNF-?) gene and ex vivo lipopolysaccharide-induced TNF-? expression in patients with aggressive periodontitis and/or type 1 diabetes mellitus
The -308 polymorphism in the promotor region of the tumor necrosis factor-alpha (TNF-alpha) gene and ex vivo lipopolysaccharide-induced TNF-alpha expression in patients with aggresive peridontitis and/or type 1 diabetes mellitus
Tumour necrosis factor-alpha (TNF-alpha) levels and influence of 2308 TNF-alpha promoter polymorphism on the responsiveness to infliximab in patients with rheumatoid arthritis
The -308 polymorphism in the tumour necrosis factor (TNF) gene promoter region and ex vivo lipopolysaccharide-induced TNF expression and cytotoxic activity in Chilean patients with rheumatoid arthritis
Tumor necrosis factor alpha genetic polymorphism as a risk factor in disease
Genetic polymorphism at position-308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population

ConferencePoster (3)

A phase I clinical trial for safety determination of the intra-articular administration of umbilical cord mesenchymal stromal cells-derived small extracellular vesicles in patients with knee osteoarthrosis
Cryopreserved Mesenchymal Stem Cells: Are they Safe and Effective for Treatment of Acute Respiratory Distress Syndrome?,
SAFETY AND EFFICACY PROFILE OF CRYOPRESERVED MESENCHYMAL STEM CELLS FOR THE TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME

Patent (1)

METHOD FOR OBTAINING A COMPOSITION CONTAINING A SPECIFIC POPULATION OF UMBILICAL CORD MESENCHYMAL CELLS AND USES THEREOF

Proyecto (10)

Desarrollo de un producto alogénico basado en un hidrogel bioactivo con nanovesículas extracelulares y su validación como tratamiento endodóntico regenerativo
Center of Interventional Medicine for Precision and Advanced Cellular Therapy (IMPACT)
Investigating the effect of MAVs-enriched mitochondrial transplantation on intracellular antiviral immunity and their restorative and immunomodulatory effects in a viral-induced acute lung injury model
Desarrollo y validación de un producto celular alogénico derivado de células madre estromales para su uso en síndrome de distrés respiratorio agudo
Investigar las propiedades terapéuticas del medio condicionado derivado de células madre de fluido menstrual en un modelo de sepsis experimental.
REGENERO THE CHILEAN STEM CELL CONSORTIUM
Investigando las propiedades inmunomoduladoras de una nueva población de células madre derivadas del fluido menstrual recientemente caracterizada y exploración de su aplicación potencial en enfermedades inflamatorias
MIRNAS IN THE PATHOGENESIS OF SYSTEMIC LUPUS ERYTHEMATOSUS (SLE). PROFILE OF EXPRESSION IN HUMAN DISEASE AND ASSESSMENT OF FUNCTIONAL EFFECTS IN A HUMANIZED MOUSE MODEL OF SLE.
POLIMORFISMO DE LA REGION PROMOTORA DEL GEN DEL FACTOR DE NECROSIS TUMORAL ASOCIADO A ARTRITIS REUMATOIDE Y ENFERMEDAD PERIODONTAL.
Investigating the anti-angiogenic effect of exosome-mediated delivery of functionally active miRNA-149-3p,145-5p and 6131 to tumor tissue.
32
Jimena Cuenca

Investigador/profesor

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

9
Maroun Khoury

Professor

Faculty of Medicine

Universidad de Los Andes

santiago, Chile

6
JUAN AGUILLON

PROFESSOR

IMMUNOLOGY PROGRAM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

5
Fernando Figueroa

Director

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago de Chile, Chile

5
Francisca Alcayaga

Profesor Asociado

Facultad de Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

3
Lorena Salazar

Profesora Asistente

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Lampa, Chile

3
Diego Catalán

Associate Professor

Programa Disciplinario de Inmunología

Universidad de Chile

Santiago, Chile

3
OCTAVIO ARAVENA

Gestión I+D

I+D+i

Comisión Chilena de Energía Nuclear

Santiago, Chile

3
Lorena Salazar

Academico

Instituto Cs Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

2
gabriela zavala

Investigador post-doctoral

Cells for Cells

Universidad de los Andes

Santiago, Chile

2
Lilian Soto

Rheumatologist

Medicine

CLINICAL HOSPITAL OF UNIVERSIDAD DE CHILE

Santiago, Chile

2
Sergio Viafara

Asistant Researcher

CiiB

Universidad de Los Andes

Santiago, Chile

2
Yessia Hidalgo

Researcher

Centro de Investigación e Innovación Biomédica

Corporación IMPACT

Santiago, Chile

2
Maria Ortúzar

Gerente de producto

Nalca Biotech SpA

Puerto Varas, Chile

2
Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

1
Patricia Luz

Profesor asistente

Universidad de los Andes

Santiago , Chile

1
Mónica Kurte

Investigador

Laboratorio de Inmunologìa

Universidad de los Andes

Santiago, Chile

1
Christina Schuh

Associate Professor

Centre for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

1
Valentina Castillo

Investigadora Postdoctoral

Instituto de Ingeniería Biológica y Médica

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Fernando Verdugo

Cardiologo

Cardiologia

Hospital del Salvador

Santiago, Chile

1
Rodrigo Villegas

Jefe Programa de Bioestadística

Bioestadística

Universidad de Chile - Facultad de Medicina

Santiago, Chile

1
Bárbara Pesce

Profesora Asistente

ICBM

Universidad de Chile

Santiago, Chile

1
Aliosha Figueroa

Asistente de Investigación

Consorcio Regenero S.A.

Santiago, Chile

1
ARTURO FERREIRA

FULL PROFESSOR, CHAIR IMMUNOLOGY DISCIPLINARY PROGRAM

IMMUNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Carolina Llanos

Associate Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Ana Martinez

Research Professor

Centro Investigaciones Biológicas (CIB)

Consejo Superior de Investigaciones Científicas (CSIC)

Madrid, Chile

1
Nuria Campillo

Científico titular

Biología Físico-Química

Centro de Investigaciones Biológicas (CIB-CSIC)

Madrid, España

1
Fermín González

Profesor Asociado

Odontología Conservadora

Universidad de Chile

Santiago, Chile