Man

Sergio Alejandro Onate Betancour

Associate Professor

UNIVERSIDAD DE CONCEPCION, DEPARTAMENTO FISIOPATOLOGIA

concepcion, Chile

Líneas de Investigación


Cancer Biology, Nuclear Receptor Coregulators, Molecular Endocrinology. Mechanism by which coregulators for nuclear receptors alter gene expression in a cell/tissue compartment-specific manner in progression to recurrence and metastasis

Educación

  •  Experimental Pathology, University of Colorado Health sciences Center. Estados Unidos, 1993
  •  Biochemist, UNIVERSIDAD DE CONCEPCION. Chile, 1986

Experiencia Académica

  •   Associate Professor Full Time

    UNIVERSIDAD DE CONCEPCION

    Concepcion, Chile

    2013 - A la fecha

  •   Associate Professor Full Time

    UNIVERSIDAD DE CONCEPCION

    Biological Sciences

    CONCEPCION, Chile

    2008 - 2013

  •   ASSISTANT PROFESSOR Full Time

    ROSWELL PARK CANCER INSTITUTE

    BUFFALO, Estados Unidos

    2004 - 2008

  •   ASSISTANT PROFESSOR ADJUNCT Other

    STATE UNIVERSITY OF NEW YORK AT BUFFALO, NY

    BUFFALO, NY, Estados Unidos

    2004 - 2008

  •   ASSISTANT PROFESSOR Full Time

    UNIVERSITY OF PITTSBURGH

    PITTSBURGH, PA, Chile

    1998 - 2004

  •   INSTRUCTOR Full Time

    BAYLOR COLLEGE OF MEDICINE

    HOUSTON, TX, Chile

    1996 - 1998

Experiencia Profesional

  •   Associate Professor Full Time

    University of Concepcion

    Chile

    2008 - 2013

  •   Assistant Professor Full Time

    Roswell Park Cancer Institute

    Buffalo, Estados Unidos

    2004 - 2008

  •   Assistant Professor Full Time

    University of pittsburgh

    Pittsburgh, Chile

    1998 - 2004

  •   Instructor Full Time

    Baylor College of Medicine

    Houston, Chile

    1995 - 1998

  •   POSTDOCTORAL FELLOW Full Time

    BAYLOR COLLEGE OF MEDICINE

    HOUSTON, TX, Estados Unidos

    1993 - 1995

  •   DOCTORAL TRAINING, EXPERIMENTAL PATHOLOGY Other

    UNIVERSITY OF COLORADO HEALTH SCIENCES CENTER

    DENVER, Chile

    1988 - 1993

Formación de Capital Humano


Student Supervisions.
Graduate Students. -Marjet Heitzer. -Marie Acquilano. -David Yeates. -Spephania Urso. -Rosalba Escamilla. -Patricia cano. -Victor M. Garcia.
Graduate Student Committees.
Lecture Title
“Nuclear/cytosol trafficking” “Mechanisms of Hormone Action” “Cell Biol. of Diseases States” “Specific Topics on gene Expression”
-Michelle Clinton. -Alvin Munk. -Stephanie Carson. -Julie E. Lehman. -Elizabeth Baine. -Candace Roman
1999. Current: Medical School. New York Inst. of Tech.
2000-2002. 2001. 1999. 2000-2001. 2002.
Current: Medical School, U. of Pittsburgh. Current: School of Pharmacy, U. of Pittsburgh Current: Research Technician, UCSF. Current: Undergraduate, U. of Pittsburgh
2002-present. 2001.
2002.
2002. 1999-2002, 2000-2003, 2003-present.
U. of Pitt.
U. of Pitt.
U. of Pitt.
U. of Pitt.
UPN, Mexico.
UPN, Mexico.
U. of Guadalajara, Mexico.
Frank Delfino, Ph.D. Graduate Committee (University of Pittsburgh). Kelly Sutter. Preliminary Exam committee (University of Pittsburgh). Rosalba Escamilla. Ph.D. Student Advisor
Patricia Cano. Ph.D. Student Advisor
Marjet Heitzer, Ph.D. Student Advisor
Un


Difusión y Transferencia


PATENTS
Steroid Receptor Coactivators, Baylor College of Medicine, Houston, TX.



 

Article (14)

Lectin-Like Oxidized LDL Receptor-1 Is an Enhancer of Tumor Angiogenesis in Human Prostate Cancer Cells

González-Chavarría, Iván; Cerro, Rita P.; Parra, Natalie P.; Sandoval, Felipe A.; Zuñiga, Felipe A.; Omazábal, Valeska A.; Lamperti, Liliana I.; Jiménez, Silvana P.; Fernandez, Edelmira A.; Gutiérrez, Nicolas A.; Rodríguez, Federico S.; Oñate, Sergio A.; Sánchez Oliberto; Vera, Juan C.; Toledo, Jorge R.; Pizzo, Salvatore V.

Article ISI
PLOS ONE  (2014)

Altered corepressor SMRT expression and recruitment to target genes as a mechanism that change the response to androgens in prostate cancer progression

Godoy, A. S.; Sotomayor, P. C.; Villagrán M.; Yacoub R.; Montecinos, V. P.; McNerney E.M.; Moser M.; Foster B.A.; Onate S.A.

Article ISI SCOPUS
Biochemical and Biophysical Research Communications  (2012)

Biochemical characterization of nuclear receptors for vitamin D-3 and glucocorticoids in prostate stroma cell microenvironment

Hidalgo, AA; Montecinos, VP; Paredes, R.; Godoy, AS; McNerney, EM; Tovar, H; Pantoja D.; Johnson C.; Trump D.; Onate, SA

Article ISI SCOPUS
Biochemical and Biophysical Research Communications  (2011)

Prx1 Enhances Androgen Receptor Function in Prostate Cancer Cells by Increasing Receptor Affinity to Dihydrotestosterone

Chhipa, RR; Lee, KS; Oñate S.; Wu, Y; Ip, C

Article ISI SCOPUS
MOLECULAR CANCER RESEARCH  (2009)

1 alpha,25-dihydroxy vitamin D-3-Enhanced expression of the osteocalcin gene involves increased promoter occupancy of basal transcription regulators and gradual recruitment of the 1 alpha,25-dihydroxy vitamin D-3 Receptor-SRC-1 coactivator complex

Carvallo L; Henriquez, B; Paredes, R.; Olate, J; Oñate S.; van Wijnen, AJ; Lian, JB; Stein, GS; Stein, JL; Montecino, M.

Article ISI SCOPUS
JOURNAL OF CELLULAR PHYSIOLOGY  (2008)

1?,25-dihydroxy vitamin D3-enhanced expression of the osteocalcin gene involves increased promoter occupancy of basal transcription regulators and gradual recruitment of the 1?,25-dihydroxy vitamin D 3 receptor-SRC-1 coactivator complex

Carvallo L; Henriquez, B; Paredes, R.; Olate, J; Montecino, M.; Oñate S.; van Wijnen A.J.; Lian J.B.; Stein G.S.; Stein J.L.

Article
JOURNAL OF CELLULAR PHYSIOLOGY  (2008)

Mechanistic insights and functional determinants of the transport cycle of the ascorbic acid transporter SVCT2

Godoy A.; Ormazabal, V; Moraga-Cid, G; Zuniga, FA; Sotomayor P.; Barra V; Vásquez O.; Montecinos, V.; Mardones L.; Guzmán C; Villagrán M.; Aguayo, LG; Onate, SA; Reyes, AM; Carcamo, JG; Rivas, CI; Vera, JC

Article ISI SCOPUS
JOURNAL OF BIOLOGICAL CHEMISTRY  (2007)

Phosphorylation at serine 208 of the 1 alpha,25-dihydroxy Vitamin D3 receptor modulates the interaction with transcriptional coactivators

Arriagada, G; Paredes, R.; Olate, J; van Wijnen A.; Lian, JB; Stein, GS; Stein, JL; Oñate S.; Montecino, M.

Article ISI SCOPUS
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY  (2007)

Phosphorylation at serine 208 of the 1?,25-dihydroxy Vitamin D3 receptor modulates the interaction with transcriptional coactivators

Arriagada, G; Paredes, R.; Olate, J; Montecino, M.; van Wijnen A.; Lian J.B.; Stein G.S.; Oñate S.; Stein J.L.

Article
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY  (2007)

The 1 alpha,25-dihydroxy Vitamin D3 receptor preferentially recruits the coactivator SRC-1 during up-regulation of the osteocalcin gene

Carvallo L; Henriquez, B; Olate, J; van Wijnen, AJ; Lian, JB; Stein, GS; Oñate S.; Stein, JL; Montecino, M.

Article ISI SCOPUS
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY  (2007)

The 1?,25-dihydroxy Vitamin D3 receptor preferentially recruits the coactivator SRC-1 during up-regulation of the osteocalcin gene

Carvallo L; Henriquez, B; Olate, J; Montecino, M.; van Wijnen A.J.; Lian J.B.; Stein G.S.; Stein J.L.; Oñate S.

Article
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY  (2007)

Vitamin C is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess of glutathione

Montecinos, V.; Guzman P.; Barra V; Villagrán M.; Munoz-Montesino, C; Sotomayor, K; Escobar, E; Godoy A.; Mardones L.; Sotomayor P.; Guzmán C; Vásquez O.; Gallardo V.; van Zundert, B; Bono, MR.; Onate, SA; Bustamante, M; Carcamo, JG; Rivas, CI; Vera, JC

Article ISI SCOPUS
JOURNAL OF BIOLOGICAL CHEMISTRY  (2007)

Hypothalamic ependymal-glial cells express the glucose transporter GLUT2, a protein involved in glucose sensing

Garcia, MD; Millán C; Balmaceda-Aguilera, C; Castro, T.; Pastor P; Montecinos, H.; Reinicke K; Zuniga, F; Vera, JC; Onate, SA; Nualart, F.

Article ISI
JOURNAL OF NEUROCHEMISTRY  (2003)

The 1 alpha,25-dihydroxyvitamin D-3-enchancement of the OC gene is dependent upon binding of bone-specific transcription factor Runx2 to gene promoter

Paredes, R.; Arriagada, G; Cruzat F.; Villagra, A; Zaidi, K; Olate, J; van Wijnen A.; Lian J.; Stein, J; Onate, SA; Montecino MA

Article
MOLECULAR BIOLOGY OF THE CELL  

Abstract (1)

Glucokinase is expressed in mouse hypothalamic tanycytes, an enzyme involved in glucose sensing

García MA; Millán C; Pastor P; Escamilla, R; Oñate S.; Nualart, F.

Abstract
JOURNAL OF NEUROCHEMISTRY  (2003)

ConferencePaper (1)

Bone Stroma induces AR basal transcriptional activity in prostate cancer cells

Villagrán M.; Mardones L.; Rivas, CI; Vera, JC; Onate, SA; Onate, SA

ConferencePaper
15th International Conference on Electronics, Communications and Computers, Proceedings  (2009)

ConferencePoster (1)

Altered androgen receptor-dependent transcriptional activity in tumoral prostatic cells in the presence of bone stromal cells

Villagrán M.; Mardones L.; Soliz, C; Rivas, C; Vera, JC; Oñate S.; Vera, JC

ConferencePoster
15th International Conference on Electronics, Communications and Computers, Proceedings  (2008)

21
Sergio Onate

Associate Professor

Medical Specialties

UNIVERSIDAD DE CONCEPCION, DEPARTAMENTO FISIOPATOLOGIA

concepcion, Chile

7
Viviana Montecinos

Assistant Professor

Hematology Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

6
CORALIA RIVAS

Associated Professor

Pathophysiology

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

6
Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

4
Lorena Mardones

ASSOCIATED PROFESSOR

BASIC SCIENCES AND MORPHOLOGY

UNIVERSIDAD CATOLICA DE LA SANTISIMA CONCEPCION

CONCEPCION, Chile

3
Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

3
Paula Sotomayor

Investigador

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

3
Juan Carcamo

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

2
Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

2
Felipe Zuñiga

Profesor Asistente

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

2
Berta Henriquez

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

2
MARCELO VILLAGRAN

Profesor asociado

Departamento de Ciencias Básicas

Universidad Catolica de la Santísima Concepción

Concepcion, Chile

1
Liliana Lamperti

Vicedecana

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE FARMACIA

Concepción, Chile

1
Jorge Toledo

Director de Departamento

Fisiopatología

Universidad de Concepción

Concepcion, Chile

1
Oliberto Sanchez

Associate Professor

Pharmacology

University of Concepción

Concepción, Chile

1
PAULA GUZMÁN

Profesional Bioquímico

Laboratorio Clínico

Hospital Clínico Regional de Concepción Guillermo Grant Benavente

Concepción, Chile

1
María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Alejandro Hidalgo

Associate Professor

Escuela de Química y Farmacia

Universidad Andres Bello

Santiago, Chile

1
Valeska Ormazabal

Profesor asistente

Farmacología

Universidad de Concepción

Concepción, Chile

1
Alejandro Reyes

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

1
Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Marcelo Bustamante

Director

Basisc Sciences

UNIVERSIDAD CATÓLICA DE LA SANTÍSIMA CONCEPCIÓN

CONCEPCIÓN, Chile

1
Gustavo Moraga

Profesor Asistente

Departamento de Fisiología

Universidad De Concepción

Concepción, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

1
IVAN GONZALEZ

Profesor Asistente

Fisiopatología

Universidad De Concepcion

Concepción, Chile

1
Maria Escobar

Postdoctorado

Biología Molecular Vegetal

Universidad de Chile

Santiago , Chile

1
Carola Muñoz

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Gloria Arriagada

Profesor Asociado-Investigador Principal

Instituto de Ciencias Biomédicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Natalie Parra

Colaborador Académico

Farmacología

Universidad de Concepción

Concepción, Chile

1
nicolas gutierrez

1
Felipe Sandoval

1
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Carola Millan

Profesor

de Ciencias

UNIVERSIDAD ADOLFO IBAÑEZ FACULTAD DE ARTES LIBERALES

Viña del Mar, Chile