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Mario I Fernandez Arancibia

Associate Professor

CLÍNICA ALEMANA DE SANTIAGO

Santiago, Chile

Translational research in urothelial cancer- molecular mechanisms, markers, early detection, natural history, treatment, and outcomes research; Minimal invasive treatment modalities for urolithiasis and upper tract malignant diseases

Medico Cirujano, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2001
Urólogo, UNIVERSIDAD DE CHILE. Chile, 2004
Urology, UNIVERSITAT HEIDELBERG. Alemania, 2007

Researcher - Associate Professor Other

Clínica Alemana Universidad del Desarrollo

Medicine

Santiago, Chile

2011 - A la fecha
Adjunct Instructor Other

UNIVERSIDAD DE CHILE

Medicine

Santiago, Chile

2004 - 2008
Visiting Scientist Full Time

UNIV TEXAS M.D. ANDERSON CANCER CENTER

Houston, Estados Unidos

2012 - 2012

Faculty - Urology Part Time

Hospital San José

Santiago, Chile

2003 - 2008
Faculty - Urology Part Time

Hospital Militar de Santiago

Santiago, Chile

2005 - 2011
Visiting Physician Full Time

Universitätsklinikum Mannheim

Mannheim, Alemania

2005 - 2006

Best Abstract

SOCIEDAD CHILENA DE UROLOGIA

Chile, 2011

Best Abstract at the XXXIII Chilean Congress of Urology "Expresión de proteínas de vía de reparación de ADN por escisión de nucleótidos en cáncer urotelial de vejiga: relación con status tabáquico y variables clinicopatológicas"
Best Video

SOCIEDAD CHILENA DE UROLOGIA

Chile, 2011

Best Video at the XXXIII Chilean Congress of Urology "Dificultades y complicaciones intraoperatorias en Ureterorrenoscopía"
Best Abstract

SOCIEDAD CHILENA DE UROLOGIA

Chile, 2015

Best Abstract at the XXXVII Chilean Congress of Urology "Asociación de variantes genéticas con la ocurrencia de cáncer de vejiga en una población expuesta a arsénico. Resultados de un estudio asociado del genoma completo"
Best Abstract

SOCIEDAD CHILENA DE UROLOGIA

Chile, 2018

Best Abstract at the XL Chilean Congress of Urology "Identificación de variantes genéticas asociadas a adaptación selectiva en una población expuesta a arsénico!
Third best Abstract

Deutsche Gesellschaft für Urologie

Alemania, 2006

Third Best Abstract at the Annual DGU Meeting 2006 "A new long-term 3D tissue culture model of benign urothelium and transitional cell carcinoma with evaluation of topical chemotherapy"


A prospective randomized study comparing bipolar plasmakinetic transurethral resection of the prostate and monopolar transurethral resection of the prostate for the treatment of Benign Prostatic Hyperplasia: efficacy, sexual function, Quality of Life, and complications Otaola-Arca, Hugo; Alvarez-Ardura, Manuel; Molina-Escudero, Roberto; Fernandez, Mario, I; Paez-Borda, Alvaro Article ISI INTERNATIONAL BRAZ J UROL (2021)
Arsenic exposure is associated with significant upper tract urothelial carcinoma health care needs and elevated mortality rates LÃ³pez J.F.; FernÃ¡ndez M.I.; Coz, L.F. Article SCOPUS Urologic Oncology: Seminars and Original Investigations (2020)
Impact of arsenic exposure on clinicopathological characteristics of bladder cancer: A comparative study between patients from an arsenic-exposed region and nonexposed reference sites Fernandez, Mario I.; Valdebenito, Patricio; Delgado, Iris; Segebre, Jorge; Chaparro, Eduardo; Fuentealba, David; Castillo, Martin; ; Vial, Cecilia; Barroso, Juan P.; Ziegler, Annemarie; Bustamante, Alberto Article ISI SCOPUS UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2020)
Post-Admixture Selection on Chileans Targets Haplotype Involved in Pigmentation and Immune Defense Against Pathogens Vicuña, Lucas; Klimenkova, Olga; Norambuena, Tomás; Martinez, Felipe I.; Fernandez, Mario I; Shchur, Vladimir; Eyheramendy, Susana; Yi, Soojin Article WOS GENOME BIOLOGY AND EVOLUTION (2020)
Adaptation to Extreme Environments in an Admixed Human Population from the Atacama Desert Vicuna, Lucas; Fernandez, Mario I.; ; Vial, Cecilia; Valdebenito, Patricio; Chaparro, Eduardo; Espinoza, Karena; Ziegler, Annemarie; Bustamante, Alberto; Eyheramendy, Susana Article ISI SCOPUS GENOME BIOLOGY AND EVOLUTION (2019)
Epidemiology, prevention, screening, diagnosis, and evaluation=> update of the ICUD-SIU joint consultation on bladder cancer. Fernández, Mario I; Brausi, Maurizio; Clark, Peter E; Cookson, Michael S; Grossman, H Barton; Khochikar, Makarand; Kiemeney, Lambertus A; Malavaud, Bernard; Sanchez-Salas, Rafael; Soloway, Mark S; Svatek, Robert S; Vikram, Raghunandan; Vrieling, Alina; Kamat, Ashish M Article World journal of urology (2018)
Prevalence of Chlamydia Trachomatis, Neisseria Gonorrhoeae, and Trichomonas Vaginalis Infection in Chilean Adolescents and Young Adults. Huneeus, Andrea; Schilling, Andrea; Fernandez, Mario I Article Journal of pediatric and adolescent gynecology (2018)
[Adolescents find it easy to collect their own samples to study sexually transmitted infections]. Huneeus, Andrea; Fernández, Mario I; Schilling, Andrea; Parra, Paulina; Zakharova, Aleksandra Article Revista chilena de infectologia => organo oficial de la Sociedad Chilena de Infectologia (2017)
Clinical risk stratification in patients with surgically resectable micropapillary bladder cancer. Fernández, Mario I; Williams, Stephen B; Willis, Daniel L; Slack, Rebecca S; Dickstein, Rian J; Parikh, Sahil; Chiong, Edmund; Siefker-Radtke, Arlene O; Guo, Charles C; Czerniak, Bogdan A; McConkey, David J; Shah, Jay B; Pisters, Louis L; Grossman, H Barton; Dinney, Colin P N; Kamat, Ashish M Article BJU international (2017)
Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC). Soria, Francesco; Shariat, Shahrokh F; Lerner, Seth P; Fritsche, Hans-Martin; Rink, Michael; Kassouf, Wassim; Spiess, Philippe E; Lotan, Yair; Ye, Dingwei; Fernández, Mario I; Kikuchi, Eiji; Chade, Daher C; Babjuk, Marko; Grollman, Arthur P; Thalmann, George N Article World journal of urology (2017)
Upper Urinary Tract Carcinoma In Situ=> Current Knowledge, Future Direction. Redrow, Grant P; Guo, Charles C; Brausi, Maurizio A; Coleman, Jonathan A; Fernandez, Mario I; Kassouf, Wassim; Keeley, Francis X; Margulis, Vitaly; Raman, Jay D; Roupret, Morgan; Shariat, Shahrokh F; Spiess, Philippe E; Thalmann, George N; Matin, Surena F Article The Journal of urology (2017)
Hemostatic agents for access tract in tubeless percutaneous nephrolithotomy: Is it worth? Sepulveda, Francisco; Aliaga, Alfredo; Fleck, Daniela; Fernandez, Mario; Mercado, Alejandro; Vilches, Roberto; Moya, Francisco; Ledezma, Rodrigo; Reyes, Diego; Marchant, Fernando Article Urology Annals (2016)
Advances in the treatment of castration-resistant prostate cancer: Emphasis in new hormonal therapies [Avances en el tratamiento de cancer de próstata resistente a la castración: énfasis en nuevas terapias hormonales] Berlin, A; Fernández M.I. Article SCOPUS Revista Medica de Chile (2015)
Clinical outcomes of cT1 micropapillary bladder cancer. Willis, Daniel L; Fernandez, Mario I; Dickstein, Rian J; Parikh, Sahil; Shah, Jay B; Pisters, Louis L; Guo, Charles C; Henderson, Samuel; Czerniak, Bogdan A; Grossman, H Barton; Dinney, Colin P; Kamat, Ashish M Article JOURNAL OF UROLOGY (2015)
Immediate postoperative morbidity in patients with indwelling double-J stent versus overnight-externalized ureteral catheter after tubeless percutaneous nephrolithotomy: a prospective, randomized study Mercado A.; Fernandez, MI; Recabal, P; Fleck D.; Ledezma R.; Moya F.; Sepulveda F.; Vilches R.; Reyes D.; Marchant F. Article UROLITHIASIS (2013)
Î³-H2AX level in peripheral blood lymphocytes as a risk predictor for bladder cancer Fernández, Mario I; Gong, Yilei; Ye, Yuanqing; Lin, Jie; Chang, David W; Kamat, Ashish M; Wu, Xifeng Article CARCINOGENESIS (2013)
Concomitant carcinoma in situ is a feature of aggressive disease in patients with organ confined urothelial carcinoma following radical nephroureterectomy. Wheat, Jeffery C; Weizer, Alon Z; Wolf, J Stuart; Lotan, Yair; Remzi, Mesut; Margulis, Vitaly; Wood, Christopher G; Montorsi, Francesco; Roscigno, Marco; Kikuchi, Eiji; Zigeuner, Richard; Langner, Cord; Bolenz, Christian; Koppie, Theresa M; Raman, Jay D; Fernández, Mario; Karakiewizc, Pierre; Capitanio, Umberto; Bensalah, Karim; Patard, Jean-Jacques; Shariat, Shahrokh F Article Seminars in Urologic Oncology (2012)
Long-Term Impact of Arsenic in Drinking Water on Bladder Cancer Health Care and Mortality Rates 20 Years After End of Exposure Fernández M.I.; Lopez J.F.; Vivaldi B.; Coz F. Article ISI SCOPUS Journal of Urology (2012)
The role of FISH and cytology in upper urinary tract surveillance after radical cystectomy for bladder cancer. Fernández, Mario I; Parikh, Sahil; Grossman, H Barton; Katz, Ruth; Matin, Surena F; Dinney, Colin P N; Kamat, Ashish M Article Seminars in Urologic Oncology (2012)
Additive antitumoral effect of interleukin-12 gene therapy and chemotherapy in the treatment of urothelial bladder cancer in vitro and in vivo Liu, WP; Cao, YW; Fernandez, MI; Niu, HT; Xiu, YC Article INTERNATIONAL UROLOGY AND NEPHROLOGY (2011)
Postoperative morbidity of tubeless versus conventional percutaneous nephrolithotomy: a prospective comparative study Marchant F.; Recabal, P; Fernandez, MI; Osorio F.; Benavides J. Article UROLOGICAL RESEARCH (2011)
Single-Session Extracorporeal Shock Wave Lithotripsy for Urinary Calculi: Factors Predicting Success after Three Weeks of Follow-Up Vivaldi, B; Fernandez, MI; Lopez, JF; Fuentes F.; Urzúa, C; Krebs, A; Domenech, A; Figueroa, PA; Pizzi, P; Westendarp M.; Zambrano, N; Castro M.; Coz, LF Article ACTAS UROLOGICAS ESPANOLAS (2011)
Impact of tumor location on prognosis for patients with upper tract urothelial carcinoma managed by radical nephroureterectomy. Raman, Jay D; Ng, Casey K; Scherr, Douglas S; Margulis, Vitaly; Lotan, Yair; Bensalah, Karim; Patard, Jean-Jacques; Kikuchi, Eiji; Montorsi, Francesco; Zigeuner, Richard; Weizer, Alon; Bolenz, Christian; Koppie, Theresa M; Isbarn, Hendrik; Jeldres, Claudio; Kabbani, Wareef; Remzi, Mesut; Waldert, Mathias; Wood, Christopher G; Roscigno, Marco; Oya, Mototsuga; Langner, Cord; Wolf, J Stuart; Ströbel, Philipp; Fernández, Mario; Karakiewcz, Pierre; Shariat, Shahrokh F Article European urology (2010)
Tumour Necrosis Is an Indicator of Aggressive Biology in Patients with Urothelial Carcinoma of the Upper Urinary Tract Zigeuner, R; Shariat, SF; Margulis, V; Karakiewicz, PI; Roscigno, M; Weizer, A; Kikuchi, E; Remzi, M; Raman, JD; Bolenz, C; Bensalah, K; Capitanio, U; Koppie, TM; Kassouf, W; Sircar, K; Patard, JJ; Fernandez, MI; Wood, CG; Montorsi, F; Strobel, P; Wheat, JC; Haitel, A; Oya, M; Guo, CC; Ng, C; Chade, DC; Sagalowsky, A; Langner, C Article EUROPEAN UROLOGY (2010)
Adjuvant Chemotherapy for High Risk Upper Tract Urothelial Carcinoma: Results From the Upper Tract Urothelial Carcinoma Collaboration Hellenthal, NJ; Shariat, SF; Margulis, V; Karakiewicz, PI; Roscigno, M; Bolenz, C; Remzi, M; Weizer, A; Zigeuner, R; Bensalah, K; Ng, CK; Raman, JD; Kikuchi, E; Montorsi, F; Oya, M; Wood, CG; Fernandez, M.; Evans, CP; Koppie, TM Article ISI SCOPUS JOURNAL OF UROLOGY (2009)
Assessment of the Minimum Number of Lymph Nodes Needed to Detect Lymph Node Invasion at Radical Nephroureterectomy in Patients With Upper Tract Urothelial Cancer Roscigno, M; Shariat, SF; Freschi, M; Margulis, V; Karakiewizc, P; Suardi, N; Remzi, M; Zigeuner, R; Bolenz, C; Kikuchi, E; Weizer, A; Bensalah, K; Sagalowsky, A; Koppie, TM; Raman, J; Fernandez, M.; Strobel P.; Kabbani, W; Langner, C; Wheat, J; Guo, CC; Kassouf W.; Haitel, A; Wood, CG; Montorsi, F Article ISI SCOPUS UROLOGY (2009)
Comparison of oncologic outcomes for open and laparoscopic nephroureterectomy: a multi-institutional analysis of 1249 cases. Capitanio, Umberto; Shariat, Shahrokh F; Isbarn, Hendrik; Weizer, Alon; Remzi, Mesut; Roscigno, Marco; Kikuchi, Eiji; Raman, Jay D; Bolenz, Christian; Bensalah, Karim; Koppie, Theresa M; Kassouf, Wassim; Fernández, Mario I; Ströbel, Philipp; Wheat, Jeffrey; Zigeuner, Richard; Langner, Cord; Waldert, Matthias; Oya, Mototsugu; Guo, Charles C; Ng, Casey; Montorsi, Francesco; Wood, Christopher G; Margulis, Vitaly; Karakiewicz, Pierre I Article European urology (2009)
Evidence-based Sex-related Outcomes After Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: Results of Large Multicenter Study Fernandez, MI; Shariat, SF; Margulis, V; Bolenz, C; Montorsi, F; Suardi, N; Remzi, M; Wood, CG; Roscigno, M; Kikuchi, E; Oya, M; Zigeuner, R; Langner, C; Weizer, A; Lotan, Y; Koppie, TM; Raman, JD; Karakiewizc, P; Bensalah, K; Schultz, M; Bernier, P Article UROLOGY (2009)
Impact of Lymph Node Dissection on Cancer Specific Survival in Patients With Upper Tract Urothelial Carcinoma Treated With Radical Nephroureterectomy Roscigno, M; Shariat, SF; Margulis, V; Karakiewicz, P; Remzi, M; Kikuchi, E; Langner, C; Lotan, Y; Weizer, A; Bensalah, K; Raman, JD; Bolenz, C; Guo, CC; Wood, CG; Zigeuner, R; Wheat, J; Kabbani, W; Koppie, TM; Ng, CK; Suardi, N; Bertini, R; Fernandez, MI; Mikami, S; Isida, M; Michel, MS; Montorsi, F Article JOURNAL OF UROLOGY (2009)
Lymphangiogenesis occurs in upper tract urothelial carcinoma and correlates with lymphatic tumour dissemination and poor prognosis Bolenz, C; Fernandez, MI; Trojan, L; Hoffmann, K; Herrmann, E; Steidler, A; Weiss, C; Strobel, P; Alken, P; Michel, MS Article BJU INTERNATIONAL (2009)
Lymphovascular Invasion Predicts Clinical Outcomes in Patients With Node-Negative Upper Tract Urothelial Carcinoma Kikuchi, E; Margulis, V; Karakiewicz, PI; Roscigno, M; Mikami, S; Lotan, Y; Remzi, M; Bolenz, C; Langner, C; Weizer, A; Montorsi, F; Bensalah, K; Koppie, TM; Fernandez, MI; Raman, JD; Kassouf, W; Wood, CG; Suardi, N; Oya, M; Shariat, SF Article JOURNAL OF CLINICAL ONCOLOGY (2009)
Risk stratification of patients with nodal involvement in upper tract urothelial carcinoma: value of lymph-node density Bolenz, C; Shariat, SF; Fernandez, MI; Margulis, V; Lotan, Y; Karakiewicz, P; Remzi, M; Kikuchi, E; Zigeuner, R; Weizer, A; Montorsi, F; Bensalah, K; Wood, CG; Roscigno, M; Langner, C; Koppie, TM; Raman, JD; Mikami, S; Michel, MS; Strobel, P Article BJU INTERNATIONAL (2009)
The extent of lymphadenectomy seems to be associated with better survival in patients with nonmetastatic upper-tract urothelial carcinoma: how many lymph nodes should be removed? Roscigno, Marco; Shariat, Shahrokh F; Margulis, Vitaly; Karakiewicz, Pierre; Remzi, Mesut; Kikuchi, Eiji; Zigeuner, Richard; Weizer, Alon; Sagalowsky, Arthur; Bensalah, Karim; Raman, Jay D; Bolenz, Christian; Kassou, Wassim; Koppie, Theresa M; Wood, Christopher G; Wheat, Jeffrey; Langner, Cord; Ng, Casey K; Capitanio, Umberto; Bertini, Roberto; Fernández, Mario I; Mikami, Shuji; Isida, Masaru; Ströbel, Philipp; Montorsi, Francesco Article European urology (2009)
The role of lymphangiogenesis in lymphatic tumour spread of urological cancers. Bolenz, Christian; Fernández, Mario I; Tilki, Derya; Herrmann, Edwin; Heinzelbecker, Julia; Ergün, Süleyman; Ströbel, Philipp; Reich, Oliver; Michel, Maurice S; Trojan, Lutz Article BJU international (2009)
Topical Chemotherapy in Human Urothelial Carcinoma Explants: A Novel Translational Tool for Preclinical Evaluation of Experimental Intravesical Therapies Bolenz, C; Ikinger, EM; Strobel, P; Trojan, L; Steidler, A; Fernandez, MI; Honeck, P; Gabriel, U; Weiss, C; Grobholz, R; Alken, P; Michel, MS Article EUROPEAN UROLOGY (2009)
Tumour architecture is an independent predictor of outcomes after nephroureterectomy: a multi-institutional analysis of 1363 patients. Remzi, Mesut; Haitel, Andrea; Margulis, Vitaly; Karakiewicz, Pierre; Karakiewizc, Pierre; Montorsi, Francesco; Kikuchi, Eiji; Zigeuner, Richard; Weizer, Alon; Bolenz, Christian; Bensalah, Karim; Suardi, Nazareno; Raman, Jay D; Lotan, Yair; Waldert, Matthias; Ng, Casey K; Fernández, Mario; Koppie, Theresa M; Ströbel, Philipp; Kabbani, Wareef; Murai, Masaru; Langner, Cord; Roscigno, Marco; Wheat, Jeffrey; Guo, Charles C; Wood, Christopher G; Shariat, Shahrokh F Article BJU international (2009)
Lymphovascular invasion and pathologic tumor stage are significant outcome predictors for patients with upper tract urothelial carcinoma Bolenz, C; Fernandez, MI; Trojan, L; Herrmann, E; Becker A.; Weiss, C; Alken, P; Strobel, P; Michel, MS Article UROLOGY (2008)
Prognostic implications of lymphangiogenesis in muscle-invasive transitional cell carcinoma of the bladder. Fernández, Mario I; Bolenz, Christian; Trojan, Lutz; Steidler, Annette; Weiss, Christel; Alken, Peter; Grobholz, Rainer; Michel, Maurice Stephan Article European urology (2008)
Newly developed mini-endoscope for diagnosis and follow-up of orthotopic bladder transitional-cell carcinoma in vivo. Bolenz, Christian; Wenzel, Melanie; Cao, Yanwei; Trojan, Lutz; Häcker, Axel; Arancibia, Mario Fernández; Alken, Peter; Michel, Maurice Stephan Article Journal of endourology / Endourological Society (2007)
The modern management of upper tract urothelial cancer: surgical treatment. Arancibia, Mario Fernández; Bolenz, Christian; Michel, Maurice-Stephan; Keeley, Francis X; Alken, Peter Article BJU international (2007)
Intravesical mitomycin C for superficial transitional cell carcinoma. Bolenz, Christian; Cao, Yanwei; Arancibia, Mario Fernández; Trojan, Lutz; Alken, Peter; Michel, Maurice Stephan Article Expert review of anticancer therapy (2006)
[Coronary artery surgery in the first 24 hours after myocardial infarction]. Villavicencio, Mauricio; Garayar, Bernardita; Irarrázaval, Manuel José; Morán, Sergio; Zalaquett, Ricardo; Becker, Pedro; Maturana, Gustavo; Corbalán, Ramón; Castro, Pablo; Fernández, Mario Article Revista espanÌƒola de cardiologiÌ�a (2002)
Coronary artery surgery in the first 24 hours after myocardial infarction Villavicencio M.; Garayar B.; Irarrazaval, MJ; Moran S.; Zalaquett R.; Becker P.; Maturana G.; Corbalan, R; Castro P. ; Fernandez, M. Article ISI SCOPUS REVISTA ESPANOLA DE CARDIOLOGIA (2002)
Coronary artery bypass grafting reoperation. A 16 years retrospective analysis Irarrazaval, MJ; Moran S.; Zalaquett R.; Becker P.; Maturana G.; Fernandez, M.; Villavicencio M.; Garayar B.; Braun, S; Castro P. Article ISI REVISTA MEDICA DE CHILE (2001)
[Diagnosis and therapeutic options for prolonged erection and priapism: up-date review]. Fernández Arancibia, M I; Martínez Portillo, F J; Musial, A; Spahn, M; Jünemann, K P; Alken, P Article Archivos espanÌƒoles de urologiÌ�a (2000)
[Influence of Professor Alexander von Lichtenberg (Berlin) on Spanish urology of the 20th century]. Martínez Portillo, F J; Fernández Arancibia, M I; Jünemann, K P; Alken, P Article Archivos espanÌƒoles de urologiÌ�a (0)


Determinantes genéticas asociadas al pronóstico clínico de pacientes con cáncer de vejiga con exposición a arsénico Fernandez, Mario I.; Encina, Gonzalo Proyecto Análisis en curso (2019)
Clinical Significance of PD-L1 Protein expression and Tumor Infiltrating Lymphocytes in Early Stage Urothelial Bladder Carcinoma” Fernandez, Mario I.; Schalper, Kurt Proyecto Manuscript in process (2015)
DESARROLLO DE LÍNEAS CELULARES DE CÁNCER DE VEJIGA RELACIONADO A EXPOSICIÓN A ARSÉNICO Fernandez, Mario I.; Ziegler, Annemarie Proyecto Etapa previa de postulación actual (2015)
ASSESSMENT OF A PANEL OF MOLECULAR BIOMARKERS AS PREDICTORS OF TUMOR RECURRENCE AND PROGRESSION IN NON-MUSCLE INVASIVE BLADDER CANCER Fernandez, Mario I.; Schultz, Marcela Proyecto Manuscript published in Revista Chilena de Urología 84 (1); 55-65, 2019 (2014)


What Is the Significance of Variant Histology in Urothelial Carcinoma? Lobo N.; Shariat S.F.; Guo C.C.; Fernandez M.A.; Kassouf W.; Choudhury A.; Gao J.; Williams, S. B.; Galsky M.D.; Taylor, J. A.; III; Roupret M.; Kamat A.M. Review ISI SCOPUS European Urology Focus (2019)