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Juan Cristóbal Opazo Carvallo

Profesor Titular

Universidad San Sebastián

Valdivia, Chile

Líneas de Investigación


Medicina Evolutiva, Evolucion Molecular, Genomica Evolutiva

Educación

  •  Evolucion molecular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2003
  •  Biologia, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1997

Experiencia Académica

  •   Inverstigador Postdoctoral Full Time

    WAYNE STATE UNIVERSITY

    Medicine

    Detroit, Estados Unidos

    2004 - 2007

  •   Investigador Postdoctoral Full Time

    UNIVERSITY OF NEBRASKA - LINCOLN

    Biological Sciences

    Lincoln, Estados Unidos

    2007 - 2008

  •   Profesor Asistente Full Time

    UNIVERSIDAD AUSTRAL DE CHILE

    de Ciencias

    Valdivia, Chile

    2008 - 2012

  •   Profesor Asociado Full Time

    UNIVERSIDAD AUSTRAL DE CHILE

    de Ciencias

    Valdivia, Chile

    2012 - 2018

  •   Profesor Titular Full Time

    UNIVERSIDAD AUSTRAL DE CHILE

    de Ciencias

    Valdivia, Chile

    2018 - 2023

  •   Profesor Titular Full Time

    Universidad San Sebastián

    Faculta de Medicina y Ciencia

    Valdivia, Chile

    2023 - A la fecha

Experiencia Profesional

  •   Investigador Adjunto Part Time

    Nucleo Milenio de Enfermedades Asociadas a Canales Ionico

    Santiago, Chile

    2019 - A la fecha

Formación de Capital Humano


Nataly Venegas, Doctorado en Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile (2022)

Daniela Tejada, Doctorado en Ciencias mencion Ecología y Evolución, Facultad de Ciencias, Universidad Austral de Chile (2020)

Jessica Toloza, Doctorado en Ciencias mencion Ecología y Evolución, Facultad de Ciencias, Universidad Austral de Chile (2014)

Mariana F. Nery, Doctorado en Ciencias mencion Ecología y Evolución, Facultad de Ciencias, Universidad Austral de Chile (2012)

Juan Diego Gaitan-Espitia, Doctorado en Ciencias mencion Ecología y Evolución, Facultad de Ciencias, Universidad Austral de Chile (2012)

Pablo Gonzalez, Magister en Ciencias mencion Genetica, Facultad de Ciencias, Universidad Austral de Chile (2018)

Kattina Zavala, Magister en Ciencias mencion Genetica, Facultad de Ciencias, Universidad Austral de Chile (2013)

Valeria Varas, Magister en Ciencias mencion Genetica, Facultad de Ciencias, Universidad Austral de Chile (2014)

Jose Ignacio Arroyo, Licenciatura en Ciencias Biologicas, Facultad de Ciencias, Universidad Austral de Chile (2010)

Dimar Gonzalez, Ingenieria Civil Informatica, Facultad de ingenieria, Universidad Austral de Chile (2012)

Hector Cespedes, Licenciatura en Ciencias Biologicas, Facultad de Ciencias, Universidad Austral de Chile (2017)


Premios y Distinciones

  •   Oliver Pearson Award

    American Society of Mammalogists

    Estados Unidos, 2008

    Premio al científico joven otorgado por la Asociación Americana de Mastozoologia.

  •   Premio al Científico Joven mas destacado de Chile

    SOCIEDAD DE BIOLOGIA DE CHILE

    Chile, 2012

    Premio al cientifico joven mas destacado de Chile otorgado por la Sociedad de Biología de Chile y el Grupo BIOS

  •   Luksic Visiting Scholar

    HARVARD UNIVERSITY

    Estados Unidos, 2016

    Beca para una estadia de 6 meses en la Universidad de Harvard.


 

Article (76)

How Many Sirtuin Genes Are Out There? Evolution of Sirtuin Genes in Vertebrates With a Description of a New Family Member
Discovery of the world's highest-dwelling mammal
Evolutionary analyses reveal independent origins of gene repertoires and structural motifs associated to fast inactivation in calcium-selective TRPV channels
Integrative taxonomy of the southernmost tucu-tucus in the world: differentiation of the nominal forms associated with Ctenomys magellanicus Bennett, 1836 (Rodentia, Hystricomorpha, Ctenomyidae)
Evolution of nodal and nodal-related genes and the putative composition of the heterodimers that trigger the nodal pathway in vertebrates
Suggestions to improve the Chilean regulation of manipulation of terrestrial vertebrates in natural populations in the context of scientific research
The Reprimo gene family member, reprimo-like (rprml), is required for blood development in embryonic zebrafish
An association between differential expression and genetic divergence in the Patagonian olive mouse (Abrothrix olivacea).
Evolution of dopamine receptors=> phylogenetic evidence suggests a later origin of the DRD and DRD dopamine receptor gene lineages.
Expression of in the Olfactory System of Embryonic Zebrafish ().
Gene Turnover and Diversification of the α- and β-Globin Gene Families in Sauropsid Vertebrates.
Phylogenetic evidence for independent origins of GDF1 and GDF3 genes in anurans and mammals.
The Reprimo Gene Family=> A Novel Gene Lineage in Gastric Cancer with Tumor Suppressive Properties.
The Reprimo Gene Family=> A Novel Gene Lineage in Gastric Cancer with Tumor Suppressive Properties.
Evolution of gremlin 2 in cetartiodactyl mammals=> gene loss coincides with lack of upper jaw incisors in ruminants.
Evolution of the α2-adrenoreceptors in vertebrates=> ADRA2D is absent in mammals and crocodiles.
Evolution of the β-adrenoreceptors in vertebrates.
Progressive erosion of the Relaxinl gene in bovids
Reprimo tissue-specific expression pattern is conserved between zebrafish and human.
Evolutionary history of the reprimo tumor suppressor gene family in vertebrates with a description of a new reprimo gene lineage
Ancient Duplications and Expression Divergence in the Globin Gene Superfamily of Vertebrates: Insights from the Elephant Shark Genome and Transcriptome
Characterization of the Kidney Transcriptome of the Long-Haired Mouse Abrothrix hirta (Rodentia, Sigmodontinae) and Comparison with That of the Olive Mouse A. olivacea
Gene turnover in the avian globin gene families and evolutionary changes in hemoglobin isoform expression.
Lineage-Specific Expansion of the Chalcone Synthase Gene Family in Rosids
The circadian clock of teleost fish=> a comparative analysis reveals distinct fates for duplicated genes.
Characterization of the kidney transcriptome of the South American olive mouse Abrothrix olivacea
Comparative genomics reveals insights into avian genome evolution and adaptation
Evolution of the Relaxin/Insulin-Like Gene Family in Anthropoid Primates
Gene turnover in the avian globin gene families and evolutionary changes in hemoglobin isoform expression
Increased rate of hair keratin gene loss in the cetacean lineage
Rodent diversity in South America: transitioning into the genomics era
The Circadian Clock of Teleost Fish: A Comparative Analysis Reveals Distinct Fates for Duplicated Genes
Three crocodilian genomes reveal ancestral patterns of evolution among archosaurs
Accelerated Evolutionary Rate of the Myoglobin Gene in Long-Diving Whales
Genomic Organization and Differential Signature of Positive Selection in the Alpha and Beta Globin Gene Clusters in Two Cetacean Species
How to Make a Dolphin: Molecular Signature of Positive Selection in Cetacean Genome
The Complete Mitochondrial Genome of the Land Snail Cornu aspersum (Helicidae: Mollusca): Intra-Specific Divergence of Protein-Coding Genes and Phylogenetic Considerations within Euthyneura
Whole-Genome Duplication and the Functional Diversification of Teleost Fish Hemoglobins
A proposal for the common names for species of Chiropotes (Pitheciinae: Primates)
A proposal for the common names for species of Chiropotes (Pitheciinae: Primates)
Evolution of the Globin Gene Family in Deuterostomes: Lineage-Specific Patterns of Diversification and Attrition
Gene Duplication and Positive Selection Explains Unusual Physiological Roles of the Relaxin Gene in the European Rabbit
Gene turnover and differential retention in the relaxin/insulin-like gene family in primates
INSL4 Pseudogenes Help Define the Relaxin Family Repertoire in the Common Ancestor of Placental Mammals
Resolution of the laurasiatherian phylogeny: Evidence from genomic data
Whole-Genome Duplications Spurred the Functional Diversification of the Globin Gene Superfamily in Vertebrates
Developmental regulation of hemoglobin synthesis in the green anole lizard Anolis carolinensis
Differential Loss and Retention of Cytoglobin, Myoglobin, and Globin-E during the Radiation of Vertebrates
Evolution of the Relaxin/Insulin-like Gene Family in Placental Mammals: Implications for Its Early Evolution
Silencing, Positive Selection and Parallel Evolution: Busy History of Primate Cytochromes c
Gene cooption and convergent evolution of oxygen transport hemoglobins in jawed and jawless vertebrates
Lineage-Specific Patterns of Functional Diversification in the alpha- and beta-Globin Gene Families of Tetrapod Vertebrates
A fully resolved genus level phylogeny of neotropical primates (Platyrrhini)
Molecular evolution of cytochrome b in high- and low-altitude deer mice (genus Peromyscus)
Origin and Ascendancy of a Chimeric Fusion Gene: The beta/delta-Globin Gene of Paenungulate Mammals
Adaptive functional divergence among triplicated a-globin genes in rodents
Differential loss of embryonic globin genes during the radiation of placental mammals
Distinct genomic signatures of adaptation in pre- and postnatal environments during human evolution
Genomic evidence for independent origins of β-like globin genes in monotremes and therian mammals
Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates
New genes originated via multiple recombinational pathways in the β-globin gene family of rodents
Phylogeography of the subterranean rodent Spalacopus cyanus (Caviomorpha, Octodontidae)
Rapid rates of lineage-specific gene duplication and deletion in the a-globin gene family
The human progesterone receptor shows evidence of adaptive evolution associated with its ability to act as a transcription factor
Complex signatures of selection and gene conversion in the duplicated globin genes of house mice
Genomics, biogeography, and the diversification of placental mammals
Phylogenetic relationships and divergence times among New World monkeys (Platyrrhini, Primates)
A molecular timescale for caviomorph rodents (Mammalia, Hystricognathi)
Adaptive evolution of the insulin gene in caviomorph rodents
Cell size and basal metabolic rate in hummingbirds
Rapid electrostatic evolution at the binding site for cytochrome c on cytochrome c oxidase in anthropoid primates
Blood glucose concentration in caviomorph rodents
Phenotypic flexibility in a novel thermal environment: Phylogenetic inertia in thermogenic capacity and evolutionary adaptation in organ size
Thermal acclimation and non-shivering thermogenesis in three species of South American rodents: a comparison between arid and mesic habitats
Arousal from torpor in the chilean mouse-opposum (Thylamys elegans): does non-shivering thermogenesis play a role?
Thermal acclimation, maximum metabolic rate, and nonshivering thermogenesis of Phyllotis xanthopygus (rodentia) in the Andes mountains

Proyecto (10)

GENOMIC SIGNATURE OF A SUBTERRANEAN WAY OF LIFE
GENOMIC RESPONSES ALONG AN ARIDITY GRADIENT=> ASSESSMENT OF GENE EXPRESSION PROFILES AND POPULATION GENOMIC STRUCTURE OF TWO RODENT SPECIES
Intra and interspecific gene copy number variation in the alpha-globin gene cluster of birds
INTRA AND INTERSPECIFIC GENE COPY NUMBER VARIATION IN THE ALPHA-GLOBIN GENE CLUSTER OF BIRDS
Evolutionary responses of southern South American rodents to precipitation gradients and biogeographical history
EVOLUTIONARY RESPONSES OF SOUTHERN SOUTH AMERICAN RODENTS TO PRECIPITATION GRADIENTS AND BIOGEOGRAPHICAL HISTORY
Natural selection, quantitative genetics and evolutionary physiology=> lessons from a cosmopolitan species, the land snail Helix aspersa
NATURAL SELECTION, QUANTITATIVE GENETICS AND EVOLUTIONARY PHYSIOLOGY=> LESSONS FROM A COSMOPOLITAN SPECIES, THE LAND SNAIL HELIX ASPERSA
Evolution of the insulin gene family=> a genomic approach
EVOLUTION OF THE INSULIN GENE FAMILY IN MAMMALS=> A GENOMIC APPROACH

Review (3)

Gene duplication, genome duplication, and the functional diversification of vertebrate globins
Phylogenetic Diversification of the Globin Gene Superfamily in Chordates
Using new tools to solve an old problem: the evolution of endothermy in vertebrates
49
Juan Opazo

Profesor Titular

Facultad de Medicina y Ciencia

Universidad San Sebastián

Valdivia, Chile

3
Jessica Toloza

Profesor Titular

Fisiología

UNIVERSIDAD SANTO TOMAS

Valdivia, Chile

3
Guillermo D'Elia

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

2
Roberto Nespolo

Titular Professor

Instituto de Ciencias Ambientales y Evolutivas

Universidad Austral de Chile

Valdivia, Chile

2
Ignacio Wichmann

Assitant Professor

Obstetrics

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Marco Mendez

Full Professor

DEPARTAMENTO CIENCIAS ECOLÓGICAS, FACULTAD DE CIENCIAS,

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Francisco Morera

Assistant Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Enrique Rodriguez

Assistant Professor

DEPARTAMENTO DE ZOOLOGIA, FACULTAD DE CS NATURALES Y OCEANOGRAFICAS, UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Karina Cáceres

Docente

univ

Santiago, Chile

1
Francisco Fonturbel

Profesor adjunto

Instituto de Biología

Pontificia Universidad Católica de Valparaíso

Valparaiso, Chile

1
Jaime Rau

Full professor

Ciencias Biológicas y Biodiversidad

Universidad de Los Lagos

Osorno, Chile

1
ALEJANDRO CORVALAN

Principal Investigator

Hematology and Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Claudio Correa

LABORATORIO DE BIOLOGÍA EVOLUTIVA

Santiago, Chile

1
Fabian Jaksic

Full Profesor

Ecology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
German Reig

Investigador Principal

Centro integrativo de Biología y Química Aplicada

Universidad Bernardo O'Higgins

Santiago, Chile

1
Miguel Concha

Full Professor

Anatomy and Developmental Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Warren Johnson

Research Scientist

SCBI

Smithsonian Institution

Frederick, Estados Unidos

1
Mauricio Soto

Director

Instituto de Ciencias Ambientales y Evolutivas

INSITUTO DE CIENCIAS AMBIENTALES Y EVOLUTIVAS, UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Leonardo Bacigalupe

Associate Professor

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Juan Gaitán

Postdoctoral Fellow

Oceans and Atmosphere

CSIRO - Commonwealth Scientific and Industrial Research Organisation

Hobart, Australia

1
GONZALO MARDONES

Associate Professor

Medicine

Universidad San Sebastián

Valdivia, Chile

1
PATRICIA BURGOS

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Francisco Bozinovic

Full professor

Ecology

Pontifical Catholic University of Chile

Santiago, Chile