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Carolina Isabel Rojas Pérez

Docente

Universidad de Los Andes

Santiago, Chile

Respuesta osteo-inmune periodontal, rol inmunomodulador de las vesículas extracelulares derivadas de los linfocitos T reguladores y el rol de las VEs periodontales derivadas del hospedero y bacterias periodontales en el desarrollo de Neuroinflamación

Cirujana Dentista, UNIVERSIDAD DE CHILE. Chile, 2018
Immunology, UNIVERSIDAD DE CHILE. Chile, 2023

Académico Part Time

UNIVERSIDAD DE LOS ANDES

Odontología

Santiago, Chile

2024 - A la fecha

2024- Alfredo Sierra
Asesora Experta, Doctorado en Ciencias Odontológicas
Título: "EFECTO DE INTERLEUQUINA-35 EN EL BALANCE TH17/TREG Y EL HUESO ALVEOLAR PERIRRADICULAR EN LESIONES PERIAPICALES EXPERIMENTALES DE ORIGEN ENDODÓNTICO"
Facultad de Odontología, Universidad de Chile.

2024- Joaquín Valenzuela
Docente guía, Programa de Inmersión en la Investigación
Título: "Efecto de la diseminación sistémica de vesículas de membrana externa (OMVs) derivadas de F. nucleatum y P. gingivalis en la tolerancia a la glucosa y el embarazo"
Facultad de Medicina, Universidad de Los Andes.

2024- Benjamín Mora
Co-tutora, Tesis de Pregrado
Título: " CARACTERIZACIÓN DE LA CANTIDAD DE PROTEÍNAS, RNA Y VESÍCULAS EXTRACELULARES OBTENIDAS DEL FLUIDO GINGIVAL CREVICULAR DE PACIENTES CON PERIODONTITIS Y SUJETOS SANOS: ESTUDIO EXPERIMENTAL"
Facultad de Odontología, Universidad de Los Andes.

2024- Gonzalo Parra
Tesis de Postítulo, Especialidad de Periodoncia
Título: "Efecto de vesículas extracelulares periodontales sobre la polarización de microglías"
Facultad de Odontología, Universidad de Los Andes.

2024-Sofía Woldarsky y Clarita Lira
Co-tutora, Tesina.
Título: "Efecto del tratamiento antigingipaínas de Porphyromonas gingivalis en la presencia de los depósitos de beta-amiloide y Tau asociados a la enfermedad de
Alzheimer".
Facultad de Odontología, Universidad de Los Andes.

[2024] "Ciencia para el futuro" Monitor de “12º Encuentro Anual Biología ABSCH 2024”
[2023] “Ciencia para el Futuro”, asesora científica en "Ciencia Aventura; Explorando el desarrollo embrionario". Laboratorio de biología de la reproducción, Centro de Investigación e Innovación Biomédica (CIIB), Universidad de Los Andes, SCL.
[2022] Asesora en feria científica, Colegio Antilhue, La Florida, SCL.
[2020-2021] “Workshop Imaginando juntos el futuro de la ciencia”. Projecto PIA SOC180039 “Producción de Conocimiento en el Chile contemporáneo”.
[2019] Asesora científica en el programa “Protagonistas de la Ciencia”, proyecto EXPLORA ANID, SCL.
[2019] Talleres y Workshop "Arte y Ciencia" de la Fundación Arte+Ciencia, SCL.
[2017] Campaña de educación en Cáncer oral “Besa la Vida, Cuida tu boca”. Facultad de Odontología, Universidad de Chile.
[2015-2017] Trabajo comunitario voluntario. Comuna de Yerbas Buenas y Casablanca, Chile. Facultad de Odontología, Universidad de Chile.
[2015] “Sonrisas de los nietos de Bello”. Monitora en el día de prevención y educación en salud oral para niños, funcionarios y académicos. Facultad de Odontología, Universidad de Chile.

The Histochemical Society Travel Award

The Histochemical Society

México, 2019

Travel Award para asistir y presentar en el "LAMIG-SMI Mucosal Immunology Symposium. Mexico City, Mexico.
Trainee Award for poster presentation

Society for Leukocyte Biology

Chile, 2019

Society for Leukocyte Biology Trainee Award for poster presentation on the LAMIG-SMI Mucosal Immunology Symposium. Mexico City, Mexico.
Chilean Division Hatton Basic Science Research Distinction for best oral presentation

International Association for Dental Research (IADR)- Chilean Division

Chile, 2019

Chilean Division Hatton Basic Science Research Distinction for best oral presentation: XXXI Annual Meeting of International Association for Dental Research. Santiago, Chile.
2020 IADR Unilever Hatton Award Competitor

International Association for Dental Research (IADR)

Estados Unidos, 2020

“2020 IADR Unilever Hatton Award Competitor”. IADR Centennial, Washington, D.C, USA.
Chilean Division Hatton Basic Science Research Distinction for oral presentation

International Association for Dental Research- Chilean Division

Chile, 2021

Chilean Division Hatton Basic Science Research Distinction for oral presentation. XXXIII Annual Meeting of International Association for Dental Research. SCL.
LAMIG-SMI Travel Award Scholarship

Latin American Immunology Group (LAMIG) and Society of Mucosal Immunology (SMI)

Cuba, 2022

LAMIG-SMI Travel Award Scholarship to attend and present at the “13th Latin American and Caribbean Congress of Immunology ALACI 22/ 7th Congress of Cuban Society for Immunology”. Varadero, Cuba.
First Place in the Senior Basic Science Category- IADR Hatton Competition.

International Association for Dental Research

China, 2022

First Place in the Senior Basic Science Category- IADR Hatton Competition. “100th General Session & Exhibition of the IADR/ 5th Meeting of the IADR Asia Pacific Region.”. Chengdu, China.
PhD student scholarship

Sociedad de Biología Celular de Chile (SBCCh)

Chile

Ph.D. student scholarship to attend and present at the XXXIV Chilean Cell Biology Society (SBCCh) Annual Meeting. Puerto Varas, Chile.
Medalla Hermann Niemeyer

Sociedad de Bioquímica y Biología Molecular (SBBMCh)

Chile, 2022

Hermann Niemeyer Medal. Recognition for excellence and scientific career awarded by the Chilean Society of Biochemistry and Molecular Biology (SBBMCh).
Premio International Association for Dental Research (IADR) Chile-ASOCHIN

Internaional Association for Dental Research (IADR)-Asociación Chilena de Inmunología (ASOCHIN)

Chile, 2022

Premio International Association for Dental Research (IADR) Chile-ASOCHIN
Best poster presentation in Mucosal Immunology Category

Asociación Chilena de Inmunología (ASOCHIN)

Chile, 2022

Best poster presentation in Mucosal Immunology Category at 5th Annual Meeting ASOCHIN.
IUIS Travel Grant

International Union of Immunology Societies (IUIS)

Suráfrica, 2023

IUIS Travel Grant to attend and present at the 18th IUIS International Congress of Immunology 2023 in Cape Town, South Africa.
Scholarship

International Union of Immunological Societies (IUIS) y Sociedad Mexicana de Inmunología (SMI)

México, 2023

Full scholarship granted by the International Union of Immunological Societies (IUIS)- Sociedad Mexicana de Inmunología (SMI)-Latin American and Caribbean Association of Immunology (ALACI) to attend the Inmuno-Mexico Course 2024 “Mechanisms for Immunotherapies” to be held in Oaxaca, Mexico.
Excelencia académica y profesional

UNIVERSIDAD DE CHILE

Chile, 2024

Premio de Excelencia académica y profesional otorgado a la mejor estudiante de la generación en la ceremonia de graduación de Doctorado.
First prize at Poster presentation

International Union of Immunology Societies (IUIS) y Sociedad Mexicana de Inmunología (SMI)

México, 2024

First prize in the Poster presentation at the IUIS-SMI-ALACI “Mechanisms for Immunotherapies” Course. Oaxaca, Mexico.
Second place for the Best oral presentation

UNIVERSIDAD DEL DESARROLLO

Chile, 2024

Second place for the Best oral presentation at the II Interdisciplinary Postdoctoral Research Symposium, Universidad del Desarrollo. Santiago, Chile.


A micro-CT analysis of radicular dentine thickness in mandibular first premolars presenting C-shaped root canals: Identification of potential danger zones Sierra-Cristancho, Alfredo; Gonzalez-Osuna, Luis; Balanta-Melo, Julian; Cafferata, Emilio A.; Rojas, Carolina; Melgar-Rodriguez, Samanta; Carvajal, Paola; Vernal, Rolando Article ISI INTERNATIONAL ENDODONTIC JOURNAL (2022)
Neuropilin-1 is present on Foxp3+ T regulatory cell-derived small extracellular vesicles and mediates immunity against skin transplantation Campos-Mora, Mauricio; De Solminihac, Javiera; Rojas, Carolina; Padilla, Cristina; Kurte, Monica; Pacheco, Rodrigo; Kaehne, Thilo; Wyneken, Ursula; Pino-Lagos, Karina Article ISI JOURNAL OF EXTRACELLULAR VESICLES (2022)
Senescent CD4(+)CD28(-) T Lymphocytes as a Potential Driver of Th17/Treg Imbalance and Alveolar Bone Resorption during Periodontitis Gonzalez-Osuna, Luis; Sierra-Cristancho, Alfredo; Cafferata, Emilio A.; Melgar-Rodriguez, Samanta; Rojas, Carolina; Carvajal, Paola; Cortez, Cristian; Vernal, Rolando Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Humanized Mouse Models for the Study of Periodontitis: An Opportunity to Elucidate Unresolved Aspects of Its Immunopathogenesis and Analyze New Immunotherapeutic Strategies Rojas, Carolina; Garcia, Michelle P.; Polanco, Alan F.; Gonzalez-Osuna, Luis; Sierra-Cristancho, Alfredo; Melgar-Rodriguez, Samanta; Cafferata, Emilio A.; Vernal, Rolando Article ISI FRONTIERS IN IMMUNOLOGY (2021)
Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells Melgar-Rodriguez, Samanta; Cafferata, Emilio A.; Diaz, Nicolas, I; Pena, Miguel A.; Gonzalez-Osuna, Luis; Rojas, Carolina; Sierra-Cristancho, Alfredo; Cardenas, Angelica M.; Diaz-Zuniga, Jaime; Vernal, Rolando Article ISI MEDIATORS OF INFLAMMATION (2021)
Premature Senescence of T-cells Favors Bone Loss During Osteolytic Diseases. A New Concern in the Osteoimmunology Arena Gonzalez-Osuna, Luis; Sierra-Cristancho, Alfredo; Rojas, Carolina; Cafferata, Emilio A.; Melgar-Rodriguez, Samanta; Cardenas, Angelica M.; Vernal, Rolando Article ISI AGING AND DISEASE (2021)
Interleukin-35 inhibits alveolar bone resorption by modulating the Th17/Treg imbalance during periodontitis Cafferata, Emilio A.; Terraza?Aguirre, Claudia; Barrera, Romina; Faúndez, Nicolás; González, Nicolás; Rojas, Carolina; Melgar?Rodríguez, Samanta; Hernández, Marcela; Carvajal, Paola; Cortez, C.; González, Fermín E.; Covarrubias, Cristian; Vernal, R. Article ISI SCOPUS JOURNAL OF CLINICAL PERIODONTOLOGY (2020)
Regulatory T cell phenotype and anti-osteoclastogenic function in experimental periodontitis Alvarez, Carla; Suliman, Salwa; Almarhoumi, Rawan; Vega, Maria Elena; Rojas, Carolina; Monasterio, Gustavo; Galindo, Mario; Vernal, Rolando; Kantarci, Alpdogan Article ISI SCIENTIFIC REPORTS (2020)
T regulatory cells-derived extracellular vesicles and their contribution to the generation of immune tolerance Rojas, Carolina; Campos-Mora, Mauricio; Carcamo, Ignacio; Villalon, Natalia; Elhusseiny, Ahmed; Contreras-Kallens, Pamina; Refisch, Aaron; Galvez-Jiron, Felipe; Emparan, Ivana; Montoya-Riveros, Andro; Vernal, Rolando; Pino-Lagos, Karina Article ISI JOURNAL OF LEUKOCYTE BIOLOGY (2020)
Capsular-defective Porphyromonas gingivalis mutant strains induce less alveolar bone resorption than W50 wild-type strain due to a decreased Th1/Th17 immune response and less osteoclast activity Monasterio G.; FernÃ¡ndez B.; Castillo F.; Rojas C.; Cafferata E.A.; Rojas L.; Alvarez C.; FernÃ¡ndez A.; HernÃ¡ndez M.; Bravo D.; Vernal R. Article ISI SCOPUS JOURNAL OF PERIODONTOLOGY (2019)
CD4+Foxp3+T Regulatory Cells Promote Transplantation Tolerance by Modulating Effector CD4+T Cells in a Neuropilin-1-Dependent Manner Campos-Mora, Mauricio; Contreras-Kallens, Pamina; Gálvez-Jirón, Felipe; Rojas, Masyelly; Rojas, Carolina; Refisch, Aarón; Cerda, Oscar; Pino-Lagos, Karina Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2019)
IL-22-expressing CD4(+)AhR(+) T lymphocytes are associated with RANKL-mediated alveolar bone resorption during experimental periodontitis Monasterio G.; Budini V.; FernÃ¡ndez B.; Castillo F.; Rojas C.; Alvarez C.; Cafferata E.A.; Vicencio E.; CortÃ©s B.I.; Cortez C.; Vernal R. Article ISI SCOPUS JOURNAL OF PERIODONTAL RESEARCH (2019)
Serotype a of Aggregatibacter actinomycetemcomitans down-regulates the increased serotype b-induced cytokine and chemokine production in dendritic cells Rojas, L; Melgar-Rodriguez, S; Diaz-Zuniga, J; Alvarez, C; Monasterio, G; Rojas, C; Carvajal, P; Vernal, R Article ISI SCOPUS ARCHIVES OF ORAL BIOLOGY (2018)


Exploring the effect of periodontitis-derived extracellular vesicles on microglial polarization and regulatory T cells neuroprotective function impairment in the brain. A possible link between Periodontitis and Neuroinflammation? Carolina Rojas; UNIVERSIDAD DE LOS ANDES Proyecto (2027)
Periodontitis derived vesicles predispose to a diabetic phenotype through beta-cell pancreatic islet dysfunction and derangement in insulin sensitivity in target organs Maria Luisa Mizgier; UNIVERSIDAD DE LOS ANDES Proyecto (2026)
The pathogenic vicious cycle between periodontitis and gestational diabetes mellitus: communication via bacterial translocation and extracellular vesicles chaparro; UNIVERSIDAD DE LOS ANDES Proyecto (2025)
The therapeutic effects of RA-induced Treg-derived extracellular vesicles in periodontitis: Inhibition of alveolar bone resorption and promotion of its formation through the modulation of the periodontal immune response. VERNAL-ASTUDILLO, ROLANDO MARCELO; Universidad de Chile Proyecto (2025)
Brain astrocyte-derived extracellular vesicles promote protective Treg induction in the GALT and restore gut tolerance in stressed rats Ursula Wyneken; UNIVERSIDAD DE LOS ANDES Proyecto (2024)
Small extracellular vesicles obtained from Neuropilin-1+ T regulatory cells as a new tool for the induction of transplantation tolerance Pino-Lagos, Karina; UNIVERSIDAD DE LOS ANDES Proyecto (2019)
Role of IL-35, all-trans retinoic acid, and T regulatory-derived exosomes in inhibiting the tooth-supporting bone resorption during periodontitis through modulation of the Th17/Treg imbalance FONDEF (1181780) Proyecto 2018-2020 Tesista
Neuropilin-1 and IL-33=> two new targets of study to comprehend Foxp3+ regulatory T cells biology in transplantation tolerance FONDECYT (1160347) Proyecto 2016-2019 Tesista
Role of Periodonto-Pathogenic Bacterial Serotypes in Promoting the Alveolar Bone Resorption During Periodontitis Through an Imbalance of Th1/Th17 versus Treg Immune Responses FONDEF (1140904) Proyecto 2014-2018 Tesista


Extracellular Vesicles from Immune Cells: A Biomedical Perspective Moya-Guzman, Maria Jose; de Solminihac, Javiera; Padilla, Cristina; Rojas, Carolina; Pinto, Camila; Himmel, Tomas; Pino-Lagos, Karina Review ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
Crosstalk between Body Microbiota and the Regulation of Immunity Rojas, Carolina; Galvez-Jiron, Felipe; De Solminihac, Javiera; Padilla, Cristina; Carcamo, Ignacio; Villalon, Natalia; Kurte, Monica; Pino-Lagos, Karina Review ISI JOURNAL OF IMMUNOLOGY RESEARCH (2022)
Regulatory T Lymphocytes in Periodontitis: A Translational View Alvarez, C; Rojas, C; Rojas, L; Cafferata, EA; Monasterio, G; Vernal, R Review ISI SCOPUS MEDIATORS OF INFLAMMATION (2018)