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DARWIN RODRIGO SAEZ POBLETE

Estudiante de Doctorado

Universidad Autónoma de Chile

Talca, Chile

Agronomia Nutricion Alimentos saludables Inmunologia Microbiologia

Microbiología, UNIVERSIDAD DE CONCEPCION. Chile, 2014
Biólogo, UNIVERSIDAD DE CONCEPCION. Chile, 2007

Profesor de Catedra Part Time

UNIVERSIDAD SAN SEBASTIAN

Concepcion, Chile

2015 - 2015
Profesor de Catedra Part Time

UNIVERSIDAD SAN SEBASTIAN

Concepcion, Chile

2016 - 2016
Profesor de Catedra Part Time

UNIVERSIDAD SAN SEBASTIAN

Concepcion, Chile

2017 - 2017
Profesor de Catedra Part Time

UNIVERSIDAD SAN SEBASTIAN

Concepcion, Chile

2018 - 2018
Profesor de Catedra Part Time

UNIVERSIDAD SAN SEBASTIAN

Concepcion, Chile

2019 - 2019
Profesor de Catedra Part Time

UNIVERSIDAD SAN SEBASTIAN

Concepcion, Chile

2020 - 2020
Profesor de Catedra Part Time

UNIVERSIDAD DEL DESARROLLO

Concepcion, Chile

2015 - 2015
Profesor de catedra Part Time

UNIVERSIDAD DEL DESARROLLO

Concepcion, Chile

2016 - 2016
Profesor de catedra Part Time

UNIVERSIDAD DEL DESARROLLO

Concepcion, Chile

2017 - 2017
Profesor de catedra Part Time

UNIVERSIDAD DEL DESARROLLO

Concepcion, Chile

2018 - 2018
Profesor de laboratorio Part Time

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

2014 - 2014
Profesor de catedra Part Time

UNIVERSIDAD DE LAS AMERICAS

Concepcion, Chile

2012 - 2013
Profesor ayudante Part Time

UNIVERSIDAD DEL DESARROLLO

Concepcion, Chile

2008 - 2013

Asesor de Biologia Molecular Part Time

Bioingentech

Concepcion, Chile

2006 - 2006


Immunogenicity of a Multi-Epitope DNA Vaccine Encoding Epitopes from Cu-Zn Superoxide Dismutase and Open Reading Frames of Brucella abortus in Mice Escalona E.; Sáez D.; Oñate A. Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2017)
Multivalent Fusion DNA Vaccine against Brucella abortus Gómez L.; Llanos J.; Escalona E.; Sáez D.; Álvarez F.; Molina R.; Flores M.; Oñate A. Article ISI SCOPUS BIOMED RESEARCH INTERNATIONAL (2017)
Mucosal immunization of BALB/c mice with DNA vaccines encoding the SEN1002 and SEN1395 open reading frames of Salmonella enterica serovar Enteritidis induces protective immunity Bello J.; Sáez D; Escalona E; Velozo, P; Santiviago, CA; Contreras, I; Oñate A. Article ISI SCOPUS EPIDEMIOLOGY AND INFECTION (2016)
Vaccination with DNA Encoding Truncated Enterohemorrhagic Escherichia coli (EHEC) Factor for Adherence-1 Gene (efa-1') Confers Protective Immunity to Mice Infected with E. coli O157:H7 Riquelme-Neira R, Rivera A, Sáez D, Fernández P, Osorio G, del Canto F, Salazar JC, Vidal RM, Oñate A. Vaccination with DNA Encoding Truncated Enterohemorrhagic Escherichia coli (EHEC) Factor for Adherence-1 Gene (efa-1') Confers Protective Immunity to Mi Article SCOPUS FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2016)
Use of S-[2,3-Bispalmitoyiloxy-(2R)-Propyl]-R-Cysteinyl-Amido-Monomethoxy Polyethylene Glycol as an Adjuvant Improved Protective Immunity Associated with a DNA Vaccine Encoding Cu, Zn Superoxide Dismutase of Brucella abortus in Mice Retamal-Diaz, A; Riquelme-Neira, R; Sáez D; Rivera A.; Fernández P.; Cabrera, A; Guzmán C; Oñate A. Article ISI SCOPUS CLINICAL AND VACCINE IMMUNOLOGY (2014)
Protective effect of a DNA vaccine containing an open reading frame with homology to an ABC-type transporter present in the genomic island 3 of Brucella abortus in BALB/c mice Riquelme-Neira, R; Retamal-Diaz, A; Acuña F.; Riquelme P.; Rivera A.; Sáez D; Oñate A. Article ISI SCOPUS Vaccine (2013)
Evaluation of protective effect of DNA vaccines encoding the BAB1_0263 and BAB1_0278 open reading frames of Brucella abortus in BALB/c mice Sislema-Egas F.; Cespedes, S; Fernández P.; Retamal-Diaz, A; Sáez D; Oñate A. Article ISI SCOPUS Vaccine (2012)
Oral immunization of mice with recombinant Lactococcus lactis expressing Cu,Zn superoxide dismutase of Brucella abortus triggers protective immunity Sáez D; Fernández P.; Rivera A.; Andrews E.; Oñate A. Article ISI SCOPUS Vaccine (2012)
Clotting, expression and immunogenicity of the translation initiation factor 3 homologue of Brucella abortus Gonzalez, M.; Andrews E.; Folch H.; Sáez D; Cabrera, A; Salgado, P.; Oñate A. Article ISI SCOPUS IMMUNOBIOLOGY (2009)
Vaccination with recombinant Semliki Forest virus particles expressing translation initiation factor 3 of Brucella abortus induces protective immunity in BALB/c mice Cabrera, A; Sáez D; Cespedes, S; Andrews E.; Oñate A. Article ISI SCOPUS IMMUNOBIOLOGY (2009)
Evaluation of Brucella abortus DNA and RNA vaccines expressing Cu-Zn superoxide dismutase (SOD) gene in cattle Sáez D; Guzmán I.; Andrews E.; Cabrera, A; Oñate A. Article ISI SCOPUS VETERINARY MICROBIOLOGY (2008)


Cytotoxic T cells CD4+ against intracellular bacteria model Saez, Darwin; Escalona, Emilia; Oñate, Angel ConferencePoster (2014)
Immunological evaluation of a new recombinant chimeric vaccine against B. abortus in infected mice Escalona, Emilia; Saez, Darwin; Oñate, Angel ConferencePoster (2014)
Contribution in cellular immunity of B1b cells against an intracellular pathogen model Saez, Darwin; Concha, Giovanni; Escalona, Emilia; Oñate, Angel ConferencePoster (2013)
Design of multi-epitope protein vaccine against B. abortus Escalona, Emilia; Saez, Darwin; Oñate, Angel ConferencePoster (2013)
Evaluación de la Respuesta Inmune Celular y Protectora de tres vacunas ADN que portan los Marcos de Lectura Abierto BruAb01_255, BruAb01_267 y BruAb01_272 de la Isla de Patogenicidad 3 de Brucella abortus Retamal-Díaz, Angello; Riquelme, Roberto; Saez, Darwin; Riquelme, Pablo; Acuna, Francisca; Oñate, Angel ConferencePoster (2012)
Predicción bioinformática de epítopes de las proteínas BAB1_0260, BAB1_0273, BAB1_0278 y SOD de Brucella abortus Escalona, Emilia; Saez, Darwin; Salas, Alexis; Oñate, Angel ConferencePoster (2012)
Rol citotóxico de los linfocitos T CD4+ contra una bacteria intracelular Saez, Darwin; Escalona, Emilia; Oñate, Angel ConferencePoster (2012)
Vacunas de ADN generan efectiva respuesta inmune contra Salmonella enteritidis Bello, Jared; Saez, Darwin; Escalona, Emilia; Santiviago, C. A.; Contreras, Ines; Oñate, Angel ConferencePoster (2012)
A derivative of MALP-2 enhancing immune response in DNA vaccine coding antigen Cu,Zn superoxide dismutase Cu,Zn against Brucella abortus Retamal-Díaz, Angello; Riquelme, Roberto; Saez, Darwin; Rivera, Alejandra; Guzman, Carlos; Oñate, Angel ConferencePoster (2011)
Cytokines genes expression profile against Brucella abortus S19 and RB51 strains in bovine dendritic cells Rivera, Alejandra; Saez, Darwin; Riquelme, Roberto; Escalona, Emilia; Concha, Giovanni; Oñate, Angel ConferencePoster (2011)
Cytotoxic effect comparison between subpopulations CD8+ and CD4+ against Brucella abortus Saez, Darwin; Rivera, Alejandra; Retamal-Díaz, Angello; Concha, Giovanni; Escalona, Emilia; Riquelme, Roberto; Oñate, Angel ConferencePoster (2011)
A DNA Vaccine encoding Cu, Zn Superoxide Dismutase protein of Brucella abortus induces an efficient immune response using BPPcysMPEG as adjuvant in BALB/c Mice Oñate, Angel; Retamal-Díaz, Angello; Saez, Darwin; Rivera, Alejandra; Riquelme, Roberto; Fernandez, Pablo; Guzman, Carlos ConferencePoster (2010)
Cellular Immune Response induced by Lactococcus lactis expressing SOD protein of Brucella abortus RB51 Saez, Darwin; Rivera, Alejandra; Fernandez, Pablo; Retamal-Díaz, Angello; Riquelme, Roberto; Oñate, Angel; Andrews, Edilia ConferencePoster (2009)
Development of DNA Vaccines against Escherichia coli STEC in C57BL/6 Mice Rivera, Alejandra; Saez, Darwin; Riquelme, Roberto; Retamal-Díaz, Angello; Fernandez, Pablo; Valenzuela, Patricio; Vidal, Roberto; Oñate, Angel ConferencePoster (2009)
Evaluation of Humoral immune Response induced by live oral Brucellosis Vaccine Fernandez, Pablo; Saez, Darwin; Rivera, Alejandra; Retamal-Díaz, Angello; Riquelme, Roberto; Oñate, Angel; Andrews, Edilia ConferencePoster (2009)
Evaluation of Brucella abortus RNA vaccines expressing Cu,Zn superoxide dismutase (SOD) gene in cattle Oñate, Angel; Saez, Darwin; Cabrera, Alex; Andrews, Edilia ConferencePoster (2008)
Immune response against Brucella abortus Cu,Zn superoxide dismutase expressed in Lactococcus lactis as mucosal vaccine Andrews, Edilia; Saez, Darwin; Rivera, Alejandra; Fernandez, Pablo; Oñate, Angel ConferencePoster (2008)
Evaluation of the immune response against Semliki Forest virus that express superoxide dismutase Cu,Zn of Brucella abortus in bovine Saez, Darwin; Cabrera, Alex; Andrews, Edilia; Oñate, Angel ConferencePoster (2007)
Immune response in BALB/c mice induced by Semliki Forest virus expressing the translation initiation factor 3 (IF-3) protein of Brucella abortus Cabrera, Alex; Saez, Darwin; Andrews, Edilia; Oñate, Angel ConferencePoster (2007)
Evaluación de la respuesta inmune de bovinos inmunizados con el virus Semliki Forest que expresa la proteína Cu,Zn superóxido dismutasa de Brucella abortus RB51 Saez, Darwin; Cabrera, Alex; Andrews, Edilia; Oñate, Angel ConferencePoster (2006)
Inmunogenicidad de la proteína IF-3 de Brucella abortus y construcción de una vacuna ARN en base al virus Semliki Forest que expresa IF-3 Saez, Darwin; Cabrera, Alex; Retamal-Díaz, Angello; Andrews, Edilia; Oñate, Angel ConferencePoster (2005)


Genomic Isle 3 (GI3) of Brucella abortus, a potential source of genes for development of vaccines. FONDECYT (1130093) Proyecto 2013-2016 Personal técnico y/o de apoyo
Identification of immunodominant antigens in Shigatoxin producing Escherichia coli that participate in adhesion to human intestinal cells=> serological characterization and possible use as immunogens for protective vaccine development. FONDECYT (1110260) Proyecto 2011-2015 Personal técnico y/o de apoyo
CHARACTERIZATION OF THE GENOMIC ISLE 3 (GI3) OF BRUCELLA ABORTUS STRAINS AND ITS POSSIBLE ROLE IN THE SURVIVAL AND INTRACELLULAR MULTIPLICATION, WITH PERSPECTIVES TO THE IDENTIFICATION OF POSSIBLE PROTECTING IMMUNOGENS FONDECYT (1100032) Proyecto 2010-2013 Personal técnico y/o de apoyo
Proyecto Anillos de Investigación en Ciencias y Tecnología ACT-08/2006. Caracterización de islas genómicas en bacterias patógenas intracelulares=> epidemiología molecular e identificación de posibles inmunógenos protectores para el desarrollo de vacunas FONDEF (ACT08/2006) Proyecto 2007-2009 Personal técnico y/o de apoyo
INMUNIZACION DE BOVINOS CON PARTICULAS RECOMBINANTES DEL VIRUS SEMLIKI FOREST (VSFr) QUE TRANSPORTAN GENES PARA PROTEINAS INMUNOGENICAS DE Brucella abortus Y ROL DE LAS CELULAS Tgamma-delta. FONDECYT (1050054) Proyecto 2005-2008 Personal técnico y/o de apoyo