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Ana Isabel Liempi Manquel

Investigador

Universidad de Chile, Facultad de Medicina

Santiago, Chile

Mecanismos antiparasitarios de la placenta en la trasmisión congénita de protozoo parasitarios

Biomedicina, UNIVERSIDAD DE CHILE. Chile, 2019
Medico Veterinaria, UNIVERSIDAD DE CHILE. Chile, 2015

Profesor Other

UNIVERSIDAD DE CHILE

Facultad de Ciencias Veterinarias y Pecuarias

Santiago, Chile

2015 - 2016
Profesor Other

UNIVERSIDAD DE CHILE

Facultad de Medicina

Santiago, Chile

2015 - A la fecha

Investigador Full Time

Universidad de Chile, Facultad de Medicina

Santiago, Chile

2014 - A la fecha

X Jornadas de Investigación del DCSAV de Campus Sur

UNIVERSIDAD DE CHILE

Chile, 2018

Liempi, A.; Castillo, C.; Medina, L.; Parraguez, V.; Kemmerling, U. “Rol de las vías de transducción de señales NF-kappa B durante la infección ex vivo de placenta hemocorial con Trypanosoma cruzi y Toxoplasma gondii”. X Jornadas de Investigación Doctorado Ciencias Silvoagropecuarias y Veterinarias. Santiago, Chile. Primer premio. 08 de octubre 2018.
IX Jornadas de Investigación Doctorado en Ciencias Silvoagropecuarias y Veterinarias.

UNIVERSIDAD DE CHILE

Chile, 2017

Liempi, Ana; Castillo; Christian; Medina, Lisvaneth; Carrillo, Ileana; Parraguez, Víctor Hugo; Kemmerling, Ulrike. MODELOS DE INFECCIÓN EX VIVO CON Toxoplasma gondii Y Trypanosoma cruzi EXPLANTES DE PLACENTA HUMANA, CANINA Y OVINA. IX Jornadas de Investigación Doctorado en Ciencias Silvoagropecuarias y Veterinarias. 2 Noviembre 2017. Santiago, Chile.
XI Jornadas de Investigación Doctorado Ciencias Silvoagropecuarias y Veterinarias.

UNIVERSIDAD DE CHILE

Chile, 2019

Medina L, Castillo C, Liempi A, Rojas M. Espinoza C, Corradi E, Prieto H, Kemmerling U. La infección ex vivo de explantes de placenta Humana, Canina y Ovina con T. cruzi y T. gondii inducen perfiles específicos de miRNAs”. XI Jornadas de Investigación Doctorado Ciencias Silvoagropecuarias y Veterinarias. Primer premio. Santiago, Chile. 22 de mayo 2019.
Congreso Anual de la Sociedad de Farmacología de Chile

SOCIEDAD DE FARMACOLOGIA DE CHILE

Chile, 2016

Gonzalez-Herrera F., Cramer A., Pimentel P., LIEMPI A., Castillo C., Guzmán-Rivera D., Machado FS., Kemmerling U., Maya JD. “Simvastatina disminuye las moléculas de adhesión endotelial induciendo la producción de 15-epi-lipoxina A4 en la Cardiopatía Chagásica Crónica murina”.* XXXVIII Congreso Anual de la Sociedad de Farmacología de Chile. 26 al 29 de noviembre 2016. Chiloé, Chile. *Primer lugar Trabajo libre.


Comparative ex vivo infection with Trypanosoma cruzi and Toxoplasma gondii of human, canine and ovine placenta: Analysis of tissue damage and infection efficiency Liempi, Ana; Castillo, Christian; Medina, Lisvaneth; Galanti, Norbel; Maya, Juan Diego; Parraguez, Victor Hugo; Kemmerling, Ulrike Article ISI SCOPUS Parasitology International (2020)
Notch receptor expression in Trypanosoma cruzi-infected human umbilical vein endothelial cells treated with benznidazole or simvastatin revealed by microarray analysis Campos-Estrada, Carolina; Gonzalez-Herrera, Fabiola; Greif, Gonzalo; Carillo, Ileana; Guzman-Rivera, Daniela; Liempi, Ana; Robello, Carlos; Kemmerling, Ulrike; Castillo, Christian; Diego Maya, Juan Article ISI SCOPUS Cell Biology International (2020)
Simvastatin Improves Cardiac Function through Notch 1 Activation in BALB/c Mice with Chronic Chagas Cardiomyopathy Guzmán-Rivera, Daniela; Liempi, Ana; González-Herrera, Fabiola; Fuentes-Retamal, Sebastián; Carrillo, Ileana; Abarca, Patricio; Castillo, Christian; Kemmerling, Ulrike; Pesce, Barbara; Maya, Juan Diego Article ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)
Ex vivo infection of human placental explants with Trypanosoma cruzi and Toxoplasma gondii: Differential activation of NF kappa B signaling pathways Liempi, Ana; Castillo, Christian; Medina, Lisvaneth; Rojas, Maura; Maya, Juan Diego; Parraguez, Victor H.; Kemmerling, Ulrike Article ISI SCOPUS ACTA TROPICA (2019)
Differential infectivity of two Trypanosoma cruzi strains in placental cells and tissue Medina, Lisvaneth; Castillo, Christian; Liempi, Ana; Herbach, Mathias; Cabrera, Gonzalo; Valenzuela, Lucía; Galanti, Norbel; de los Angeles Curto, María; Schijman, Alejandro G.; Kemmerling, Ulrike Article ISI SCOPUS ACTA TROPICA (2018)
Old Yellow Enzyme from Trypanosoma cruzi Exhibits In Vivo Prostaglandin F-2 alpha Synthase Activity and Has a Key Role in Parasite Infection and Drug Susceptibility Diaz-Viraque, F; Chiribao, ML; Trochine, A; Gonzalez-Herrera, F; Castillo, C; Liempi, A; Kemmerling, U; Maya, JD; Robello C. Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2018)
Ex vivo infection of human placental chorionic villi explants with Trypanosoma cruzi and Toxoplasma gondii induces different Toll-like receptor expression and cytokine/chemokine profiles Castillo, Christian; Mu?oz, Lorena; Carrillo, Ileana; Liempi, Ana; Gallardo, Christian; Galanti, Norbel; Maya, Juan Diego; Kemmerling, Ulrike Article ISI SCOPUS AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2017)
Simvastatin Attenuates Endothelial Activation through 15-Epi-Lipoxin A4 Production in Murine Chronic Chagas Cardiomyopathy Gonz?lez-Herrera, Fabiola; Cramer, Allysson; Pimentel, Pollyana; Castillo, Christian; Liempi, Ana; Kemmerling, Ulrike; Machado, Fabiana S.; Maya, Juan D. Article ISI SCOPUS ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2017)
Toll-like receptor-2 mediates local innate immune response against Trypanosoma cruzi in ex vivo infected human placental chorionic villi explants Castillo, C; Munoz, L; Carrillo, I; Liempi, A; Medina, L; Galanti, N; Maya, JD; Kemmerling, U Article ISI SCOPUS Placenta (2017)
A local innate immune response against Trypanosoma cruzi in the human placenta: The epithelial turnover of the trophoblast Liempi, Ana; Castillo, Christian; Carrillo, Ileana; Mu?oz, Lorena; Droguett, Daniel; Galanti, Norbel; Maya, Juan Diego; Kemmerling, Ulrike Article ISI SCOPUS MICROBIAL PATHOGENESIS (2016)
Caspase-8 activity is part of the BeWo trophoblast cell defense mechanisms against Trypanosoma cruzi infection Carrillo, I; Droguett, D.; Castillo C.; Liempi, A; Munoz L.; Maya J.D.; Galanti N.; Kemmerling U. Article ISI SCOPUS EXPERIMENTAL PARASITOLOGY (2016)
Simvastatin and Benznidazole-Mediated Prevention of Trypanosoma cruzi-Induced Endothelial Activation: Role of 15-epi-lipoxin A4 in the Action of Simvastatin Campos Estrada C; Liempi, A; Gonzalez-Herrera, F; Lapier, M.; Kemmerling U.; Pesce B,; Ferreira J.; Lopez-Munoz, R; Maya, JD Article ISI SCOPUS PLoS Neglected Tropical Diseases (2015)
Trypanosoma cruzi infectivity assessment in "in vitro" culture systems by automated cell counting Liempi, A; Castillo C.; Cerda M.; Droguett, D.; Duaso, J.; Barahona, K; Hernandez A.; Diaz-Lujan, C; Fretes R.; Hartel, S; Kemmerling U. Article ISI SCOPUS ACTA TROPICA (2015)
Toxic and therapeutic effects of Nifurtimox and Benznidazol on Trypanosoma cruzi ex vivo infection of human placental chorionic villi explants rojo, gemma; Castillo, Christian; Duaso, Juan; Liempi, Ana; Droguett, D.; Galanti, Norbel; Maya, Juan Diego.; López-Muñoz, Rodrigo; Kemmerling, Ulrike Article ISI ACTA TROPICA (2014)
Trypanosoma cruzi induces trophoblast differentiation: A potential local antiparasitic mechanism of the human placenta? Liempi, Ana; Castillo, Christian; Duaso, Juan; Droguett, Daniel; Sandoval, Alexandra; Barahona Katherine; Hernández Ariane; Galanti, Norbel; Maya, Juan Diego.; Kemmerling, Ulrike Article ISI SCOPUS PLACENTA (2014)


CONGENITAL CHAGAS DISEASE: THE TROPHOBLAST TURNOVER AS A POSSIBLE LOCAL DEFENSE MECHANISM OF THE HUMAN PLACENTA Castillo C.; Liempi, A; Droguett, D.; Carillo, I; Gomez, F; Negrete, M.; Barahona, K; Hernandez A.; Maya, JD; Galanti N.; Kemmerling U. Abstract ISI PLACENTA (2015)
CONGENITAL INFECTION OF PROTOZOA: HISTOPATHOLOGICAL AND HISTOCHEMICAL ANALYSIS OF HUMAN CHORIONIC VILLI EXPLANTS INFECTED EX VIVO WITH TRYPANOSOMA CRUZI AND TOXOPLASMA GONDII Liempi, A; Droguett, D.; Castillo C.; Sandoval A.; Figueroa P.; Galanti N.; Maya, JD; Kemmerling U. Abstract ISI PLACENTA (2014)
TRYPANOSOMA CRUZI INDUCES CELLULAR PROLIFERATION IN THE TROPHOBLASTIC CELL LINE BEWO Droguett, D.; Liempi, A; Castillo C.; Duaso, J.; Cerda M.; Hartel, S; Galanti N.; Maya, JD; Kemmerling U. Abstract ISI PLACENTA (2013)
TRYPANOSOMA CRUZI INDUCES DIFFERENTIATION OF THE TROPHOBLAST Castillo C.; Liempi, A; Droguett, D.; Duaso, J.; Cerda M.; Hartel, S; Galanti N.; Maya, JD; Kemmerling U. Abstract ISI PLACENTA (2013)


Mechanism of Congenital Chagas disease: Effective placental Trypanosoma cruzi infection depends on specific host-derived microRNAs Kemmerling Weis U.; Castillo, Christian; Olea Azar, Claudio; Maya J.D. Proyecto (2019)
Molecular mechanisms of endothelial dysfunction in chronic chagas' heart Disease=> a therapeutic approach for the statins FONDECYT (1130189) Proyecto 2013-2016 Personal técnico y/o de apoyo
Mechanism of congenital Chagas disease=> Effecctive infection depends on the interplay between T. cruzi and the trophoblast in the human placenta FONDECYT (1120230) Proyecto 2012-2015 Tesista
Advanced Center for Traning and Research in the Design of Pharmacological and Immunological Strategies for the Control of Parasitic and Neoplasic Aggressions PIA (ACT 112) Proyecto 2011-2013 Tesista