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Fernán Gómez Valenzuela

Profesor Asistente

Universidad Mayor de Chile

Santiago, Chile

Analysis of the inflammatory profile of the tumor microenvironment in solid tumors. Immuno-oncology of HPV-associated cancer. Bioinformatics.

Cirujano Dentista, UNIVERSIDAD DE CHILE. Chile, 2017
Ciencias Médicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2024

Estudiante Doctorado Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicina

Santiago, Chile

2020 - 2024
Profesor Asistente Full Time

UNIVERSIDAD MAYOR

Facultad de Medicina y Ciencias de la Salud

Santiago, Chile

2024 - A la fecha
Docente Part Time

UNIVERSIDAD DEL DESARROLLO

Facultad de Odontología

Santiago, Chile

2017 - A la fecha

Ayudante Académico Part Time

Departamento de Patología y Medicina Oral, Facultad de Odontología, Universidad de Chile

Santiago, Chile

2017 - 2019
Docente Medicina Oral Part Time

Universidad del Desarrollo

Santiago, Chile

2017 - A la fecha

Dedicated to the study of cellular processes involved in inflammation and cell signaling that perpetuate the development of oral cancer associated with local and chronic tissue inflammation, with special emphasis on inflammation-associated biomarkers such as cyclooxygenase-2 (COX-2), among others, whose expression is increased in various neoplasias. Analysis of the immuno-oncological context of HPV-associated malignant tumors.


Complement activation at the interface between adipocytes and cancer cells drives tumor progression Valdivia, Andres; Isac, Ana Maria; Cardenas, Horacio; Zhao, Guangyuan; Zhang, Yaqi; Huang, Hao; Wei, Jian-Jun; Cuello-Fredes, Mauricio; Kato, Sumie; Gomez-Valenzuela, Fernan; et al. Article ISI JCI INSIGHT (2025)
Re-evaluating prognostic indicators: The critical role of body composition and gene expression in endometrial cancer outcomes Cuello, Mauricio A.; Gomez-Valenzuela, Fernan; Ossandon, Enrique; Wichmann, Ignacio; Orlandini, Elisa; Saez, Nicolas; Branes, Jorge; Kato, Sumie; Ibanez, Carolina Article ISI INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS (2025)
Cyclooxygenase-2 Blockade Is Crucial to Restore Natural Killer Cell Activity before Anti-CTLA-4 Therapy against High-Grade Serous Ovarian Cancer Kato, Sumie; Ossandon, Enrique; Cuello, Mauricio A. Article ISI CANCERS (2024)
Immunohistochemical evaluation of cyclin D1 and p63 in odontogenic keratocyst and unicystic ameloblastoma Escobar, E; Gomez-Valenzuela, F.; Penafiel, C; Chimenos-Kustner, E; Pérez-Tomás, R Article ISI (2024)
Aberrant immunoexpression of p53 tumour-suppressor and Bcl-2 family proteins (Bcl-2 and Bax) in ameloblastomas and odontogenic keratocysts Article SCOPUS Journal of Clinical and Experimental Dentistry (2023)
Body Composition and Metabolic Dysfunction Really Matter for the Achievement of Better Outcomes in High-Grade Serous Ovarian Cancer Cuello, Mauricio A.; Gomez, Fernan; Kato, Sumie Article ISI CANCERS (2023)
Immunohistochemical expression of COX-2, Ki-67, Bcl-2, Bax, VEGF and CD105 according to histological grading in oral squamous cell carcinoma Expresión inmunohistoquímica de COX-2, Ki-67, Bcl-2, Bax, VEGF y CD105 según el grado histológico en el carcinoma oral de células escamosas Hormazábal-Hevia, Alondra; Herrera-Fuentes, Constanza; Mori-Aliaga, Diana Article SCOPUS Revista Espanola de Patologia (2023)
Odontogenic tumours in a Chilean population: a retrospective study of 544 cases based on 2022 WHO classification Article ISI MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL (2023)
Mechanical Disturbance of Osteoclasts Induces ATP Release That Leads to Protein Synthesis in Skeletal Muscle through an Akt-mTOR Signaling Pathway Morales-Jimenez, Camilo; Gomez-Valenzuela, Fernan; Buvinic, Sonja Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
THE EXPRESSION LEVEL OF OBESITY AND LIPID METABOLISM RELATED GENES CONDITIONS TUMOR BEHAVIOR AND SURVIVAL IN GYNECOLOGICAL CANCERS Cuello, Mauricio; Kato, Sumie Article ISI INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2022)
Cyclooxygenase-2 protein expression modulates cell proliferation and apoptosis in solid ameloblastoma and odontogenic keratocyst. An immunohistochemical study Escobar, Enrico; Chimenos-Kustner, Eduardo; Perez-Tomas, Ricardo Article ISI JOURNAL OF ORAL PATHOLOGY & MEDICINE (2021)
ADENOMATOID ODONTOGENIC TUMOR. A CLINICAL-PATHOLOGIC STUDY OF 27 CASES Article Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology (2020)
CYCLOOXYGENASE-2 AND ANGIOGENESIS IN ORAL SQUAMOUS CELL CARCINOMA: AN IMMUNOHISTOCHEMICAL STUDY Article Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology (2020)
The Challenge by Multiple Environmental and Biological Factors Induce Inflammation in Aging: Their Role in the Promotion of Chronic Disease Bellalta, Sofia; Matamoros, Anibal Article ISI FRONTIERS IN IMMUNOLOGY (2020)


CORRELACIÓN Y CARACTERIZACIÓN ENTRE INFLAMACIÓN (COX-2), APOPTOSIS VÍA MITOCONDRIAL (FAMILIA BCL-2), DENSIDAD MICROVASCULAR (CD105) Y ANGIOGÉNESIS (VEGF) EN CARCINOMAS ESPINOCELULARES DE MUCOSA BUCAL SEGÚN GRADO DE DIFERENCIACIÓN. ESTUDIO INMUNOHISTOQUIMICO Fondo para la Investigación en Odontología Universidad de Chile - FIOUCH (DIFO 17/017) Proyecto 2016-2018 Personal técnico y/o de apoyo
Unveiling Molecular Basis For Muscle Remodeling And Muscle-Bone Crosstalk At The Masticatory Apparatus=> Extracellular Atp As A Signaling Molecule. FONDECYT (1151353) Proyecto 2015-2018 Tesista


Comprehensive <i>in-silico</i> molecular analysis of early-onset gastric cancer identifies novel genes implicated in disease characterization and progression (Review) Gomez-Valenzuela, Fernan; Silva, Ian; Retamal, Ignacio N.; Garcia-Bloj, Benjamin; De Mayo Glasser, Tomas; Munoz-Medel, Matias; Gomez, Alex; San Martin, Cristopher; Sanchez, Carolina; Pinto, Felipe; et al. Review ISI ONCOLOGY REPORTS (2025)
Isocitrate dehydrogenase 1 gene mutations: a case review unveiling its biological impact on disease progression, prognosis and treatment in Chilean patients Glasser, TD; Garcia-Bloj, B; Godoy JA; Chávez, FS; Retamal, IN; Gomez-Valenzuela, F.; Silva I; Munoz-Medel, M; Sánchez, C; Pinto, F; et al. Review ISI (2025)
The Inflammatory Profile of the Tumor Microenvironment, Orchestrated by Cyclooxygenase-2, Promotes Epithelial-Mesenchymal Transition Montecinos, Viviana P. Review ISI FRONTIERS IN ONCOLOGY (2021)