Transplante de células madre (mesenquimales, neurales) en estudios preclínicos y clínicos. Modulación de células madre por moléculas del Complemento: identificación de los mecanismos moleculares, receptores y vías de señalización intracelular.

Mentoría
Universidad de California, Irvine Supervisión y tutoría de estudiantes

2018-2019 Briana Feld, CIRM intern
2017-2019 David Creasman doctoral student.
2017-2019 Karishma Kumar Undergraduate student
2016-2019 Sarah Royer doctoral student
2015-2019 Kiana Panbechi, Undergraduate student, awarded excellence in research.
2018 Giselle Dalirifar, Bsc. volunteer.
2016- 2017 Rami Fadi Halaseh, Undergraduate student
2017 Joshua David, CIRM intern
2015-2016 Sonia Talukder Bsc, volunteer.
2015 Jason Bahremand, CIRM intern
2016 Golara Zahmatkesh Volunteer Medical doctor applying for residency.
2013-2016 Phoebe Bui, Undergraduate student. Currently accepted in medical school, awarded excellence in research.

Resúmenes Publicados

“Direct modulation of neural stem cell by complement C1q” Francisca Benavente; Katja Piltti; David Creasman; Aileen Anderson; Molecular Immunology.102():134, OCT 2018 DOI: 10.1016/j.molimm.2018.06.030 Issn Print: 0161-5890 Publication Date: 2018/10/01

“C1q modulates acute glial progenitor response after spinal cord injury” Katja Piltti, Francisca Benavente, Joseph Requejo, Olivia Tsai, Jessica Sanchez, Janna Shim, Bryant Le, Krystal Carta, Aileen Anderson. Molecular Immunology.102():134, OCT 2018 DOI: 10.1016/j.molimm.2018.06.030 Issn Print: 0161-5890 Publication Date: 2018/10/01

“Novel C1q-receptor interaction mediates chemotaxis in neural stem cells” David Creasman, Francisca Benavente, Mitra Hooshmand, Katja Piltti, Aileen Anderson Molecular Immunology 102. Molecular Immunology.102():134, OCT 2018 DOI: 10.1016/j.molimm.2018.06.030 Issn Print: 0161-5890 Publication Date: 2018/10/01

“C1q induces a program of gene expression in amyloid beta injured neurons necessary for neuron survival” Marie E Benoit, Michael X Hernandez, Minhan L Dinh, Francisca Benavente, Osvaldo Vasquez, Andrea J Tenner. Immunobiology, vol: 217, Issue 11, November 2012, Page 114

Congresos y Conferencias

Benavente F, Piltti K, Hooshmand, M, Nguyen H., and Anderson A., “Neuroimmune modulation of Neural and Glioma Stem Cells by Complement molecules” (Invited speaker). FASEB Translational Neuroimmunology, Snowmass, Colorado, 2018.

Benavente F, Piltti K, Creasman D, Anderson A. “Direct Modulation of Neural Stem Cells by Complement C1q.” (Poster) 27th International Complement Workshop, Santa Fe, New Mexico, 2018.

Benavente F, Creasman D., Hooshmand M., Piltti K., and Anderson A. “Novel C1q-Receptor Interaction Mediates Chemotaxis in Neural Stem Cells.” (Poster) 27th International Complement Workshop, Santa Fe, New Mexico, 2018.

Piltti, K., Benavente F., Requejo J., Tsai O., Sanchez J., Shim J., Le B., Carta K., and Anderson A. “C1q modulates endogenous stem cell responses acutely after spinal cord injury.” (Poster) 27th International Complement Workshop, Santa Fe, New Mexico, 2018.

Benavente F, Piltti K, Creasman D, Anderson A. “Modulation of Neural Stem Cells by Complement C1q.” (Poster) American Society for Neurochemistry Riverside, California, 2018.
Benavente F, Creasman D., Hooshmand M., Piltti K., and Anderson A. “Novel C1q-Receptor Interaction Mediates Chemotaxis in Neural Stem Cells.” (Poster) American Society for Neurochemistry Riverside, California, 2018.

Royer S*, Benavente F*, Piltti, K., Su, D., and Anderson A.J, “C1q deficiency ameliorates decline in neurogenesis and cognitive function in aged mouse model.” (Poster) American Society for Neurochemistry Riverside, California, 2018.

Piltti, K., Benavente F., Requejo J., Tsai O., Sanchez J., Shim J., Le B., Carta K., and Anderson A. “C1q modulates endogenous stem cell responses acutely after spinal cord injury.” (Poster) American Society for Neurochemistry Riverside, California, 2018.

Benavente F and Aileen J. Anderson “Self-renewal in neural and glioblastoma stem cells: New mechanisms and clinical targets” Stem Cell Science Symposium, Stem Cells and the Brain Research Progress, Clinical Opportunities, and Policy Challenges, Irvine, California, 2017.

Benavente F, Piltti K., Anzalone A, Di K, David J, Bui P., Cummings B., Bota D., Anderson A. “Complement C3a-C3aR Interaction is Essential for Survival and Self-Renewal of Human Neural Stem Cells and Inhibition Prevents Glioblastoma Growth” (Poster) 15th Annual UC Irvine Immunology Fair. UCI. Irvine, California, USA, 2017.

Benavente F, Piltti K, Anzalone A., Anderson A. “Novel Mechanism of Autocrine Regulation and Paracrine Modulation of Neural Stem Cell by Complement C3a” (Poster) GORDON conference, Neuroimmune Communications in Health and Disease, Ventura California, USA, 2017.

Benavente F, Piltti K, Ara A. Salibian, Brian J. Cummings, and Aileen J. Anderson. “Novel Mechanism of Autocrine Regulation and Paracrine Modulation of Neural Stem Cell by Complement C3a”. FASEB Summer Conference on Translational Neuroimmunology: From Mechanisms to Therapeutics, Big Sky, Montana, USA, 2016.

Benavente F, Piltti K., Bahremand J., Salibian A., Cummings B., Anderson A. “Effects of Complement C1q and C3a on Neural Stem Cells: Molecular Mechanisms.”. 13th Annual UC Irvine Immunology Fair. UCI. Irvine, California, USA, 2015.

Benavente F, Piltti K., Bahremand J., Salibian A., Cummings B., Anderson A. “Effects of Complement C1q and C3a on Neural Stem Cells: Molecular Mechanisms.” XXIX Reunión anual de la Sociedad de Biología Celular de Chile. Puerto Varas, Chile, 2015.

Benavente F, Piltti K., Salibian A., Cummings B., Anderson A. “Effect of neutrophil and macrophage-secreted concentrations of complement proteins C1q and C3a on human neural stem cells in vitro”. FASEB Summer Conference on Translational Neuroimmunology: From Mechanisms to Therapeutics. Big Sky, Montana, USA, 2014.

Benavente F, Piltti K, Gershon P., Cummings B., and Anderson A, “The Missing Link: Mechanisms of Action for the Effect of Complement Proteins on Human Neural Stem Cells” XXVII Reunión anual de la Sociedad de Biología Celular de Chile. Puerto Varas, Chile, 2013.

Benavente F, Pinto C, Parada M, Henríquez JP, and Osses N, “Bone morphogenetic protein 2 inhibits neurite outgrowth of motoneuron-like NSC-34 cells and up-regulates its type II receptor” (Poster). I Meeting of the Federation of Latin-American and Caribbean Neuroscience Societies, FALAN. Cancún, México, 2012.

Benoit M. Hernandez M, Dinh M, Benavente F, Vasquez O, and Tenner A, “C1q induces a program of gene expression in amyloid beta injured neurons necessary for neuron survival” (Poster) XXIV International Complement Workshop. Crete, Greece, 2012.

Blurton-Jones M, Ager R, Nerhus J, Benavente F, Agazaryan A, Huhn S, Capela A and, La Ferla F. “Restoration of memory in mouse models of Alzheimer disease and neuronal loss: a new paradigm using human neural stem cell transplantation” (Poster). Alzheimer Association International Conference, AAIC. Vancouver, Canada, 2012.

Benavente F, Pinto C, Parada M, Henríquez JP, and Osses N, “Bone morphogenetic protein 2 inhibits neurite outgrowth of motoneuron-like NSC-34 cells and up-regulates its type II receptor” XXV Reunión anual de la Sociedad de Biología Celular de Chile. Pucón, Chile, 2011.

Benavente F, Henríquez JP, and Osses N, “BMP-2 Inhibits morphological differentiation of motoneuron-like cells” (Poster) XXIV Reunión anual de la Sociedad de Biología Celular de Chile. Pucón, Chile, 2010.

Benavente F, and Osses N, “Relevance of the BMP Type II Receptor-Tail in non-transcriptional activity.” (Poster) XXVI Annual Meeting of Chilean Biochemistry Students. Antofagasta, Chile, 2010.

Benavente F, and Osses N. “The BMP Type II Receptor-Tail involved in its degradation and recycling” (Poster). XXIII Reunión anual de la Sociedad de Biología Celular de Chile. Pucón, Chile, 2009.

Benavente F, Avilez E, Henríquez J.P, and Osses N, “BMP Type II Receptor is induced during differentiation of motoneuron-like cells” (Poster). EMBO Meeting. Amsterdam, Holland, 2009.

Benavente F, Henríquez J.P, and Osses N, “BMP Type II Receptor is induced during differentiation of motoneuron-like cells” (Poster). XXII Reunión anual de la Sociedad de Biología Celular de Chile. Pucón, Chile, 2008.

Charlas y Presentaciones

Seminario, Facultad de Medicina, Universidad del Desarrollo: "Nuevas funciones para el complemento y las interacciones inmunitarias en la regulación autocrina y la modulación paracrina de las células madre neurales y las células madre del glioma" Universidad del Desarrollo. Santiago, Chile, 2019.

Seminario, Departamento de Biología Celular, Universidad de Concepción: "Reparación del sistema nervioso central desde la perspectiva de un nicho inflamatorio y la cascada del complemento" Universidad de Concepción. Concepción, Chile, 2018.

Serie de seminarios, Centro de biología integrativa: "Nuevas funciones para el complemento y las interacciones inmunitarias en la regulación autocrina y la modulación paracrina de las células madre neurales. Universidad Mayor. Santiago, Chile, 2018

Christopher and Dana Reeve Foundation Consortium Meeting October, Dublin, Ireland, 2018.

Anatomy & Neurobiology department, Progress in Neurobiology. University of California, Irvine. California, USA, 2016.

UCI ReMIND Emerging Scientists Symposium, University of California, Irvine. California, USA, 2016.

Christopher and Dana Reeve Foundation Consortium Meeting. Chicago, USA, 2015.

Anatomy & Neurobiology Graduate Day, University of California, Irvine. California, USA, 2015.

Christopher and Dana Reeve Foundation Consortium Meeting. New Jersey, USA, 2014.

Anatomy & Neurobiology Graduate Day, University of California, Irvine. California, USA, 2014.

UCI ReMIND Emerging Scientists Symposium, University of California, Irvine. California, USA, 2013.

Christopher and Dana Reeve Foundation Consortium, Washington, D.C, USA, 2013.