PDI - Resultado de Búsqueda

Pabla Francisca Aguirre Ortiz

Asistente de investigación

Universidad de Chile

Santiago, Chile

Biología Celular, Hierro, Enfermedad de Parkinson

Ingeniera en Biotecnología Molecular, UNIVERSIDAD DE CHILE. Chile, 2013

Asistente de Investigación Full Time

Laboratorio Biología del Envejecimiento, Facultad de Ciencias, Universidad de Chile

Santiago, Chile

2004 - A la fecha

Mi trabajo como asistente de Investigación del Laboratorio de Biología del Envejecimiento, incluye guiar: a los pasantes de primer año del curso de Biología Celular que hacen la pasantía con nosotros y a los estudiantes de pregrado que desarrollan sus unidades de investigación en el laboratorio. Además de asesorar en su pasantía a los alumnos de doctorado que hacen su unidad de investigación en nuestro laboratorio.
Previamente mientras cursaba el pregrado fuí ayudante del curso de Genética coordinado por el Dr. Víctor Cifuentes (años 2001, 2002 y 2003), y ayudante del curso Ingeniería Genética y Biotecnología coordinado por el Dr. Víctor Cifuentes (años 2001, 2002 y 2003).


Iron Chelators and Antioxidants Regenerate Neuritic Tree and Nigrostriatal Fibers of MPP plus /MPTP-Lesioned Dopaminergic Neurons Aguirre P.; Mena, NP; Carrasco, CM; Muñoz Y.; Perez-Henriquez, P; Morales, RA; CASSELS, BK; Mendez-Galvez, C; Garcia-Beltran, O; Gonzalez-Billault, C; Nunez, MT Article ISI SCOPUS PLOS ONE (2015)
Synthesis and characterization of a novel fluorescent and colorimetric probe for the detection of mercury (II) even in the presence of relevant biothiols Garcia-Beltran, O; Rodríguez A.; Trujillo A.; Cañete Á.; Aguirre P.; Gallego-Quintero, S; Nunez, MT; Aliaga, ME Article ISI SCOPUS Tetrahedron Letters (2015)
Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells Urrutia, P; Aguirre P.; Esparza A.; Tapia, V; Mena, NP; Arredondo M.; Gonzalez-Billault, C; Nunez, MT Article ISI SCOPUS Journal of Neurochemistry (2013)
Iron toxicity in neurodegeneration Núñez M.T.; Urrutia, P; Mena N.; Aguirre P.; Tapia, V; Salazar J. Article ISI SCOPUS BioMetals (2012)
The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1 Aguirre P.; Urrutia, P; Tapia, V; Villa, M; Paris, I; Segura-Aguilar, J; Núñez M.T. Article ISI SCOPUS BioMetals (2012)
Iron mediates neuritic tree collapse in mesencephalic neurons treated with 1-methyl-4-phenylpyridinium (MPP+) Gomez F.J.; Aguirre P.; Gonzalez-Billault, C; Núñez M.T. Article ISI SCOPUS Journal of neural transmission (Vienna, Austria : 1996) (2011)
Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters DMT1 and ferroportin 1 Nunez, MT; Tapia, V; Rojas A.; Aguirre P.; Gomez, F; Nualart, F. Article ISI SCOPUS American Journal of Physiology - Cell Physiology (2010)
Upregulation of ?-glutamate-cysteine ligase as part of the long-term adaptation process to iron accumulation in neuronal SH-SY5Y cells Aguirre P.; Valdés P.; Aracena-Parks, P; Tapia, V; Núñez M.T. Article AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)
Upregulation of gamma-glutamate-cysteine ligase as part of the long-term adaptation process to iron accumulation in neuronal SH-SY5Y cells Aguirre P.; Valdés P.; Aracena-Parks, P; Tapia, V; Nunez, MT Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)
Antioxidant responses of cortex neurons to iron loading Aguirre P.; Mena N.; Tapia, V; Rojas A.; Arredondo M.; Nunez, MT Article ISI SCIELO BIOLOGICAL RESEARCH (2006)
Apical distribution of HFE-?2-microglobulin is associated with inhibition of apical iron uptake in intestinal epithelia cells Arredondo M.; Tapia, V; Rojas A.; Aguirre P.; Reyes, F.; Marzolo M.P.; Núñez M.T. Article BIOMETALS (2006)
Apical distribution of HFE-beta 2-microglobulin is associated with inhibition of apical iron uptake in intestinal epithelia cells Arredondo M.; Tapia, V; Rojas A.; Aguirre P.; Reyes, F.; Marzolo, MP; Nunez, MT Article ISI SCOPUS BIOMETALS (2006)
Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells Muñoz P; Zavala, G; Castillo, K; Aguirre P.; Hidalgo C.; Nunez, MT Article ISI SCIELO BIOLOGICAL RESEARCH (2006)
Iron and glutathione at the crossroad of redox metabolism in neurons Aracena P.; Aguirre P.; Muñoz P; Nunez, MT Article ISI SCIELO BIOLOGICAL RESEARCH (2006)
Quiescence induced by iron challenge protects neuroblastoma cells from oxidative stress Mura, CV; Delgado, R; Aguirre P.; Bacigalupo, J; Nunez, MT Article ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2006)
Iron homeostasis in neuronal cells: a role for IREGI Aguirre P.; Mena N.; Tapia, V; Arredondo M.; Nunez, MT Article ISI SCOPUS BMC NEUROSCIENCE (2005)


Neuroprotective effects of coumarin-based iron chelators in the MPP+ model of Parkinson's disease Nunez, M; Aguirre P.; Muñoz Y.; Garcia-Beltran, O Abstract ISI JOURNAL OF NEUROCHEMISTRY (2015)
Inflammatory stimuli and iron accumulation in neurons: two processes linked by hepcidin Urrutia, P; Esparza A.; Aguirre P.; Tapia, V; Gonzalez-Billault, C; Nunez, MT Abstract JOURNAL OF NEUROCHEMISTRY (2013)
SHORT-TERM REGULATION OF INTESTINAL IRON ABSORPTION BY TRANSPORTERS RELOCALIZATION Nunez, MT; Tapia, V; Rojas A.; Aguirre P.; Gomez, F; Nualart, F. Abstract JOURNAL OF PHYSIOLOGICAL SCIENCES (2009)
Physiology and pathology of iron in neuronal function Muñoz P; Aguirre P.; Hidalgo C.; Nunez, MT Abstract ISI PLACENTA (2006)