Man

Mabel Elizabeth Catalán Díaz

Profesora Asistente

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Química farmacológica del cáncer y la obesidad; Farmacología mitocondrial; Cáncer de colorrectal; Obesidad

Educación

  •  Licenciatura en Farmacia, UNIVERSIDAD DE CHILE. Chile, 2007
  •  Doctorado en Farmacología, UNIVERSIDAD DE CHILE. Chile, 2014
  •  Químico Farmacéutico, UNIVERSIDAD DE CHILE. Chile, 2007

Experiencia Académica

  •   Profesora Asistente Full Time

    UNIVERSIDAD DE CHILE

    de Medicina

    Santiago, Chile

    2018 - A la fecha

  •   Profesora por proyecto de inserción Other

    UNIVERSIDAD DE CHILE

    de Medicina

    Santiago, Chile

    2014 - 2017

Experiencia Profesional

  •   Academico con proyecto de inserción

    Universidad de Chile

    Chile

    2014 - A la fecha

  •   Profesora Asistente Full Time

    Universidad de Chile

    Chile

    2018 - A la fecha

Premios y Distinciones

  •   Medalla Doctoral

    UNIVERSIDAD DE CHILE

    Chile, 2014

    Distinción al grado de doctor otorgado por la Universidad de Chile


 

Article (15)

Boldine prevents the inflammatory response of cardiac fibroblasts induced by SGK1-NFκB signaling pathway activation

Catalán M.; Gonzalez-Herrera, F; Maya, JD; Lorenzo, O; Pedrozo, Z; Olmedo, I; Suarez-Rozas, C; Molina-Berrios, A; Diaz-Araya, G; Vivar, R

Article
CELLULAR SIGNALLING  (2024)

Gallic acid triphenylphosphonium derivatives TPP+-C10 and TPP+-C12 inhibit mitochondrial function in Candida albicans exerting antifungal and antibiofilm effects

Valderrama, Victoria; Sánchez, Paula; Delso, Macarena; Díaz-Bosque, Mario; Escobar, Alejandro; Budini, Mauricio; Catalán, Mabel; Vivar, Raúl; López-Muñoz, Rodrigo; Jara, José A.; Molina-Berríos, Alfredo

Article
JOURNAL OF APPLIED MICROBIOLOGY  (2024)

Lipoxin A4 prevents high glucose-induced inflammatory response in cardiac fibroblast through FOXO1 inhibition

Gonzalez-Herrera, Fabiola; Anfossi, Renatto; Catalan, Mabel; Gutierrez-Figueroa, Renata; Maya, Juan Diego; Diaz-Araya, Guillermo; Vivar, Raul

Article ISI
CELLULAR SIGNALLING  (2023)

SGK1 is necessary to FoxO3a negative regulation, oxidative stress and cardiac fibroblast activation induced by TGF-β1

Gonzalez-Herrera, Fabiola; Catalan, Mabel; Anfossi, Renatto; Maya, Juan Diego; Pedrozo, Zully; Diaz-Araya, Guillermo; Vivar, Raill

Article ISI
CELLULAR SIGNALLING  (2023)

Statins change the cytokine profile in Trypanosoma cruzi-infected U937 macrophages and murine cardiac tissue through Rho-associated kinases inhibition

Gonzalez-Herrera, Fabiola; Clayton, Natasha S.; Guzman-Rivera, Daniela; Carrillo, Ileana; Castillo, Christian; Catalan, Mabel; Anfossi, Renatto; Quintero-Pertuz, Helena; Quilaqueo, Maria Elena; Olea-Azar, Claudio; Rivera-Meza, Mario; Kemmerling, Ulrike; Ridley, Anne J.; Vivar, Raul; Diego Maya, Juan

Article ISI
FRONTIERS IN IMMUNOLOGY  (2023)

FoxO1 is required for high glucose-dependent cardiac fibroblasts into myofibroblast phenoconversion

Vivar, Raúl; Anfossi, Renatto; Humeres, Claudio; Catalán, Mabel; Reyes, Christopher; Cárdenas, Simone; Contreras, Alejandra; Aránguiz, Pablo; González, Fabiola; Diaz-Araya, Guillermo

Article
CELLULAR SIGNALLING  (2021)

Complex Mitochondrial Dysfunction Induced by TPP+-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells

Fuentes-Retamal, Sebastián; Sandoval-Acuña, Cristian; Peredo-Silva, Liliana; Guzmán-Rivera, Daniela; Pavani, Mario; Torrealba, Natalia; Truksa, Jaroslav; Castro-Castillo, Vicente; Catalán, Mabel; Kemmerling, Ulrike; Urra, Félix A.; Ferreira, Jorge

Article
CELLS  (2020)

Continuous flow synthesis of lipophilic cations derived from benzoic acid as new cytotoxic chemical entities in human head and neck carcinoma cell lines

Catalán, Mabel; Castro-Castillo, Vicente; Gajardo-de la Fuente, Javier; Aguilera, Jocelyn; Ferreira, Jorge; Fernández-Ramires, Ricardo; Olmedo, Ivonne; Molina-Berrios, Alfredo; Palominos, Charlotte; Valencia, Marcelo; Dominguez, Marta; Souto, José A.; Jara, José Antonio

Article
RSC MEDICINAL CHEMISTRY  (2020)

Medicinal Chemistry Targeting Mitochondria: From New Vehicles and Pharmacophore Groups to Old Drugs with Mitochondrial Activity

Catalán, Mabel; Olmedo, Ivonne; Faundez, Jennifer; Jara, José Antonio

Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2020)

Novel benzoate-lipophilic cations selectively induce cell death in human colorectal cancer cell lines

Jara, José Antonio; Rojas, Diego.; Castro-Castillo, Vicente; Fuentes-Retamal, Sebastián; Sandoval-Acuña, Cristian; Parra, Eduardo; Pavani, Mario; Maya, Juan Diego.; Ferreira, Jorge; Catalán, Mabel

Article
Toxicology in vitro : an international journal published in association with BIBRA.  (2020)

Role of FoxO3a as a negative regulator of the cardiac myofibroblast conversion induced by TGF-β1

Vivar, Raúl; Humeres, Claudio; Anfossi, Renatto; Bolivar, Samir; Catalán, Mabel; Hill, Joseph; Lavandero, Sergio; Diaz-Araya, Guillermo

Article
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH  (2020)

The Microbiota-Derived Metabolite of Quercetin, 3,4-Dihydroxyphenylacetic Acid Prevents Malignant Transformation and Mitochondrial Dysfunction Induced by Hemin in Colon Cancer and Normal Colon Epithelia Cell Lines

Catalán, Mabel; Ferreira, Jorge; Carrasco-Pozo, Catalina

Article
MOLECULES  (2020)

Antiproliferative and proapoptotic activities of aza-annulated naphthoquinone analogs

Suárez-Rozas, Cristian; Simpson, Sebastián; Fuentes-Retamal, Sebastián; Catalán, Mabel; Ferreira, Jorge; THEODULOZ, CRISTINA; Mella, Jaime; Cabezas, David; Cassels, Bruce K.; Yañez, Claudi; Castro-Castillo, Vicente

Article
TOXICOLOGY IN VITRO  (2019)

TGF‑β1 induced up‑regulation of B1 kinin receptor promotes antifibrotic activity in rat cardiac myofibroblasts

Catalán, Mabel; Aránguiz, Pablo; Boza, Pía; Olmedo, Ivonne; Humeres, Claudio; Vivar, Raúl; Anfossi, Renatto; Ayala, Pedro; Espinoza, Claudio; Lavandero, Sergio; Diaz-Araya, Guillermo

Article
MOLECULAR BIOLOGY REPORTS  (2019)

Destabilization of mitochondrial functions as a target against breast cancer progression: Role of TPP(+)-linked-polyhydroxybenzoates

Sandoval-Acuña, Cristian; Fuentes-Retamal, Sebastián; Guzmán-Rivera, Daniela; Peredo-Silva, Liliana; Madrid-Rojas, Matías; Rebolledo, Solange; Castro-Castillo, Vicente; Pavani, Mario; Catalán, Mabel; Maya, Juan Diego; Jara, José A.; Parra, Eduardo; Calaf, Gloria M.; Speisky, Hernan E.; Ferreira, Jorge

Article
TOXICOLOGY AND APPLIED PHARMACOLOGY  (2016)

Proyecto (4)

Targeting decyl polyOH benzoate esters coupled to triphenylphosphonium towards mitochondrial respiratory chain is an efficient approach for cancer treatment. Antitumor activity against several human lung cancer cell types. Basic and Preclinical studies

Ferreira, Jorge; Catalan, Mabel; Jara, José Antonio

Proyecto
 (2017)

In vitro and in vivo pre-clinical antineoplastic evaluation of new delocalized lipophilic cation derivatives in metastatic colorectal cancer

Catalán, Mabel

Proyecto
 (2016)

In vitro and in vivo pre-clinical antineoplastic evaluation of new delocalized lipophilic cation derivatives in metastatic colorectal cancer.

Catalán, Mabel; Universidad de Chile

Proyecto
 (2016)

Estudio de mecanismos de acción de Cationes Lipofilicos deslocalizados derivados de Alquil- Polihidroxibenzoatos unidos al grupo Trifenilfosfonio como Antineoplasicos de acción mitocondrial

Catalán, Mabel

Proyecto
 (2014)

19
Mabel Catalán

Profesora Asistente

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

3
Renatto Anfossi

Coordinador de Investigación

Unidad de Investigación

Hospital Regional Libertador Bernardo O'Higgins

Rancagua, Chile

3
Fabiola González

Investigadora Postdoctoral

Universidad de Chile

Santiago, Chile

1
Christian Castillo

Profesor Asistente

Instituto Ciencias Biomédicas

Universidad de Chile

Santiago, Chile