Man

Roberto Díaz Peña

Docente e Investigador

UNIVERSIDAD AUTONOMA DE CHILE

Talca, Chile

Líneas de Investigación


Estudio de la variabilidad genética en humanos, y cómo esta puede influir en la susceptibilidad a padecer determinados fenotipos complejos. Autoinmunidad, Reumatología, Histocompatibilidad y trasplante, Oncología, Bioinformática, Estadística.

Educación

  •  Bioquímica, UNIVERSIDAD DE OVIEDO. España, 2003
  •  Doctorado, UNIVERSIDAD DE OVIEDO. España, 2010
  •  Estadística, UNED, Universidad Nacional a Distancia. España, 2017
  •  Bioinformática, Universidad Pablo de Olavide. España, 2019

Experiencia Académica

  •   Docente e Investigador Full Time

    UNIVERSIDAD AUTONOMA DE CHILE

    Ciencias de la Salud

    Talca, Chile

    2013 - A la fecha

Experiencia Profesional

  •   Becario de Investigación Full Time

    Hospital Universitario Central de Asturias

    Oviedo, España

    2005 - 2006

  •   Investigador Contratado Full Time

    Hospital Universitario Central de Asturias

    Oviedo, España

    2007 - 2010

  •   Responsable de I+D Full Time

    Healthsens SL

    Oviedo, España

    2010 - 2012

  •   Docente e Investigador Full Time

    Universidad Autónoma de Chile

    Talca, Chile

    2013 - A la fecha

  •   Investigador Visitante Full Time

    Sistemas Genómicos SL

    Valencia, España

    2017 - 2017

  •   Investigador Visitante Full Time

    Unidad de Biopsia Líquida, Oncología Médica

    Santiago de Compostela, España

    2019 - 2020

Premios y Distinciones

  •   II Premio iberoamericano José Román

    Asociación cordobesa de enfermos afectados de espondilitis

    España, 2011

    Premio otorgado por la Asociación cordobesa de enfermos afectados de espondilitis (ACEADE), por la investigación desarrollada en dicha enfermedad.

  •   Premio Extraordinario de Doctorado

    Universidad de Oviedo

    Chile, 2011

    Premio a una de las mejores Tesis Doctorales presentadas ese año en la Universidad de Oviedo. España.


 

Article (51)

Rapid Idylla mutational testing to detect EGFR mutations in plasma samples and to monitor therapy in advanced non-small cell lung cancer patients
Somatic mutations in tumor and plasma of locoregional recurrent and/or metastatic head and neck cancer using a next-generation sequencing panel: A preliminary study
Advances of Genomic Medicine in Psoriatic Arthritis
Pharmacogenetic Variation and Its Clinical Relevance in a Latin American Rural Population
Plasma cell-free DNA and circulating tumor cells as prognostic biomarkers in small cell lung cancer patients
Polymorphisms in the FRMD4A Gene Are Associated With Chronic Obstructive Pulmonary Disease Susceptibility in a Latin American Population
Specific miRNA Profile in Chronic Obstructive Pulmonary Disease Related to Biomass Smoke Exposure
Acquisition of New Migratory Properties by Highly Differentiated CD4+CD28null T Lymphocytes in Rheumatoid Arthritis Disease
Circulating Free DNA and Its Emerging Role in Autoimmune Diseases
Clinical potential of circulating free DNA and circulating tumour cells in patients with metastatic non-small-cell lung cancer treated with pembrolizumab
Current Status and Future Perspectives of Liquid Biopsy in Small Cell Lung Cancer
Immunotherapy in nonsmall-cell lung cancer: current status and future prospects for liquid biopsy
Amerindian Ancestry Influences Genetic Susceptibility to Chronic Obstructive Pulmonary Disease
Analysis of Killer Immunoglobulin-Like Receptor Genes in Colorectal Cancer
Association analysis in a Latin American population revealed ethnic differences in rheumatoid arthritis-associated SNPs in Caucasian and Asian populations
Contribution of Multiplex Immunoassays to Rheumatoid Arthritis Management: From Biomarker Discovery to Personalized Medicine
Detection of MET Alterations Using Cell Free DNA and Circulating Tumor Cells from Cancer Patients
HLA-A, B, C and DRB1 alleles in a Chilean population from Talca
HLA-DRB1 alleles are associated with COPD in a Latin American admixed population
HLA-DRB1*07:01 and*08:02 Alleles Confer a Protective Effect Against ACPA-Positive Rheumatoid Arthritis in a Latin American Admixed Population
Interindividual Variation in Cardiorespiratory Fitness: A Candidate Gene Study in Han Chinese People
Latin American Genes: The Great Forgotten in Rheumatoid Arthritis
PRDM15 Is Associated with Risk of Chronic Obstructive Pulmonary Disease in a Rural Population in Chile
The Genetics of Spondyloarthritis
A Novel Saliva-Based miRNA Signature for Colorectal Cancer Diagnosis
Interaction between the functional SNP rs2070951 in NR3C2 gene and high levels of plasma corticotropin-releasing hormone associates to postpartum depression
Killer cell immunoglobulin-like receptor genotypes in a Chilean population from Talca
Epistasis, physical capacity-related genes and exceptional longevity: FNDC5 gene interactions with candidate genes FOXOA3 and APOE
ERAP1 and HLA-C interaction in inflammatory bowel disease in the Spanish population
Genomics and epigenomics in rheumatic diseases: what do they provide in terms of diagnosis and disease management?
A Single Nucleotide Polymorphism in the Il17ra Promoter Is Associated with Functional Severity of Ankylosing Spondylitis
HLA-B*40:01 Is Associated With Ankylosing Spondylitis in HLA-B27-positive Populations
rs2802292 Polymorphism in the FOXO3A Gene and Exceptional Longevity in Two Ethnically Distinct Cohorts
Significant association of the KIR2DL3/HLA-C1 genotype with susceptibility to Crohn's disease
Activating Killer Immunoglobulin-Like Receptors Genes Are Associated With Increased Susceptibility to Ankylosing Spondylitis
Genomics, Proteomics and Metabolomics: Their Emerging Roles in the Discovery and Validation of Rheumatoid Arthritis Biomarkers
Th17 response and autophagy - Main pathways implicated in the development of inflammatory bowel disease by genome-wide association studies
Genetic study confirms association of HLA-DPA1*01:03 subtype with ankylosing spondylitis in HLA-B27-positive populations
A high density SNP genotyping approach within the 19q13 chromosome region identifies an association of a CNOT3 polymorphism with ankylosing spondylitis
Ankylosing spondylitis in three Sub-Saharan populations: HLA-B*27 and HLA-B*14 contribution
Old and new HLA associations with ankylosing spondylitis
Fine Mapping of a Major Histocompatibility Complex in Ankylosing Spondylitis Association of the HLA-DPA1 and HLA-DPB1 Regions
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
Association of the KIR3DS1*013 and KIR3DL1*004 Alleles With Susceptibility to Ankylosing Spondylitis
Effect of Killer Immunoglobulin-Like Receptors in the Response to Combined Treatment in Patients with Chronic Hepatitis C Virus Infection
CD8dim and NKG2D Expression Defines Related Subsets of CD4+ T Cells in HIV-infected Patients With Worse Prognostic Factors
HLA-B27 polymorphism at position 116 critically influences the association with TAP/tapasin, intracellular trafficking and conformational homodimers formation
Activating KIR genes are associated with ankylosing spondylitis in Asian populations
Influence of HLA-B*5703 and HLA-B*1403 on Susceptibility to Spondyloarthropathies in the Zambian Population
The allele MICB*0050204, over-represented in the Caucasian population, has an additional exon resulting from a new splice junction sequence
Post-transplant soluble MICA and MICA antibodies predict subsequent heart graft outcome

BookSection (2)

Pharmacoepigenetics of Rheumatic Disorders
KIR genes and their role in spondyloarthropathies

BookWhole (1)

Molecular mechanisms of spondyloarthropathies

Proyecto (9)

A Personalized Medicine Approach to Improve the Prediction of anti-TNF Response in Patients with Rheumatoid Arthritis
Brecan Risk © personalised test: towards a more efficient and targeted prevention in Breast Cancer
Identificación de marcadores de diagnóstico, pronóstico y seguimiento mediante el análisis de Biopsia Líquida en pacientes con cáncer
Involvement of IL-15 in the migration of CD4+CD28null T cells in patients with rheumatoid arthritis. Study of potential inhibitory mechanisms.
Estudio de variabilidad de alelos HLA-B en pacientes de Espondilitis Anquilosante en Población Chilena
Genetic study of RA in latinoamerican populations=> High-density SNP genotyping in candidate genes and pharmacogenetics of metrotrexate
Implicación de los receptores KIR en la susceptibilidad a la Enfermedad Inflamatoria Intestinal
Estudio del efecto de dosis génica en la patogenia de la espondilitis anquilosante mediante secuenciación masiva de regiones exónicas e identificación de CNVs en individuos HLA-B27 positivos
Genotipado mediante SNPs de alta densidad de las regiones MHC (6p21) y LCR (19q3.4), en poblaciones HLA-B27 de diferente origen étnico. Análisis de marcadores de susceptibilidad genética adicionales en espondilitis anquilosante

Review (3)

Understanding the role of killer cell immunoglobulin-like receptors in pregnancy complications
Genetics of rheumatoid arthritis: a new boost is needed in Latin American populations
Genética, HLA-B27 y espondilitis anquilosante: 40 años
60
Roberto Díaz

Docente e Investigador

UNIVERSIDAD AUTONOMA DE CHILE

Talca, Chile

9
PATRICIA CASTRO

PROFESORA TITULAR

UNIVERSIDAD AUTONOMA DE CHILE

Talca, Chile

4
Jordi Olloquequi

Profesor Titular

Instituto de Ciencias Biomédicas

UNIVERSIDAD AUTONOMA DE CHILE

Talca, Chile

3
Luis Quinones

PROFESOR TITULAR

ONCOLOGIA BASICO-CLINICA

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Ricardo Verdugo

Asistant Professor

Facultad de Medicina

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Josefina Duran

Associate Professor

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Gonzalo Valdivia

Division Head, Full Professor

Medical School

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
José Suazo

Profesor Asociado

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

1
JUAN AGUILLON

PROFESSOR

IMMUNOLOGY PROGRAM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile