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Patricia Muñoz Salvatierra

Co-investigador

Universidad de Chile

SANTIAGO, Chile

ESTUDIOS DE MECANISMO MOLECULAR DE LA EP. POSIBLE ROL NEUROPROTECTIVO DE DT-DIAFORASA.; Generación de animales Knock-out como modelo pre-clínico para EP Desarrollo de organoides como modelos para EP

MAGISTER EN BIOQUIMICA, UNIVERSIDAD ANDRES BELLO. Chile, 2009
Doctorado en Farmacologia, UNIVERSIDAD DE CHILE. Chile, 2015
Bioquímica, UNIVERSIDAD ANDRES BELLO. Chile, 2009

Personal de colaboración en proyectos de investigacion Part Time

UNIVERSIDAD DE CHILE

Chile

2015 - 2017
Profesor Part Time

UNIVERSIDAD DE CHILE

Medicina

santiago, Chile

2017 - 2017

Encargada de Validacion de metodos Full Time

Labser

Rancagua, Chile

2010 - 2010
Profesional de colaboracion Part Time

Universidad de Chile

Santiago, Chile

2015 - 2017
Profesor cátedra de fisiologia Part Time

CFT La Araucana

Santiago, Chile

2009 - 2009
Academico Part Time

Universidad de Chile

Santiago, Chile

2014 - 2017


DT-Diaphorase Prevents Aminochrome-Induced Lysosome Dysfunction in SH-SY5Y Cells Melendez, C; Munoz, P; Segura-Aguilar, J Article ISI SCOPUS NEUROTOXICITY RESEARCH (2019)
Novel Alpha-Synuclein Oligomers Formed with the Aminochrome-Glutathione Conjugate Are Not Neurotoxic Huenchuguala, S; Sjodin, B; Mannervik, B; Segura-Aguilar, J Article ISI SCOPUS NEUROTOXICITY RESEARCH (2019)
Protective Effects of Crude Plant Extracts Against Aminochrome-induced Toxicity in Human Astrocytoma Cells: Implications for Parkinson's Disease Viviane L Ndam Ngoungoure 1 2, Patricia Muñoz 2, Yousef Tizabi 3, Raul Valdes 2, Paul Fewou Moundipa 1, Juan Segura-Aguilar 2 Affiliations expand Article Clin Pharmacol Transl Med (2019)
Are Dopamine Oxidation Metabolites Involved in the Loss of Dopaminergic Neurons in the Nigrostriatal System in Parkinson's Disease? Herrera A, Muñoz P, Steinbusch HW, Segura-Aguilar J Article ACS Chemical Neuroscience (2017)
Autophagy protects against neural cell death induced by piperidine alkaloids present in Prosopis juliflora (Mesquite) SILVA, VICTOR D.A.; CUEVAS, CARLOS; MUÑOZ, PATRICIA; VILLA, MONICA; AHUMADA-CASTRO, ULISES; Huenchuguala, Sandro; SANTOS, CLEONICE C. DOS; ARAUJO, FILLIPE M. DE; FERREIRA, RAFAEL S; SILVA, VANESSA B. DA; SILVA, JULIANA H.C. E; SOARES, ÉRICA N.; VELOZO, EUDES S.; Segura-Aguilar, Juan; COSTA, SILVIA L. Article ISI SCOPUS ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS (2017)
DT-diaphorase Protects Against Autophagy Induced by Aminochrome-Dependent Alpha-Synuclein Oligomers Muñoz P.S.; Segura-Aguilar J. Article ISI SCOPUS NEUROTOXICITY RESEARCH (2017)
On the Role of DT-Diaphorase Inhibition in Aminochrome-Induced Neurotoxicity In Vivo Herrera-Soto A.; Díaz-Veliz G.; Mora S.; Muñoz P.; Henny P.; Steinbusch H.W.M.; Segura-Aguilar J. Article ISI SCOPUS NEUROTOXICITY RESEARCH (2017)
On the Role of DT-Diaphorase Inhibition in Aminochrome-Induced Neurotoxicity In Vivo. Herrera-Soto A, Díaz-Veliz G, Mora S, Muñoz P, Henny P, Steinbusch HW, Segura-Aguilar J. Article NEUROTOXICITY RESEARCH (2017)
On the Role of Mining Exposure in Epigenetic Effects in Parkinson's Disease Castillo, Sebastian; Muñoz, Patricia; Behrens, María Isabel; Diaz-Grez, Fernando; Segura-Aguilar, Juan Article ISI SCOPUS NEUROTOXICITY RESEARCH (2017)
The Importance of Mitophagy in Maintaining Mitochondrial Function in U373MG Cells. Bafilomycin A1 Restores Aminochrome-Induced Mitochondrial Damage.. Huenchuguala S, Muñoz P Article ACS Chem Neurosci. (2017)
The Importance of Mitophagy in Maintaining Mitochondrial Function in U373MG Cells. Bafilomycin A1 Restores Aminochrome-lnduced Mitochondrial Damage Huenchuguala, Sandro; Muñoz, Patricia; Segura-Aguilar, Juan Article ISI SCOPUS ACS Chemical Neuroscience (2017)
Aminochrome as New Preclinical Model to Find New Pharmacological Treatment that Stop the Development of Parkinson's Disease Segura-Aguilar, J; Muñoz, P; Paris, I Article ISI CURRENT MEDICINAL CHEMISTRY (2016)
Aminochrome as new preclinical model to find new pharmacological treatment that stop the development of parkinsons disease Segura-Aguilar, J; Muñoz P; Paris, I Article SCOPUS Current Medicinal Chemistry (2016)
Aminochrome induces dopaminergic neuronal dysfunction: a new animal model for Parkinson's disease Herrera, A; Muñoz P; Paris, I; Díaz-Véliz G.; Mora S.; Inzunza, J; Hultenby K.; Cárdenas C; Jaña F; Raisman-Vozari R.; Gysling, K; Abarca, J; Steinbusch H.W.M.; Segura-Aguilar, J Article ISI SCOPUS CELLULAR AND MOLECULAR LIFE SCIENCES (2016)
Aminochrome Toxicity is Mediated by Inhibition of Microtubules Polymerization Through the Formation of Adducts with Tubulin Briceño A.; Muñoz P; Brito P.; Huenchuguala, S; Segura-Aguilar, J; Paris I.B. Article ISI SCOPUS NEUROTOXICITY RESEARCH (2016)
DT-diaphorase protects astrocytes from aminochrome-induced toxicity Huenchuguala, S; Muñoz P; Graumann R; Paris, I; Segura-Aguilar, J Article ISI SCOPUS NEUROTOXICOLOGY (2016)
Impact of Plant-Derived Flavonoids on Neurodegenerative Diseases Costa S.L.; Silva V.D.A.; Dos Santos Souza C.; Santos C.C.; Paris, I; Muñoz P; Segura-Aguilar, J Article ISI SCOPUS NEUROTOXICITY RESEARCH (2016)
DT-Diaphorase Prevents Aminochrome-Induced Alpha-Synuclein Oligomer Formation and Neurotoxicity Muñoz P; Cardenas, S; Huenchuguala, S; Briceño A.; Couve, E.; Paris, I; Segura-Aguilar, J Article ISI SCOPUS Toxicological Sciences (2015)
Glutathione transferase-M2-2 secreted from glioblastoma cell protects SH-SY5Y cells from aminochrome neurotoxicity. Cuevas, C; Huenchuguala, S; Muñoz, P; Villa, M; Paris, I; Mannervik, B; Segura-Aguilar J. Article NEUROTOXICITY RESEARCH (2015)
Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction Huenchuguala, S; Muñoz P; Zavala P.; Villa, M; Cuevas, C; Ahumada, U; Graumann R; Nore, BF; Couve, E.; Mannervik, B; Paris, I; Segura-Aguilar, J Article ISI SCOPUS AUTOPHAGY (2014)
One-Electron Reduction of 6-Hydroxydopamine Quinone is Essential in 6-Hydroxydopamine Neurotoxicity Villa, M; Muñoz P; Ahumada-Castro, U; Paris, I; Jiménez A; Martínez I.; Sevilla F.; Segura-Aguilar, J Article ISI SCOPUS Neurotoxicity Research (2013)
Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity Muñoz P; Paris, I; Sanders L.H.; Greenamyre J.T.; Segura-Aguilar, J Article ISI SCOPUS Biochimica et Biophysica Acta - Molecular Basis of Disease (2012)
Protective Effects of Nicotine Against Aminochrome-Induced Toxicity in Substantia Nigra Derived Cells: Implications for Parkinson's Disease Muñoz P; Huenchuguala, S; Paris, I; Cuevas, C; Villa, M; Caviedes P.; Segura-Aguilar, J; Tizabi Y. Article ISI SCOPUS NEUROTOXICITY RESEARCH (2012)
Autophagy Protects Against Aminochrome-Induced Cell Death in Substantia Nigra-Derived Cell Line Paris, I; Muñoz P; Huenchuguala, S; Couve, E.; Sanders, LH; Greenamyre, JT; Caviedes P.; Segura-Aguilar, J Article ISI SCOPUS TOXICOLOGICAL SCIENCES (2011)
Aminochrome Induces Disruption of Actin, Alpha-, and Beta-Tubulin Cytoskeleton Networks in Substantia-Nigra-Derived Cell Line Paris, I; Perez-Pastene, C; Cardenas, S; Iturra, P; Muñoz P; Couve, E.; Caviedes P.; Segura-Aguilar, J Article ISI SCOPUS Neurotoxicity Research (2010)
Stable Expression of Short Interfering RNA for DT-Diaphorase Induces Neurotoxicity Lozano, J; Muñoz P; Nore, BF; LeDoux, S; Segura-Aguilar, J Article ISI SCOPUS Chemical Research in Toxicology (2010)
Molecular and Neurochemical Mechanisms in PD Pathogenesis Paris, I; Lozano, J; Perez-Pastene, C; Muñoz P; Segura-Aguilar, J Article ISI SCOPUS NEUROTOXICITY RESEARCH (2009)


Molecular and neurochemical mechanisms dopamine oxidation to O-Quinones in parkinson’s disease pathogenesis Muñoz P; Melendez, C; Paris, I; Segura-Aguilar, J BookWhole SCOPUS Toxicity and Autophagy in Neurodegenerative Disorders (2015)


Aminochrome Induces Irreversible Mitochondrial Dysfunction by Inducing Autophagy Dysfunction in Parkinsons Disease Segura-Aguilar, J; Huenchuguala, S EditorialMaterial ISI SCOPUS FRONTIERS IN NEUROSCIENCE (2018)


Commentary: Evaluation of Models of Parkinson's Disease (vol 10, 161, 2016) Muñoz, P; Paris, I; Segura-Aguilar, J Errata ISI SCOPUS FRONTIERS IN NEUROSCIENCE (2016)
Protective Effects of Nicotine Against Aminochrome-Induced Toxicity in Substantia Nigra Derived Cells: Implications for Parkinson's Disease (vol 22, pg 177, 2012) Muñoz P; Huenchuguala, S; Paris, I; Cuevas, C; Villa, M; Caviedes P.; Segura-Aguilar, J; Tizabi Y. Errata ISI SCOPUS Neurotoxicity Research (2012)
Erratum to: Aminochrome Induces Disruption of Actin, Alpha-, and Beta-Tubulin Cytoskeleton Networks in Substantia-Nigra-Derived Cell Line (Neurotoxicity Research DOI: 10.1007/s12640-009-9148-4) Paris, I; Perez-Pastene C; Cardenas, S; Iturriaga-Vasquez, P.; Muñoz P; Couve, E.; Caviedes P.; Segura-Aguilar, J Errata SCOPUS Neurotoxicity Research (2010)


The need of a new and more physiological preclinical model for Parkinson's disease Segura-Aguilar, J; Paris, I; Muñoz P Letter ISI SCOPUS CELLULAR AND MOLECULAR LIFE SCIENCES (2016)


Commentary: Evaluation of models of Parkinson's disease Muñoz P; Paris, I; Segura-Aguilar, J Note SCOPUS Frontiers in Neuroscience (2016)


Development of disease-relevant brain organoids for Parkinson´s disease research Conicyt-STINT (CS2018-7940) Proyecto 2019-2021 Investigador(a)
Studies on the role of ectosomes on astrocytes secretion of GSTM2 to extracellular medium and its internalization into dopaminergic neurons FONDECYT (1170033) Proyecto 2017-2019 Coinvestigador(a)
IMPLANTAÇÃO DO MODELO EXPERIMENTAL PRÉ-CLÍNICO DE DOENÇA DE PARKINSON INDUZIDA POR AMINOCROMO=> PROSPECÇÃO FARMACOLÓGICA DE POTENCIAL NEUROPROTETOR DE FLAVONÓIDES EXTRAÍDOS DE PLANTAS DO ESTADO DA BAHIA CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO Proyecto 2015-2017 Personal técnico y/o de apoyo
ESTUDIOS SOBRE EL EFECTO DEL COBRE EN LA FUSION DE AGRESOMAS CON LISOSOMAS MEDIADO POR LA AGREGACION DE TUBULINA EN CELULAS SH-SY5Y UNIVERSIDAD SANTO TOMAS Proyecto 2014-2015 Personal técnico y/o de apoyo
ESTUDIOS EN EL ROL DE LA ENERGIA Y AMINOCROMO EN LA FUSION DE AUTOFAGOSOMAS Y AGRESOMAS CON LISOSOMAS MEDIADOS POR LA INTERACCION DE TUBULINA CON DINEINA/DINACTINA EN CELULAS IPS DERIVADAS DESDE PACIENTES CON LA ENFERMEDAD DE PARKINSON EN CHILE. FONDECYT (1120337) Proyecto 2012-2014 Personal técnico y/o de apoyo
ESTUDIOS DEL PAPEL DE LA DT-DIAFORASa EN LA NEUROTOXICIDAD DE AMINOCROMO EN UN MODELO ANIMAL DE LA ENFERMEDAD DE PARKINSON. PCI (2010-002) Proyecto 2011-2013 Tesista
ESTUDIOS EN MECANISMOS DE DEGENERACION DE NEURONAS DOPAMINERGICAS INDUCIDO POR AMINOCROMO Y LA PREVALENCIA POLIMORFICA EN PACIENTES CON PARKINSON EN CHILE FONDECYT (1100165) Proyecto 2010-2013 Tesista
ESTUDIOS EN EL MECANISMO MOLECULAR DE LA ENFERMEDAD DE PARKINSON. POSIBLE ROL NEUROPROTECTIVO DE DT-DIAFORASA Y GST M2-2 EN CULTIVO CELULAR Y LA COEXISTENCIA DE POLIMORFISMO DE DT-DIAFORASA Y ALFA-SINUCLEINA FONDECYT (1061083) Proyecto 2006-2009 Tesista


Are Dopamine Oxidation Metabolites Involved in the Loss of Dopaminergic Neurons in the Nigrostriatal System in Parkinson's Disease? Herrera A.; Muñoz P.; Steinbusch H.W.M.; Segura-Aguilar J. Review ISI SCOPUS ACS Chemical Neuroscience (2017)
Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease Zucca F.A.; Segura-Aguilar, J; Ferrari E.; Muñoz P.; Paris, I; Sulzer D.; Sarna T.; Casella L.; Zecca L. Review ISI SCOPUS PROGRESS IN NEUROBIOLOGY (2017)
Protective and toxic roles of dopamine in Parkinson's disease Segura-Aguilar, J; Paris, I; Muñoz P; FERRARI E.; Zecca, L; Zucca, FA Review ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2014)
Dopamine Oxidation and Autophagy Muñoz P; Huenchuguala, S; Paris, I; Segura-Aguilar, J Review ISI SCOPUS Parkinson's Disease (2012)