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Emma Rey Jurado

Professor/Researcher

Universidad del Desarrollo

Santiago, Chile

- Primary immunodeficiencies - Susceptibility to infections - Immunopathogenesis of respiratory viruses; - Host-pathogen interactions - Efficiency of drug-combinations against M. tuberculosis

Biología. Especialidad Microbiología, UNIVERSIDAD AUTONOMA DE BARCELONA. España, 2007
Doctor en Biología, UNIVERSIDAD DE BARCELONA. España, 2013

Postdoctorante Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

2014 - 2018
Profesora Part Time

Universidad Santo Tomás

Chile

2019 - 2020
Professor/Researcher Full Time

Universidad del Desarrollo

Chile

2020 - A la fecha

Estudiante predoctoral

Hospital Clínico de Barcelona. Universidad de Barcelona

España

2008 - 2013
Visitante predoctoral

National Institute for Medical Research

Reino Unido

2011 - 2011
Investigador postdoctoral

Public Health Research Institute

Estados Unidos

2013 - 2014
Postdoctorante Full Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2014 - 2018
Profesora Part Time

Universidad Santo Tomás

Santiago, Chile

2019 - A la fecha
Profesora/Postdoctorante Full Time

Universidad del Desarrollo

Chile

2020 - A la fecha

I have mentored graduated and PhD students to obtain their degrees:

Álex López-Galvín, Master student at University of Barcelona.
Derek Ray, graduate student at Rutgers University.
Andrés Mansilla, PhD student at Pontificia Universidad Católica de Chile.
Nicolás Gálvez, PhD student at Pontificia Universidad Católica de Chile.

I have presented our results at scientific meetings at national and international annual meetings including Federation of Clinical Immunology Societies (FOCIS) meetings, Congress of the Latin American Society of Immunology (ALAI) and Sociedad de Microbiología de Chile (SOMICH), Sociedad Española de Microbiología (SEIMC) and ESCMID. These events brought together national and international investigators, thus promoting collaborations in the field of immunology and translational biomedicine.
I were present in El Mostrador national newspaper on 4th November of 2015, contributing to better knowledge about Tuberculosis as well as the project granted by CONICYT. At such occasion, we were accessible to a significant number of people in Chile.

Pumarola Award

Societat Catalana de Malalties Infeccioses i Microbiologia Clínica i de la Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica (SEIMC)

España, 2008

Award “Agustí Pumarola” by the “ Societat Catalana de Malalties Infeccioses i Microbiología Clínica i de la Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica (SEIMC)” to develop a project entitled “Study of the infective capacity over macrophages of drug-resistant Mycobacterium tuberculosis and evaluation of the synergic activity of different drug combinations.
LASID fellowship award

Latin American Society for Immunodeficiencies

México, 2020

The Latin American Society of Primary Immunodeficiency LASID is an association of professionals dedicated to develop and perfect education, scientific research and health care within the field of Inborn Errors of Immunity (IEI). Scholarship Program Fellowship Award, which offers an award to an individual for training during two years in the field of primary immunodeficiency diseases.


Refractory systemic juvenile idiopathic arthritis successfully treated with rapamycin. Concha S, Rey-Jurado E, Poli MC, Hoyos-Bachiloglu R, Borzutzky A. Article Rheumatology (Oxford) (2021)
Contribution of NKT cells to the immune response and pathogenesis triggered by respiratory viruses Emma Rey-Jurado, Karen Bohmwald, Nicolás M.S. Gálvez, Daniela Becerra, Steven A. Porcelli, Leandro J. Carreño and Alexis M. Kalergis Article VIRULENCE (2020)
TCR Repertoire Characterization for T Cells Expanded in Response to hRSV Infection in Mice Immunized with a Recombinant BCG Vaccine Rey-Jurado E.; Bohmwald K.; Correa H.G.; Kalergis A.M. Article ISI SCOPUS VIRUSES-BASEL (2020)
High-efficiency nuclear transformation of the microalgae Nannochloropsis oceanica using Tn5 Transposome for the generation of altered lipid accumulation phenotypes Osorio, Hector; Jara, Carol; Fuenzalida, Karen; Rey-Jurado, Emma; Vasquez, Monica Article ISI SCOPUS BIOTECHNOLOGY FOR BIOFUELS (2019)
Assessing the Importance of Domestic Vaccine Manufacturing Centers=> An Overview of Immunization Programs, Vaccine Manufacture, and Distribution. Rey-Jurado, Emma; Tapia, Felipe; Muñoz-Durango, Natalia; Lay, Margarita K; Carreño, Leandro J; Riedel, Claudia A; Bueno, Susan M; Genzel, Yvonne; Kalergis, Alexis M Article Frontiers in immunology (2018)
Insights on the crosstalk between dendritic cells and helper T cells in novel genetic etiology for mendelian susceptible mycobacterial disease Rey-Jurado E.; Pizarro-Ortega M.S.; Kalergis A.M. Article ISI SCOPUS Cellular and Molecular Immunology (2018)
Insights on the crosstalk between dendritic cells and helper T cells in novel genetic etiology for mendelian susceptible mycobacterial disease. Rey-Jurado, Emma; Pizarro-Ortega, Magdalena S; Kalergis, Alexis M Article Cellular & molecular immunology (2018)
Patterns of antibody response during natural hRSV infection=> insights for the development of new antibody-based therapies. Muñoz-Durango, Natalia; Pizarro-Ortega, Magdalena S; Rey-Jurado, Emma; Díaz, Fabián E; Bueno, Susan M; Kalergis, Alexis M Article Expert opinion on investigational drugs (2018)
Recombinant BCG Vaccines Reduce Pneumovirus-Caused Airway Pathology by Inducing Protective Humoral Immunity Soto J.A.; GÃ¡lvez N.M.S.; Rivera C.A.; Palavecino C.E.; CÃ©spedes P.F.; Rey-Jurado E.; Bueno, S. M.; Kalergis A.M. Article ISI SCOPUS (2018)
Recombinant BCG Vaccines Reduce Pneumovirus-Caused Airway Pathology by Inducing Protective Humoral Immunity. Soto, Jorge A; Gálvez, Nicolás M S; Rivera, Claudia A; Palavecino, Christian E; Céspedes, Pablo F; Rey-Jurado, Emma; Bueno, Susan M; Kalergis, Alexis M Article Frontiers in immunology (2018)
A safe and efficient BCG vectored vaccine to prevent the disease caused by the human Respiratory Syncytial Virus. Rey-Jurado, Emma; Soto, Jorge; Gálvez, Nicolás; Kalergis, Alexis M Article Human vaccines & immunotherapeutics (2017)
A single, low dose of a cGMP recombinant BCG vaccine elicits protective T cell immunity against the human respiratory syncytial virus infection and prevents lung pathology in mice. Céspedes, Pablo F; Rey-Jurado, Emma; Espinoza, Janyra A; Rivera, Claudia A; Canedo-Marroquín, Gisela; Bueno, Susan M; Kalergis, Alexis M Article Vaccine (2017)
Immunological Features of Respiratory Syncytial Virus-Caused Pneumonia-Implications for Vaccine Design. Rey-Jurado, Emma; Kalergis, Alexis M Article International journal of molecular sciences (2017)
Modulation of Host Immunity by Human Respiratory Syncytial Virus Virulence Factors=> A Synergic Inhibition of Both Innate and Adaptive Immunity Canedo-Marroquín, Gisela; Acevedo-Acevedo, Orlando; Rey-Jurado, Emma; Saavedra, Juan M.; Lay, Margarita K.; Bueno, Susan M.; Riedel, Claudia A.; Kalergis, Alexis M. Article Frontiers in Cellular and Infection Microbiology (2017)
Human Respiratory Syncytial Virus=> Infection and Pathology. Bohmwald, Karen; Espinoza, Janyra A; Rey-Jurado, Emma; Gómez, Roberto S; González, Pablo A; Bueno, Susan M; Riedel, Claudia A; Kalergis, Alexis M Article Seminars in respiratory and critical care medicine (2016)
In vitro time-kill curves study of three antituberculous combinations against Mycobacterium tuberculosis clinical isolates Lopez-Gavin, A; Tudo G., Rey-Jurado; E, Vergara A.; Hurtado, JC; Gonzalez-Martin, J Article International Journal of Antimicrobial Agents (2016)
In vitro time-kill curves study of three antituberculous combinations against Mycobacterium tuberculosis clinical isolates Lopez-Gavin, A; Tudo G.; Rey-Jurado, E; Vergara, A; Hurtado, JC; Gonzalez-Martin, J Article International Journal of Antimicrobial Agents (2016)
Contribution of autophagy to antiviral immunity. Rey-Jurado, Emma; Riedel, Claudia A; González, Pablo A; Bueno, Susan M; Kalergis, Alexis M Article FEBS letters (2015)
Activity and interactions of levofloxacin, linezolid, ethambutol and amikacin in three-drug combinations against Mycobacterium tuberculosis isolates in a human macrophage model Rey-Jurado, Emma; Tudo, Griselda; Soy, Dolors; Gonzalez-Martin, Julian Article ISI INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2013)
Detection of streptomycin and quinolone resistance in Mycobacterium tuberculosis by a low-density DNA array Moure, Raquel; Tudo, Griselda; Medina, Rebeca; Vicente, Eva; Maria Caldito, Jose; Gemma Codina, Maria; Coll, Pere; Espanol, Montserrat; Gonzalez-Martin, Julian; Rey-Jurado, Emma; Salvado, Margarita; Teresa Tortola, Maria; Alcaide, Fernando Article ISI TUBERCULOSIS (2013)
In vitro effect of three-drug combinations of antituberculous agents against multidrug-resistant Mycobacterium tuberculosis isolates Rey-Jurado, Emma; Tudo, Griselda; Puig de la Bellacasa, Jorge; Espasa, Mateu; Gonzalez-Martin, Julian Article ISI INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2013)
Synergistic effect of two combinations of antituberculous drugs against Mycobacterium tuberculosis Rey-Jurado, Emma; Tudo, Griselda; Antonio Martinez, Jose; Gonzalez-Martin, Julian Article ISI TUBERCULOSIS (2012)
Impaired fitness of Mycobacterium tuberculosis resistant isolates in a cell culture model of murine macrophages Rey-Jurado, Emma; Tudo, Griselda; Borrell, Sonia; Alcaide, Fernando; Coll, Pere; Espanol, Montserrat; Martin-Casabona, Nuria; Mick, Virginie; Montemayor, Michel; Moure, Raquel; Salvado, Margarita; Vicente, Eva; Gonzalez-Martin, Julia Article ISI JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2011)
Characterization of mutations in streptomycin-resistant Mycobacterium tuberculosis clinical isolates in the area of Barcelona Tudo, Griselda; Rey, Emma; Borrell, Sonia; Alcaide, Fernando; Codina, Gemma; Coll, Pere; Martin-Casabona, Nuria; Montemayor, Michel; Moure, Raquel; Orcau, Angels; Salvado, Margarita; Vicente, Eva; Gonzalez-Martin, Julia Article ISI JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2010)
Tuberculosis transmission patterns among Spanish-born and foreign-born populations in the city of Barcelona Borrell, S.; Espanol, M.; Orcau, A.; Tudo, G.; March, F.; Cayla, J. A.; Jansa, J. M.; Alcaide, F.; Martin-Casabona, N.; Salvado, M.; Martinez, J. A.; Vidal, R.; Sanchez, F.; Altet, N.; Rey, E.; Coll, P.; Gonzalez-Martin, J. Article ISI CLINICAL MICROBIOLOGY AND INFECTION (2010)


Antibodies Secretion Promoted by a Recombinant BCG Strain Induces a Protective Immune Response Against Human Respiratory Viruses Soto J, Gálvez N, Rivera C, Palavecino C, Céspedes P, Rey-Jurado E, Bueno S and Kalergis AM. ConferencePoster (2018)
Contribution of CD1d to immune responses and pathogenesis in mouse models of human respiratory syncytial virus and the human metapneumovirus infections. Rey-Jurado E, Bohmwald K, Gálvez N, Becerra D, Carreño LC, Kalergis AM. ConferencePoster (2018)
Phase I clinical trial for a recombinant BCG expressing the nucleoprotein of the human respiratory syncytial virus (hRSV) in healthy adults Abarca K, Rey-Jurado E, Muñoz-Durango N, Vázquez Y, Iturriaga C, Marcela Urzúa M, Borzutzky A, Valdés J, Soto JA, Gálvez NMS, Madrid V, Bueno SM, Alexis M Kalergis ConferencePoster (2018)
Role of CD1d receptor in the pathology caused by the human respiratory syncytial virus and the human metapneumovirus Rey-Jurado E, Bohmwald K, Gálvez N, Becerra D, Carreño LC, Kalergis AM ConferencePoster (2018)
Contribution of Natural Killer T cells to the pathology caused by the Respiratory Syncytial Virus and the Metapneumovirus Rey-Jurado E, Bohmwald K, Gálvez N, Becerra D, Carreño LC, Kalergis AM ConferencePoster (2017)
Contribution of Natural Killer T cells to the pathology caused by the Respiratory Syncytial Virus and the Metapneumovirus. Rey-Jurado E, Bohmwald K, Gálvez N, Becerra D, Carreño LC, Kalergis AM. ConferencePoster (2017)
A single, low dose of a current Good Manufacturing Practive (cGMP) recombinant BCG vaccine confers protection against human respiratory syncytial virus (hRSV) infection and lung pathology in mice Céspedes, P., Rey-Jurado, E., Espinoza, J., Rivera, C., Bueno, S., and Kalergis A. ConferencePoster (2016)
Synergism of linezolid, levofloxacin and amikacin combination against multidrug-resistant and drug-susceptible isolates of M. tuberculosis Rey E., Tudó G., González-Martín J. ConferencePoster (2011)
Caracterización, diagnóstico y estudio de la capacidad de infección de aislados de Mycobacterium tuberculosis resistentes a los fármacos Rey E., Tudó G ConferencePoster (2010)
Intracellular penetration capacity of Mycobacterium tuberculosis drug-resistant isolates using a murine macrophage model. Intracellular penetration capacity of Mycobacterium tuberculosis drug-resistant isolates using a murine macrophage model Rey E., Tudó G., Borrell S., Alcaide F., Codina G., Coll P., Martín N., Mick V., Montemayor M., Salvadó M., Vicente E., González J. ConferencePoster (2010)
Synergistic activity of three antituberculous drug combinations against clinical isolates of Mycobacterium tuberculosis resistant to different drugs. Rey E., Tudó G., Borrell S. and Gonzalez J. ConferencePoster (2010)
Análisis epidemiológico de los mecanismos moleculares más frecuentemente implicados en la resistencia al etambutol y su relación con la multirresistencia en Mycobacterium tuberculosis Moure R., Andreu A., Coll P., Fernández R., Martín-Casabona N., Mick V., Montemayor M., Ortíz E., Rey E., Salvadó M., Tudó G., Alcaide F. ConferencePoster (2009)
Estudio de la capacidad infectiva sobre macrófagos de aislados clínicos de Mycobacterium tuberculosis resistentes a los fármacos de primera línea y evaluación de la actividad sinérgica de diversas combinaciones de fármacos Rey E. ConferencePoster (2009)
Synergistic activity of two antituberculous drug combinations against clinical isolates of Mycobacterium tuberculosis resistant to isoniazid Rey E., Tudó G. and González-Martín J. ConferencePoster (2009)
Comparison of four colour IS6110-fAFLP with the classic IS6110 RFLP on the ability to detect recent transmission in the city of Barcelona, Spain Poster. Borrell S., Thorne N., Mortimer C., Espanyol M., Rey E., Gonzalez-Martin J., Coll P., Gharbia S. and Arnold C ConferencePoster (2008)
High frequency of embB codon 406 mutations in ethambutol-resistant isolates of Mycobacterium tuberculosis Moure R., Andreu A., Castelblanco E., Coll P., Fernández R., Martín- Casabona N., Mick V., Montemayor M., Rey E., Salvadó M., Tudó G., Alcaide F. ConferencePoster (2008)


Clinical trial of safety, tolerability and immunogenicity of a recombinant vaccine against respiratory syncytial virus FONDEF (D11E1080) Proyecto 2016-2019 Postdoctorado
CHARACTERIZATION AND FUNCTIONAL RELEVANCE OF THE T CELL RECEPTOR REPERTOIRE OF HRSV-SPECIFIC T CELLS EXPANDED IN RESPONSE TO HRSV INFECTION IN NAIVE AND VACCINATED MICE. FONDECYT (3160249) Proyecto 2015-2018 Inv. Responsable
ELUCIDATING THE MECHANISMS OF PATHOGENICITY USED BY THE HUMAN RESPIRATORY SYNCYTIAL VIRUS TO PREVENT T CELL ACTIVATION AND CAUSE CENTRAL NERVOUS SYSTEM INFLAMMATION. FONDECYT (1150862) Proyecto 2015-2019 Personal técnico y/o de apoyo
Estudio de la actividad sinérgica de combinaciones de fármacos antituberculosos frente a aislados clínicos de M.tuberculosis multirresistentes utilizando un modelo in vitro y un modelo ex-vivo con macrófagos humanos. Sociedad Española de Pneumología y Cirugía Torácica (SEPAR) (1007/2010) Proyecto 2011-2013 Tesista
Detección rápida de la resistencia a los fármacos de primera línea en Mycobacterium tuberculosis mediante chips de DNA de baja densidad. Estudio in vitro de la infectividad en macrófagos humanos de los genotipos resistentes más relevantes. Fondo Investigación Sanitaria (FIS) (FIS10/00712) Proyecto 2007-2010 Tesista
Eficacia in vitro del tratamiento antibiótico frente a cepas resistentes de Mycobacterium tuberculosis. Estudio de la capacidad infectiva sobre macrófagos y evaluación de la actividad sinérgica de diversas combinaciones de fármacos Fondo Investigación Sanitaria (FIS) (FIS06/0328) Proyecto 2006-2008 Tesista


Assessing the Importance of Domestic Vaccine Manufacturing Centers: An Overview of Immunization Programs, Vaccine Manufacture, and Distribution Rey-Jurado, E; Tapia, F; Munoz-Durango, N; Lay, MK; Carreno, LJ; Riedel, CA; Bueno, SM; Genzel, Y; Kalergis, AM Review ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2018)
Patterns of antibody response during natural hRSV infection: insights for the development of new antibody-based therapies Munoz-Durango, N; Pizarro-Ortega, MS; Rey-Jurado, E; Diaz, FE; Bueno, SM; Kalergis, AM Review ISI SCOPUS EXPERT OPINION ON INVESTIGATIONAL DRUGS (2018)
Human Respiratory Syncytial Virus: Infection and Pathology Bohmwald, K; Espinoza, JA; Rey-Jurado, E; Gomez, RS; Gonzalez, PA; Bueno, SM; Riedel, CA; Kalergis, AM Review ISI SCOPUS SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE (2016)