Man

Eduardo Melkon Karahanian Vartevanian

Professor

UNIVERSIDAD AUTONOMA DE CHILE

Santiago, Chile

Líneas de Investigación


Molecular mechanisms of alcohol addiction Pharmacotherapy for alcoholism

Educación

  •  Biologo, Universidad de Buenos Aires. Argentina, 1994
  •  Ciencias mención Biología, UNIVERSIDAD DE CHILE. Chile, 2000

Experiencia Académica

  •   Profesor Asociado Full Time

    UNIVERSIDAD DIEGO PORTALES

    Faculty of Medicine

    Santiago, Chile

    2002 - 2013

  •   Instructor Part Time

    UNIVERSIDAD DE CHILE

    Fac Chemistry & Pharmaceutical Sciences

    Santiago, Chile

    2000 - 2002

  •   Post-doc Full Time

    Fac Chemistry & Pharmaceutical Sciences

    Santiago, Chile

    1999 - 2001

  •   Instructor Part Time

    Faculty of Medicine

    Santiago, Chile

    2001 - 2002

  •   Profesor Asociado Full Time

    UNIVERSIDAD AUTONOMA DE CHILE

    CIENCIAS DE LA SALUD

    SANTIAGO, Chile

    2013 - A la fecha

Experiencia Profesional

  •   Professor Full Time

    Universidad Diego Portales

    Santiago, Chile

    2002 - 2013

  •   Professor Full Time

    Universidad Autonoma de Chile

    Santiago, Chile

    2013 - A la fecha

Formación de Capital Humano


Development of a multiplex PCR to detect different genes of metallo ?-lactamase of Pseudomonas aeruginosa.
Alexis Luengo Yañez. Universidad Tecnológica Metropolitana, Facultad de Ciencias naturales matemáticas y del medio ambiente. Undergraduate thesis, 2014.

Design and evaluation of a new system for gene silencing therapy for alcoholism.
Dagoberto Sepúlveda Araneda. Facultad de Ciencias Básicas y Matemáticas, Pontificia Universidad Católica de Valparaíso.
Undergraduate thesis, 2008.

Evaluation of fenofibrate as a new drug for alcoholism treatment
Daniel Muñoz Uribe. Universidad Autónoma de Chile. PhD Thesis. Writing in preparation.

Relationship between the melanocortin system and alcohol consumption in adolescence
Osvaldo Flores Bastías. Universidad Autónoma de Chile. PhD Thesis. Writing in preparation.


Premios y Distinciones

  •   Doctoral Fellowship

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 1995

    Doctoral Fellowship


 

Article (20)

Neuroinflammation produced by heavy alcohol intake is due to loops of interactions between Toll-like 4 and TNF receptors, peroxisome proliferator-activated receptors and the central melanocortin system: A novel hypothesis and new therapeutic avenues.

Flores-Bastías, Osvaldo; Karahanian, Eduardo

Article ISI
NEUROPHARMACOLOGY  (2018)

Fenofibrate Administration Reduces Alcohol and Saccharin Intake in Rats: Possible Effects at Peripheral and Central Levels

Rivera-Meza, Mario; Muñoz, Daniel; Jerez, Erik; Quintanilla, María E.; Salinas-Luypaert, Catalina; Fernandez, Katia; Karahanian, Eduardo

Article ISI SCOPUS
FRONTIERS IN BEHAVIORAL NEUROSCIENCE  (2017)

New Implications for the Melanocortin System in Alcohol Drinking Behavior in Adolescents: The Glial Dysfunction Hypothesis

Orellana, Juan A.; Cerpa, Waldo; Carvajal, Maria F.; Lerma-Cabrera, José M.; Karahanian, Eduardo; Osorio-Fuentealba, Cesar; Quintanilla, Rodrigo A.

Article ISI SCOPUS
FRONTIERS IN CELLULAR NEUROSCIENCE  (2017)

Draft Genome sequence of a copper resistant marine bacterium, Pantoea agglomerans strain LMAE-2, a bacterial strain with potential use in bioremediation

Corsini, Gino; Valdés, Natalia; Tello, Mario; Pradel, Paulina; Cottet, Luis; Muiño, Laura; Karahanian, Eduardo; González, Alex

Article WOS-ESCI SCOPUS
Genome Announcements  (2016)

Long-term inhibition of ethanol intake by the administration of an aldehyde dehydrogenase-2 (ALDH2)-coding lentiviral vector into the ventral tegmental area of rats

Karahanian, E; Rivera-Meza, M; Tampier, L; Quintanilla M.E.; Herrera-Marschitz, M; Israel, Y

Article ISI SCOPUS
ADDICTION BIOLOGY  (2015)

Fenofibrate - A lipid-lowering drug - Reduces voluntary alcohol drinking in rats

Karahanian, E; Quintanilla, ME; Fernández K.; Israel, Y

Article ISI SCOPUS
ALCOHOL  (2014)

Salsolinol, free of isosalsolinol, exerts ethanol-like motivational/sensitization effects leading to increases in ethanol intake

Quintanilla, ME; Rivera-Meza, M; Berrios-Cárcamo, PA; Bustamante D.; Buscaglia M.; Morales P.; Karahanian, E; Herrera-Marschitz, M; Israel, Y

Article ISI SCOPUS
ALCOHOL  (2014)

Salt-Urea, Sulfopropyl-Sepharose, and Covalent Chromatography Methods for Histone Isolation and Fractionation

Rodriguez-Collazo, P; Leuba, S; Karahanian, E; Zlatanova, J

Article ISI
NEISSERIA MENINGITIDIS  (2014)

The Alcohol Deprivation Effect: Marked Inhibition by Anticatalase Gene Administration into the Ventral Tegmental Area in Rats

Tampier, L; Quintanilla, ME; Karahanian, E; Rivera-Meza, M; Herrera-Marschitz, M; Israel, Y

Article ISI SCOPUS
Alcoholism: Clinical and Experimental Research  (2013)

Reward and Relapse: Complete Gene-Induced Dissociation in an Animal Model of Alcohol Dependence

Quintanilla M.E.; Tampier, L; Karahanian, E; Rivera-Meza, M; Herrera-Marschitz, M; Israel, Y

Article ISI SCOPUS
Alcoholism: Clinical and Experimental Research  (2012)

Ethanol as a Prodrug: Brain Metabolism of Ethanol Mediates its Reinforcing Effects

Karahanian, E; Quintanilla, ME; Tampier, L; Rivera-Meza, M; Bustamante D.; Gonzalez-Lira, V; Morales P.; Herrera-Marschitz, M; Israel, Y

Article ISI SCOPUS
Alcoholism: Clinical and Experimental Research  (2011)

Purification and characterization of the antimicrobial peptide microcin N

Corsini, G; Karahanian, E; Tello, M; Fernández K.; Rivero D.; Saavedra, JM; Ferrer A.

Article ISI SCOPUS
FEMS Microbiology Letters  (2010)

Gene therapy reduces ethanol intake in an animal model of alcohol dependence

Ocaranza, P; Quintanilla, ME; Tampier, L; Karahanian, E; Sapag, A; Israel, Y

Article ISI SCOPUS
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH  (2008)

Aldehyde dehydrogenase (ALDH2) activity in hepatoma cells is reduced by an adenoviral vector coding for an ALDH2 antisense mRNA

Karahanian, E; Ocaranza, P; Israel, Y

Article ISI SCOPUS
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH  (2005)

Use of an acetaldehyde clamp" in the determination of low-K-M aldehyde dehydrogenase activity in H4-II-E-C3 rat hepatoma cells"

Moncada, C; Fuentes N.; Lladser, A; Encina G.; Sapag, A; Karahanian, E; Israel, Y

Article ISI SCOPUS
ALCOHOL  (2003)

Gene and antisense delivery in alcoholism research

Israel, Y; Crews, FT; Thurman, RG; Tu, GC; Garver, E; Ponnappa, B; Karahanian, E; Rubin, R; Hoplight, B; Sethna, M; Hanes, R; Wilkie, MB; Wheeler, MD

Article ISI SCOPUS
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH  (2002)

Cloning and molecular analysis of a cDNA and the Cs-mnp1 gene encoding a manganese peroxidase isoenzyme from the lignin-degrading basidiomycete Ceriporiopsis subvermispora

Lobos, S; Larrondo, L; Salas, L; Karahanian, E; VICUNA, R

Article ISI
GENE  (1998)

Structure and expression of a laccase gene from the ligninolytic basidiomycete Ceriporiopsis subvermispora

Karahanian, E; Corsini, G; VICUNA, R; Lobos S.

Article
Biochimica et Biophysica Acta - Gene Structure and Expression  (1998)

Lip-like genes in Phanerochaete sordida and Ceriporiopsis subvermispora, white rot fungi with no detectable lignin peroxidase activity.

Rajakumar, S.; Gaskell, J.; Cullen, D.; Lobos, S.; Karahanian, E.; Vicuña, R.

Article
Appl Environ Microbiol.  (1996)

Isolation and partial purification of mitochondrial and cytosolic rhodanese from liver of normal and p-dimethylaminoazobenzene treated mice.

Vasquez, E.; Polo, C.; Stedile, G.; Schebor, C.; Karahanian, E.; Batlle, A

Article
Int J Biochem Cell Biol.  (1995)

Letter (1)

PPAR? agonists reduce alcohol drinking: Do they act in the brain or in the liver?

Karahanian, E; Rivera-Meza, M; Quintanilla M.E.; Muñoz D; Fernández K.; Israel, Y

Letter ISI SCOPUS
Alcohol and Alcoholism  (2015)

Review (3)

Neuroinflammation produced by heavy alcohol intake is due to loops of interactions between Toll-like 4 and TNF receptors, peroxisome proliferator-activated receptors and the central melanocortin system: A novel hypothesis and new therapeutic avenues

Flores-Bastias, O; Karahanian, E

Review ISI SCOPUS
NEUROPHARMACOLOGY  (2018)

The "First Hit" Toward Alcohol Reinforcement: Role of Ethanol Metabolites

Israel, Y; Quintanilla, ME; Karahanian, E; Rivera-Meza, M; Herrera-Marschitz, M

Review ISI SCOPUS
Alcoholism: Clinical and Experimental Research  (2015)

Gene specific modifications unravel ethanol and acetaldehyde actions

Israel, Y; Rivera-Meza, M; Karahanian, E; Quintanilla, ME; Tampier, L; Morales P.; Herrera-Marschitz, M

Review ISI SCOPUS
Frontiers in Behavioral Neuroscience  (2013)

24
Eduardo Karahanian

Professor

INSTITUTO DE CIENCIAS BIOMEDICAS

UNIVERSIDAD AUTONOMA DE CHILE

Santiago, Chile

16
Eduardo Karahanian

Académico Investigador

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Santiago, Chile

11
Yedy Israel

Profesor Titular

Farmacologia Molecular y Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE CS QUIMICAS Y FARMACÉUTICAS, LAB. FARMACOTERAPIA GÉNICA

Santiago, Chile

7
Mario Herrera-Marschitz

Profesor titular

Mol. & Clin. Pharmacology

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, PROGRAMA FARMACOLOGIA MOLECULAR & CLINICA, ICBM

Santiago, Chile

7
María Quintanilla

PROFESOR ASOCIADO

FARMACOLOGÍA MOLECULAR Y CLÍNICA

UNIVERSIDAD DE CHILE, FACULLTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

4
Katia Fernández

Académico - Profesor Asociado

Facultad de Salud y Odontología

Universidad Diego Portales

Santiago, Chile

3
Gino Corsini

Director Instituto Ciencias Biomédicas

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

3
Paola Morales

Profesor Asociado

Programa Farmacología Molecular & Clínica, ICBM,

Universidad de Chile

Santiago, Chile

2
Mario Tello

Académico

Biología

Universidad de Santiago de Chile

Santiago, Chile

2
Alvaro Lladser

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

1
Alex Gonzalez

Profesor Asociado

Ciencias Biologicas

Universidad de los Lagos

Osorno, Chile

1
Laura Muiño

Docente

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

1
Waldo Cerpa

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Alonso Ferrer

Académico regular

Universidad Mayor de Chile

Santiago, Chile

1
Gonzalo Encina

Investigador

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

1
Marianne Buscaglia

Estudiante de Doctorado en Ciencias Biológicas, mención Genética Molecular y Microbiología

Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Natalia Valdés

Investigador

Universidad de Santiago de Chile

Santiago, Chile

1
Pablo Berríos

Asistente de investigación

Universidad del Desarrollo

Santiago, Chile