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JOSE LEONARDO GUZMAN GONZALEZ

Full professor

Universidad de Concepción

Concepcion, Chile

Molecular biology Molecular neurobiology Neurophamacology

Cellular and Molecular Biology, UNIVERSIDAD DE CONCEPCION. Chile, 2005
Biochemist, UNIVERSIDAD DE CONCEPCION. Chile, 1998

Full Professor Full Time

UNIVERSIDAD DE CONCEPCION

Faculty of Biological Sciences

Concepcion, Chile

2005 - A la fecha
Subdirector de Postgrado Other

UNIVERSIDAD DE CONCEPCION

Dirección de Postgrado

Concepción, Chile

2018 - A la fecha
Director de Departamento Part Time

UNIVERSIDAD DE CONCEPCION

Ciencias Biológicas

Concepción, Chile

2017 - 2018
Director de Programa de Doctorado Part Time

UNIVERSIDAD DE CONCEPCION

Ciencias Biológicas

Concepción, Chile

2011 - 2014

Postdoctoral Full Time

University of Concepcion

Concepcion, Chile

2005 - 2008

UNDERGRADUATE THESIS

ARIEL SALVATORE AVILA MACAYA, Biochemistry degree, “Analisis de la regulacion e interaccion de canales ionicos activados por ligando con G beta gamma”, December, 2008.

PIA MARIA VIOLE VIDAL VERA, Bioingeneer degree, “Activacion de proteinas G alfa por concentraciones farmacologicas de etanol”, December, 2008.

LORETO SOLEDAD SAN MARTIN VASQUEZ, Biochemistry degree, “Inhibicion del Efecto de Etanol en Receptor de Glicina por peptidos bloqueadores de Gbeta gamma”, March, 2011.

FABIAN CERDA, Bioingeneer degree, “Definicion de una estructura química no proteica para la inhibición de los efectos de etanol sobre el receptor de glicina”, 2011.

CAMILA ROMINA RIQUELME BAHAMONDES, Bioingeneer degree, “Efecto de etanol en el intercambio de GDP/GTP en las subunidades Galpha i1, Galpha OA, Galph aq”, March, 2011.

DANIELA ALEJANDRA NOVA BAZA, Biochemistry degree, “Efecto de etanol en el estado de disociación de la proteína G heterotrimerica”, March, 2012.

PILAR VASQUEZ. Undergraduate thesis "Diseño de ligandos peptídicos para el direccionamiento específico de nanotransportadores de farmacos al espacio sinaptico". Biochemistry degree.

POSTGRADUATE THESIS

LORETO SOLEDAD SAN MARTÍN VASQUEZ, Doctorado en Ciencias Biologicas area Biologia Celular y Molecular. 2016. Completed.

FABIAN CERDA, Magister en Bioquimica y Bioinformatica. “Busqueda de moléculas activas que inhiben la potenciacion del Receptor de Glicina por etanol a traves de G beta gamma”. November, 2013. Completed

SORAYA DEL CARMEN QUEZADA LOZANO, Magister en Fisiologia Humana. “Regulacion de la hormona liberadora de gonadotropina (GnRH) y aspectos fisiopatológicos”. December, 2013. Completed.

DANIELA GONZALEZ LEIVA, Magister en Fisiologia Humana. “Rol de Proteinas de la Densidad Postsinaptica Glutamatergica”. January, 2014. Completed,.

FELIPE BURGOS, PhD thesis, "Requerimientos moleculares y bioquímicos para la modulación por etanol de los receptores de glicina y GABAA", Doctorado en Ciencias Biologicas area Biologia Celular y Molecular. 2016. Completed.

FELIPE VIDAL, PhD thesis, "Estudio de la internalización celular y potencial uso como nanotransportadores de fármacos de dendrímeros PAMAM en neuronas". Doctorado en Ciencias Biologicas area Biologia Celular y Molecular. 2018. Completed.

CAMILO SAN MARTÍN. Master Thesis. "Rol del ejercicio físico en el control de la Diabetes Mellitus 2". Masther degree in Physiology. 2018. Completed.

Premio Henri Nestle

NESTLE CHILE S.A.

Chile, 2011

Co-suthor of the paper: Fuentealba J, Dibarrart AJ, Fuentes-Fuentes MC, Saez-Orellana F, Quiñones K, Guzmán L, Perez C, Becerra J, Aguayo LG. 2011. Synaptic failure and adenosine triphosphate imbalance induced by amyloid-? aggregates are prevented by blueberry-enriched polyphenols extract. J Neurosci 89(9):1499-508.
Premio Henri Nestle

NESTLE CHILE S.A.

Chile, 2012

Co-author of the paper: Fuentealba J, Dibarrart A, Saez-Orellana F, Fuentes-Fuentes MC, Oyanedel CN, Guzmán J, Perez C, Becerra J, Aguayo LG. Synaptic Silencing and Plasma Membrane Dyshomeostasis Induced by Amyloid-? Peptide are Prevented by Aristotelia Chilensis Enriched Extract. J Alzheimers Dis. 2012, 31(4):879-89.
Asignacion Academica

UNIVERSIDAD DE CONCEPCION

Chile, 2016

Recognition of scientific productivity and student formation. Periods: 2010 - 2012, 2013 - 2015 and 2016 - 2018.
IUBMB and SBBq Award for best poster

International Union of Biochemistry and Molecular Biology

Brasil, 2015

Poster selected as one of the 50th best of the meeting.


Mechanism-Based Rational Discovery and In Vitro Evaluation of Novel Microtubule Stabilizing Agents with Non-Taxol-Competitive Activity Zuniga-Bustos, Matias; Vasquez, Pilar A.; Jana, Gonzalo A.; Guzman, Jose L.; Alderete, Joel B.; Jimenez, Veronica A. Article ISI JOURNAL OF CHEMICAL INFORMATION AND MODELING (2020)
Modulation of glycine receptor single-channel conductance by intracellular phosphorylation Moraga-Cid G.; San MartÃn V.P.; Lara C.O.; MuÃ±oz B.; Marileo A.M.; Sazo A.; MuÃ±oz-Montesino C.; Fuentealba, J; Castro P.A.; GuzmÃ¡n L.; Burgos C.F.; Zeilhofer H.U.; Aguayo, L. G.; Corringer P.-J.; YÃ©venes G.E. Article ISI SCOPUS SCIENTIFIC REPORTS (2020)
Rational Design and In Vitro Evaluation of Novel Peptides Binding to Neuroligin-1 for Synaptic Targeting Vásquez, Pilar; Vidal, Felipe; Torres, Josefa; Jiménez, Verónica A.; Guzmán, Leonardo Article ISI SCOPUS JOURNAL OF CHEMICAL INFORMATION AND MODELING (2020)
Stereospecific Inhibition of Ethanol Potentiation on Glycine Receptor by M554 Stereoisomers Vásquez, Pilar A.; San Martín, Loreto; Argel, Yenifer; Riquelme, Camila; Torres, Josefa; Vidal, Felipe; Cayuman, Francisca; Castro, Patricio; Fuentealba, Jorge; Moraga-Cid, Gustavo; Yevenes, Gonzalo; Jin, Chunyang; Jiménez, Verónica A.; Guzmán, Leonardo Article Journal of Chemical Information and Modeling (2020)
Visible-light-responsive folate-conjugated titania and alumina nanotubes for photodynamic therapy applications Jimenez, Veronica A.; Moreno, Nicolas; Guzman, Leonardo; Torres, Cecilia C.; Campos, Cristian H.; Alderete, Joel B Article ISI SCOPUS JOURNAL OF MATERIALS SCIENCE (2020)
17 Oxo Sparteine and Lupanine, Obtained from Cytisus scoparius, Exert a Neuroprotection against Soluble Oligomers of Amyloid-beta Toxicity by Nicotinic Acetylcholine Receptors Gavilan, Javiera; Mennickent, Daniela; Ramirez-Molina, Oscar; Trivino, Sergio; Perez, Claudia; Silva-Grecchi, Tiare; Godoy, Pamela A.; Becerra, Jose; Aguayo, Luis G; Moraga-Cid, Gustavo; San Martin, Victoria; Yevenes, Gonzalo E.; Castro, Patricio A.; Guzman, Leonardo; Fuentealba, Jorge Article ISI SCOPUS JOURNAL OF ALZHEIMERS DISEASE (2019)
Inhibitory Actions of Tropeines on the alpha 3 Glycine Receptor Function San Martin, Victoria P.; Burgos, Carlos F.; Marileo, Ana M.; Lara, Cesar O.; Sazo, Anggelo; Fuentealba, Jorge; Guzman, Leonardo; Castro, Patricio A.; Aguayo, Luis G; Moraga-Cid, Gustavo; Yevenes, Gonzalo E. Article ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2019)
Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors Lara, Cesar O.; Burgos, Carlos F.; Silva-Grecchi, Tiare; Munoz-Montesino, Carola; Aguayo, Luis G; Fuentealba, Jorge; Castro, Patricio A.; Guzman, Jose L.; Corringer, Pierre-Jean; Yevenes, Gonzalo E.; Moraga-Cid, Gustavo Article ISI SCOPUS ACS Chemical Neuroscience (2019)
Cytotoxicity and in vivo plasma kinetic behavior of surface-functionalized PAMAM dendrimers Diaz, Carola; Benitez, Carolina; Vidal, Felipe; Barraza, Luis F.; Jiménez, Verónica A.; Guzman, Leonardo; Fuentealba, Jorge; Yevenes, Gonzalo E.; Alderete, Joel B Article ISI SCOPUS NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)
P2X receptor overexpression induced by soluble oligomers of amyloid beta peptide potentiates synaptic failure and neuronal dyshomeostasis in cellular models of Alzheimer's disease Saez-Orellana, F; Fuentes-Fuentes, MC; Godoy, PA; Silva-Grecchi, T; Panes, JD; Guzman, L; Yevenes, GE; Gavilan, J; Egan, TM; Aguayo, LG; Fuentealba, J Article ISI SCOPUS NEUROPHARMACOLOGY (2018)
Partially PEGylated PAMAM dendrimers as solubility enhancers of Silybin Diaz, C; Guzman, J; Jimenez, VA; Alderete, JB Article ISI PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2018)
Polyamido amine (PAMAM)-grafted magnetic nanotubes as emerging platforms for the delivery and sustained release of silibinin Ch?vez, Gloria; Campos, Cristian H.; Jim?nez, Ver?nica A.; Torres, Cecilia C.; D?az, Carola; Salas, Gorka; Guzm?n, Leonardo; Alderete, Joel B. Article ISI SCOPUS JOURNAL OF MATERIALS SCIENCE (2017)
Prevention of Synaptic Alterations and Neurotoxic Effects of PAMAM Dendrimers by Surface Functionalization Vidal, Felipe; Vasquez, Pilar; Cayuman, Francisca R.; Fuentealba, Jorge; Aguayo, Luis G; Yevenes, Gonzalo E.; Alderete, Joel B; Yevenes, Gonzalo E.; Guzmán, Leonardo Article WOS NANOMATERIALS (2017)
ATP leakage induces P2XR activation and contributes to acute synaptic excitotoxicity induced by soluble oligomers of beta-amyloid peptide in hippocampal neurons Saez-Orellana, Francisco; Godoy, Pamela A.; Bastidas, Camila Y.; Silva-Grecchi, Tiare; Guzmán, Leonardo; Aguayo, Luis G; Fuentealba, Jorge Article WOS NEUROPHARMACOLOGY (2016)
ATP leakage induces P2XR activation and contributes to acute synaptic excitotoxiciw induced by soluble oligomers of beta-amyloid peptide in hippocampal neurons Saez-Orellana, F; Godoy PA; Bastidas, CY; Silva-Grecchi, T; Guzman, L; Aguayo, LG; Fuentealba, J Article ISI SCOPUS NEUROPHARMACOLOGY (2016)
Functional modulation of glycine receptors by the alkaloid gelsemine Lara C.O.; Murath P.; Muñoz B.; Marileo A.M.; Martín L.S.; San Martín V.P.; Burgos, C. F.; Mariqueo, T. A.; Aguayo, L. G.; Fuentealba, J; Godoy, P; Guzman, L; Yévenes G.E. Article ISI SCOPUS BRITISH JOURNAL OF PHARMACOLOGY (2016)
Mechanism of PAMAM Dendrimers Internalization in Hippocampal Neurons Vidal, Felipe; V?squez, Pilar; D?az, Carola; Nova, Daniela; Alderete, Joel; Guzm?n, Leonardo Article ISI SCOPUS MOLECULAR PHARMACEUTICS (2016)
PAMAM-Conjugated Alumina Nanotubes as Novel Noncytotoxic Nanocarriers with Enhanced Drug Loading and Releasing Performances Campos, Cristian H.; D?az, Carola F.; Guzm?n, Jos? L.; Alderete, Joel B.; Torres, Cecilia C.; Jim?nez, Ver?nica A. Article ISI SCOPUS MACROMOLECULAR CHEMISTRY AND PHYSICS (2016)
PAMAM-grafted TiO2 nanotubes as novel versatile materials for drug delivery applications Torres C.C.; Campos, C. H.; Díaz, C.; Jiménez V.A.; Vidal F.; Guzman, L; Alderete, J. B. Article ISI SCOPUS MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2016)
Reversal of Ethanol-induced Intoxication by a Novel Modulator of Gbetagamma Protein Potentiation of the Glycine Receptor San Martin, Loreto; Cerda, Fabian; Jin, Chunyang; Jimenez, Veronica A.; Yevenes, Gonzalo E.; Hernandez, Tania; Nova, Daniela; Fuentealba, Jorge; Aguayo, Luis G; Guzmán, Leonardo Article WOS JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Dendrimer nanocarriers drug action: perspective for neuronal pharmacology Vidal F.; Guzman, L Article ISI SCOPUS Neural Regeneration Research (2015)
Evidence for alpha-Helices in the Large Intracellular Domain Mediating Modulation of the alpha 1-Glycine Receptor by Ethanol and G beta gamma Burgos, C. F.; Castro P.A.; Mariqueo T; Bunster, M; Guzman, L; Aguayo, L. G. Article ISI SCOPUS JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2015)
Modulation of Neuronal Nicotinic Receptor by Quinolizidine Alkaloids Causes Neuroprotection on a Cellular Alzheimer Model Araya, Juan A; Ramírez, Alejandra E.; Figueroa-Aroca, Daniela F; Sotes, Gaston J.; Perez, Caudia; Becerra, Jose; Saez-Orellana, Francisco; Guzman, Leonardo; Aguayo, LG; Fuentealba, Jorge P Article ISI SCOPUS JOURNAL OF ALZHEIMERS DISEASE (2014)
Inhibition of the Ethanol-induced Potentiation of alpha 1 Glycine Receptor by a Small Peptide That Interferes with G beta gamma Binding San Martin, L.; Cerda, F; Jimenez, V; Fuentealba, J; Muñoz B.; Aguayo, L. G.; Guzman, L Article ISI SCOPUS Journal of Biological Chemistry (2012)
Inhibition of the ethanol-induced potentiation of alpha1 glycine receptor by small peptide that interferes with G beta gamma San Martin, L.; Cerda, F; Jimenez, V; Fuentealba, J; Muñoz B.; Aguayo, LG; Guzman, L Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Synaptic Silencing and Plasma Membrane Dyshomeostasis Induced by Amyloid-beta Peptide are Prevented by Aristotelia chilensis Enriched Extract Fuentealba, J; Dibarrart A; Saez-Orellana, F; Fuentes-Fuentes M C; Oyanedel, C N; Guzmán J; Pérez, C.; Becerra, J. ; Aguayo, L. G. Article ISI SCOPUS Journal of Alzheimer's Disease (2012)
Inhibitory Activities on Mammalian Central Nervous System Receptors and Computational Studies of Three Sesquiterpene Lactones from Coriaria ruscifolia subsp ruscifolia Pérez, C.; Becerra, J. ; Manriquez-Navarro, P; Silva M.; Aguayo, L. G.; Fuentealba, J; Guzmán J.L.; Joseph-Nathan, P; Jimenez, V; Muñoz M.A. Article ISI SCOPUS Chemical and Pharmaceutical Bulletin (2011)
Potentiation and inhibition of glycine receptors by tutin Fuentealba, J; Muñoz B.; Yevenes, G; Moraga-Cid, G; Guzman, L; Aguayo, L. G.; Pérez, C.; Rigo J.M. Article ISI SCOPUS Neuropharmacology (2011)
Synaptic Failure and Adenosine Triphosphate Imbalance Induced by Amyloid-beta Aggregates Are Prevented by Blueberry-Enriched Polyphenols Extract Fuentealba, J; Dibarrart, AJ; Fuentes-Fuentes, MC; Saez-Orellana, F; Quinones, K; Guzman, L; Pérez, C.; Becerra, J. ; Aguayo, LG Article ISI SCOPUS Journal of Neuroscience Research (2011)
Molecular Requirements for Ethanol Differential Allosteric Modulation of Glycine Receptors Based on Selective G beta gamma Modulation Yevenes, GE; Moraga-Cid, G; Avila, A; Guzman, L; Figueroa, M; Peoples, RW; Aguayo, LG Article ISI SCOPUS Journal of Biological Chemistry (2010)
Blockade of Ethanol-Induced Potentiation of Glycine Receptors by a Peptide That Interferes with GB gamma Binding Guzman, L; Moraga-Cid, G; Avila, A; Figueroa, M; Yevenes, GE; Fuentealba, J; Aguayo, LG Article ISI SCOPUS JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
Inhibitory effects of tutin on glycine receptors in spinal neurons Fuentealba, J; Guzman, L; Manriquez-Navarro, P; Pérez, C.; Silva M.; Becerra, J. ; Aguayo, LG Article ISI SCOPUS EUROPEAN JOURNAL OF PHARMACOLOGY (2007)
Molecular determinants for G protein beta gamma modulation of ionotropic glycine receptors Yevenes, GE; Moraga-Cid, G; Guzman, L; Haeger, S; Oliveira L.; Olate, J; Schmalzing, G; Aguayo, LG Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
A g beta gamma stimulated adenylyl cyclase is involved in Xenopus laevis oocyte maturation Guzman, L; Romo, X.; Grandy, R; Soto, X; Montecino, M.; Hinrichs, M; Olate, J Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2005)
Human brain synembryn interacts with Gs alpha and Gq alpha and is translocated to the plasma membrane in response to isoproterenol and carbachol Klattenhoff, C; Montecino, M.; Soto, X; Guzman, L; Romo, X.; Garcia, MD; Mellstrom, B; Naranjo, JR; Hinrichs, MV; Olate, J Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2003)
(SN)-N-111 mutation in the helical domain of human Gs alpha reduces its GDP/GTP exchange rate Brito M.; Guzman, L; Romo, X.; Soto, X; Hinrichs, MV; Olate, J Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2002)
G alpha s levels regulate Xenopus laevis oocyte maturation Romo, X.; Hinrichs, MV; Guzman, L; Olate, J Article ISI SCOPUS MOLECULAR REPRODUCTION AND DEVELOPMENT (2002)
The C 2 cytosolic loop of adenylyl cyclase interacts with the activated form of G?s Torrejón M.; Echeverria, V; Guzman, L; Hinrichs M.V.; Geneviere A.-M.; Olate, J Article FEBS LETTERS (1998)
Chemical modification of Genypterus maculatus arginase by Woodward's reagent K and diethyl pyrocarbonate: Evidence for an essential carboxylate and a nonessential, albeit important histidine residue Carvajal N.; Uribe, E; López, V.; Salas, M; Muller, D; Celis, R.; Guzmán J Article COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY MOLECULAR BIOLOGY (1997)
ELECTROPHORETIC PATTERNS OF LIPOPOLYSACCHARIDE OF ACINETOBACTER BAUMANNII FROM DIFFERENT SOURCES Zemelman Raul; Guzmán J; Gonzalez G. ; García, Apolinaria; Dominguez M.; Bello, H. Article BIOMEDICAL LETTERS (1996)


CONTROL OF GAIN AND LOSS OF ETHANOL ALLOSTERIC POTENTIATION BY RESIDUES WITHIN THE GLYCINE RECEPTOR Aguayo, LG; Yevenes, GE; Moraga-Cid, G; Avila, A; Guzman, L; Figueroa, M; Peoples, RW Abstract Alcoholism Clinical and Experimental Research (2010)
The Gq alpha signaling pathway antagonizes Wnt8 induced-dorsalization in early embryonic development of Xenopus laevis. Soto, X; Hinrichs, MV; Guzman, L; Olate, J Abstract MOLECULAR BIOLOGY OF THE CELL (2004)
Functional characterization of Xenopus laevis oocyte adenylyl cyclases Hinrichs, M; Guzman, L; Romo, X.; Olate, J Abstract MOLECULAR BIOLOGY OF THE CELL (2002)
The (SN)-N-96 mutation in the helical domain of human gas affects its GDP/GTP exchange rate Olate, JA; Brito M.; Guzman, L; Romo, X.; Soto, X; Hinrichs, V Abstract MOLECULAR BIOLOGY OF THE CELL (2001)


Mecanismos celulares de internalización de dendrímeros PAMAM Guzmán, L. ConferencePoster (2016)
Design of Small molecules to inhibit the ethanol potentiation of Glycine receptor. In vivo evidences Guzman, L. ConferencePoster (2015)
Drug delivery from structured Al2O3/NT funcionalizated with PAMAM dendrimer. C.C.Torres, C.H."Campos, J. Alderete, F.A. Vidal and J.L. Guzmán ConferencePoster (2015)
Inhibition of etanol potentiation of glycine receptor by small molecules. In vitro and in vivo studies Guzmán, L. ConferencePoster (2015)
PAMAM dendrimer functionalized TiO2 nanotubes as novel versatile platform for drug delivery . Joel Alderete, Cecilia Carolina Torres, Cristian Hugo Campos, Carola Fernanda Díaz, Felipe Andres Vidal, Jose Leonardo Guzman ConferencePoster (2015)
Study of celular internalization mechanism of polyamidoamine dendrimers drug nanocarriers. Vidal, F., Vasquez, P., Soto, R., Diaz, C., Alderete, J., Guzman, L ConferencePoster (2015)
Inhibición de la potenciación inducida por etanol del receptor de glicina por moléculas pequeñas que se unen a Gbeta gamma San Martín, L.S, Cerda, F.E., Jin, C., Aguayo, L.G., Fuentealba, J., Guzmán, L. ConferencePoster (2014)
Small molecules that inhibits ethanol potentiation of glycine receptors Guzman, L. ConferencePoster (2014)
Inhibition of the Ethanol-induced Potentiation of Glycine Receptor by Small Peptides and Molecules That Interfere with Gbeta gamma Binding. San Martín, L.; Cerda, F.; Sanchez, A.; Aguayo, L.; Guzmán, L. ConferencePoster (2013)
Small molecules that inhibit ethanol potentiation of glycine receptors Guzman, L. ConferencePoster (2013)


Moléculas que interaccionan con la proteína G con efecto inhibidor sobre la potenciación del etanol sobre el receptor de glicina en el sistema nervioso central Guzmán, L.; Aguayo, L.; Jiménez, V.; San Martín, L.; Cerda, F.; Chunyang, J.; Nova, D.; González, D.; Fuentealba, J. Patent
Moléculas que interaccionan con la proteína G, obstaculizando los efectos de etanol a nivel molecular en el sistema nervioso central Guzmán, L.; Aguayo, L.; Jiménez, V.; San Martín, L.; Cerda, F.; Chunyang, J.; Nova, D.; González, D.; Fuentealba, J Patent


Natural Halloysite nanotubes-based composites for biomedical and catalytic applications Campos, Cristian; Guzman, Jose Leonardo Proyecto (2023)
Design of multifunctional nanoplatforms with potential applications in combination cancer therapy Alderete, Joel; Guzman, Jose Leonardo Proyecto (2022)
Rational design and in vitro evaluation of novel microtubule-stabilizing peptides with potential neuroprotective activity Jimenez Verónica; Guzman, Jose Leonardo Proyecto (2020)
Rational design of bioisosteric derivatives of lead compounds that inhibit the ethanol effects on glycine receptor Leonardo Guzman; Jimenez, Veronica A.; Aguayo, Luis Gerardo Proyecto (2017)
Desarrollo y Caracterización de Moléculas con Utilidad Clínica en Intoxicación Aguda con Etanol Guzman, Leonardo; Aguayo, Luis; Fuentealba, Jorge Proyecto (0)
Determination of the contact surface between G beta gamma and glycine receptor cytoplasmic domain Guzman, Leonardo Proyecto (0)
G beta gamma binding peptides that inhibit the ethanol potentiation of glycine receptor activity Guzman, Leonardo; Fuentealba, Jorge Proyecto (0)
Plan de Mejoramiento Institucional UCO1311 del Doctorado en Ciencias Biologicas area Biologia Celular y Molecular Guzman, L Proyecto (0)
Potentiation of Glycine Receptors by Ethanol Aguayo, L; Guzman, L Proyecto (0)
Rational design of bioisosteric derivatives of lead compounds that inhibits the ethanol effects on glycine receptor. Guzman, Leonardo; Jimenez, Veronica; Aguayo, Luis Proyecto (0)


Ethanol effects on glycinergic transmission: From molecular pharmacology to behavior responses Burgos, CF; Muñoz B.; Guzman, L; Aguayo, LG Review ISI SCOPUS Pharmacological Research (2015)
Historical and current perspectives of neuroactive compounds derived from Latin America Aguayo, LG; Guzman, L; Pérez, C.; Aguayo, LJ; Silva M.; Becerra, J. ; Fuentealba, J Review ISI MINI-REVIEWS IN MEDICINAL CHEMISTRY (2006)

JOSE GUZMAN

Full professor

Fisiología

Universidad de Concepción

Concepcion, Chile

JORGE FUENTEALBA

Dean

Physiology

UNIVERISDAD DE CONCEPCION

Concepcion, Chile

Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

Veronica Jimenez

Assistant Professor

Chemistry

Universidad Andres Bello

Talcahuano, Chile

Gonzalo Yévenes

Associate Professor

Universidad de Concepcion

Concepcion, Chile

Claudia Perez

Academic

Botany

University of Concepción

Concepción, Chile

Carola Díaz

Investigadora Fondecyt Postdoctoral

Departamento de Química

Universidad Andrés Bello

Talcahuano, Chile

JOSE BECERRA

Professor

Botany Department

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Gustavo Moraga

Profesor Asistente

Departamento de Fisiología

Universidad De Concepción

Concepción, Chile

Carlos Burgos

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

Joel Alderete

Full Professor

Universidad de Talca

Talca, Chile

Patricio Castro

profesor asistente

fisiologia

UNIVERSIDAD Concepcion

concepcion, Chile

Mario Silva

Emeritus Professor

Botany Department

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

Francisco Sáez

Investigador asistente

Fisiología

Universidad de Concepción

Concepción, Chile

Cristian Campos

Associate Professor

Físico-Química

Universidad de Concepción

Concepcion, Chile

Cecilia Torres

Profesor Asistente

Ciencias Químicas

UNIVERSIDAD ANDRES BELLO

Talcahuano, Chile

Ana Marileo

Tesista de Doctorado

De Fisiología

Universidad de Concepción

Concepción, Chile

Pamela Godoy

Colaboradora académica

Fisiología

Universidad de Concepción

Concepcion, Chile

Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Maximiliano Figueroa

Profesor Asociado

Bioquímica y Biología Molecular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Loreto San Martín

Victoria San Martín

Tesista Doctorado

Fisiologia

Universidad de Concepción

Concepción, Chile

Maximiliano Figueroa

Assstant Professor

Universidad de Concepción

Concepción, Chile

Trinidad Mariqueo

Profesor Conferenciante

Escuela de Medicina

Universidad de Talca

Talca, Chile

JAVIERA GAVILAN

Estudiante de Doctorado

Fisiología

Universidad de Concepción

Concepcion, Chile

Camila Bastidas

Docente

Universidad de Concepción

Concepción, Chile

Patricio Godoy

Group leader

System sToxicology

Leibniz Research Centre for Working Environment and Human Factors at the TU Dortmund

Dortmund, Alemania

Luis Barraza

ACADEMICO-INVESTIGADOR

DEPARTAMENTO DE CIENCIAS QUIMICAS

UNIVERSIDAD DE ANDRES BELLO

Concepción, Chile

Marta Cecilia Bunster

DIRECTORA

Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Pablo Murath

PhDc y COLABORADOR ACADÉMICO

CIENCIA Y TECNOLOGÍA DE LOS ALIMENTOS

UNIVERSIDAD DE CONCEPCIÓN

Concepción , Chile

María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Oscar Ramírez

PhD Candidate

Fisiología

Universidad de Concepción

Concepción, Chile

Raúl Zemelman

Investigador

Universidad Arturo Prat

Talcahuano, Chile

Carlos Oyanedel

Research Assistant

Institute of Medical Psychology and Behavioral Neurobiology

Eberhard Karl University of Tübingen

Tübingen, Alemania

Juan Araya

Instructor

Análisis Instrumental

Universidad de Concepción

Concepción, Chile

Apolinaria García

Investigador

Microbiology

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Marcelo Muñoz

Profesor Auxiliar

Instituto de Ciencias Químicas

Universidad Austral de Chile

Valdivia, Chile

Tiare Silva-Grecchi

Jessica Panes

Alumna de Doctorado

Fisiología

Universidad de Concepción

Concepcion, Chile

Carola Muñoz

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

Matías Zúñiga

Postdoctorado

Centro de Bioinformática y Simulación Molecular

Universidad de Talca

TALCA, Chile

Daniela Mennickent

Académica

Departamento de Ciencias Básicas

Universidad Católica de la Santísima Concepción

Concepción, Chile

JOSE LEONARDO GUZMAN GONZALEZ

Líneas de Investigación

Educación

Cellular and Molecular Biology, UNIVERSIDAD DE CONCEPCION. Chile, 2005

Biochemist, UNIVERSIDAD DE CONCEPCION. Chile, 1998

Experiencia Académica

Full Professor Full Time

Subdirector de Postgrado Other

Director de Departamento Part Time

Director de Programa de Doctorado Part Time

Experiencia Profesional

Postdoctoral Full Time

Formación de Capital Humano

Premios y Distinciones

Premio Henri Nestle

Premio Henri Nestle

Asignacion Academica

IUBMB and SBBq Award for best poster

Article (40)

Abstract (4)

ConferencePoster (10)

Patent (2)

Proyecto (10)

Review (2)