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Jorge Andrés Soto Delgado

Profesor Asistente

Universidad Andrés Bello

Viña del Mar, Chile

Quimica Medicinal, Quimica Computacional, Diseño de Farmacos Asistido por Computador, Sintesis Organica

Quimica , UNIVERSIDAD DE CHILE. Chile, 2006
Quimica , UNIVERSIDAD DE CHILE. Chile, 2011

Post-Doctorado Other

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Facultad de Quimica

Santiago, Chile

2012 - 2014
Post-Doctorado Full Time

NÚCLEO MILENIO CENTRO INTERDISCIPLINARIO DE LÍQUIDOS IÓNICOS - CILIS

Santiago, Chile

2011 - 2011

Profesor Asistente Full Time

Universidad Andres Bello

Viña del Mar, Chile

2014 - A la fecha

- Claudio Aurelio Godoy Castillo, Memoria de Título para la obtención del título de Químico Farmacéutico (2020): Titulo: “Síntesis química y evaluación in vitro del efecto citotóxico de derivados 2-bencil-1,4-naftoquinona diseñados como inhibidores farmacológicos de la proteína chaperona Hsp90a”
- Nicolás Benjamín Bravo Acuña, Memoria de Título para la obtención del título de Ingeniero en Biotecnología (2020) “Estudio estructural y energético de la inhibición selectiva de Grp94. diseño racional de antitumorales contra cáncer de mama”
- Stefano Franco Simonetti Macaya Memoria de Título para la obtención del título de Ingeniero en Biotecnología (2020) “Síntesis y evaluación antitumoral de moléculas hibridas feniltiazolo-naftoquinona como inhibidores de hsp90”
- Jorge González Higueras, Programa Magister en Ciencias Mención Química, Universidad Técnica Federico Santa María. (2018) Titulo: “Estudio estructural de la interacción de inhibidores naftoquinonicos con HDAC6 y Hsp90, para el diseño de drogas multitarget.”


New benzimidazolequinones as trypanosomicidal agents Lopez-Lira, C; Tapia, R.A.; Herrera, A; Lapier, M.; Maya, JD; Soto-Delgado, J; Oliver, A.G.; Lappin A.G.; Uriarte, E Article BIOORGANIC CHEMISTRY (2021)
Identification of the naphthoquinone derivative inhibitors binding site in heat shock protein 90: an induced-fit docking, molecular dynamics and 3D-QSAR study Godoy-Castillo, Claudio; Bravo-Acuna, Nicolas; Arriagada, Gloria; Faunes, Fernando; Leon, Roberto; Soto-Delgado, Jorge Article ISI JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2020)
Experimental and Theoretical Approaches in the Study of Phenanthroline-Tetrahydroquinolines for Alzheimer's Disease Duarte, Yorley; Gutierrez, Margarita; Álvarez, Rocío; Alzate?Morales, Jans H.; Soto?Delgado, Jorge Article ISI SCOPUS CHEMISTRYOPEN (2019)
Ion-Ion Repulsions and Charge-Shielding Effects Dominate the Permeation Mechanism through the OmpF Porin Channel Ahumada, JC; Aleman, C; Soto-Delgado, J; Torras, J Article ISI SCOPUS JOURNAL OF PHYSICAL CHEMISTRY B (2019)
State of the art of Smo antagonists for cancer therapy: advances in the target receptor and new ligand structures Espinosa-Bustos, Christian; Mella, Jaime; Soto-Delgado, Jorge; Salas, Cristian O Article ISI SCOPUS FUTURE MEDICINAL CHEMISTRY (2019)
Combined molecular modelling and 3D-QSAR study for understanding the inhibition of NQO1 by heterocyclic quinone derivatives Lopez-Lira, C; Alzate-Morales, JH; Paulino, M; Mella-Raipan, J; Salas, CO; Tapia, RA; Soto-Delgado, J Article ISI SCOPUS CHEMICAL BIOLOGY & DRUG DESIGN (2018)
Influence of structural changes on photophysical properties of terpyridine derivates: Experimental studies and theoretical calculations toledo, d; Brovelli, F; Soto-Delgado, J; Pena, O; Pivan, JY; Moreno, Y Article ISI SCOPUS JOURNAL OF MOLECULAR STRUCTURE (2018)
Structure-Activity Relationships Based on 3D-QSAR CoMFA/CoMSIA and Design of Aryloxypropanol-Amine Agonists with Selectivity for the Human 3-Adrenergic Receptor and Anti-Obesity and Anti-Diabetic Profiles Lorca M.; Morales-Verdejo, C; Vasquez-Velasquez, D; Andrades-Lagos, J; Campanini-Salinas, J; Soto-Delgado, J; Recabarren-Gajardo, G; Mella, J Article ISI SCOPUS MOLECULES (2018)
2D-QSAR and 3D-QSAR/CoMSIA Studies on a Series of (R)-2-((2-(1H-Indol-2-yl)ethyl)amino)-1-Phenylethan-1-ol with Human beta(3)-Adrenergic Activity Apablaza, Gastón; Montoya, Luisa; Morales-Verdejo, Cesar; Mellado, Marco; Cuellar, Mauricio; Lagos, Carlos; Soto-Delgado, Jorge; Chung, Hery; Pessoa-Mahana, Carlos; Mella, Jaime Article ISI SCOPUS MOLECULES (2017)
Structural analysis and molecular docking of trypanocidal aryloxy-quinones in trypanothione and glutathione reductases: a comparison with biochemical data Vera, Brenda; Vazquez, Karina; Tapia, Ricardo A.; Mascayano, Carolina; Espinosa, Victoria; Soto-Delgado, Jorge; Salas, Cristian O.; Paulino, Margot Article ISI SCOPUS JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2017)
Multiscale Treatment for the Molecular Mechanism of a Diels-Alder Reaction in Solution: A QM/MM-MD Study Soto-Delgado, J; Tapia, RA; Torras, J Article ISI SCOPUS JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2016)
Structural, electrochemical and theoretical study of a new chalcone derivative containing 3-thiophene rings Baggio R.; Brovelli F.; Moreno Y.; Pinto, M; Soto-Delgado, J Article ISI SCOPUS JOURNAL OF MOLECULAR STRUCTURE (2016)
Examining the compatibility of collagen and a polythiophene derivative for the preparation of bioactive platforms Soto-Delgado, J; Torras, J; Del Valle L.J.; Estrany F.; Aleman, C Article ISI SCOPUS JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING (2015)
New aryloxy-quinone derivatives as potential antiChagasic agents: synthesis, trypanosomicidal activity, electrochemical properties, pharmacophore elucidation and 3D-QSAR analysis Vazquez, K; Espinosa-Bustos, C; Soto-Delgado, J; Tapia, RA; Varela, J; Birriel, E; Segura, R; Pizarro J.; Cerecetto, H.; Gonzalez, M.; Paulino M.; Salas, CO Article ISI SCOPUS JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING (2015)
Synthesis and biological characterization of new aryloxyindole-4,9-diones as potent trypanosomicidal agents Tapia, RA; Salas, CO; Vazquez, K; Espinosa-Bustos, C; Soto-Delgado, J; Varela, J; Birriel, E; Cerecetto, H.; Gonzalez, M.; Paulino M. Article ISI SCOPUS BIOORGANIC MEDICINAL CHEMISTRY LETTERS (2014)
On the mechanism of biological activity of hydroquinone derivatives that inhibit tumor cell respiration. A theoretical study Soto-Delgado, J; Bahamonde-Padilla, V; Araya-Maturana, R; Weiss-Lopez, BE Article ISI SCOPUS Computational and Theoretical Chemistry (2013)
Theoretical study on the molecular mechanism of the [5+2] vs. [4+2] cyclization mediated by Lewis acid in the quinone system Soto-Delgado, J; Saez, JA; Tapia, RA; Domingo, LR Article ISI SCOPUS ORGANIC AND BIOMOLECULAR CHEMISTRY (2013)
Bond Fukui Functions As Descriptor of the Electron Density Reorganization in pi Conjugated Systems Gonzalez-Suarez, M; Aizman A.; Soto-Delgado, J; Contreras R. Article ISI SCOPUS Journal of Organic Chemistry (2012)
LOCATION, ORIENTATION AND DYNAMICS OF TWO MOLECULES WITH MITOCHONDRIAL ACTIVITY DISSOLVED IN ANIONIC LYOMESOPHASE: A ²H-NMR AND MD STUDY BAHAMONDE-PADILLA, VÍCTOR E; MARTINEZ-CIFUENTES, MAXIMILIANO; MUÑOZ-MASSON, DANIEL; Ruiz, Alvaro; Ahumada, Hernan; Araya-Maturana, Ramiro; Soto?Delgado, Jorge; WEISS-LÓPEZ, BORIS E Article SCIELO Journal of the Chilean Chemical Society (2012)
On the Catalytic Effect of Water in the Intramolecular Diels-Alder Reaction of Quinone Systems: A Theoretical Study Jorge S.-D.; Aizman A.; Contreras R.; Domingo, L.R. Article ISI SCOPUS MOLECULES (2012)
STRUCTURAL REASSIGNMENT OF EPIERYTHRATIDINE, AN ALKALOID FROM Erythrinafusca, BASED ON NMR STUDIES AND COMPUTATIONAL METHODS Garcia-Beltrán, Olimpo; Soto?Delgado, Jorge; Iturriaga-Vásquez, Patricio; Areche, Carlos; Cassels, Bruce K. Article SCIELO Journal of the Chilean Chemical Society (2012)
A DFT Study of the Regioselectivity in Intramolecular Diels-Alder Reactions with Formation of a Tricyclodecane Skeleton Soto-Delgado, J; Aizman A.; Contreras R.; Domingo, LR Article ISI SCOPUS Letters in Organic Chemistry (2011)
Biotransformation of Stypotriol triacetate by Aspergillus niger Areche, C; Vaca I.; Labbé P.; Soto-Delgado, J; Astudillo, L; Silva M.; Rovirosa, J; San Martin, A Article ISI SCOPUS Journal of Molecular Structure (2011)
Invariance of electrophilicity of independent fragments. Application to intramolecular Diels-Alder reactions Soto-Delgado, J; Aizman A.; Domingo, LR; Contreras R. Article ISI SCOPUS Chemical Physics Letters (2010)
Quantitative characterization of group electrophilicity and nucleophilicity for intramolecular Diels-Alder reactions Soto-Delgado, J; Domingo, LR; Contreras R. Article ISI SCOPUS ORGANIC AND BIOMOLECULAR CHEMISTRY (2010)
An unusual halogenated meroditerpenoid from Stypopodium flabelliforme: Studies by NMR spectroscopic and computational methods Areche, C; San Martin, A; Rovirosa, J; Soto-Delgado, J; Contreras R. Article ISI SCOPUS PHYTOCHEMISTRY (2009)
Understanding the influence of Lewis acids in the regioselectivity of the Diels-Alder reactions of 2-methoxy-5-methyl-1,4-benzoquinone: A DFT study Soto-Delgado, J; Domingo, LR; Contreras R. Article ISI SCOPUS JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM (2009)
Understanding the stereo- and regioselectivities of the polar Diels-Alder reactions between 2-acetyl-1,4-benzoquinone and methyl substituted 1,3-butadienes: a DFT study Soto-Delgado, J; Domingo, LR; Araya-Maturana, R; Contreras R. Article ISI SCOPUS JOURNAL OF PHYSICAL ORGANIC CHEMISTRY (2009)
Antioxidant properties and free radical-scavenging reactivity of a family of hydroxynaphthalenones and dihydroxyanthracenones Rodriguez J.; Olea Azar C.; Cavieres, C; Norambuena E.; Delgado-Castro, T; Soto-Delgado, J; Araya-Maturana, R Article ISI SCOPUS BIOORGANIC & MEDICINAL CHEMISTRY (2007)
Effects of 9,10-dihydroxy-4,4-dimethyl-5,8-dihydro-1(4H)-anthracenone derivatives on tumor cell respiration Araya-Maturana, R; Cardona W.; CASSELS, BK; Delgado-Castro, T; Ferreira J.; Miranda D.; Pavani, M.; Pessoa-Mahana H.; Soto-Delgado, J; Weiss-Lopez, B Article ISI SCOPUS BIOORGANIC & MEDICINAL CHEMISTRY (2006)
Synthesis of 9-and 10-membered macrolactones by selective ozonolysis of 1,4-diazaphenanthrene derivatives Perez-Sacau, E; Soto-Delgado, J; Estevez-Braun, A; Ravelo, AG Article ISI TETRAHEDRON (2005)


Núcleo Interdisciplinario para desarrollo de Fármacos=> Diseño computacional, síntesis y evaluación biológica de antitumorales inhibidores de HSP90 Universidad Andres Bello (DI-37-18/N) Proyecto 2018-2022 Inv. Responsable
Antioxidant Chilean Plants as possible gastroprotective agents FONDECYT (1170871) Proyecto 2017-2019 Coinvestigador(a)
Diseño y Síntesis de Arilnaftoquinonas heterocíclicas con potencial actividad antitumoral Universidad Andrés Bello (DI-1292-16/R) Proyecto 2016-2017 Inv. Responsable
BENZIMIDAZOLEQUINONES AND BIOISOSTERES AS ANTI-CHAGASIC AGENT=> TRYPANOCIDAL EFFECT, SELECTIVITY AND 3D-QSAR STUDIES FONDECYT (1150307) Proyecto 2015-2018 Coinvestigador(a)
DEVELOPMENT OF NEW MOLECULES HSP90 INHIBITORS=> COMPUTATIONAL DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION FONDECYT (11150988) Proyecto 2015-2017 Inv. Principal
THEORETICAL STUDY OF THE HETERO-DIELS-ALDER REACTIONS IN DIFFERENT REACTIONS MEDIA FONDECYT (3130359) Proyecto 2012-2015 Inv. Responsable

Jorge Soto

Profesor Asistente

Departamento de Ciencias Quimicas

Universidad Andrés Bello

Viña del Mar, Chile

Renato Contreras

professor

Quimica

Universidad de Chile

Santiago, Chile

Ramiro Araya Maturana

Profesor Titular

Universidad de Talca

SantiaTalcago, Chile

JAIME MELLA

PROFESOR ADJUNTO

INSTITUTO DE QUIMICA Y BIOQUIMICA

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

Ricardo Tapia

Full Professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Juana Rovirosa

Professor Ad. Honorem

Ciencias

Facultad de Ciencias y Recursos Naturales

Punta Arenas, Chile

Carlos Areche

ASSOCIATE PROFESSOR

CHEMISTRY

UNIVERSIDAD DE CHILE

Santiago, Chile

Cristian Salas

Associate professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Inmaculada Vaca

Associate Professor

Chemistry Department

UNIVERSIDAD DE CHILE

Santiago, Chile

Jans Alzate

Associate Professor

Departamento de Bioinformática

UNIVERSIDAD DE TALCA

Talca, Chile

AURELIO SAN MARTIN

Profesor Asociado (media jornada)

de Ciencias y Recursos Naturales

FACULTAD DE CIENCIAS

Punta Arenas, Chile

Wilson Cardona

Chemistry Department Area Coordinator

Chemistry

Universidad Andrés Bello

Talcahuano, Chile

Mario Silva

Emeritus Professor

Botany Department

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

Cesar Morales

Associate Professor

Universidad Bernardo O'Higgins

Santiago, Chile

Jaime Pizarro

Postdoctorando

Química de los Materiales

Universidad de Santiago de Chile

Santiago, Chile

José González

Director

Ciencias Físicas

Universidad Andres Bello

Santiago, Chile

RODRIGO SEGURA

Academico

DEPARTAMENTO DE QUIMICA DE LOS MATERIALES

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Mauricio Cuellar

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

Gonzalo Recabarren

Académico

Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Dominique Toledo

claudio olea

Full Professor

Inorganica y Analitica

UNIVERSIDAD DE CHILE

Santiago, Chile

YORLEY DUARTE

profesor Asistente

Universidad Andrés Bello

Santiago, Chile

Bruce Cassels

Profesor Titular

Departamento de Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA

Santiago, Chile

Carlos Pessoa

Profesor Titular

Departamento de Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Marco Mellado

Profesor / Investigador

Facultad de Medicina y Ciencias de la Salud

Universidad Central de Chile

Santiago, Chile

Claudia López

Investigador Asociado

Food Science and Technology

The Ohio State University

Columbus, Estados Unidos

Gloria Arriagada

Profesor Asociado-Investigador Principal

Instituto de Ciencias Biomédicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

ROBERTO LEON

Academic

Computer Science

Universidad Técnica Federico Santa María

Santiago, Chile

Jorge Rodriguez

Professor

Department of Chemistry

UNIVERSIDAD METROPOLITANA DE CIENCIAS DE LA EDUCACIÓN

La Florida, Chile

Dante Miranda

Director de Extensión

Bioquímica y Biología Molecular

Universidad de Chile, Faculatd de Ciencias Químicas y Farmacéuticas

Santiago, Chile

Jorge Andrés Soto Delgado

Líneas de Investigación

Educación

Quimica , UNIVERSIDAD DE CHILE. Chile, 2006

Quimica , UNIVERSIDAD DE CHILE. Chile, 2011

Experiencia Académica

Post-Doctorado Other

Post-Doctorado Full Time

Experiencia Profesional

Profesor Asistente Full Time

Formación de Capital Humano

Article (31)

Proyecto (6)

Núcleo Interdisciplinario para desarrollo de Fármacos=> Diseño computacional, síntesis y evaluación biológica de antitumorales inhibidores de HSP90

Antioxidant Chilean Plants as possible gastroprotective agents

Diseño y Síntesis de Arilnaftoquinonas heterocíclicas con potencial actividad antitumoral

BENZIMIDAZOLEQUINONES AND BIOISOSTERES AS ANTI-CHAGASIC AGENT=> TRYPANOCIDAL EFFECT, SELECTIVITY AND 3D-QSAR STUDIES

DEVELOPMENT OF NEW MOLECULES HSP90 INHIBITORS=> COMPUTATIONAL DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION

THEORETICAL STUDY OF THE HETERO-DIELS-ALDER REACTIONS IN DIFFERENT REACTIONS MEDIA